Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ESAM Gene

Aliases for ESAM Gene

  • Endothelial Cell Adhesion Molecule 2 3 5
  • Endothelial Cell-Selective Adhesion Molecule 3
  • HUEL (C4orf1)-Interacting Protein 3
  • LP4791 Protein 3
  • 2310008D05Rik 3
  • W117m 3

External Ids for ESAM Gene

Previous GeneCards Identifiers for ESAM Gene

  • GC11M126623
  • GC11M126136
  • GC11M124656
  • GC11M124160
  • GC11M124128
  • GC11M124622
  • GC11M120565

Summaries for ESAM Gene

GeneCards Summary for ESAM Gene

ESAM (Endothelial Cell Adhesion Molecule) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is IGSF11.

UniProtKB/Swiss-Prot for ESAM Gene

  • Can mediate aggregation most likely through a homophilic molecular interaction.

Gene Wiki entry for ESAM Gene

Additional gene information for ESAM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ESAM Gene

Genomics for ESAM Gene

GeneHancer (GH) Regulatory Elements for ESAM Gene

Promoters and enhancers for ESAM Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124757 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 663.3 +1.2 1190 6.4 HDGF ATF1 ZFP64 ARID4B SIN3A ZNF2 ZNF48 YY1 ETS1 SLC30A9 ESAM ROBO4 VSIG2 SPA17 NRGN GC11P124760 LOC101929340
GH11J124717 Enhancer 1.3 FANTOM5 Ensembl ENCODE 15.2 +44.4 44392 1.3 KLF17 MZF1 FEZF1 BATF IRF4 ZNF335 GLIS2 ZNF366 SCRT2 ATF7 SPA17 ESAM NRGN ENSG00000255045 VSIG2 SIAE LOC101929340 ROBO3 ROBO4 GC11P124740
GH11J124836 Enhancer 0.9 Ensembl ENCODE 11 -74.8 -74752 2 CTCF ZSCAN4 ERF ZNF384 KLF14 BATF RAD21 ZNF335 ZFHX2 VEZF1 ROBO3 LOC100507283 MSANTD2 SIAE SPA17 ESAM LOC101929340 VSIG2 ENSG00000255045 NRGN
GH11J124793 Enhancer 0.6 ENCODE 11.7 -31.5 -31533 0.2 CTCF PKNOX1 ZNF654 NR2F1 TRIM22 ZNF384 EP300 RAD21 KLF16 SCRT2 ENSG00000279342 LOC101929340 ESAM VSIG2 ENSG00000255045 SIAE SPA17 NRGN ROBO3 LOC100507283
GH11J124768 Enhancer 0.9 ENCODE dbSUPER 0.4 -8.3 -8285 3.3 JUN ZNF384 TEAD3 FOSL1 ZFHX2 ZNF316 EGR1 FOSL2 FOS EGR2 NRGN SIAE SPA17 LOC100507283 MSANTD2 ROBO3 VSIG2 ESAM ENSG00000254509
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ESAM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ESAM gene promoter:
  • Tal-1beta
  • ITF-2
  • Nkx2-5
  • POU3F1
  • STAT5A
  • En-1
  • ZID
  • POU3F2
  • Nkx5-1
  • Roaz

Genomic Locations for ESAM Gene

Genomic Locations for ESAM Gene
9,745 bases
Minus strand
10,198 bases
Minus strand

Genomic View for ESAM Gene

Genes around ESAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ESAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ESAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ESAM Gene

Proteins for ESAM Gene

  • Protein details for ESAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endothelial cell-selective adhesion molecule
    Protein Accession:
    Secondary Accessions:
    • B4DVN8
    • Q96T50

    Protein attributes for ESAM Gene

    390 amino acids
    Molecular mass:
    41176 Da
    Quaternary structure:
    • Interacts with BAIAP1.

    Alternative splice isoforms for ESAM Gene


neXtProt entry for ESAM Gene

Post-translational modifications for ESAM Gene

  • Glycosylation at Asn236, isoforms=2213, isoforms=169, and isoforms=108
  • Modification sites at PhosphoSitePlus

Other Protein References for ESAM Gene

No data available for DME Specific Peptides for ESAM Gene

Domains & Families for ESAM Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ESAM: view

No data available for UniProtKB/Swiss-Prot for ESAM Gene

Function for ESAM Gene

Molecular function for ESAM Gene

UniProtKB/Swiss-Prot Function:
Can mediate aggregation most likely through a homophilic molecular interaction.
genes like me logo Genes that share phenotypes with ESAM: view

Animal Models for ESAM Gene

MGI Knock Outs for ESAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for ESAM

miRNA for ESAM Gene

miRTarBase miRNAs that target ESAM

Clone Products

  • Addgene plasmids for ESAM

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ESAM Gene

Localization for ESAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ESAM Gene

Cell junction, adherens junction. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ESAM gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005912 adherens junction IEA --
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ESAM: view

Pathways & Interactions for ESAM Gene

genes like me logo Genes that share pathways with ESAM: view

Pathways by source for ESAM Gene

Interacting Proteins for ESAM Gene

Gene Ontology (GO) - Biological Process for ESAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0050900 leukocyte migration TAS --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ESAM: view

No data available for SIGNOR curated interactions for ESAM Gene

Drugs & Compounds for ESAM Gene

No Compound Related Data Available

Transcripts for ESAM Gene

mRNA/cDNA for ESAM Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(318) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ESAM Gene

Endothelial cell adhesion molecule:
Representative Sequences:

Clone Products

  • Addgene plasmids for ESAM

Alternative Splicing Database (ASD) splice patterns (SP) for ESAM Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -
SP7: -

Relevant External Links for ESAM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ESAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ESAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ESAM Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.1), Platelet (16.8), and Placenta (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ESAM Gene

Protein tissue co-expression partners for ESAM Gene

NURSA nuclear receptor signaling pathways regulating expression of ESAM Gene:


SOURCE GeneReport for Unigene cluster for ESAM Gene:


mRNA Expression by UniProt/SwissProt for ESAM Gene:

Tissue specificity: Highly expressed in endothelial cells.

Evidence on tissue expression from TISSUES for ESAM Gene

  • Spleen(4.4)
  • Intestine(4.3)
  • Liver(4.3)
  • Nervous system(3.8)
  • Heart(3.4)
  • Lung(3.4)
  • Blood(3.1)
  • Muscle(2.5)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ESAM: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ESAM Gene

Orthologs for ESAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ESAM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ESAM 34 33
  • 99.66 (n)
(Canis familiaris)
Mammalia ESAM 34 33
  • 83.89 (n)
(Bos Taurus)
Mammalia ESAM 34 33
  • 82.91 (n)
(Rattus norvegicus)
Mammalia Esam 33
  • 78.13 (n)
(Mus musculus)
Mammalia Esam 16 34 33
  • 78.12 (n)
(Monodelphis domestica)
Mammalia ESAM 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia ESAM 34
  • 51 (a)
(Gallus gallus)
Aves ESAM 34 33
  • 55.49 (n)
(Anolis carolinensis)
Reptilia ESAM 34
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia esam 33
  • 52.12 (n)
(Danio rerio)
Actinopterygii LOC562934 33
  • 50.35 (n)
esamb 34
  • 36 (a)
esama 34
  • 35 (a)
Species where no ortholog for ESAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ESAM Gene

Gene Tree for ESAM (if available)
Gene Tree for ESAM (if available)
Evolutionary constrained regions (ECRs) for ESAM: view image

Paralogs for ESAM Gene

Paralogs for ESAM Gene

(1) SIMAP similar genes for ESAM Gene using alignment to 4 proteins:

  • F8WDW9_HUMAN Pseudogenes for ESAM Gene

genes like me logo Genes that share paralogs with ESAM: view

Variants for ESAM Gene

Sequence variations from dbSNP and Humsavar for ESAM Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000088138 -- 124,764,272(-) G/A upstream_transcript_variant
rs1000496097 -- 124,757,502(-) G/A intron_variant
rs1000650208 -- 124,757,228(-) C/T intron_variant
rs1000783278 -- 124,755,928(-) G/A intron_variant
rs1001000467 -- 124,763,278(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ESAM Gene

Variant ID Type Subtype PubMed ID
nsv556487 CNV loss 21841781

Variation tolerance for ESAM Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ESAM Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ESAM Gene

Disorders for ESAM Gene

Additional Disease Information for ESAM

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ESAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ESAM Gene

Publications for ESAM Gene

  1. Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. (PMID: 11279107) Hirata Ki … Quertermous T (The Journal of biological chemistry 2001) 2 3 4 58
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ESAM Gene

Sources for ESAM Gene

Loading form....