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Aliases for ERVK13-1 Gene

Subcategory (RNA class) for ERVK13-1 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for ERVK13-1 Gene

  • Endogenous Retrovirus Group K13 Member 1 2 3 5
  • HERV-K_16p13.3 Provirus Ancestral Env Polyprotein 4
  • HERV-K_16p3.3 Provirus Ancestral Env Polyprotein 2
  • Endogenous Retrovirus Group K13, Member 1 2
  • Envelope Polyprotein 4

External Ids for ERVK13-1 Gene

Previous GeneCards Identifiers for ERVK13-1 Gene

  • GC16M002710

Summaries for ERVK13-1 Gene

GeneCards Summary for ERVK13-1 Gene

ERVK13-1 (Endogenous Retrovirus Group K13 Member 1) is an RNA Gene, and is affiliated with the ncRNA class. Gene Ontology (GO) annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for ERVK13-1 Gene

  • Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).

  • SU mediates receptor recognition.

  • TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

Additional gene information for ERVK13-1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERVK13-1 Gene

Genomics for ERVK13-1 Gene

GeneHancer (GH) Regulatory Elements for ERVK13-1 Gene

Promoters and enhancers for ERVK13-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I002672 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 568.8 -0.4 -351 2.8 PKNOX1 ATF1 SMAD1 ARNT ARID4B SIN3A ZNF143 KLF13 SP3 NFYC ERVK13-1 ENSG00000261613 ENSG00000269937 PRSS27 SRRM2-AS1 ABCA17P ABCA3 GC16P003029 PIR59611
GH16I003019 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 67.8 -348.9 -348859 5.2 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 NFYC THOC6 HCFC1R1 TNFRSF12A ZNF263 ENSG00000261938 E4F1 SRRM2 TSC2 ERVK13-1 ZNF75A
GH16I002147 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.4 +517.7 517654 17.4 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 TRAF7 SNORD60 SNHG19 ENSG00000281010 GC16M002156 GC16M002158 RAB26 ENSG00000261505 ENSG00000260051 SRRM2
GH16I001962 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 34.2 +709.2 709222 4.1 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ENSG00000255513 SNORA64 SNHG9 RPS2 GC16M001962 GC16M001965 GC16M001966 GC16P001995 SNORA10 SNORA78
GH16I002750 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31.4 -79.6 -79628 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 SRRM2 GC16P003013 SRRM2-AS1 ZNF75A ERVK13-1 TSC2 ZNF263 ENSG00000255513 LOC105371055 SNORA64
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERVK13-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ERVK13-1 Gene

Genomic Locations for ERVK13-1 Gene
chr16:2,658,389-2,673,444
(GRCh38/hg38)
Size:
15,056 bases
Orientation:
Minus strand
chr16:2,708,390-2,723,445
(GRCh37/hg19)

Genomic View for ERVK13-1 Gene

Genes around ERVK13-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERVK13-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERVK13-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERVK13-1 Gene

Proteins for ERVK13-1 Gene

  • Protein details for ERVK13-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX77-ENK13_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 13-1 Env polyprotein
    Protein Accession:
    Q9NX77
    Secondary Accessions:
    • A8K9G3

    Protein attributes for ERVK13-1 Gene

    Size:
    482 amino acids
    Molecular mass:
    55045 Da
    Quaternary structure:
    • The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).

neXtProt entry for ERVK13-1 Gene

Post-translational modifications for ERVK13-1 Gene

  • Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.

No data available for DME Specific Peptides for ERVK13-1 Gene

Domains & Families for ERVK13-1 Gene

Protein Domains for ERVK13-1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NX77

UniProtKB/Swiss-Prot:

ENK13_HUMAN :
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-4) env subfamily.
Family:
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-4) env subfamily.
genes like me logo Genes that share domains with ERVK13-1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ERVK13-1 Gene

Function for ERVK13-1 Gene

Molecular function for ERVK13-1 Gene

UniProtKB/Swiss-Prot Function:
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity).
UniProtKB/Swiss-Prot Function:
SU mediates receptor recognition.
UniProtKB/Swiss-Prot Function:
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).

Phenotypes From GWAS Catalog for ERVK13-1 Gene

Gene Ontology (GO) - Molecular Function for ERVK13-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with ERVK13-1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERVK13-1 Gene

Localization for ERVK13-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERVK13-1 Gene

Virion.
Transmembrane protein: Cell membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ERVK13-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0019031 viral envelope IEA --
genes like me logo Genes that share ontologies with ERVK13-1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ERVK13-1 Gene

Pathways & Interactions for ERVK13-1 Gene

SuperPathways for ERVK13-1 Gene

No Data Available

Interacting Proteins for ERVK13-1 Gene

Gene Ontology (GO) - Biological Process for ERVK13-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERVK13-1 Gene

Drugs & Compounds for ERVK13-1 Gene

No Compound Related Data Available

Transcripts for ERVK13-1 Gene

mRNA/cDNA for ERVK13-1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ERVK13-1 Gene

Endogenous retrovirus group K13, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ERVK13-1 Gene

No ASD Table

Relevant External Links for ERVK13-1 Gene

GeneLoc Exon Structure for
ERVK13-1
ECgene alternative splicing isoforms for
ERVK13-1

Expression for ERVK13-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERVK13-1 Gene

Protein differential expression in normal tissues from HIPED for ERVK13-1 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERVK13-1 Gene



Protein tissue co-expression partners for ERVK13-1 Gene

SOURCE GeneReport for Unigene cluster for ERVK13-1 Gene:

Hs.406976

mRNA Expression by UniProt/SwissProt for ERVK13-1 Gene:

Q9NX77-ENK13_HUMAN
Tissue specificity: Primary culture of CD34+, lung, thymus, ileal mucosa, small intestine, and testis.
genes like me logo Genes that share expression patterns with ERVK13-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERVK13-1 Gene

Orthologs for ERVK13-1 Gene

Evolution for ERVK13-1 Gene

ENSEMBL:
Gene Tree for ERVK13-1 (if available)
TreeFam:
Gene Tree for ERVK13-1 (if available)

No data available for Orthologs for ERVK13-1 Gene

Paralogs for ERVK13-1 Gene

No data available for Paralogs for ERVK13-1 Gene

Variants for ERVK13-1 Gene

Sequence variations from dbSNP and Humsavar for ERVK13-1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000020028 -- 2,660,659(-) G/C non_coding_transcript_variant
rs1000072401 -- 2,660,437(-) T/C non_coding_transcript_variant
rs1000260064 -- 2,669,458(-) T/C non_coding_transcript_variant
rs1000539847 -- 2,673,357(-) G/A non_coding_transcript_variant
rs1000826386 -- 2,673,482(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ERVK13-1 Gene

Variant ID Type Subtype PubMed ID
dgv110n111 CNV duplication 26073780
dgv2693n100 CNV gain 25217958
dgv4870n54 CNV gain 21841781
dgv780e212 CNV gain 25503493
esv2421848 CNV duplication 20811451
esv2422427 CNV duplication 17116639
esv2750386 CNV deletion 23290073
esv2760067 CNV gain+loss 17122850
esv2762199 CNV gain+loss 21179565
esv2763126 CNV gain 21179565
esv29849 CNV gain+loss 19812545
esv33514 CNV gain+loss 17666407
esv3553016 CNV deletion 23714750
esv3570075 CNV gain 25503493
esv3570143 CNV gain 25503493
esv3570154 CNV gain 25503493
esv3637635 CNV gain 21293372
esv3892757 CNV gain 25118596
esv8446 CNV loss 19470904
nsv1037150 CNV gain 25217958
nsv1071252 CNV deletion 25765185
nsv1140247 OTHER inversion 24896259
nsv442390 CNV gain 18776908
nsv457354 CNV gain 19166990
nsv571226 CNV gain 21841781
nsv571244 CNV gain 21841781
nsv7275 OTHER inversion 18451855
nsv827518 CNV gain 20364138
nsv833122 CNV loss 17160897
nsv833123 CNV gain+loss 17160897
nsv977898 CNV duplication 23825009

Additional Variant Information for ERVK13-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERVK13-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ERVK13-1 Gene

Disorders for ERVK13-1 Gene

Additional Disease Information for ERVK13-1

No disorders were found for ERVK13-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERVK13-1 Gene

Publications for ERVK13-1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan JA … Goldberg AL (The EMBO journal 2013) 3 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ERVK13-1 Gene

Sources for ERVK13-1 Gene

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