Aliases for ERVK-19 Gene

Aliases for ERVK-19 Gene

  • Endogenous Retrovirus Group K Member 19, Envelope 2 3
  • HERV-K_19q11 Provirus Ancestral Env Polyprotein 2 3 4
  • HERV-K_19q11 Provirus Ancestral Gag Polyprotein 2 3 4
  • HERV-K_19q11 Provirus Ancestral Pol Protein 2 3 4
  • HERV-K_19q12 Provirus Ancestral Pro Protein 2 3 4
  • Endogenous Retrovirus Group K Member 19 Gag Polyprotein 3 4
  • Endogenous Retrovirus Group K Member 19 Pro Protein 3 4
  • Endogenous Retrovirus Group K Member 19 Pol Protein 3 4
  • Endogenous Retrovirus Group K, Member 19 2 3
  • HERV-K(C19) Gag Protein 3 4
  • HERV-K(C19) Pro Protein 3 4
  • Envelope Polyprotein 3 4
  • Gag Polyprotein 3 4
  • HERV-K(C19) 2 3
  • Proteinase 3 4
  • Protease 3 4
  • EnvK3 2 3
  • P1.8 2 3
  • PR 3 4
  • Endogenous Retrovirus Group K Member 19 Env Polyprotein 4
  • Endogenous Retrovirus Group K Member 19 Rec Protein 4
  • Endogenous Retrovirus Group K Member 19 2
  • HERV-K_19q11 Provirus Rec Protein 4
  • HERV-K(C19) Envelope Protein 4
  • HERV-K(C19) Pol Protein 4
  • HERV-K(C19) Rec Protein 4
  • EnvK3 Protein 4
  • EC 3.4.23.50 4
  • Polymerase 3
  • EC 3.4.23 51

External Ids for ERVK-19 Gene

Previous GeneCards Identifiers for ERVK-19 Gene

  • GC00U933535
  • GC19M027521

Summaries for ERVK-19 Gene

GeneCards Summary for ERVK-19 Gene

ERVK-19 (Endogenous Retrovirus Group K Member 19, Envelope) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot Summary for ERVK-19 Gene

  • Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.
  • SU mediates receptor recognition.
  • TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
  • The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
  • Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.
  • Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).
  • Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.

Additional gene information for ERVK-19 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ERVK-19 Gene

Genomics for ERVK-19 Gene

Genomic Locations for ERVK-19 Gene

Genomic Locations for ERVK-19 Gene
chr19:-
(GRCh38/hg38)
Orientation:
Unknown strand

Genomic View for ERVK-19 Gene


Cytogenetic band:
GeneLoc Logo Gene Density

No data available for GeneHancer (GH) Regulatory Elements and RefSeq DNA sequence for ERVK-19 Gene

Proteins for ERVK-19 Gene

  • Protein details for ERVK-19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O71037-ENK19_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 19 Env polyprotein
    Protein Accession:
    O71037
    Secondary Accessions:
    • Q69386
    • Q9YNA7

    Protein attributes for ERVK-19 Gene

    Size:
    699 amino acids
    Molecular mass:
    79252 Da
    Quaternary structure:
    • The surface (SU) and transmembrane (TM) proteins form a heterodimer. SU and TM are attached by noncovalent interactions or by a labile interchain disulfide bond (By similarity).
    SequenceCaution:
    • Sequence=CAA76883.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • ERVK-19 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene resulting in Env proteins of distinct sizes. Despite their overall retroviral envelope structure HERV-K(HML-2) type 1 envelope proteins lack a predictable signal sequence. Subgenomic RNA transcripts coding for full-length envelope proteins have been detected for both type of genomes.
  • Protein details for ERVK-19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9YNA8-GAK19_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 19 Gag polyprotein
    Protein Accession:
    Q9YNA8

    Protein attributes for ERVK-19 Gene

    Size:
    666 amino acids
    Molecular mass:
    74183 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ERVK-19 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for ERVK-19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9WJR5-POK19_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 19 Pol protein
    Protein Accession:
    Q9WJR5
    Secondary Accessions:
    • O15312

    Protein attributes for ERVK-19 Gene

    Size:
    959 amino acids
    Molecular mass:
    108106 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AC112702; Type=Frameshift; Note=The frameshift results from the integration of a SINE element AluYa5.; Evidence={ECO:0000305}; Sequence=CAA76882.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Exact N-terminus of this protein has not been formally described.

    Alternative splice isoforms for ERVK-19 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for ERVK-19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61572-REC19_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 19 Rec protein
    Protein Accession:
    P61572

    Protein attributes for ERVK-19 Gene

    Size:
    105 amino acids
    Molecular mass:
    11828 Da
    Quaternary structure:
    • Forms homodimers, homotrimers, and homotetramers via a C-terminal domain. Associates with XPO1 and with ZNF145 (By similarity).
    Miscellaneous:
    • Despite functional similarity, Rec shares almost no sequence homology with HIV-1 Rev and HTLV-1 Rex.
    • ERVK-19 has a type 2 genome. The HERV-K(HML-2) family contains type 1 and type 2 genomes depending on the absence or presence of 292 nucleotides at the 5'-end of the env gene. Rec proteins are translated from a doubly spliced transcript expressed exclusively by HERV-K(HML-2) type 2 proviral genomes. The first exon comprises the 87 N-terminal amino acids of the HERV-K(HMLM-2) type 2 envelope protein. The second exon (18 amino acids) is positioned in the 3' part of the proviral genome.
  • Protein details for ERVK-19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63120-VPK19_HUMAN
    Recommended name:
    Endogenous retrovirus group K member 19 Pro protein
    Protein Accession:
    P63120

    Protein attributes for ERVK-19 Gene

    Size:
    156 amino acids
    Molecular mass:
    17107 Da
    Quaternary structure:
    • Active as a homodimer.

    Alternative splice isoforms for ERVK-19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERVK-19 Gene

Selected DME Specific Peptides for ERVK-19 Gene

P63120:
  • VTGLVGI
  • GLVGIGTASEVYQS
  • GKGLGKNEDGIK
  • PVEAKINQ

Post-translational modifications for ERVK-19 Gene

  • Specific enzymatic cleavages in vivo yield the mature SU and TM proteins.
  • Myristoylation is essential for retroviral assembly. Alteration of the glycine residue leads to a block in the budding of particles and an accumulation of Gag inside the cell (By similarity).
  • Specific enzymatic cleavages may yield mature proteins.
  • Autoproteolytically processed at the N-terminus. Expected C-terminal autoprocessing not detected. The sequence shown is that of the processed Pro protein (By similarity).
  • Glycosylation at Asn100, Asn128, Asn153, Asn274, Asn355, Asn372, Asn461, Asn507, Asn554, Asn566, and Asn585
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ERVK-19 Gene

Gene Families for ERVK-19 Gene

Protein Domains for ERVK-19 Gene

Graphical View of Domain Structure for InterPro Entry

O71037

UniProtKB/Swiss-Prot:

VPK19_HUMAN :
  • HERV-K Gag polyprotein contains regions homologous to the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins from infectious retroviruses. Evidence suggests that HERV-K(HML-2) Gag polyprotein can be cleaved into mature MA, CA and NC under certain circumstances. However, the exact boundaries as well as the size of processed Gag proteins have not been precisely determined yet.
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.
Domain:
  • HERV-K Gag polyprotein contains regions homologous to the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins from infectious retroviruses. Evidence suggests that HERV-K(HML-2) Gag polyprotein can be cleaved into mature MA, CA and NC under certain circumstances. However, the exact boundaries as well as the size of processed Gag proteins have not been precisely determined yet.
  • The LPQG and YXDD motifs are catalytically important and conserved among many retroviruses.
Family:
  • Belongs to the beta type-B retroviral envelope protein family. HERV class-II K(HML-2) env subfamily.
  • Belongs to the beta type-B retroviral Gag protein family. HERV class-II K(HML-2) gag subfamily.
  • Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily.
  • Belongs to the peptidase A2 family. HERV class-II K(HML-2) subfamily.
genes like me logo Genes that share domains with ERVK-19: view

No data available for Suggested Antigen Peptide Sequences for ERVK-19 Gene

Function for ERVK-19 Gene

Molecular function for ERVK-19 Gene

UniProtKB/Swiss-Prot Function:
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.
UniProtKB/Swiss-Prot Function:
SU mediates receptor recognition.
UniProtKB/Swiss-Prot Function:
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity).
UniProtKB/Swiss-Prot Function:
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
UniProtKB/Swiss-Prot Function:
Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-ProRule:PRU00405};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; Evidence={ECO:0000255|PROSITE-ProRule:PRU00408};.
UniProtKB/Swiss-Prot Function:
Retroviral replication requires the nuclear export and translation of unspliced, singly-spliced and multiply-spliced derivatives of the initial genomic transcript. Rec interacts with a highly structured RNA element (RcRE) present in the viral 3'LTR and recruits the cellular nuclear export machinery. This permits export to the cytoplasm of unspliced genomic or incompletely spliced subgenomic viral transcripts (By similarity).
UniProtKB/Swiss-Prot Function:
Retroviral proteases have roles in the processing of the primary translation products and the maturation of the viral particle. Endogenous Pro proteins may have kept, lost or modified their original function during evolution.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.; EC=3.4.23.50;.

Enzyme Numbers (IUBMB) for ERVK-19 Gene

No data available for Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERVK-19 Gene

Localization for ERVK-19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERVK-19 Gene

[Transmembrane protein]: Cell membrane. Single-pass type I membrane protein.
[Surface protein]: Cell membrane. Peripheral membrane protein. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.
[Endogenous retrovirus group K member 19 Env polyprotein]: Virion.
Cell membrane. Lipid-anchor. Note=Cytoplasmic membrane (in a transfection system). {ECO:0000250}.
Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ERVK-19 Gene

Pathways & Interactions for ERVK-19 Gene

PathCards logo

SuperPathways for ERVK-19 Gene

No Data Available

Interacting Proteins for ERVK-19 Gene

Selected Interacting proteins: Q9WJR5-POK19_HUMAN for ERVK-19 Gene via IID

Gene Ontology (GO) - Biological Process for ERVK-19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERVK-19 Gene

Drugs & Compounds for ERVK-19 Gene

No Compound Related Data Available

Transcripts for ERVK-19 Gene

mRNA/cDNA for ERVK-19 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for ERVK-19 Gene

No ASD Table

Expression for ERVK-19 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERVK-19 Gene

Orthologs for ERVK-19 Gene

No data available for Orthologs and Evolution for ERVK-19 Gene

Paralogs for ERVK-19 Gene

No data available for Paralogs for ERVK-19 Gene

Variants for ERVK-19 Gene

Additional Variant Information for ERVK-19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERVK-19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for ERVK-19 Gene

Disorders for ERVK-19 Gene

Additional Disease Information for ERVK-19

No disorders were found for ERVK-19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERVK-19 Gene

Publications for ERVK-19 Gene

  1. Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins. (PMID: 12970426) de Parseval N … Heidmann T (Journal of virology 2003) 2 3 4
  2. Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K. (PMID: 10516026) Tönjes RR … Kurth R (Journal of virology 1999) 2 3 4
  3. Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses. (PMID: 9460924) Zsíros J … Berkhout B (The Journal of general virology 1998) 2 3 4
  4. A revised nomenclature for transcribed human endogenous retroviral loci. (PMID: 21542922) Mayer J … Seal RL (Mobile DNA 2011) 2 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4

Products for ERVK-19 Gene

Sources for ERVK-19 Gene