Aliases for ERRFI1 Gene
External Ids for ERRFI1 Gene
Previous GeneCards Identifiers for ERRFI1 Gene
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ERRFI1 Gene
ERRFI1 (ERBB Receptor Feedback Inhibitor 1) is a Protein Coding gene. Diseases associated with ERRFI1 include Endometrial Disease and Progesterone Resistance. Among its related pathways are Tyrosine Kinases / Adaptors and EGF/EGFR Signaling Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and kinase binding.
UniProtKB/Swiss-Prot Summary for ERRFI1 Gene
Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).