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Aliases for ERN2 Gene
Aliases for ERN2 Gene
External Ids for ERN2 Gene
- HGNC: 16942
- Entrez Gene: 10595
- Ensembl: ENSG00000134398
- OMIM: 604034
- UniProtKB: Q76MJ5
Previous GeneCards Identifiers for ERN2 Gene
- GC16M023110
- GC16M023789
- GC16M023617
- GC16M023668
- GC16M023684
- GC16M023609
- GC16U900517
- GC16M023701
- GC16M021791
Summaries for ERN2 Gene
GeneCards Summary for ERN2 Gene
ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2) is a Protein Coding gene. Diseases associated with ERN2 include Orbital Granuloma and Ileocolitis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ERN1.
UniProtKB/Swiss-Prot Summary for ERN2 Gene
-
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Additional gene information for ERN2 Gene
- HGNC(16942)
- Entrez Gene(10595)
- Ensembl(ENSG00000134398)
- OMIM(604034)
- UniProtKB(Q76MJ5)
- Open Targets Platform(ENSG00000134398)
- Search for ERN2 at DataMed
- Search for ERN2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ERN2 Gene
Genomics for ERN2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ERN2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16J023711 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE | 600.7 | +0.7 | 741 | 1.8 | CTBP1 KLF4 ZNF217 GATAD2B BCOR DPF2 NFIB FOXA1 RCOR1 MAZ | ENSG00000261583 ERN2 PLK1 | |
| GH16J023676 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 11.7 | +34.2 | 34185 | 4.7 | SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 LEF1 IKZF1 | PLK1 piR-46201 DCTN5 PALB2 ERN2 NDUFAB1 CHP2 ENSG00000260482 ENSG00000261266 | |
| GH16J023690 | Enhancer | 0.7 | Ensembl ENCODE | 11.9 | +21.9 | 21852 | 1.3 | RBFOX2 KLF9 POLR2A ZKSCAN1 SCRT1 STAT5A MAFK | DCTN5 ERN2 PALB2 ENSG00000261266 ENSG00000278912 PLK1 | |
| GH16J023788 | Enhancer | 0.5 | Ensembl | 11.2 | -76.3 | -76253 | 2.2 | NR2C2 SPI1 ZNF589 POLR2A MYC MAX L3MBTL2 | PRKCB CHP2 ERN2 lnc-CHP2-2 piR-38579-017 | |
| GH16J023682 | Enhancer | 0.2 | FANTOM5 | 11.5 | +30.7 | 30709 | 0 | ERN2 PALB2 DCTN5 NDUFAB1 CHP2 PLK1 ENSG00000261266 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ERN2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ERN2
- Top Transcription factor binding sites by QIAGEN in the ERN2 gene promoter:
-
- AML1a
- c-Myb
- c-Myc
- ER-alpha
- GATA-1
- HEN1
- Max
- Pax-2
- Pax-2a
- RSRFC4
Genomic Locations for ERN2 Gene
Genomic Locations for ERN2 Gene
- chr16:23,690,310-23,713,248
- (GRCh38/hg38)
- Size:
- 22,939 bases
- Orientation:
- Minus strand
- chr16:23,701,625-23,724,821
- (GRCh37/hg19)
- Size:
- 23,197 bases
- Orientation:
- Minus strand
Genomic View for ERN2 Gene
Genes around ERN2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.2 by HGNC
- 16p12.2 by Entrez Gene
- 16p12.2 by Ensembl
ERN2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ERN2 Gene
Proteins for ERN2 Gene
-
Protein details for ERN2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q76MJ5-ERN2_HUMAN
- Recommended name:
- Serine/threonine-protein kinase/endoribonuclease IRE2
- Protein Accession:
- Q76MJ5
- Q6ZNC0
Protein attributes for ERN2 Gene
- Size:
- 926 amino acids
- Molecular mass:
- 102480 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAD18455.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for ERN2 Gene
Selected DME Specific Peptides for ERN2 Gene
- Q76MJ5:
-
- HRDLKPGN
- VHRDLKP
- IVHRDLK
Post-translational modifications for ERN2 Gene
- Autophosphorylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ERN2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Magic™ Anti-IRE1 (Phospho S724) monoclonal antibody, clone FQS6364
-
Custom Antibody ServicesOriGene Antibodies for ERN2
- Novus Biologicals Antibodies for ERN2
- Invitrogen Antibodies for ERN2 (AFLGC-ERN2)
-
Biorbyt antibodies for ERN2
-
Boster Bio Antibodies for ERN2
- Sino Biological Antibodies for ERN2
Protein Products
-
OriGene Purified Proteins for ERN2
- Search Origene for MassSpec and Protein Over-expression Lysates for ERN2
- Origene Custom Protein Services for ERN2
- Novus Biologicals lysates for ERN2
- antibodies-online: Show 8 available ERN2 Proteins ranked by validation data
- Compare Top ERN2 Proteins
-
Quality Products:
-
Abcam proteins for ERN2
Assay Products
- antibodies-online: Show 5 available ERN2 Elisa Kits ranked by validation data
- Compare Top ERN2 Elisa Kits
-
Quality Products:
Domains & Families for ERN2 Gene
Gene Families for ERN2 Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ERN2 Gene
- InterPro:
- Blocks:
-
- Bacterial quinoprotein
- PUG
- Ribonuclease 2-5A
- ProtoNet:
Suggested Antigen Peptide Sequences for ERN2 Gene
- GenScript: Design optimal peptide antigens:
-
- ERN2 protein (A5YM46_HUMAN)
- ERN2 protein (A5YM65_HUMAN)
- Ire1-beta (ERN2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q76MJ5UniProtKB/Swiss-Prot:
ERN2_HUMAN :- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Function for ERN2 Gene
Molecular function for ERN2 Gene
- UniProtKB/Swiss-Prot Function:
- Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:11175748};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:11175748};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain (By similarity).
Phenotypes From GWAS Catalog for ERN2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000287 | magnesium ion binding | IDA | 11175748 |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004519 | endonuclease activity | IDA | 11175748 |
| GO:0004521 | endoribonuclease activity | IBA | 21873635 |
Phenotypes for ERN2 Gene
- MGI mutant phenotypes for ERN2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ERN2:
-
- Increased vaccinia virus (VACV) infection
- Increased cell death HMECs cells
- Synthetic lethal with Ras
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased lymphocytic choriomeningitis virus (LCMV) infection
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell elongation
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased viability in ovarian lineage
- Decreased substrate adherent cell growth
Animal Models for ERN2 Gene
- MGI Knock Outs for ERN2:
-
- Ern2 Ern2<tm1Dron>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ERN2 - Select products 50% OFF >
- * ERN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ERN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ERN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERN2
miRNA for ERN2 Gene
- miRTarBase miRNAs that target ERN2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ERN2
- Browse OriGene Inhibitory RNA Products For ERN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERN2
Clone Products
- Applied Biological Materials (abm): Clones for ERN2 - Select products 50% OFF >
- * ERN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ERN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ERN2
Cell Line Products
-
Horizon Cell Lines for ERN2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ERN2 Gene
Localization for ERN2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ERN2 Gene
- Endoplasmic reticulum membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:1990604 | IRE1-TRAF2-ASK1 complex | IEA,ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ERN2 Gene
Pathways & Interactions for ERN2 Gene
Interacting Proteins for ERN2 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| DYRK2 | ||
| DYRK3 | ||
| ENSG00000272822 | ||
| HIPK1 | ||
| HIPK2 |
GPS-Prot Interaction Network for ERN2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0006468 | protein phosphorylation | IDA | 11175748 |
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0007050 | cell cycle arrest | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ERN2 Gene
Drugs & Compounds for ERN2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| 4μ8C | Pharma | IRE1 Rnase inhibitor, potent and non-toxic | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
(1) ApexBio Compounds for ERN2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 4μ8C | IRE1 Rnase inhibitor, potent and non-toxic | 14003-96-4 |
Transcripts for ERN2 Gene
mRNA/cDNA for ERN2 Gene
- 2 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256797 3337 nts (view in UCSC)
- ENST00000457008 3169 nts (view in UCSC)
- ENST00000561478 412 nts (view in UCSC)
- ENST00000562458 759 nts (view in UCSC)
- ENST00000562562 2263 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ERN2 - Select products 50% OFF >
- * ERN2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ERN2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ERN2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERN2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ERN2
- Browse OriGene Inhibitory RNA Products For ERN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERN2
Clone Products
- Applied Biological Materials (abm): Clones for ERN2 - Select products 50% OFF >
- * ERN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ERN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ERN2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - |
| ExUns: | 23 | ^ | 24 | ^ | 25a | · | 25b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: |
Relevant External Links for ERN2 Gene
- GeneLoc Exon Structure for
- ERN2
Expression for ERN2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for ERN2 Gene
This gene is overexpressed in Colon - Transverse (x18.0), Stomach (x9.1), Minor Salivary Gland (x7.5), Cervix - Endocervix (x5.9), and Small Intestine - Terminal Ileum (x4.2).
This gene is overexpressed in Stomach (34.7), Pancreatic juice (24.2), and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERN2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ERN2
SOURCE GeneReport for Unigene cluster for ERN2 Gene:
Hs.592041Evidence on tissue expression from TISSUES for ERN2 Gene
- Intestine(2.7)
- Stomach(2.5)
- Kidney(2.4)
- Blood(2.3)
- Lung(2.2)
- Skin(2.2)
- Nervous system(2.1)
- Pancreas(2.1)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for ERN2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERN2 Gene
Orthologs for ERN2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ERN2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ERN2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ERN2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ern2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ern2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | ERN2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ERN1 30 |
|
||
| ERN2 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | ERN2 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | ern2 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | ire-1 32 |
|
|
|
| Ire1 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | ire-1 31 32 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IRE1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6665 31 |
|
OneToOne |
- Species where no ortholog for ERN2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for ERN2 Gene
- ENSEMBL:
- Gene Tree for ERN2 (if available)
- TreeFam:
- Gene Tree for ERN2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ERN2: view image
Paralogs for ERN2 Gene
Variants for ERN2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ERN2 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 638406 | Uncertain Significance: not specified | 23,691,010(-) | G/A | NONSENSE | |
| 724965 | Likely Benign: not provided | 23,695,947(-) | G/A | SYNONYMOUS_VARIANT | |
| 736799 | Likely Benign: not provided | 23,694,785(-) | G/T | SYNONYMOUS_VARIANT | |
| 736800 | Benign: not provided | 23,700,648(-) | A/G | SYNONYMOUS_VARIANT | |
| 736801 | Likely Benign: not provided | 23,706,388(-) | G/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.23;
81.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ERN2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ERN2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ERN2 Gene
Disorders for ERN2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| orbital granuloma |
|
|
| ileocolitis |
|
|
Search ERN2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ERN2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ERN2 Gene
Publications for ERN2 Gene
- Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress. (PMID: 11175748) Iwawaki T … Kohno K (Nature cell biology 2001) 2 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Cloning of mammalian Ire1 reveals diversity in the ER stress responses. (PMID: 9755171) Wang XZ … Ron D (The EMBO journal 1998) 2 3
ExternalLinks
Products for ERN2 Gene
- Custom Antibody ServicesOriGene Antibodies for ERN2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ERN2
- Search Origene for MassSpec and Protein Over-expression Lysates for ERN2
- Origene Custom Protein Services for ERN2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ERN2
- Browse OriGene Inhibitory RNA Products For ERN2
- OriGene qPCR primer pairs for ERN2
- OriGene CRISPR knockouts for ERN2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ERN2
- Sino Biological Human cDNA Clone for ERN2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ERN2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ERN2
- Novus Biologicals lysates for ERN2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for ERN2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for ERN2 (AFLGC-ERN2)
- ApexBio compounds for ERN2
- VectorBuilder Custom and pre-made DNA vectors for ERN2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ERN2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ERN2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ERN2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ERN2
- antibodies-online: Show 50 available ERN2 Antibodies ranked by validation data
- Compare Top ERN2 Antibodies
- antibodies-online: Show 5 available ERN2 Elisa Kits ranked by validation data
- Compare Top ERN2 Elisa Kits
- Quality Products:
- antibodies-online: Show 8 available ERN2 Proteins ranked by validation data
- Compare Top ERN2 Proteins
- Quality Products:
- Horizon Cell Lines for ERN2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ERN2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ERN2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ERN2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERN2
- Boster Bio Antibodies for ERN2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ERN2
Sources for ERN2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB