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ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2) is a Protein Coding gene. Diseases associated with ERN2 include Orbital Granuloma and Ileocolitis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ERN1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J023711 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE | 600.7 | +0.7 | 741 | 1.8 | CTBP1 KLF4 ZNF217 GATAD2B BCOR DPF2 NFIB FOXA1 RCOR1 MAZ | ENSG00000261583 ERN2 PLK1 | |
GH16J023676 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 11.7 | +34.2 | 34185 | 4.7 | SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 LEF1 IKZF1 | PLK1 piR-46201 DCTN5 PALB2 ERN2 NDUFAB1 CHP2 ENSG00000260482 ENSG00000261266 | |
GH16J023690 | Enhancer | 0.7 | Ensembl ENCODE | 11.9 | +21.9 | 21852 | 1.3 | RBFOX2 KLF9 POLR2A ZKSCAN1 SCRT1 STAT5A MAFK | DCTN5 ERN2 PALB2 ENSG00000261266 ENSG00000278912 PLK1 | |
GH16J023788 | Enhancer | 0.5 | Ensembl | 11.2 | -76.3 | -76253 | 2.2 | NR2C2 SPI1 ZNF589 POLR2A MYC MAX L3MBTL2 | PRKCB CHP2 ERN2 lnc-CHP2-2 piR-38579-017 | |
GH16J023682 | Enhancer | 0.2 | FANTOM5 | 11.5 | +30.7 | 30709 | 0 | ERN2 PALB2 DCTN5 NDUFAB1 CHP2 PLK1 ENSG00000261266 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | IDA | 11175748 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004519 | endonuclease activity | IDA | 11175748 |
GO:0004521 | endoribonuclease activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IBA | 21873635 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:1990604 | IRE1-TRAF2-ASK1 complex | IEA,ISS | -- |
Symbol | External ID(s) | Details |
---|---|---|
DYRK2 | ||
DYRK3 | ||
ENSG00000272822 | ||
HIPK1 | ||
HIPK2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0006468 | protein phosphorylation | IDA | 11175748 |
GO:0006915 | apoptotic process | IEA | -- |
GO:0007050 | cell cycle arrest | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
4μ8C | Pharma | IRE1 Rnase inhibitor, potent and non-toxic | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Compound | Action | Cas Number |
---|---|---|
4μ8C | IRE1 Rnase inhibitor, potent and non-toxic | 14003-96-4 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - |
ExUns: | 23 | ^ | 24 | ^ | 25a | · | 25b |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ERN2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ERN2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ERN2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ern2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ern2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | ERN2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ERN1 30 |
|
||
ERN2 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | ERN2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | ern2 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | ire-1 32 |
|
|
|
Ire1 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | ire-1 31 32 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IRE1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6665 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
638406 | Uncertain Significance: not specified | 23,691,010(-) | G/A | NONSENSE | |
724965 | Likely Benign: not provided | 23,695,947(-) | G/A | SYNONYMOUS_VARIANT | |
736799 | Likely Benign: not provided | 23,694,785(-) | G/T | SYNONYMOUS_VARIANT | |
736800 | Benign: not provided | 23,700,648(-) | A/G | SYNONYMOUS_VARIANT | |
736801 | Likely Benign: not provided | 23,706,388(-) | G/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
orbital granuloma |
|
|
ileocolitis |
|
|