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Aliases for ERMP1 Gene

Aliases for ERMP1 Gene

  • Endoplasmic Reticulum Metallopeptidase 1 2 3 3 5
  • Felix-Ina 2 3 4
  • KIAA1815 2 3 4
  • FXNA 3 4
  • BA207C16.3 (Novel Protein Similar To Predicted Yeast, Plant And Worm Proteins) 3
  • Aminopeptidase Fxna 3
  • BA207C16.3 3
  • EC 3.4.-.- 4

External Ids for ERMP1 Gene

Previous HGNC Symbols for ERMP1 Gene

  • KIAA1815

Summaries for ERMP1 Gene

GeneCards Summary for ERMP1 Gene

ERMP1 (Endoplasmic Reticulum Metallopeptidase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and metallopeptidase activity.

UniProtKB/Swiss-Prot for ERMP1 Gene

  • Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.

Additional gene information for ERMP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERMP1 Gene

Genomics for ERMP1 Gene

GeneHancer (GH) Regulatory Elements for ERMP1 Gene

Promoters and enhancers for ERMP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J005830 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 657.8 +0.6 574 3.4 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF143 DEK NFYC MXD4 ERMP1 UHRF2 KIAA2026 RIC1 AK4P4 PDSS1P1 PIR31344
GH09J005878 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.3 -47.2 -47245 2.8 PKNOX1 ATF1 ARNT SIN3A NCOA2 TCF12 ZNF766 GATA2 ZFP91 ATF7 ERMP1 MLANA AK4P4 KIAA2026
GH09J005892 Enhancer 1.2 FANTOM5 ENCODE 18 -60.9 -60862 2.9 PKNOX1 FOXA2 ARID4B ZNF48 YY1 FOS RXRA MIER2 REST PPARG ERMP1 MLANA GC09P005918 KIAA2026
GH09J005841 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -10.7 -10670 4.9 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF121 ATF7 RUNX3 GC09M005843 ERMP1 RANBP6 AK4P4
GH09J006014 Promoter/Enhancer 1.5 Ensembl ENCODE 9.9 -182.3 -182262 2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 ZNF207 RANBP6 ERMP1 KIAA2026
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERMP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ERMP1 gene promoter:
  • FOXO4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-5
  • HOXA9
  • HOXA9B

Genomic Locations for ERMP1 Gene

Genomic Locations for ERMP1 Gene
chr9:5,764,061-5,833,117
(GRCh38/hg38)
Size:
69,057 bases
Orientation:
Minus strand
chr9:5,765,076-5,833,117
(GRCh37/hg19)
Size:
68,042 bases
Orientation:
Minus strand

Genomic View for ERMP1 Gene

Genes around ERMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERMP1 Gene

Proteins for ERMP1 Gene

  • Protein details for ERMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2K6-ERMP1_HUMAN
    Recommended name:
    Endoplasmic reticulum metallopeptidase 1
    Protein Accession:
    Q7Z2K6
    Secondary Accessions:
    • B2RNA4
    • B3KSB1
    • Q8N5T5
    • Q9H5M1

    Protein attributes for ERMP1 Gene

    Size:
    904 amino acids
    Molecular mass:
    100231 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15604.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ERMP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERMP1 Gene

Post-translational modifications for ERMP1 Gene

  • Glycosylation at isoforms=730 and Asn182
  • Modification sites at PhosphoSitePlus

Other Protein References for ERMP1 Gene

No data available for DME Specific Peptides for ERMP1 Gene

Domains & Families for ERMP1 Gene

Gene Families for ERMP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ERMP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z2K6

UniProtKB/Swiss-Prot:

ERMP1_HUMAN :
  • Belongs to the peptidase M28 family.
Family:
  • Belongs to the peptidase M28 family.
genes like me logo Genes that share domains with ERMP1: view

Function for ERMP1 Gene

Molecular function for ERMP1 Gene

UniProtKB/Swiss-Prot Function:
Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures.

Enzyme Numbers (IUBMB) for ERMP1 Gene

Phenotypes From GWAS Catalog for ERMP1 Gene

Gene Ontology (GO) - Molecular Function for ERMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ERMP1: view
genes like me logo Genes that share phenotypes with ERMP1: view

Animal Models for ERMP1 Gene

MGI Knock Outs for ERMP1:
  • Ermp1 Ermp1<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for ERMP1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ERMP1 Gene

Localization for ERMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERMP1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERMP1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ERMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ERMP1: view

Pathways & Interactions for ERMP1 Gene

SuperPathways for ERMP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ERMP1: view

No data available for Pathways by source and SIGNOR curated interactions for ERMP1 Gene

Drugs & Compounds for ERMP1 Gene

No Compound Related Data Available

Transcripts for ERMP1 Gene

mRNA/cDNA for ERMP1 Gene

Unigene Clusters for ERMP1 Gene

Endoplasmic reticulum metallopeptidase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERMP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for ERMP1 Gene

GeneLoc Exon Structure for
ERMP1
ECgene alternative splicing isoforms for
ERMP1

Expression for ERMP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERMP1 Gene

Protein differential expression in normal tissues from HIPED for ERMP1 Gene

This gene is overexpressed in Nasal epithelium (52.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ERMP1 Gene



Protein tissue co-expression partners for ERMP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERMP1 Gene:

ERMP1

SOURCE GeneReport for Unigene cluster for ERMP1 Gene:

Hs.591078

Evidence on tissue expression from TISSUES for ERMP1 Gene

  • Nervous system(4.6)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ERMP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERMP1 Gene

Orthologs for ERMP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERMP1 34 33
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ERMP1 34 33
  • 89.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ERMP1 34
  • 87 (a)
OneToOne
LOC484188 33
  • 83.3 (n)
rat
(Rattus norvegicus)
Mammalia Ermp1 33
  • 84.82 (n)
mouse
(Mus musculus)
Mammalia Ermp1 16 34 33
  • 84.04 (n)
oppossum
(Monodelphis domestica)
Mammalia ERMP1 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERMP1 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERMP1 34 33
  • 71.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERMP1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ermp1 33
  • 67.39 (n)
zebrafish
(Danio rerio)
Actinopterygii ERMP1 (1 of 2) 34
  • 53 (a)
OneToMany
ERMP1 (2 of 2) 34
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10062 34 33
  • 44.95 (n)
OneToMany
CG9416 34
  • 29 (a)
OneToMany
CG30049 34
  • 29 (a)
OneToMany
CG30043 34
  • 29 (a)
OneToMany
CG30047 34
  • 29 (a)
OneToMany
CG10051 34
  • 28 (a)
OneToMany
CG11961 34
  • 28 (a)
OneToMany
CG10081 34
  • 28 (a)
OneToMany
CG13160 34
  • 27 (a)
OneToMany
CG10073 34
  • 27 (a)
OneToMany
CG33012 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0495.7 34 33
  • 47.21 (n)
OneToMany
C44B7.11 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 18 (a)
OneToOne
PFF1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67420 33
  • 44.13 (n)
rice
(Oryza sativa)
Liliopsida Os07g0295800 33
  • 43.46 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1259.02c 33
  • 43.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for ERMP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ERMP1 Gene

ENSEMBL:
Gene Tree for ERMP1 (if available)
TreeFam:
Gene Tree for ERMP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ERMP1: view image

Paralogs for ERMP1 Gene

(1) SIMAP similar genes for ERMP1 Gene using alignment to 4 proteins:

  • ERMP1_HUMAN
  • B3KSB1_HUMAN
  • E7ER77_HUMAN
  • Q6ZMD3_HUMAN
genes like me logo Genes that share paralogs with ERMP1: view

No data available for Paralogs for ERMP1 Gene

Variants for ERMP1 Gene

Sequence variations from dbSNP and Humsavar for ERMP1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000026131 -- 5,793,429(-) G/A intron_variant
rs1000041524 -- 5,827,790(-) G/A intron_variant
rs1000049221 -- 5,778,863(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000054927 -- 5,809,541(-) TTT/T/TTTT intron_variant
rs1000110210 -- 5,774,658(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERMP1 Gene

Variant ID Type Subtype PubMed ID
nsv1140390 OTHER inversion 24896259
nsv1115153 CNV deletion 24896259
nsv1029665 CNV gain 25217958
nsv1016365 CNV gain 25217958
esv3573095 CNV loss 25503493

Variation tolerance for ERMP1 Gene

Residual Variation Intolerance Score: 7.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERMP1 Gene

Human Gene Mutation Database (HGMD)
ERMP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERMP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERMP1 Gene

Disorders for ERMP1 Gene

Additional Disease Information for ERMP1

No disorders were found for ERMP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERMP1 Gene

Publications for ERMP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for ERMP1 Gene

Sources for ERMP1 Gene

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