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Aliases for ERICH6B Gene

Aliases for ERICH6B Gene

  • Glutamate Rich 6B 2 3 5
  • Family With Sequence Similarity 194, Member B 2 3
  • Protein FAM194B 3 4
  • FAM194B 3 4
  • Glutamate-Rich Protein 6B 3
  • Glutamate-Rich 6B 2

External Ids for ERICH6B Gene

Previous HGNC Symbols for ERICH6B Gene

  • FAM194B

Previous GeneCards Identifiers for ERICH6B Gene

  • GC13M046108

Summaries for ERICH6B Gene

GeneCards Summary for ERICH6B Gene

ERICH6B (Glutamate Rich 6B) is a Protein Coding gene. An important paralog of this gene is ERICH6.

Additional gene information for ERICH6B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH6B Gene

Genomics for ERICH6B Gene

GeneHancer (GH) Regulatory Elements for ERICH6B Gene

Promoters and enhancers for ERICH6B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J045615 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.7 +0.1 83 1.1 MXI1 SP3 RFX1 NRF1 MAX BACH1 SIN3A BMI1 ZFHX2 POLR2A ERICH6B TIMM9P3
GH13J046163 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.9 -559.1 -559057 21.8 HDGF PKNOX1 SMAD1 ZNF2 IRF4 YY1 POLR2B ZNF766 ZNF143 JUNB LCP1 ERICH6B COG3 RNU2-6P RUBCNL LRRC63 TPT1-AS1 ZC3H13 RN7SL288P LOC105370192
GH13J044712 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18 +901.3 901306 3.8 ZFP64 ZNF213 RCOR1 FOS ZNF202 ZNF680 RXRA ZC3H11A CEBPB REST TSC22D1 COG3 GPALPP1 ERICH6B RN7SL49P TPT1-AS1 RCN1P2 SMARCE1P5 CCDC122 KCTD4
GH13J045695 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -79.7 -79746 0.8 PKNOX1 SMAD1 EBF1 BMI1 BATF IRF4 NFATC1 EED ATF7 ZSCAN29 LINC01055 ERICH6B SPERT AKR1B1P4
GH13J044917 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +697.3 697339 2.8 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SSRP1 ZNF610 TRE-TTC2-1 GPALPP1 RN7SL49P COG3 NUFIP1 TSC22D1 RCN1P2 ERICH6B TPT1-AS1 KCTD4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERICH6B on UCSC Golden Path with GeneCards custom track

Genomic Locations for ERICH6B Gene

Genomic Locations for ERICH6B Gene
chr13:45,534,522-45,615,739
(GRCh38/hg38)
Size:
81,218 bases
Orientation:
Minus strand
chr13:46,108,657-46,189,874
(GRCh37/hg19)
Size:
81,218 bases
Orientation:
Minus strand

Genomic View for ERICH6B Gene

Genes around ERICH6B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH6B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH6B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH6B Gene

Proteins for ERICH6B Gene

  • Protein details for ERICH6B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0A0-ERI6B_HUMAN
    Recommended name:
    Glutamate-rich protein 6B
    Protein Accession:
    Q5W0A0
    Secondary Accessions:
    • Q96MB5

    Protein attributes for ERICH6B Gene

    Size:
    696 amino acids
    Molecular mass:
    81686 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ERICH6B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERICH6B Gene

Post-translational modifications for ERICH6B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERICH6B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ERICH6B Gene

Domains & Families for ERICH6B Gene

Gene Families for ERICH6B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERICH6B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ERICH6B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5W0A0

UniProtKB/Swiss-Prot:

ERI6B_HUMAN :
  • Belongs to the ERICH6 family.
Family:
  • Belongs to the ERICH6 family.
genes like me logo Genes that share domains with ERICH6B: view

Function for ERICH6B Gene

Phenotypes From GWAS Catalog for ERICH6B Gene

genes like me logo Genes that share phenotypes with ERICH6B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERICH6B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERICH6B Gene

Localization for ERICH6B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH6B gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ERICH6B Gene

Pathways & Interactions for ERICH6B Gene

SuperPathways for ERICH6B Gene

No Data Available

Interacting Proteins for ERICH6B Gene

Selected Interacting proteins: Q5W0A0-ERI6B_HUMAN for ERICH6B Gene via IID

Symbol External ID(s) Details
CD247

Gene Ontology (GO) - Biological Process for ERICH6B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH6B Gene

Drugs & Compounds for ERICH6B Gene

No Compound Related Data Available

Transcripts for ERICH6B Gene

mRNA/cDNA for ERICH6B Gene

(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERICH6B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH6B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3: - -

Relevant External Links for ERICH6B Gene

GeneLoc Exon Structure for
ERICH6B
ECgene alternative splicing isoforms for
ERICH6B

Expression for ERICH6B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH6B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERICH6B Gene

This gene is overexpressed in Testis (x42.8).

Protein differential expression in normal tissues from HIPED for ERICH6B Gene

This gene is overexpressed in Fetal heart (36.3) and Heart (32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH6B Gene



Protein tissue co-expression partners for ERICH6B Gene

NURSA nuclear receptor signaling pathways regulating expression of ERICH6B Gene:

ERICH6B
genes like me logo Genes that share expression patterns with ERICH6B: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH6B Gene

Orthologs for ERICH6B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH6B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM194B 34 33
  • 98.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM194B 34 33
  • 68.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM194B 33
  • 68.28 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911795 33
  • 63.08 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM194B 34
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM194B 34
  • 20 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Erich6b 16
4930564B18Rik 33
chicken
(Gallus gallus)
Aves FAM194B 34
  • 20 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM194B 34
  • 46 (a)
OneToOne
Species where no ortholog for ERICH6B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERICH6B Gene

ENSEMBL:
Gene Tree for ERICH6B (if available)
TreeFam:
Gene Tree for ERICH6B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ERICH6B: view image

Paralogs for ERICH6B Gene

Paralogs for ERICH6B Gene

genes like me logo Genes that share paralogs with ERICH6B: view

Variants for ERICH6B Gene

Sequence variations from dbSNP and Humsavar for ERICH6B Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000005749 -- 45,571,697(-) G/A intron_variant
rs1000091393 -- 45,563,861(-) A/C intron_variant
rs1000144784 -- 45,577,177(-) T/C intron_variant
rs1000146192 -- 45,596,332(-) T/C intron_variant
rs1000160051 -- 45,566,383(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH6B Gene

Variant ID Type Subtype PubMed ID
nsv561579 CNV loss 21841781
nsv510583 CNV deletion 20534489
esv3631959 CNV loss 21293372
esv275007 CNV loss 21479260
esv2747350 CNV deletion 23290073
esv2747349 CNV deletion 23290073
esv1002062 CNV loss 20482838
dgv325n67 CNV gain 20364138
dgv223e201 CNV deletion 23290073

Variation tolerance for ERICH6B Gene

Gene Damage Index Score: 16.90; 97.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERICH6B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH6B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH6B Gene

Disorders for ERICH6B Gene

Additional Disease Information for ERICH6B

No disorders were found for ERICH6B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH6B Gene

Publications for ERICH6B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ERICH6B Gene

Sources for ERICH6B Gene

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