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Aliases for ERICH6 Gene

Aliases for ERICH6 Gene

  • Glutamate Rich 6 2 3 5
  • Family With Sequence Similarity 194, Member A 2 3
  • Glutamate-Rich 6A 2 3
  • Protein FAM194A 3 4
  • C3orf44 3 4
  • FAM194A 3 4
  • Chromosome 3 Open Reading Frame 44 2
  • Glutamate-Rich Protein 6 3
  • Glutamate-Rich 6 2
  • ERICH6A 3

External Ids for ERICH6 Gene

Previous HGNC Symbols for ERICH6 Gene

  • C3orf44
  • FAM194A

Previous GeneCards Identifiers for ERICH6 Gene

  • GC03M150379

Summaries for ERICH6 Gene

GeneCards Summary for ERICH6 Gene

ERICH6 (Glutamate Rich 6) is a Protein Coding gene. An important paralog of this gene is ERICH6B.

Additional gene information for ERICH6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH6 Gene

Genomics for ERICH6 Gene

GeneHancer (GH) Regulatory Elements for ERICH6 Gene

Promoters and enhancers for ERICH6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J150702 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 654.9 +0.9 875 2.2 HDGF PKNOX1 ARID4B NEUROD1 SIN3A YBX1 ZBTB7B BRCA1 ZNF48 YY1 ERICH6-AS1 ERICH6 EIF2A SIAH2-AS1 COMMD2
GH03J150598 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.7 +102.0 101978 8.8 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 MEF2D ZNF610 ZNF585B SELENOT SERP1 EIF2A RPL32P9 LOC730021 COMMD2 TSC22D2 ERICH6 ERICH6-AS1
GH03J150733 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -34.9 -34851 12.4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B NEUROD1 DMAP1 YY1 SLC30A9 LOC101928105 SIAH2 SIAH2-AS1 ERICH6 ERICH6-AS1 TSC22D2 SERP1 CLRN1 PIR41342
GH03J150724 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 12.4 -23.1 -23088 5.6 HDGF CLOCK SMAD1 ATF1 FOXA2 ARNT TCF12 GATA2 ARID2 ZNF143 ERICH6-AS1 SIAH2 ERICH6 SIAH2-AS1 MINDY4B ENSG00000243273 SNRPCP3 LOC101928105
GH03J150750 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.3 -47.3 -47250 2.5 MEIS2 PKNOX1 CLOCK USF1 SIN3A ZMYM3 EBF1 ZNF48 ZBTB40 ZNF507 EIF2A ERICH6 ERICH6-AS1 SIAH2-AS1 SIAH2 LOC105374155 PIR41342
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ERICH6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ERICH6 Gene

Genomic Locations for ERICH6 Gene
44,682 bases
Minus strand
44,087 bases
Minus strand

Genomic View for ERICH6 Gene

Genes around ERICH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH6 Gene

Proteins for ERICH6 Gene

  • Protein details for ERICH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamate-rich protein 6
    Protein Accession:
    Secondary Accessions:
    • Q8N9Y8
    • Q8NCQ6
    • Q8NCZ6

    Protein attributes for ERICH6 Gene

    663 amino acids
    Molecular mass:
    75255 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ERICH6 Gene


neXtProt entry for ERICH6 Gene

Post-translational modifications for ERICH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERICH6 Gene

No data available for DME Specific Peptides for ERICH6 Gene

Domains & Families for ERICH6 Gene

Gene Families for ERICH6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERICH6 Gene


Suggested Antigen Peptide Sequences for ERICH6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERICH6 family.
  • Belongs to the ERICH6 family.
genes like me logo Genes that share domains with ERICH6: view

Function for ERICH6 Gene

Phenotypes From GWAS Catalog for ERICH6 Gene

genes like me logo Genes that share phenotypes with ERICH6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERICH6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERICH6 Gene

Localization for ERICH6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH6 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ERICH6 Gene

Pathways & Interactions for ERICH6 Gene

SuperPathways for ERICH6 Gene

No Data Available

Interacting Proteins for ERICH6 Gene

Selected Interacting proteins: Q7L0X2-ERIP6_HUMAN for ERICH6 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ERICH6 Gene


No data available for Pathways by source and SIGNOR curated interactions for ERICH6 Gene

Drugs & Compounds for ERICH6 Gene

No Compound Related Data Available

Transcripts for ERICH6 Gene

mRNA/cDNA for ERICH6 Gene

(3) REFSEQ mRNAs :
(17) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERICH6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH6 Gene

No ASD Table

Relevant External Links for ERICH6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERICH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERICH6 Gene

This gene is overexpressed in Testis (x42.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH6 Gene

Protein tissue co-expression partners for ERICH6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ERICH6 Gene:

genes like me logo Genes that share expression patterns with ERICH6: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH6 Gene

Orthologs for ERICH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM194A 34 33
  • 98.64 (n)
(Canis familiaris)
Mammalia FAM194A 34 33
  • 82.91 (n)
(Bos Taurus)
Mammalia FAM194A 34 33
  • 82.64 (n)
(Rattus norvegicus)
Mammalia Fam194a 33
  • 73.77 (n)
(Mus musculus)
Mammalia Fam194a 34 33
  • 69.93 (n)
Erich6 16
(Monodelphis domestica)
Mammalia FAM194A 34
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia FAM194A 34
  • 34 (a)
(Gallus gallus)
Aves FAM194A 34 33
  • 56.05 (n)
(Anolis carolinensis)
Reptilia FAM194A 34
  • 36 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam194a 33
  • 52.16 (n)
Species where no ortholog for ERICH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ERICH6 Gene

Gene Tree for ERICH6 (if available)
Gene Tree for ERICH6 (if available)
Evolutionary constrained regions (ECRs) for ERICH6: view image

Paralogs for ERICH6 Gene

Paralogs for ERICH6 Gene

genes like me logo Genes that share paralogs with ERICH6: view

Variants for ERICH6 Gene

Sequence variations from dbSNP and Humsavar for ERICH6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000048698 -- 150,668,336(-) A/G intron_variant
rs1000090175 -- 150,673,368(-) T/C intron_variant
rs1000337630 -- 150,685,037(-) A/G intron_variant
rs1000337636 -- 150,660,351(-) G/A intron_variant
rs1000356500 -- 150,705,206(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH6 Gene

Variant ID Type Subtype PubMed ID
esv2672200 CNV deletion 23128226
esv3598162 CNV loss 21293372

Variation tolerance for ERICH6 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.73; 78.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERICH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH6 Gene

Disorders for ERICH6 Gene

Additional Disease Information for ERICH6

No disorders were found for ERICH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH6 Gene

Publications for ERICH6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for ERICH6 Gene

Sources for ERICH6 Gene

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