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Aliases for ERICH2 Gene

Aliases for ERICH2 Gene

  • Glutamate Rich 2 2 3 5
  • Glutamate-Rich 2 2

External Ids for ERICH2 Gene

Previous GeneCards Identifiers for ERICH2 Gene

  • GC02P171643

Summaries for ERICH2 Gene

GeneCards Summary for ERICH2 Gene

ERICH2 (Glutamate Rich 2) is a Protein Coding gene.

Additional gene information for ERICH2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH2 Gene

Genomics for ERICH2 Gene

GeneHancer (GH) Regulatory Elements for ERICH2 Gene

Promoters and enhancers for ERICH2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I170769 Promoter/Enhancer 1.7 Ensembl ENCODE 550.8 +0.6 554 2.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A SLC30A9 POLR2B E2F8 ZNF263 ERICH2 ENSG00000239467 LOC101926913 DAP3P2 RPS15P4 DCAF17
GH02I170783 Promoter 0.7 EPDnew 550.4 +13.2 13231 0.1 CREB1 CREM ENSG00000222509 ERICH2 GC02M170795
GH02I170817 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 4.6 +46.6 46599 1.6 PKNOX1 ATF1 ARNT SIN3A ZNF766 SP3 REST ZNF610 SMARCA4 GLIS1 GAD1 ENSG00000235934 ERICH2 GC02P170803
GH02I170826 Enhancer 0.8 dbSUPER 4.6 +52.4 52432 0.2 HDAC1 TCF12 GATA2 NCOA1 NFIC KLF16 SMARCA4 KDM1A ZBTB33 SETDB1 ERICH2 GC02M170820 GAD1 GC02P170803 GC02P170876
GH02I170764 Enhancer 0.6 ENCODE 0.4 -5.5 -5546 1.7 SMARCA5 LEF1 SOX6 CBFA2T3 ZMYM3 DPF2 BATF ZNF148 CC2D1A SMARCA4 GAD1 GC02M170760 ERICH2 LOC101926913
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERICH2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ERICH2 Gene

Genomic Locations for ERICH2 Gene
chr2:170,770,541-170,798,971
(GRCh38/hg38)
Size:
28,431 bases
Orientation:
Plus strand
chr2:171,640,296-171,655,481
(GRCh37/hg19)

Genomic View for ERICH2 Gene

Genes around ERICH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH2 Gene

Proteins for ERICH2 Gene

  • Protein details for ERICH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L162-ERIC2_HUMAN
    Recommended name:
    Glutamate-rich protein 2
    Protein Accession:
    A1L162
    Secondary Accessions:
    • A7E2T7

    Protein attributes for ERICH2 Gene

    Size:
    156 amino acids
    Molecular mass:
    17672 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI50547.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ERICH2 Gene

Post-translational modifications for ERICH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ERICH2 Gene

Domains & Families for ERICH2 Gene

Gene Families for ERICH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERICH2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ERICH2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ERICH2 Gene

Function for ERICH2 Gene

Phenotypes From GWAS Catalog for ERICH2 Gene

Gene Ontology (GO) - Molecular Function for ERICH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ERICH2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ERICH2 Gene

Localization for ERICH2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH2 gene
Compartment Confidence
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERICH2 Gene

Pathways & Interactions for ERICH2 Gene

SuperPathways for ERICH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERICH2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH2 Gene

Drugs & Compounds for ERICH2 Gene

No Compound Related Data Available

Transcripts for ERICH2 Gene

mRNA/cDNA for ERICH2 Gene

Unigene Clusters for ERICH2 Gene

Glutamate-rich 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH2 Gene

No ASD Table

Relevant External Links for ERICH2 Gene

GeneLoc Exon Structure for
ERICH2
ECgene alternative splicing isoforms for
ERICH2

Expression for ERICH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH2 Gene

mRNA differential expression in normal tissues according to GTEx for ERICH2 Gene

This gene is overexpressed in Testis (x31.4).

Protein differential expression in normal tissues from HIPED for ERICH2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERICH2 Gene



Protein tissue co-expression partners for ERICH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERICH2 Gene:

ERICH2

SOURCE GeneReport for Unigene cluster for ERICH2 Gene:

Hs.443729
genes like me logo Genes that share expression patterns with ERICH2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH2 Gene

Orthologs for ERICH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERICH2 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia ERICH2 33 34
  • 84.13 (n)
cow
(Bos Taurus)
Mammalia ERICH2 33 34
  • 81.69 (n)
mouse
(Mus musculus)
Mammalia Erich2 33 16 34
  • 76.58 (n)
rat
(Rattus norvegicus)
Mammalia Erich2 33
  • 76.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ERICH2 34
  • 30 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERICH2 34
  • 24 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ERICH2 34
  • 19 (a)
OneToOne
Species where no ortholog for ERICH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERICH2 Gene

ENSEMBL:
Gene Tree for ERICH2 (if available)
TreeFam:
Gene Tree for ERICH2 (if available)

Paralogs for ERICH2 Gene

No data available for Paralogs for ERICH2 Gene

Variants for ERICH2 Gene

Sequence variations from dbSNP and Humsavar for ERICH2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000052677 -- 170,784,761(+) C/A coding_sequence_variant, genic_downstream_transcript_variant, non_coding_transcript_variant, synonymous_variant
rs1000075362 -- 170,772,181(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000111671 -- 170,791,737(+) TAATTA/TA genic_downstream_transcript_variant, intron_variant
rs1000122502 -- 170,789,781(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000333006 -- 170,786,947(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH2 Gene

Variant ID Type Subtype PubMed ID
esv3415379 CNV insertion 20981092
nsv1131527 CNV deletion 24896259

Variation tolerance for ERICH2 Gene

Gene Damage Index Score: 1.24; 24.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERICH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH2 Gene

Disorders for ERICH2 Gene

Additional Disease Information for ERICH2

No disorders were found for ERICH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH2 Gene

Publications for ERICH2 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ERICH2 Gene

Sources for ERICH2 Gene

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