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Aliases for ERICH1 Gene

Aliases for ERICH1 Gene

  • Glutamate Rich 1 2 3 5
  • Glutamate-Rich Protein 1 3
  • Glutamate-Rich 1 2
  • HSPC319 3

External Ids for ERICH1 Gene

Previous GeneCards Identifiers for ERICH1 Gene

  • GC08M000605
  • GC08M000614
  • GC08M000454

Summaries for ERICH1 Gene

GeneCards Summary for ERICH1 Gene

ERICH1 (Glutamate Rich 1) is a Protein Coding gene.

Additional gene information for ERICH1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERICH1 Gene

Genomics for ERICH1 Gene

GeneHancer (GH) Regulatory Elements for ERICH1 Gene

Promoters and enhancers for ERICH1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J000729 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 671.9 +7.1 7107 2 PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 POLR2B GLIS2 E2F8 ZNF143 ERICH1 ENSG00000254207 DLGAP2
GH08J000670 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 664.7 +65.6 65572 3.3 TFAP4 MXI1 FOXA2 SAP130 ARID4B MAX ETS1 YY1 FOXK2 SCRT2 ERICH1 PIR43730 LOC105377774
GH08J000737 Promoter 0.7 EPDnew 650.7 +0.5 464 0.1 ZNF335 ZBTB26 EZH2 DLGAP2 ERICH1 LOC401442
GH08J000686 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 35.1 +50.4 50382 2.8 PKNOX1 FOXA2 ARNT FEZF1 GLIS2 ZNF143 SP3 TSHZ1 ZNF610 GLIS1 ERICH1 ENSG00000254207 ENSG00000272812 ENSG00000272240 ENSG00000273402 ZNF596 PIR53847 GC08M000701
GH08J000627 Enhancer 1.5 Ensembl ENCODE dbSUPER 35.4 +108.3 108307 4.6 CLOCK MLX FEZF1 ZNF416 ZNF548 SP3 MEF2D SSRP1 GLIS1 NBN ENSG00000273402 ENSG00000272812 ENSG00000272240 ZNF596 ENSG00000272293 ERICH1 RPL23AP53 TDRP ENSG00000254207 LOC105377773
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERICH1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ERICH1 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • Egr-2
  • CUTL1
  • E2F
  • E2F-1
  • AhR
  • Arnt
  • LCR-F1
  • NF-AT

Genomic Locations for ERICH1 Gene

Genomic Locations for ERICH1 Gene
chr8:614,737-738,106
(GRCh38/hg38)
Size:
123,370 bases
Orientation:
Minus strand
chr8:564,746-688,106
(GRCh37/hg19)
Size:
123,361 bases
Orientation:
Minus strand

Genomic View for ERICH1 Gene

Genes around ERICH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERICH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERICH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERICH1 Gene

Proteins for ERICH1 Gene

  • Protein details for ERICH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X53-ERIC1_HUMAN
    Recommended name:
    Glutamate-rich protein 1
    Protein Accession:
    Q86X53
    Secondary Accessions:
    • A8K2J9
    • Q9P063

    Protein attributes for ERICH1 Gene

    Size:
    443 amino acids
    Molecular mass:
    48984 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28997.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ERICH1 Gene

Post-translational modifications for ERICH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ERICH1 Gene

Domains & Families for ERICH1 Gene

Gene Families for ERICH1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERICH1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ERICH1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ERICH1: view

No data available for UniProtKB/Swiss-Prot for ERICH1 Gene

Function for ERICH1 Gene

Phenotypes From GWAS Catalog for ERICH1 Gene

genes like me logo Genes that share phenotypes with ERICH1: view

Animal Model Products

miRNA for ERICH1 Gene

miRTarBase miRNAs that target ERICH1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERICH1 Gene

Localization for ERICH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERICH1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERICH1 Gene

Pathways & Interactions for ERICH1 Gene

SuperPathways for ERICH1 Gene

No Data Available

Interacting Proteins for ERICH1 Gene

Selected Interacting proteins: Q86X53-ERIC1_HUMAN for ERICH1 Gene via IID

Gene Ontology (GO) - Biological Process for ERICH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ERICH1 Gene

Drugs & Compounds for ERICH1 Gene

No Compound Related Data Available

Transcripts for ERICH1 Gene

Unigene Clusters for ERICH1 Gene

Glutamate-rich 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERICH1 Gene

No ASD Table

Relevant External Links for ERICH1 Gene

GeneLoc Exon Structure for
ERICH1
ECgene alternative splicing isoforms for
ERICH1

Expression for ERICH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERICH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERICH1 Gene

This gene is overexpressed in Pancreas (34.0), Adrenal (18.3), and Pancreatic juice (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ERICH1 Gene



Protein tissue co-expression partners for ERICH1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERICH1 Gene:

ERICH1

SOURCE GeneReport for Unigene cluster for ERICH1 Gene:

Hs.655310

Evidence on tissue expression from TISSUES for ERICH1 Gene

  • Bone(2.7)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ERICH1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERICH1 Gene

Orthologs for ERICH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ERICH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERICH1 34 33
  • 96.02 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Erich1 16 34 33
  • 68.64 (n)
dog
(Canis familiaris)
Mammalia ERICH1 34 33
  • 66.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Erich1 33
  • 61.53 (n)
cow
(Bos Taurus)
Mammalia ERICH1 34
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERICH1 34
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ERICH1 34
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERICH1 34 33
  • 58.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERICH1 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100144976 33
  • 49.46 (n)
zebrafish
(Danio rerio)
Actinopterygii ERICH1 34
  • 27 (a)
OneToOne
Species where no ortholog for ERICH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERICH1 Gene

ENSEMBL:
Gene Tree for ERICH1 (if available)
TreeFam:
Gene Tree for ERICH1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ERICH1: view image

Paralogs for ERICH1 Gene

No data available for Paralogs for ERICH1 Gene

Variants for ERICH1 Gene

Sequence variations from dbSNP and Humsavar for ERICH1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs774405503 A colorectal cancer sample 668,763(-) G/A/C coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, synonymous_variant
rs1000004114 -- 616,427(-) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000015464 -- 702,290(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000035119 -- 616,543(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000037486 -- 662,154(-) C/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERICH1 Gene

Variant ID Type Subtype PubMed ID
nsv951691 CNV deletion 24416366
nsv951690 CNV deletion 24416366
nsv609480 CNV loss 21841781
nsv609479 CNV loss 21841781
nsv609477 CNV loss 21841781
nsv609472 CNV gain 21841781
nsv609460 CNV loss 21841781
nsv609458 CNV gain 21841781
nsv609452 CNV loss 21841781
nsv609451 CNV loss 21841781
nsv6037 CNV deletion 18451855
nsv6036 CNV deletion 18451855
nsv472252 CNV novel sequence insertion 20440878
nsv470163 CNV loss 18288195
nsv465264 CNV loss 19166990
nsv397438 CNV deletion 16902084
nsv1161676 CNV deletion 26073780
nsv1161675 CNV deletion 26073780
nsv1124990 CNV duplication 24896259
nsv1028828 CNV loss 25217958
nsv1027283 CNV gain 25217958
nsv1024325 CNV gain 25217958
nsv1023335 CNV gain 25217958
esv990762 CNV insertion 20482838
esv3615798 CNV gain 21293372
esv3615796 CNV gain 21293372
esv3615795 CNV loss 21293372
esv3615792 CNV gain 21293372
esv3615771 CNV gain 21293372
esv3414251 CNV duplication 20981092
esv3360002 CNV duplication 20981092
esv2761394 CNV gain 21179565
esv275416 CNV gain+loss 21479260
esv2736078 CNV deletion 23290073
esv2736077 CNV deletion 23290073
esv2736071 CNV deletion 23290073
esv2736070 CNV deletion 23290073
esv2736069 CNV deletion 23290073
esv2736068 CNV deletion 23290073
esv2736067 CNV deletion 23290073
esv2736066 CNV deletion 23290073
esv2736065 CNV deletion 23290073
esv2736064 CNV deletion 23290073
esv2736063 CNV deletion 23290073
esv2736062 CNV deletion 23290073
esv2736060 CNV deletion 23290073
esv2736059 CNV deletion 23290073
esv2736058 CNV deletion 23290073
esv2736057 CNV deletion 23290073
esv2736056 CNV deletion 23290073
esv26461 CNV gain+loss 19812545
esv2593775 CNV insertion 19546169
esv2484664 CNV deletion 19546169
esv23103 CNV loss 19812545
esv2095527 CNV deletion 18987734
esv1743407 CNV deletion 17803354
esv1576160 CNV deletion 17803354
esv1532105 CNV deletion 17803354
esv1434125 CNV deletion 17803354
esv1247467 CNV insertion 17803354
esv1206108 CNV deletion 17803354
esv1096681 CNV deletion 17803354
esv1091730 CNV deletion 17803354
esv1085855 CNV insertion 17803354
esv1056975 CNV insertion 17803354
esv1024510 CNV deletion 17803354
dgv6795n100 CNV gain 25217958
dgv11815n54 CNV loss 21841781
dgv11814n54 CNV loss 21841781
dgv11813n54 CNV loss 21841781
dgv11812n54 CNV loss 21841781
dgv1171e201 CNV deletion 23290073
dgv1170e201 CNV deletion 23290073
dgv1156n67 CNV gain 20364138

Variation tolerance for ERICH1 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERICH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERICH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERICH1 Gene

Disorders for ERICH1 Gene

Additional Disease Information for ERICH1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ERICH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERICH1 Gene

Publications for ERICH1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi DJ … Shiio Y (Journal of proteome research 2014) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58

Products for ERICH1 Gene

Sources for ERICH1 Gene

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