Aliases for ERI3 Gene

Aliases for ERI3 Gene

  • ERI1 Exoribonuclease Family Member 3 2 3 5
  • Prion Protein-Interacting Protein 3 4
  • ERI1 Exoribonuclease 3 3 4
  • Prion Interactor 1 3 4
  • PRNPIP 3 4
  • PINT1 3 4
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 3 (C.Elegans) 2
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 3 3
  • Prion Protein Interacting Protein 2
  • Exoribonuclease 3 2
  • EC 3.1.-.- 4
  • PRNPIP1 4

External Ids for ERI3 Gene

Previous HGNC Symbols for ERI3 Gene

  • PRNPIP

Previous GeneCards Identifiers for ERI3 Gene

  • GC01M044459
  • GC01M044686
  • GC01M042800

Summaries for ERI3 Gene

GeneCards Summary for ERI3 Gene

ERI3 (ERI1 Exoribonuclease Family Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ERI1.

Additional gene information for ERI3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ERI3 Gene

Genomics for ERI3 Gene

GeneHancer (GH) Regulatory Elements for ERI3 Gene

Promoters and enhancers for ERI3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J044354 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.4 378 2.2 SP1 SIX5 POLR2A ATF1 FOS CREB1 HCFC1 MYC NFYC HLF ERI3 TOE1 DMAP1 SZT2 MUTYH ZSWIM5 KIF2C MED8 lnc-KLF18-11
GH01J044212 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 28.6 +141.8 141797 2.3 FOXK2 ZNF785 ZNF24 SP1 ZBTB40 SIX5 ZBTB6 MLX SMARCE1 RBPJ DMAP1 lnc-ERI3-8 SZT2 ARTN HYI HECTD3 KDM4A-AS1 MED8 RPS8 KDM4A
GH01J045009 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19 -657.1 -657065 5.5 SP1 ZBTB40 CTCF SIX5 ZBTB6 MLX SMARCE1 POLR2A USF2 ATF1 UROD HECTD3 TOE1 KIF2C MUTYH GPBP1L1 RPS15AP10 RPS8 NASP PTCH2
GH01J044985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 19 -631.0 -631022 2.2 ZNF785 SIN3A ZNF24 ZBTB40 SP1 ZBTB6 MLX SMARCE1 RBPJ POLR2A EIF2B3 TOE1 GPBP1L1 ENSG00000234329 RPS15AP10 RPS8 HECTD3 PTCH2 ERI3 TMA16P2
GH01J044047 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 19 +306.3 306303 3.5 ZBTB40 CTCF SMARCE1 POLR2A CC2D1A DACH1 RAD21 TEAD4 GTF2F1 CSDE1 KLF17 SZT2 ENSG00000237950 PTCH2 DMAP1 ARTN ERI3 KDM4A IPO13 ENSG00000230615
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ERI3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ERI3 gene promoter:
  • c-Myc
  • Evi-1
  • Gfi-1
  • HTF
  • Max1
  • p300
  • Pax-3
  • SEF-1 (1)
  • USF-1
  • USF1

Genomic Locations for ERI3 Gene

Genomic Locations for ERI3 Gene
chr1:44,221,070-44,355,279
(GRCh38/hg38)
Size:
134,210 bases
Orientation:
Minus strand
chr1:44,686,742-44,820,939
(GRCh37/hg19)
Size:
134,198 bases
Orientation:
Minus strand

Genomic View for ERI3 Gene

Genes around ERI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERI3 Gene

Proteins for ERI3 Gene

  • Protein details for ERI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43414-ERI3_HUMAN
    Recommended name:
    ERI1 exoribonuclease 3
    Protein Accession:
    O43414
    Secondary Accessions:
    • B1AK98
    • Q5T2T7
    • Q5T2T9
    • Q5TG35
    • Q9BQA0
    • Q9UEB4

    Protein attributes for ERI3 Gene

    Size:
    337 amino acids
    Molecular mass:
    37238 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PRNP.
    SequenceCaution:
    • Sequence=AAC19158.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERI3 Gene

    Alternative splice isoforms for ERI3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERI3 Gene

Post-translational modifications for ERI3 Gene

  • Ubiquitination at Lys321 and Lys331
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERI3 Gene

Domains & Families for ERI3 Gene

Gene Families for ERI3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ERI3 Gene

Suggested Antigen Peptide Sequences for ERI3 Gene

GenScript: Design optimal peptide antigens:
  • Prion protein interacting protein (B1AK96_HUMAN)
  • Prion protein interacting protein (B1AK97_HUMAN)
  • cDNA FLJ60449, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA (B4DEX5_HUMAN)
  • cDNA FLJ56336, highly similar to Homo sapiens prion protein interacting protein (PRNPIP), mRNA (B4DN03_HUMAN)
  • Prion protein-interacting protein (ERI3_HUMAN)
genes like me logo Genes that share domains with ERI3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ERI3 Gene

Function for ERI3 Gene

Enzyme Numbers (IUBMB) for ERI3 Gene

Phenotypes From GWAS Catalog for ERI3 Gene

Gene Ontology (GO) - Molecular Function for ERI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3'-5'-exoribonuclease activity IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with ERI3: view
genes like me logo Genes that share phenotypes with ERI3: view

Animal Models for ERI3 Gene

MGI Knock Outs for ERI3:
  • Eri3 Eri3<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ERI3 Gene

miRTarBase miRNAs that target ERI3

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ERI3 Gene

Localization for ERI3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERI3 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ERI3 Gene

Pathways & Interactions for ERI3 Gene

PathCards logo

SuperPathways for ERI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
GO:0000738 DNA catabolic process, exonucleolytic IBA 21873635
genes like me logo Genes that share ontologies with ERI3: view

No data available for Pathways by source and SIGNOR curated interactions for ERI3 Gene

Drugs & Compounds for ERI3 Gene

No Compound Related Data Available

Transcripts for ERI3 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERI3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for ERI3 Gene

GeneLoc Exon Structure for
ERI3
ECgene alternative splicing isoforms for
ERI3

Expression for ERI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ERI3 Gene



Protein tissue co-expression partners for ERI3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ERI3 Gene:

ERI3

SOURCE GeneReport for Unigene cluster for ERI3 Gene:

Hs.731413

Evidence on tissue expression from TISSUES for ERI3 Gene

  • Nervous system(4.9)
  • Lung(4.6)
  • Skin(2.5)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with ERI3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERI3 Gene

Orthologs for ERI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERI3 33 32
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ERI3 33 32
  • 97.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ERI3 33 32
  • 96.74 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eri3 32
  • 95.45 (n)
mouse
(Mus musculus)
Mammalia Eri3 17 33 32
  • 93.87 (n)
oppossum
(Monodelphis domestica)
Mammalia ERI3 33
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ERI3 33 32
  • 81.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ERI3 33
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eri3 32
  • 73.19 (n)
Str.15577 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.1845 32
worm
(Caenorhabditis elegans)
Secernentea CELE_R02D3.8 32
  • 51.66 (n)
R02D3.8 33
  • 38 (a)
OneToMany
M02B7.2 33
  • 36 (a)
OneToMany
Species where no ortholog for ERI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ERI3 Gene

ENSEMBL:
Gene Tree for ERI3 (if available)
TreeFam:
Gene Tree for ERI3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ERI3: view image

Paralogs for ERI3 Gene

Paralogs for ERI3 Gene

(1) SIMAP similar genes for ERI3 Gene using alignment to 4 proteins:

  • ERI3_HUMAN
  • F6QUN3_HUMAN
  • F6UGJ8_HUMAN
  • H0Y4B0_HUMAN
genes like me logo Genes that share paralogs with ERI3: view

Variants for ERI3 Gene

Sequence variations from dbSNP and Humsavar for ERI3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000025757 -- 44,271,058(-) C/T intron_variant
rs1000036743 -- 44,225,304(-) T/G intron_variant
rs1000041562 -- 44,313,707(-) T/A intron_variant
rs1000059905 -- 44,356,209(-) C/T upstream_transcript_variant
rs1000074235 -- 44,314,060(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERI3 Gene

Variant ID Type Subtype PubMed ID
esv24567 CNV loss 19812545
esv3399053 CNV insertion 20981092
esv3585881 CNV loss 21293372
esv998002 CNV deletion 20482838
nsv508011 OTHER sequence alteration 20534489
nsv829715 CNV gain 17160897

Variation tolerance for ERI3 Gene

Residual Variation Intolerance Score: 18.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERI3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERI3 Gene

Disorders for ERI3 Gene

Additional Disease Information for ERI3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ERI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERI3 Gene

Publications for ERI3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  3. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 56
  4. Failure to Replicate an Association of a LINE-1 Element in ERI1 Exoribonuclease Family Member 3 (ERI3) with Schizophrenia. (PMID: 29123232) Doyle GA … Berrettini WH (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017) 3 56
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 56

Products for ERI3 Gene

Sources for ERI3 Gene