Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ERI2 Gene

Aliases for ERI2 Gene

  • ERI1 Exoribonuclease Family Member 2 2 3 5
  • Exonuclease Domain-Containing Protein 1 3 4
  • Zinc Finger, GRF-Type Containing 5 2 3
  • Exonuclease Domain Containing 1 2 3
  • Exoribonuclease 2 2 3
  • EXOD1 3 4
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 2 (C.Elegans) 2
  • Enhanced RNAi Three Prime MRNA Exonuclease Homolog 2 3
  • ERI1 Exoribonuclease 2 3
  • EC 3.1.-.- 4
  • KIAA1504 4
  • ZGRF5 3

External Ids for ERI2 Gene

Previous HGNC Symbols for ERI2 Gene

  • EXOD1

Previous GeneCards Identifiers for ERI2 Gene

  • GC16M020703
  • GC16M019326

Summaries for ERI2 Gene

GeneCards Summary for ERI2 Gene

ERI2 (ERI1 Exoribonuclease Family Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity. An important paralog of this gene is ERI1.

Additional gene information for ERI2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERI2 Gene

Genomics for ERI2 Gene

GeneHancer (GH) Regulatory Elements for ERI2 Gene

Promoters and enhancers for ERI2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J020804 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.2 +93.6 93610 3.6 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 REXO5 ERI2 SMG1P3 THUMPD1 NPIPB3 ACSM1 ACSM3 ENSG00000275908
GH16J021819 Promoter/Enhancer 1.5 Ensembl ENCODE 19.2 -920.0 -919952 1.8 HDGF SMAD1 ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF207 ZNF143 RRN3P1 NPIPB4 NPIPB5 NPIPB3 SMG1P3 ENSG00000260635 SMG1P4 SMG1P1 ENSG00000260905 POLR3E
GH16J020743 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.9 +154.3 154265 4.3 HDGF PKNOX1 SMAD1 ATF1 FOXA2 ARNT ZNF280A TCF12 ZNF766 CBX5 THUMPD1 ACSM3 NPIPB3 SMG1P3 REXO5 ERI2 GC16P020744 ENSG00000260510
GH16J021624 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -727.2 -727172 6.3 PKNOX1 FOXA2 ARID4B DMAP1 ZNF48 SLC30A9 ATF7 NFKBIZ NFYC KAT8 ENSG00000261596 METTL9 IGSF6 MOSMO ERI2 ENSG00000260905 ENSG00000260973 CRYM GC16P021642
GH16J021083 Enhancer 0.8 ENCODE 11.8 -183.6 -183636 0.2 ARID4B NFXL1 RAD21 ARID2 ZNF143 RCOR1 ZNF263 ZNF654 NCOA1 MXD4 GC16P021084 NPIPB4 NPIPB3 THUMPD1 ERI2 ENSG00000260306 REXO5 RRN3P1 DCUN1D3 LYRM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ERI2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ERI2 gene promoter:
  • Oct-B1
  • Nkx2-5
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for ERI2 Gene

Genomic Locations for ERI2 Gene
120,157 bases
Minus strand
120,157 bases
Minus strand

Genomic View for ERI2 Gene

Genes around ERI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERI2 Gene

Proteins for ERI2 Gene

  • Protein details for ERI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ERI1 exoribonuclease 2
    Protein Accession:
    Secondary Accessions:
    • Q6ZSJ2
    • Q96FR9
    • Q9P224
    • Q9Y6V3

    Protein attributes for ERI2 Gene

    691 amino acids
    Molecular mass:
    77401 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAC31669.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ERI2 Gene


neXtProt entry for ERI2 Gene

Post-translational modifications for ERI2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ERI2 Gene

No data available for DME Specific Peptides for ERI2 Gene

Domains & Families for ERI2 Gene

Gene Families for ERI2 Gene

Protein Domains for ERI2 Gene

Suggested Antigen Peptide Sequences for ERI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERI2 family.
  • Belongs to the ERI2 family.
genes like me logo Genes that share domains with ERI2: view

Function for ERI2 Gene

Enzyme Numbers (IUBMB) for ERI2 Gene

Gene Ontology (GO) - Molecular Function for ERI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity IBA --
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ERI2: view
genes like me logo Genes that share phenotypes with ERI2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERI2

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERI2 Gene

Localization for ERI2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERI2 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ERI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ERI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ERI2 Gene

Pathways & Interactions for ERI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000467 exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000738 DNA catabolic process, exonucleolytic IBA --
GO:0006259 DNA metabolic process IBA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ERI2: view

No data available for Pathways by source and SIGNOR curated interactions for ERI2 Gene

Drugs & Compounds for ERI2 Gene

No Compound Related Data Available

Transcripts for ERI2 Gene

mRNA/cDNA for ERI2 Gene

Unigene Clusters for ERI2 Gene

ERI1 exoribonuclease family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERI2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERI2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP1: -
SP2: - - - -
SP5: - -
SP6: -
SP7: - - - -
SP8: - - -
SP9: - - - -
SP12: - -
SP15: -

ExUns: 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: -
SP3: -

Relevant External Links for ERI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERI2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERI2 Gene

Protein tissue co-expression partners for ERI2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERI2 Gene:


SOURCE GeneReport for Unigene cluster for ERI2 Gene:


Evidence on tissue expression from TISSUES for ERI2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ERI2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERI2 Gene

Orthologs for ERI2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERI2 34 33
  • 99.32 (n)
(Canis familiaris)
Mammalia ERI2 34 33
  • 87.63 (n)
(Bos Taurus)
Mammalia ERI2 34 33
  • 86.43 (n)
(Rattus norvegicus)
Mammalia Eri2 33
  • 81.63 (n)
(Mus musculus)
Mammalia Eri2 16 34 33
  • 80.72 (n)
(Monodelphis domestica)
Mammalia ERI2 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ERI2 34
  • 56 (a)
(Gallus gallus)
Aves ERI2 34 33
  • 56.19 (n)
(Anolis carolinensis)
Reptilia ERI2 34
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia eri2 33
  • 57.31 (n)
Str.2674 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7002 33
fruit fly
(Drosophila melanogaster)
Insecta Snp 33
  • 50.28 (n)
(Caenorhabditis elegans)
Secernentea crn-4 34
  • 21 (a)
eri-1 34
  • 16 (a)
Species where no ortholog for ERI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ERI2 Gene

Gene Tree for ERI2 (if available)
Gene Tree for ERI2 (if available)
Evolutionary constrained regions (ECRs) for ERI2: view image

Paralogs for ERI2 Gene

Paralogs for ERI2 Gene

genes like me logo Genes that share paralogs with ERI2: view

Variants for ERI2 Gene

Sequence variations from dbSNP and Humsavar for ERI2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs997506328 A colorectal cancer sample 20,799,983(-) A/G coding_sequence_variant, missense_variant
rs1000296370 -- 20,793,948(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000551004 -- 20,793,865(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000776653 -- 20,806,614(-) A/T upstream_transcript_variant
rs1000794830 -- 20,784,666(-) T/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERI2 Gene

Variant ID Type Subtype PubMed ID
nsv833165 CNV loss 17160897
nsv436835 CNV insertion 17901297
nsv1050009 CNV loss 25217958

Variation tolerance for ERI2 Gene

Gene Damage Index Score: 8.09; 84.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERI2 Gene

Disorders for ERI2 Gene

Additional Disease Information for ERI2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ERI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERI2 Gene

Publications for ERI2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn LW … O'Brien SJ (The Journal of infectious diseases 2010) 44 58

Products for ERI2 Gene

Sources for ERI2 Gene

Loading form....