Aliases for ERI1 Gene
External Ids for ERI1 Gene
Previous HGNC Symbols for ERI1 Gene
Previous GeneCards Identifiers for ERI1 Gene
GeneCards Summary for ERI1 Gene
ERI1 (Exoribonuclease 1) is a Protein Coding gene. Diseases associated with ERI1 include Locked-In Syndrome and Retinitis Pigmentosa 7. Among its related pathways are rRNA processing in the nucleus and cytosol and DDX1 as a regulatory component of the Drosha microprocessor. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribosome binding. An important paralog of this gene is ERI3.
UniProtKB/Swiss-Prot Summary for ERI1 Gene
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.