Aliases for ERI1 Gene
External Ids for ERI1 Gene
Previous HGNC Symbols for ERI1 Gene
Previous GeneCards Identifiers for ERI1 Gene
GeneCards Summary for ERI1 Gene
ERI1 (Exoribonuclease 1) is a Protein Coding gene. Diseases associated with ERI1 include Locked-In Syndrome and Renal Hypodysplasia/Aplasia 3. Among its related pathways are rRNA processing in the nucleus and cytosol and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribosome binding. An important paralog of this gene is ERI3.
UniProtKB/Swiss-Prot Summary for ERI1 Gene
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.