ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008] See more...

Aliases for ERGIC2 Gene

Aliases for ERGIC2 Gene

  • ERGIC And Golgi 2 2 3 5
  • PTX1 2 3 4
  • Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 2 3 4
  • Erv41 2 3
  • CD14 Protein 3
  • ERGIC2 5
  • CDA14 3
  • Cd002 3
  • ERV41 4

External Ids for ERGIC2 Gene

Previous GeneCards Identifiers for ERGIC2 Gene

  • GC12M029382
  • GC12M029493
  • GC12M029262

Summaries for ERGIC2 Gene

Entrez Gene Summary for ERGIC2 Gene

  • ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]

GeneCards Summary for ERGIC2 Gene

ERGIC2 (ERGIC And Golgi 2) is a Protein Coding gene. Diseases associated with ERGIC2 include Acute Maxillary Sinusitis and Temtamy Syndrome. An important paralog of this gene is ERGIC3.

UniProtKB/Swiss-Prot Summary for ERGIC2 Gene

Gene Wiki entry for ERGIC2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ERGIC2 Gene

Genomics for ERGIC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ERGIC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J029379 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.4 389 3.2 CHD2 TBP SP1 CEBPA NR2C1 MNT DEK BRCA1 SMAD5 MBD2 ERGIC2 HSALNG0090099 LOC100506606 FAR2 piR-43325-022
GH12J029163 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 8.3 +213.6 213647 7.5 SP1 BCL11A ZNF395 TRIM22 IRF4 JUND FOSL1 SPI1 NFE2 BATF piR-36434 LOC100506606 ERGIC2 piR-60592-002 ENSG00000257258 lnc-CCDC91-3 FAR2
GH12J029428 Enhancer 1 Ensembl ENCODE 10.7 -47.7 -47717 4.2 CEBPB REST GTF2E2 CTCF MAX TRIM22 EP300 RXRA SMC3 ZBTB33 ERGIC2 OVCH1 LOC100506606 piR-37670 OVCH1-AS1 RF00017-1119
GH12J029319 Enhancer 0.9 FANTOM5 Ensembl ENCODE 10 +60.6 60599 2.4 RXRA HNF4A JUND ZNF680 EP300 CEBPB FOS SP1 ERGIC2 LOC100506606 ENSG00000274315 FAR2
GH12J029346 Enhancer 0.3 ENCODE 11.2 +34.1 34054 1.1 HNF4A HSALNG0090098 LOC100506606 ERGIC2 lnc-OVCH1-1 FAR2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ERGIC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ERGIC2

Top Transcription factor binding sites by QIAGEN in the ERGIC2 gene promoter:
  • ATF-2
  • CRE-BP1
  • FOXO1
  • FOXO1a
  • GR-alpha
  • GR-beta
  • LCR-F1
  • POU2F1
  • POU2F1a
  • RP58

Genomic Locations for ERGIC2 Gene

Latest Assembly
44,646 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
43,821 bases
Minus strand

(GRCh37/hg19 by Ensembl)
43,838 bases
Minus strand

Genomic View for ERGIC2 Gene

Genes around ERGIC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERGIC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERGIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERGIC2 Gene

Proteins for ERGIC2 Gene

  • Protein details for ERGIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endoplasmic reticulum-Golgi intermediate compartment protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NHH6
    • Q53GY2
    • Q8N2Q9
    • Q9BVV9
    • Q9NZA3

    Protein attributes for ERGIC2 Gene

    377 amino acids
    Molecular mass:
    42549 Da
    Quaternary structure:
    • May interact with EEF1A1.
    • Sequence=AAF61208.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for ERGIC2 Gene

Post-translational modifications for ERGIC2 Gene

  • Glycosylation at Thr154 and Asn212
  • Ubiquitination at Lys14 and Lys146
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERGIC2 Gene

Domains & Families for ERGIC2 Gene

Gene Families for ERGIC2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ERGIC2 Gene

  • Protein of unknown function DUF1692

Suggested Antigen Peptide Sequences for ERGIC2 Gene

GenScript: Design optimal peptide antigens:
  • Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGI2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERGIC family.
  • Belongs to the ERGIC family.
genes like me logo Genes that share domains with ERGIC2: view

Function for ERGIC2 Gene

Molecular function for ERGIC2 Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.

Phenotypes From GWAS Catalog for ERGIC2 Gene

Gene Ontology (GO) - Molecular Function for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17980171
genes like me logo Genes that share ontologies with ERGIC2: view
genes like me logo Genes that share phenotypes with ERGIC2: view

miRNA for ERGIC2 Gene

miRTarBase miRNAs that target ERGIC2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERGIC2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC2 Gene

Localization for ERGIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERGIC2 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. According to a report, localizes to the nucleus (PubMed:11445006). Another report shows a partial localization in the nucleus (PubMed:17980171). {ECO:0000269 PubMed:11445006, ECO:0000269 PubMed:17980171}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERGIC2 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoli rim (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17980171
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 17980171
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

Pathways & Interactions for ERGIC2 Gene

PathCards logo

SuperPathways for ERGIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA 21873635
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24768165
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

No data available for Pathways by source and SIGNOR curated interactions for ERGIC2 Gene

Drugs & Compounds for ERGIC2 Gene

No Compound Related Data Available

Transcripts for ERGIC2 Gene

mRNA/cDNA for ERGIC2 Gene

13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERGIC2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for ERGIC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP3: - -

Relevant External Links for ERGIC2 Gene

GeneLoc Exon Structure for

Expression for ERGIC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ERGIC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ERGIC2 Gene

This gene is overexpressed in Islet of Langerhans (11.1), Placenta (8.0), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERGIC2 Gene

Protein tissue co-expression partners for ERGIC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ERGIC2

SOURCE GeneReport for Unigene cluster for ERGIC2 Gene:


mRNA Expression by UniProt/SwissProt for ERGIC2 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ERGIC2 Gene

  • Liver(4.4)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ERGIC2: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERGIC2 Gene

Orthologs for ERGIC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERGIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERGIC2 30
  • 98.74 (n)
(Canis familiaris)
Mammalia ERGIC2 30 31
  • 94.78 (n)
(Bos Taurus)
Mammalia ERGIC2 30 31
  • 93.19 (n)
(Mus musculus)
Mammalia Ergic2 30 17 31
  • 91.42 (n)
(Ornithorhynchus anatinus)
Mammalia ERGIC2 31
  • 89 (a)
(Monodelphis domestica)
Mammalia ERGIC2 31
  • 86 (a)
(Gallus gallus)
Aves ERGIC2 30 31
  • 82.22 (n)
(Anolis carolinensis)
Reptilia ERGIC2 31
  • 86 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ergic2 30
  • 70.2 (n)
MGC75899 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16162 30
(Danio rerio)
Actinopterygii ergic2 30 31
  • 72.99 (n)
ERGIC2 (1 of 2) 31
  • 60 (a)
zgc64005 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3142 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005044 30
  • 46.15 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG4293 30 31
  • 41.31 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV41 30
  • 46.27 (n)
ERV46 31
  • 21 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04950g 30
  • 45.79 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AER136W 30
  • 41.29 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3984 31
  • 50 (a)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G5.04c 30
  • 43.45 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU04293 30
  • 41.07 (n)
Species where no ortholog for ERGIC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ERGIC2 Gene

Gene Tree for ERGIC2 (if available)
Gene Tree for ERGIC2 (if available)
Evolutionary constrained regions (ECRs) for ERGIC2: view image

Paralogs for ERGIC2 Gene

Paralogs for ERGIC2 Gene

(2) SIMAP similar genes for ERGIC2 Gene using alignment to 10 proteins:

  • F8VR88_HUMAN
  • F8W0R1_HUMAN
  • H0YI50_HUMAN
  • H0YI58_HUMAN
genes like me logo Genes that share paralogs with ERGIC2: view

Variants for ERGIC2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ERGIC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ERGIC2 Gene

Variant ID Type Subtype PubMed ID
esv3344998 CNV insertion 20981092

Variation tolerance for ERGIC2 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERGIC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ERGIC2 Gene

Disorders for ERGIC2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ERGIC2 Gene - From: COP

Disorder Aliases PubMed IDs
acute maxillary sinusitis
  • acute antritis
temtamy syndrome
  • temtys
cantu syndrome
  • hypertrichotic osteochondrodysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ERGIC2

genes like me logo Genes that share disorders with ERGIC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ERGIC2 Gene

Publications for ERGIC2 Gene

  1. Molecular cloning, expression, localization, and gene organization of PTX1, a human nuclear protein that is downregulated in prostate cancer. (PMID: 11445006) Kwok SC … Daskal I (DNA and cell biology 2001) 2 3 4
  2. The possible interaction of CDA14 and protein elongation factor 1alpha. (PMID: 17980171) Yang YF … Tseng TL (Biochimica et biophysica acta 2008) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L … Hauri HP (The Journal of biological chemistry 2004) 3 4

Products for ERGIC2 Gene

Sources for ERGIC2 Gene