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ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008] See more...
Aliases for ERGIC2 Gene
Aliases for ERGIC2 Gene
External Ids for ERGIC2 Gene
- HGNC: 30208
- NCBI Entrez Gene: 51290
- Ensembl: ENSG00000087502
- OMIM®: 612236
- UniProtKB/Swiss-Prot: Q96RQ1
Previous GeneCards Identifiers for ERGIC2 Gene
- GC12M029382
- GC12M029493
- GC12M029262
Summaries for ERGIC2 Gene
-
ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]
GeneCards Summary for ERGIC2 Gene
ERGIC2 (ERGIC And Golgi 2) is a Protein Coding gene. Diseases associated with ERGIC2 include Acute Maxillary Sinusitis and Temtamy Syndrome. An important paralog of this gene is ERGIC3.
UniProtKB/Swiss-Prot Summary for ERGIC2 Gene
-
Possible role in transport between endoplasmic reticulum and Golgi.
Additional gene information for ERGIC2 Gene
- HGNC (30208)
- NCBI Entrez Gene (51290)
- Ensembl (ENSG00000087502)
- OMIM® (612236)
- UniProtKB/Swiss-Prot (Q96RQ1)
- Open Targets Platform(ENSG00000087502)
- Search for ERGIC2 at DataMed
- Search for ERGIC2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ERGIC2 Gene
Genomics for ERGIC2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ERGIC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ERGIC2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ERGIC2
- Top Transcription factor binding sites by QIAGEN in the ERGIC2 gene promoter:
-
- ATF-2
- CRE-BP1
- FOXO1
- FOXO1a
- GR-alpha
- GR-beta
- LCR-F1
- POU2F1
- POU2F1a
- RP58
Genomic Locations for ERGIC2 Gene
Latest Assembly
- chr12:29,336,544-29,381,189
- (GRCh38/hg38)
- Size:
- 44,646 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:29,490,285-29,534,105
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 43,821 bases
- Orientation:
- Minus strand
- chr12:29,490,285-29,534,122
- (GRCh37/hg19 by Ensembl)
- Size:
- 43,838 bases
- Orientation:
- Minus strand
Genomic View for ERGIC2 Gene
Genes around ERGIC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.22 by HGNC
- 12p11.22 by Entrez Gene
- 12p11.22 by Ensembl
ERGIC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ERGIC2 Gene
Proteins for ERGIC2 Gene
-
Protein details for ERGIC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RQ1-ERGI2_HUMAN
- Recommended name:
- Endoplasmic reticulum-Golgi intermediate compartment protein 2
- Protein Accession:
- Q96RQ1
- A6NHH6
- Q53GY2
- Q8N2Q9
- Q9BVV9
- Q9NZA3
Protein attributes for ERGIC2 Gene
- Size:
- 377 amino acids
- Molecular mass:
- 42549 Da
- Quaternary structure:
-
- May interact with EEF1A1.
- SequenceCaution:
-
- Sequence=AAF61208.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for ERGIC2 Gene
Post-translational modifications for ERGIC2 Gene
Other Protein References for ERGIC2 Gene
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for ERGIC2
- Novus Biologicals Antibodies for ERGIC2
-
Abcam antibodies for ERGIC2
- Invitrogen Antibodies for ERGIC2 (AFLGC-ERGIC2)
-
Boster Bio Antibodies for ERGIC2
Protein products for research
-
OriGene Purified Proteins for ERGIC2
- Search Origene for MassSpec and Protein Over-expression Lysates for ERGIC2
- Origene Custom Protein Services for ERGIC2
- antibodies-online: Show 5 available ERGIC2 Proteins ranked by validation data
- Compare Top ERGIC2 Proteins
-
Quality Products:
-
Abcam proteins for ERGIC2
Assay products for research
- antibodies-online: Show 4 available ERGIC2 Elisa Kits ranked by validation data
- Compare Top ERGIC2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ERGIC2 Gene
Domains & Families for ERGIC2 Gene
Gene Families for ERGIC2 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ERGIC2 Gene
Suggested Antigen Peptide Sequences for ERGIC2 Gene
- GenScript: Design optimal peptide antigens:
-
- Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGI2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96RQ1- Family:
-
- Belongs to the ERGIC family.
Function for ERGIC2 Gene
Molecular function for ERGIC2 Gene
- UniProtKB/Swiss-Prot Function:
- Possible role in transport between endoplasmic reticulum and Golgi.
Phenotypes From GWAS Catalog for ERGIC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17980171 |
Phenotypes for ERGIC2 Gene
- MGI mutant phenotypes for ERGIC2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ERGIC2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Synthetic lethal with Ras
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Increased G1 DNA content
- Weakly decreased NFAT1-GFP nuclear translocation
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ERGIC2 - Starting at $85 >
- * ERGIC2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ERGIC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ERGIC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERGIC2
miRNA for ERGIC2 Gene
- miRTarBase miRNAs that target ERGIC2
-
- hsa-miR-98-5p (MIRT027760)
- hsa-miR-32-5p (MIRT028384)
- hsa-let-7b-5p (MIRT032433)
- hsa-miR-671-3p (MIRT037771)
- hsa-miR-92a-3p (MIRT049453)
- hsa-miR-1277-5p (MIRT064112)
- hsa-miR-6079 (MIRT477242)
- hsa-miR-1273e (MIRT477243)
- hsa-miR-6894-5p (MIRT477244)
- hsa-miR-671-5p (MIRT477245)
- hsa-miR-6828-5p (MIRT477246)
- hsa-miR-4722-5p (MIRT477247)
- hsa-miR-151b (MIRT477248)
- hsa-miR-151a-5p (MIRT477249)
- hsa-miR-3131 (MIRT477250)
- hsa-miR-611 (MIRT477251)
- hsa-miR-6840-3p (MIRT477252)
- hsa-miR-665 (MIRT477253)
- hsa-miR-4433a-3p (MIRT477254)
- hsa-miR-4459 (MIRT477255)
- hsa-miR-6165 (MIRT477256)
- hsa-miR-448 (MIRT477257)
- hsa-miR-153-3p (MIRT477258)
- hsa-miR-6800-5p (MIRT477259)
- hsa-miR-6739-5p (MIRT477260)
- hsa-miR-6733-5p (MIRT477261)
- hsa-miR-3153 (MIRT477262)
- hsa-miR-135a-3p (MIRT477263)
- hsa-miR-9500 (MIRT477264)
- hsa-miR-6822-5p (MIRT477265)
- hsa-miR-5584-5p (MIRT477266)
- hsa-miR-6750-5p (MIRT477267)
- hsa-miR-495-5p (MIRT477268)
- hsa-miR-520e (MIRT477269)
- hsa-miR-520d-3p (MIRT477270)
- hsa-miR-520c-3p (MIRT477271)
- hsa-miR-520b (MIRT477272)
- hsa-miR-520a-3p (MIRT477273)
- hsa-miR-373-3p (MIRT477274)
- hsa-miR-372-3p (MIRT477275)
- hsa-miR-302e (MIRT477276)
- hsa-miR-302d-3p (MIRT477277)
- hsa-miR-302c-3p (MIRT477278)
- hsa-miR-302b-3p (MIRT477279)
- hsa-miR-302a-3p (MIRT477280)
- hsa-miR-4796-3p (MIRT477281)
- hsa-miR-93-5p (MIRT477282)
- hsa-miR-526b-3p (MIRT477283)
- hsa-miR-519d-3p (MIRT477284)
- hsa-miR-20b-5p (MIRT477285)
- hsa-miR-20a-5p (MIRT477286)
- hsa-miR-17-5p (MIRT477287)
- hsa-miR-106b-5p (MIRT477288)
- hsa-miR-106a-5p (MIRT477289)
- hsa-miR-3609 (MIRT477290)
- hsa-miR-548ah-5p (MIRT477291)
- hsa-miR-3613-3p (MIRT537635)
- hsa-miR-561-3p (MIRT537636)
- hsa-miR-5687 (MIRT537637)
- hsa-miR-4699-5p (MIRT537638)
- hsa-miR-500a-5p (MIRT537639)
- hsa-miR-3121-3p (MIRT537640)
- hsa-miR-5585-3p (MIRT537641)
- hsa-miR-6844 (MIRT537642)
- hsa-miR-4795-3p (MIRT537643)
- hsa-miR-4477a (MIRT537644)
- hsa-miR-627-3p (MIRT537645)
- hsa-miR-195-3p (MIRT537646)
- hsa-miR-16-2-3p (MIRT537647)
- hsa-miR-126-5p (MIRT537648)
- hsa-miR-338-5p (MIRT537649)
- hsa-miR-25-3p (MIRT537650)
- hsa-miR-363-3p (MIRT537651)
- hsa-miR-367-3p (MIRT537652)
- hsa-miR-92b-3p (MIRT537653)
- hsa-miR-4778-3p (MIRT567661)
- hsa-miR-5009-3p (MIRT567662)
- hsa-miR-761 (MIRT567663)
- hsa-miR-3619-5p (MIRT567664)
- hsa-miR-214-3p (MIRT567665)
- hsa-miR-6510-5p (MIRT567666)
- hsa-miR-944 (MIRT567667)
- hsa-miR-4518 (MIRT567668)
- hsa-miR-1266-5p (MIRT567669)
- hsa-miR-3664-3p (MIRT567670)
- hsa-miR-654-3p (MIRT567671)
- hsa-miR-329-5p (MIRT567672)
- mmu-miR-466h-3p (MIRT583727)
- mmu-miR-590-3p (MIRT583728)
- hsa-miR-4446-5p (MIRT615013)
- hsa-miR-4307 (MIRT615014)
- hsa-miR-576-3p (MIRT615015)
- hsa-miR-33a-3p (MIRT615016)
- hsa-miR-6839-3p (MIRT668528)
- hsa-miR-4507 (MIRT668529)
- hsa-miR-3940-5p (MIRT668530)
- hsa-miR-6740-5p (MIRT668531)
- hsa-miR-629-5p (MIRT668532)
- hsa-miR-500b-5p (MIRT668533)
- hsa-miR-362-5p (MIRT668534)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ERGIC2
- Browse OriGene Inhibitory RNA Products For ERGIC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERGIC2
Clone products for research
- Applied Biological Materials (abm): Clones for ERGIC2 - Starting at $45 >
- * ERGIC2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205862
- MG205880
- MG205883
- MG205889
- MG215730
- MR205862
- MR205862L3
- MR205862L4
- MR205880
- MR205880L3
- MR205880L4
- MR205883
- MR205883L3
- MR205883L4
- MR205889
- MR205889L3
- MR205889L4
- MR215730
- MR215730L3
- MR215730L4
- MR229067
- RC201479
- RC201479L3
- RC201479L4
- RG201479
- RR212302
- RR212302L3
- RR212302L4
- MR205862L3V
- MR205862L4V
- MR205880L3V
- MR205880L4V
- MR205883L3V
- MR205883L4V
- MR205889L3V
- MR205889L4V
- MR215730L3V
- MR215730L4V
- RC201479L3V
- RC201479L4V
- RR212302L3V
- RR212302L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ERGIC2
- Addgene plasmids for ERGIC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ERGIC2
Cell Lines for research
-
Horizon Cell Lines for ERGIC2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC2 Gene
Localization for ERGIC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ERGIC2 Gene
- Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. Multi-pass membrane protein. Endoplasmic reticulum membrane. Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. According to a report, localizes to the nucleus (PubMed:11445006). Another report shows a partial localization in the nucleus (PubMed:17980171). {ECO:0000269 PubMed:11445006, ECO:0000269 PubMed:17980171}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| golgi apparatus | 5 |
| endoplasmic reticulum | 4 |
| plasma membrane | 2 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Golgi apparatus (3)
- Nucleoli rim (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 17980171 |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 17980171 |
| GO:0005783 | endoplasmic reticulum | IBA | 21873635 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
Pathways & Interactions for ERGIC2 Gene
Interacting Proteins for ERGIC2 Gene
GPS-Prot Interaction Network for ERGIC2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | IBA | 21873635 |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | IMP | 24768165 |
| GO:0016192 | vesicle-mediated transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ERGIC2 Gene
Transcripts for ERGIC2 Gene
mRNA/cDNA for ERGIC2 Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360150 5033 nts (view in UCSC)
- ENST00000546509 308 nts (view in UCSC)
- ENST00000546839 1274 nts (view in UCSC)
- ENST00000548098 318 nts (view in UCSC)
- ENST00000548441 432 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ERGIC2 - Starting at $85 >
- * ERGIC2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ERGIC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ERGIC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERGIC2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ERGIC2
- Browse OriGene Inhibitory RNA Products For ERGIC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERGIC2
Clone products for research
- Applied Biological Materials (abm): Clones for ERGIC2 - Starting at $45 >
- * ERGIC2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205862
- MG205880
- MG205883
- MG205889
- MG215730
- MR205862
- MR205862L3
- MR205862L4
- MR205880
- MR205880L3
- MR205880L4
- MR205883
- MR205883L3
- MR205883L4
- MR205889
- MR205889L3
- MR205889L4
- MR215730
- MR215730L3
- MR215730L4
- MR229067
- RC201479
- RC201479L3
- RC201479L4
- RG201479
- RR212302
- RR212302L3
- RR212302L4
- MR205862L3V
- MR205862L4V
- MR205880L3V
- MR205880L4V
- MR205883L3V
- MR205883L4V
- MR205889L3V
- MR205889L4V
- MR215730L3V
- MR215730L4V
- RC201479L3V
- RC201479L4V
- RR212302L3V
- RR212302L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ERGIC2
- Addgene plasmids for ERGIC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ERGIC2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||
| SP3: | - | - |
Relevant External Links for ERGIC2 Gene
- GeneLoc Exon Structure for
- ERGIC2
Expression for ERGIC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Islet of Langerhans (11.1), Placenta (8.0), and Breast (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERGIC2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ERGIC2
SOURCE GeneReport for Unigene cluster for ERGIC2 Gene:
Hs.339453mRNA Expression by UniProt/SwissProt for ERGIC2 Gene:
Q96RQ1-ERGI2_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for ERGIC2 Gene
- Liver(4.4)
- Nervous system(3.4)
Primer products for research
-
OriGene qPCR primer pairs for ERGIC2
-
OriGene qPCR primer pairs and template standards for ERGIC2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERGIC2 Gene
Orthologs for ERGIC2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ERGIC2 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | ERGIC2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ERGIC2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ergic2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ERGIC2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ERGIC2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ERGIC2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ERGIC2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ergic2 30 |
|
||
| MGC75899 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16162 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ergic2 30 31 |
|
OneToMany | |
| ERGIC2 (1 of 2) 31 |
|
OneToMany | |||
| zgc64005 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3142 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005044 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG4293 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ERV41 30 |
|
||
| ERV46 31 |
|
OneToMany | |||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0B04950g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER136W 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3984 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPBC2G5.04c 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04293 30 |
|
- Species where no ortholog for ERGIC2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for ERGIC2 Gene
- ENSEMBL:
- Gene Tree for ERGIC2 (if available)
- TreeFam:
- Gene Tree for ERGIC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ERGIC2: view image
Paralogs for ERGIC2 Gene
(2) SIMAP similar genes for ERGIC2 Gene using alignment to 10 proteins:
- ERGI2_HUMAN
- F8VPA6_HUMAN
- F8VR88_HUMAN
- F8VRW9_HUMAN
- F8VUZ2_HUMAN
- F8W0R1_HUMAN
- H0YHJ8_HUMAN
- H0YHS0_HUMAN
- H0YI50_HUMAN
- H0YI58_HUMAN
Variants for ERGIC2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3344998 | CNV | insertion | 20981092 |
Residual Variation Intolerance Score:
27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.35;
7.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ERGIC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ERGIC2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ERGIC2 Gene
Disorders for ERGIC2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute maxillary sinusitis |
|
|
| temtamy syndrome |
|
|
| cantu syndrome |
|
|
Search ERGIC2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ERGIC2
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ERGIC2 Gene
Publications for ERGIC2 Gene
- Molecular cloning, expression, localization, and gene organization of PTX1, a human nuclear protein that is downregulated in prostate cancer. (PMID: 11445006) Kwok SC … Daskal I (DNA and cell biology 2001) 2 3 4
- The possible interaction of CDA14 and protein elongation factor 1alpha. (PMID: 17980171) Yang YF … Tseng TL (Biochimica et biophysica acta 2008) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L … Hauri HP (The Journal of biological chemistry 2004) 3 4
ExternalLinks
Products for ERGIC2 Gene
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Sources for ERGIC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
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- (20) MINT
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
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- (53) PubMed
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- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (122) ENCODE
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- (148) RNAcentral
- (149) LncRNADisease
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- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
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- (172) GENCODE
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- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB