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Aliases for ERGIC2 Gene

Aliases for ERGIC2 Gene

  • ERGIC And Golgi 2 2 3 5
  • PTX1 3 4
  • Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 2 3
  • CD14 Protein 3
  • CDA14 3
  • Erv41 3
  • Cd002 3
  • ERV41 4

External Ids for ERGIC2 Gene

Previous GeneCards Identifiers for ERGIC2 Gene

  • GC12M029382
  • GC12M029493
  • GC12M029262

Summaries for ERGIC2 Gene

Entrez Gene Summary for ERGIC2 Gene

  • ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]

GeneCards Summary for ERGIC2 Gene

ERGIC2 (ERGIC And Golgi 2) is a Protein Coding gene. An important paralog of this gene is ERGIC3.

UniProtKB/Swiss-Prot for ERGIC2 Gene

  • Possible role in transport between endoplasmic reticulum and Golgi.

Gene Wiki entry for ERGIC2 Gene

Additional gene information for ERGIC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERGIC2 Gene

Genomics for ERGIC2 Gene

GeneHancer (GH) Regulatory Elements for ERGIC2 Gene

Promoters and enhancers for ERGIC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J029379 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.5 452 3 FOXA2 PKNOX1 CLOCK SMAD1 SIN3A YY1 POLR2B ZNF766 KLF13 DEK ERGIC2 LOC100506606 FAR2 ENSG00000273680
GH12J029163 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +213.7 213668 7.5 SMAD1 BMI1 BATF IRF4 ZNF766 ZNF366 ZNF207 ATF7 FOS BCLAF1 PIR59479 LOC100506606 ERGIC2 PIR55591 ENSG00000275278 FAR2
GH12J029428 Enhancer 1 Ensembl ENCODE 10.7 -47.4 -47391 1.2 PKNOX1 BATF RAD21 YY1 GTF3C2 ZNF766 POLR3A ZNF143 FOS IKZF2 ERGIC2 OVCH1 LOC100506606 PIR60715 OVCH1-AS1 GC12P029484
GH12J029319 Enhancer 1 FANTOM5 Ensembl ENCODE 10 +60.6 60620 2.4 SP1 JUND ZNF680 RXRA JUN FOS HNF4A ERGIC2 LOC100506606 ENSG00000274315 GC12P029288 FAR2
GH12J029435 Enhancer 0.6 Ensembl 10.7 -54.4 -54367 0.8 ATF4 MTA1 L3MBTL2 POLR2A CEBPB CEBPG REST ATF7 ATF2 ERGIC2 PIR60715 GC12P029484 OVCH1-AS1 OVCH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ERGIC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ERGIC2 gene promoter:
  • RP58
  • FOXO1a
  • FOXO1
  • CRE-BP1
  • ATF-2
  • POU2F1a
  • POU2F1
  • LCR-F1
  • GR-beta
  • GR-alpha

Genomic Locations for ERGIC2 Gene

Genomic Locations for ERGIC2 Gene
43,859 bases
Minus strand
43,859 bases
Minus strand

Genomic View for ERGIC2 Gene

Genes around ERGIC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERGIC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERGIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERGIC2 Gene

Proteins for ERGIC2 Gene

  • Protein details for ERGIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Endoplasmic reticulum-Golgi intermediate compartment protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NHH6
    • Q53GY2
    • Q8N2Q9
    • Q9BVV9
    • Q9NZA3

    Protein attributes for ERGIC2 Gene

    377 amino acids
    Molecular mass:
    42549 Da
    Quaternary structure:
    • May interact with EEF1A1.
    • Sequence=AAF61208.1; Type=Frameshift; Positions=202, 209, 212; Evidence={ECO:0000305};

neXtProt entry for ERGIC2 Gene

Post-translational modifications for ERGIC2 Gene

  • Glycosylation at Asn212 and Thr154
  • Ubiquitination at isoforms=146 and Lys14
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ERGIC2 Gene

Domains & Families for ERGIC2 Gene

Gene Families for ERGIC2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ERGIC2 Gene


Suggested Antigen Peptide Sequences for ERGIC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ERGIC family.
  • Belongs to the ERGIC family.
genes like me logo Genes that share domains with ERGIC2: view

Function for ERGIC2 Gene

Molecular function for ERGIC2 Gene

UniProtKB/Swiss-Prot Function:
Possible role in transport between endoplasmic reticulum and Golgi.

Gene Ontology (GO) - Molecular Function for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17980171
genes like me logo Genes that share ontologies with ERGIC2: view
genes like me logo Genes that share phenotypes with ERGIC2: view

Animal Model Products

miRNA for ERGIC2 Gene

miRTarBase miRNAs that target ERGIC2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ERGIC2 Gene

Localization for ERGIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERGIC2 Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm. Nucleus. Note=Cycles between the endoplasmic reticulum and the Golgi. According to a report, localizes to the nucleus (PubMed:11445006). Another report shows a partial localization in the nucleus (PubMed:17980171). {ECO:0000269 PubMed:11445006, ECO:0000269 PubMed:17980171}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERGIC2 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
golgi apparatus 4
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17980171
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,IDA 17980171
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

Pathways & Interactions for ERGIC2 Gene

SuperPathways for ERGIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ERGIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IMP 24768165
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ERGIC2: view

No data available for Pathways by source and SIGNOR curated interactions for ERGIC2 Gene

Drugs & Compounds for ERGIC2 Gene

No Compound Related Data Available

Transcripts for ERGIC2 Gene

mRNA/cDNA for ERGIC2 Gene

Unigene Clusters for ERGIC2 Gene

ERGIC and golgi 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERGIC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP3: - -

Relevant External Links for ERGIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ERGIC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ERGIC2 Gene

Protein differential expression in normal tissues from HIPED for ERGIC2 Gene

This gene is overexpressed in Islet of Langerhans (11.1), Placenta (8.0), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ERGIC2 Gene

Protein tissue co-expression partners for ERGIC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ERGIC2 Gene:


SOURCE GeneReport for Unigene cluster for ERGIC2 Gene:


mRNA Expression by UniProt/SwissProt for ERGIC2 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ERGIC2 Gene

  • Liver(4.3)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with ERGIC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERGIC2 Gene

Orthologs for ERGIC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ERGIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ERGIC2 33
  • 98.74 (n)
(Canis familiaris)
Mammalia ERGIC2 34 33
  • 94.78 (n)
(Bos Taurus)
Mammalia ERGIC2 34 33
  • 93.19 (n)
(Mus musculus)
Mammalia Ergic2 16 34 33
  • 91.42 (n)
(Ornithorhynchus anatinus)
Mammalia ERGIC2 34
  • 89 (a)
(Monodelphis domestica)
Mammalia ERGIC2 34
  • 86 (a)
(Gallus gallus)
Aves ERGIC2 34 33
  • 82.22 (n)
(Anolis carolinensis)
Reptilia ERGIC2 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ergic2 33
  • 70.2 (n)
MGC75899 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16162 33
(Danio rerio)
Actinopterygii ergic2 34 33
  • 72.99 (n)
ERGIC2 (1 of 2) 34
  • 60 (a)
zgc64005 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3142 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005044 33
  • 46.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4293 34 33
  • 41.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERV41 33
  • 46.27 (n)
ERV46 34
  • 21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04950g 33
  • 45.79 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER136W 33
  • 41.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3984 34
  • 50 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC2G5.04c 33
  • 43.45 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04293 33
  • 41.07 (n)
Species where no ortholog for ERGIC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ERGIC2 Gene

Gene Tree for ERGIC2 (if available)
Gene Tree for ERGIC2 (if available)
Evolutionary constrained regions (ECRs) for ERGIC2: view image

Paralogs for ERGIC2 Gene

Paralogs for ERGIC2 Gene

(2) SIMAP similar genes for ERGIC2 Gene using alignment to 10 proteins:

  • F8VR88_HUMAN
  • F8W0R1_HUMAN
  • H0YI50_HUMAN
  • H0YI58_HUMAN
genes like me logo Genes that share paralogs with ERGIC2: view

Variants for ERGIC2 Gene

Sequence variations from dbSNP and Humsavar for ERGIC2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000037745 -- 29,341,653(-) G/A intron_variant
rs1000145425 -- 29,356,730(-) G/A intron_variant
rs1000202987 -- 29,374,121(-) T/C intron_variant
rs1000212584 -- 29,379,649(-) T/C intron_variant
rs1000244337 -- 29,361,304(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ERGIC2 Gene

Variant ID Type Subtype PubMed ID
esv3344998 CNV insertion 20981092

Variation tolerance for ERGIC2 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERGIC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERGIC2 Gene

Disorders for ERGIC2 Gene

Additional Disease Information for ERGIC2

No disorders were found for ERGIC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ERGIC2 Gene

Publications for ERGIC2 Gene

  1. Molecular cloning, expression, localization, and gene organization of PTX1, a human nuclear protein that is downregulated in prostate cancer. (PMID: 11445006) Kwok SC … Daskal I (DNA and cell biology 2001) 2 3 4 58
  2. The possible interaction of CDA14 and protein elongation factor 1alpha. (PMID: 17980171) Yang YF … Tseng TL (Biochimica et biophysica acta 2008) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PMID: 15308636) Breuza L … Hauri HP (The Journal of biological chemistry 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ERGIC2 Gene

Sources for ERGIC2 Gene

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