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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family mem... See more...
Aliases for ERBB3 Gene
Aliases for ERBB3 Gene
- Erb-B2 Receptor Tyrosine Kinase 3 2 3 5
- HER3 2 3 4
- V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3 2 3
- Tyrosine Kinase-Type Cell Surface Receptor HER3 3 4
- Human Epidermal Growth Factor Receptor 3 2 3
- Receptor Tyrosine-Protein Kinase ErbB-3 3 4
- Proto-Oncogene-Like Protein C-ErbB-3 3 4
- EC 2.7.10.1 4 51
- Lethal Congenital Contracture Syndrome 2 2
- P180-ErbB3 3
External Ids for ERBB3 Gene
- HGNC: 3431
- Entrez Gene: 2065
- Ensembl: ENSG00000065361
- OMIM: 190151
- UniProtKB: P21860
Previous HGNC Symbols for ERBB3 Gene
- LCCS2
Previous GeneCards Identifiers for ERBB3 Gene
- GC12M056386
- GC12M056841
- GC12P056190
- GC12P054760
- GC12P056473
- GC12P053512
- GC12P056079
- GC12P056080
- GC12P056086
Summaries for ERBB3 Gene
-
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ERBB3 Gene
ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Erythroleukemia, Familial. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERBB4.
UniProtKB/Swiss-Prot Summary for ERBB3 Gene
-
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
-
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.
Additional gene information for ERBB3 Gene
- HGNC(3431)
- Entrez Gene(2065)
- Ensembl(ENSG00000065361)
- OMIM(190151)
- UniProtKB(P21860)
- Open Targets Platform(ENSG00000065361)
- Monarch Initiative
- Search for ERBB3 at DataMed
- Search for ERBB3 at HumanCyc
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ERBB3 Gene
Genomics for ERBB3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ERBB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ERBB3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ERBB3
- Top Transcription factor binding sites by QIAGEN in the ERBB3 gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alpha isoform 4
- AP-2alphaA
Genomic Locations for ERBB3 Gene
Genomic Locations for ERBB3 Gene
- chr12:56,076,799-56,103,505
- (GRCh38/hg38)
- Size:
- 26,707 bases
- Orientation:
- Plus strand
- chr12:56,473,641-56,497,291
- (GRCh37/hg19)
- Size:
- 23,651 bases
- Orientation:
- Plus strand
Genomic View for ERBB3 Gene
Genes around ERBB3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by HGNC
- 12q13.2 by Entrez Gene
- 12q13.2 by Ensembl
ERBB3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ERBB3 Gene
Proteins for ERBB3 Gene
-
Protein details for ERBB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21860-ERBB3_HUMAN
- Recommended name:
- Receptor tyrosine-protein kinase erbB-3
- Protein Accession:
- P21860
- A8K6L6
- B4DIK7
- B4DV32
- E9PDT8
- Q9BUD7
Protein attributes for ERBB3 Gene
- Size:
- 1342 amino acids
- Molecular mass:
- 148098 Da
- Quaternary structure:
-
- Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 (PubMed:15358134). Interacts with GRB7 (PubMed:9516479). Interacts with MUC1 (PubMed:12939402). Interacts with MYOC (By similarity). Interacts with isoform 2 of PA2G4 (PubMed:11325528, PubMed:16832058). Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).
Three dimensional structures from OCA and Proteopedia for ERBB3 Gene
Protein Expression for ERBB3 Gene
Selected DME Specific Peptides for ERBB3 Gene
- P21860:
-
- CPHNFVVD
- QTVDSSNID
- MVKCWMID
- SLQLVTQ
- SDVWSYGVT
- DTDCFAC
- CFSCHPEC
- CEVVMGNLEI
- FNDSGACVPRCP
- AARNVLL
- VCDPLCS
- SLKEISAG
- MARDPPRYLVI
- YGVTVWE
- REVTGYVLVA
- KETELRK
- PLVYNKLTFQLEPNPH
- YTHQSDVWS
- AFDNPDYW
- TCNGSGS
- LNIQSWPP
- ECAGGCSGP
Post-translational modifications for ERBB3 Gene
- Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
-
Glycosylation at Asn126, Asn250, Asn353, Asn408, Asn414, Asn437, Asn469, Asn522, Asn566, and Asn616
- NX_P21860 (NX_P21860-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- ERBB3_HUMAN (1711)
Other Protein References for ERBB3 Gene
Antibody Products
- G Biosciences Immunotag™ ERBB3 Antibody and Immunotag™ Phospho-HER3/ErbB3 (Tyr1289) Antibody
- NSJ Bioreagents HER3 Antibody (ERBB3)
-
Custom Antibody ServicesOriGene Antibodies for ERBB3
- AM00054BT-N
- AM00054PU-N
- AM00055PU-N
- AM06263SU-N
- AM06264SU-N
- AM06356SU-N
- AM20448SU-N
- AM31752PU-N
- AM31753PU-N
- AM31754PU-N
- AP01222PU-N
- AP08032PU-N
- AP08032PU-S
- AP08087PU-N
- AP08087PU-S
- AP09510PU-N
- AP09510PU-S
- AP14328PU-N
- AP20237PU-N
- CF803687
- CF803694
- CF803702
- CF803738
- CF803819
- CF803827
- CF803828
- CF806202
- CF809228
- CF809282
- DM1221
- SM1444P
- TA303054
- TA303500
- TA313843
- TA319323
- TA323486
- TA323487
- TA323488
- TA332752
- TA353168L
- TA354269
- TA354383
- TA354707
- TA354708
- TA354709
- TA590106
- TA803687
- TA803687S
- TA803694
- TA803694S
- TA803702
- TA803702S
- TA803738
- TA803738S
- TA803819
- TA803819S
- TA803827
- TA803827S
- TA803828
- TA803828S
- TA806202
- TA806202S
- TA809228
- TA809228S
- TA809282
- TA809282S
- Novus Biologicals Antibodies for ERBB3
-
Abcam antibodies for ERBB3
- Invitrogen Antibodies for ERBB3 (AFLGC-ERBB3)
- antibodies-online: Show 132 available ERBB3 Antibodies ranked by validation data
- Compare Top ERBB3 Antibodies
-
Recommended
- 314 WB Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 30 FACS Antibodies (anti-human)
- 24 IHC Antibodies (anti-human)
- 13 IHC (p) Antibodies (anti-human)
- 13 IP Antibodies (anti-human)
- 10 IF Antibodies (anti-human)
- 6 Neut Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 142 WB Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 10 IHC Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 121 WB Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 10 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
-
Boster Bio Antibodies for ERBB3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ERBB3
- Sino Biological Antibodies for ERBB3
Protein Products
- G Biosciences Human ERBB3/HER3, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for ERBB3
- Origene Custom Protein Services for ERBB3
- Sino Biological Recombinant Proteins for ERBB3
- Sino Biological Cell Lysates for ERBB3
- ProSpec Recombinant Proteins for ERBB3
-
Abcam proteins for ERBB3
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for ERBB3
- Novus Biologicals ELISA Kits for ERBB3
- antibodies-online: Show 43 available ERBB3 Elisa Kits ranked by validation data
- Compare Top ERBB3 Elisa Kits
-
Quality Products:
- Sino Biological Assays for ERBB3
Domains & Families for ERBB3 Gene
Gene Families for ERBB3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ERBB3 Gene
- InterPro:
- Blocks:
-
- Tyrosine protein kinase, active site
- Epidermal growth-factor receptor (EGFR), L domain
- Furin-like cysteine rich region
- Furin-like repeat
- ProtoNet:
Suggested Antigen Peptide Sequences for ERBB3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (B3KWG5_HUMAN)
- cDNA FLJ59207, highly similar to Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (B4DGQ7_HUMAN)
- Tyrosine kinase-type cell surface receptor HER3 (ERBB3_HUMAN)
- ErbB-3 R1 (O75810_HUMAN)
- ErbB-3 R2 (O75811_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P21860UniProtKB/Swiss-Prot:
ERBB3_HUMAN :- The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
- Domain:
-
- The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Function for ERBB3 Gene
Molecular function for ERBB3 Gene
- UniProtKB/Swiss-Prot Function:
- Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000269|PubMed:20351256};.
- GENATLAS Biochemistry:
- avian erythroblastic leukemia,viral (v-erb-b) oncogene homolog 3,heregulin beta 1 receptor,signal transducer receptor,heterodimerizing with the ligand less recetpor ERBB2
Enzyme Numbers (IUBMB) for ERBB3 Gene
Phenotypes From GWAS Catalog for ERBB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | NOT protein tyrosine kinase activity | IEA,IDA | 7556068 |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA | 21873635 |
| GO:0004888 | transmembrane signaling receptor activity | ISS | 7514177 |
Phenotypes for ERBB3 Gene
- MGI mutant phenotypes for ERBB3:
-
inferred from 11 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- GenomeRNAi human phenotypes for ERBB3:
-
- no effect
- Increased cell death HMECs cells
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability ratio
- Reduced mammosphere formation
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Increased cell viability after pRB stimulation
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased homologous recombination repair frequency
- Decreased substrate adherent cell growth
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Decreased viability with SS1P at EC30
- Increased viability
- Diffuse cis-Golgi, diffuse trans-Golgi
Animal Models for ERBB3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ERBB3 - Select products 50% OFF >
- * ERBB3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ERBB3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ERBB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERBB3
miRNA for ERBB3 Gene
- miRTarBase miRNAs that target ERBB3
-
- hsa-miR-125b-5p (MIRT002938)
- hsa-miR-205-5p (MIRT003659)
- hsa-miR-125a-5p (MIRT005117)
- mmu-miR-22-3p (MIRT006013)
- hsa-miR-22-3p (MIRT006210)
- hsa-miR-24-3p (MIRT030589)
- hsa-miR-199a-5p (MIRT053607)
- hsa-miR-143-3p (MIRT053647)
- hsa-miR-33a-3p (MIRT065956)
- hsa-miR-592 (MIRT065961)
- hsa-miR-2113 (MIRT065963)
- hsa-miR-4698 (MIRT065968)
- hsa-miR-6507-5p (MIRT065971)
- hsa-miR-597-5p (MIRT537654)
- hsa-miR-8063 (MIRT537655)
- hsa-miR-7109-3p (MIRT537656)
- hsa-miR-548e-5p (MIRT537657)
- hsa-miR-4446-5p (MIRT615956)
- hsa-miR-3679-3p (MIRT615957)
- hsa-miR-6826-3p (MIRT615958)
- hsa-miR-4732-5p (MIRT615959)
- hsa-miR-6832-5p (MIRT615960)
- hsa-miR-331-3p (MIRT615961)
- hsa-miR-6810-3p (MIRT615962)
- hsa-miR-6801-3p (MIRT615963)
- hsa-miR-4328 (MIRT630919)
- hsa-miR-301a-5p (MIRT719394)
- hsa-miR-5701 (MIRT719395)
- hsa-miR-323b-3p (MIRT719396)
- hsa-miR-219a-2-3p (MIRT733913)
- hsa-miR-143-5p (MIRT734641)
- hsa-miR-1273f (MIRT783296)
- hsa-miR-1276 (MIRT783358)
- hsa-miR-4311 (MIRT785707)
- hsa-miR-583 (MIRT787937)
- hsa-miR-6751-5p (MIRT788557)
- hsa-miR-6752-5p (MIRT788561)
- hsa-miR-6803-5p (MIRT788821)
- hsa-miR-6835-5p (MIRT789021)
- hsa-miR-6842-5p (MIRT789043)
- hsa-miR-7110-5p (MIRT789412)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ERBB3
- Browse OriGene Inhibitory RNA Products For ERBB3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERBB3
Clone Products
- Applied Biological Materials (abm): Clones for ERBB3 - Select products 50% OFF >
- * ERBB3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG211935
- MG227559
- MR211935
- MR211935L3
- MR211935L4
- MR227559
- MR227559L3
- MR227559L4
- RC209954
- RC209954L1
- RC209954L2
- RC209954L3
- RC209954L4
- RC224398
- RC224398L1
- RC224398L2
- RC224398L3
- RC224398L4
- RC600006
- RC600007
- RG209954
- RG224398
- RR210665
- MR211935L3V
- MR211935L4V
- MR227559L3V
- MR227559L4V
- RC209954L1V
- RC209954L2V
- RC209954L3V
- RC209954L4V
- RC224398L1V
- RC224398L2V
- RC224398L3V
- RC224398L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ERBB3
- Addgene plasmids for ERBB3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ERBB3
Cell Line Products
-
Horizon Cell Lines for ERBB3
No data available for Transcription Factor Targets and HOMER Transcription for ERBB3 Gene
Localization for ERBB3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ERBB3 Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Actin filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 11389077 |
| GO:0005886 | plasma membrane | TAS | 17701904 |
| GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
| GO:0009925 | basal plasma membrane | IBA | 21873635 |
Pathways & Interactions for ERBB3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Signaling by ERBB2 | ||
| 5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
Pathways by source for ERBB3 Gene
7 BioSystems pathways for ERBB3 Gene
69 Reactome pathways for ERBB3 Gene
1 PharmGKB pathway for ERBB3 Gene
7 KEGG pathways for ERBB3 Gene
3 GeneGo (Thomson Reuters) pathways for ERBB3 Gene
- Apoptosis and survival Role of CDK5 in neuronal death and survival
- Development ERBB-family signaling
- Development Ligand-independent activation of ESR1 and ESR2
3 R&D Systems pathways for ERBB3 Gene
4 Tocris pathways for ERBB3 Gene
35 Qiagen pathways for ERBB3 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
1 Cell Signaling Technology pathway for ERBB3 Gene
Interacting Proteins for ERBB3 Gene
Selected Interacting proteins:
P21860-ERBB3_HUMAN
ENSP00000267101
for ERBB3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ERBB3
SIGNOR curated interactions for ERBB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0003197 | endocardial cushion development | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007162 | negative regulation of cell adhesion | IDA | 7556068 |
| GO:0007165 | signal transduction | IDA | 10572067 |
Drugs & Compounds for ERBB3 Gene
(60) Drugs for ERBB3 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Gefitinib | Approved, Investigational | Pharma | Biomarker, inhibitor | EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors | 409 | |
| Trastuzumab | Approved, Investigational | Pharma | HER2 antagonist, HER2 Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 1006 | ||
| Tyrosine | Approved, Investigational | Nutra | 1044 | |||
| Tucatinib | Approved, Investigational | Pharma | Target, inhibitor | 0 | ||
| Carboplatin | Approved | Pharma | Antitumor agent that forms platinum-DNA adducts., Platinum | 2588 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
||
| CP 724714 |
|
383432-38-0 |
|
|
(4) Tocris Compounds for ERBB3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AG 490 | EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor | 133550-30-8 |
| CGP 52411 | EGFR inhibitor. Also inhibits Abeta42 fibril formation | 145915-58-8 |
| CP 724714 | Potent and selective ErbB2 inhibitor | 383432-38-0 |
| Genistein | EGFR kinase inhibitor. Also estrogen and PPARgamma ligand | 446-72-0 |
(3) ApexBio Compounds for ERBB3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD8931 (Sapitinib) | ErbB inhibitor | 848942-61-0 |
| Poziotinib | irreversible pan-HER inhibitor | 1092364-38-9 |
| Varlitinib (ARRY334543) | ErbB inhibitor | 845272-21-1 |
Transcripts for ERBB3 Gene
mRNA/cDNA for ERBB3 Gene
- 2 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000267101 5615 nts (view in UCSC)
- ENST00000411731 1027 nts (view in UCSC)
- ENST00000415288 4353 nts (view in UCSC)
- ENST00000546748 574 nts (view in UCSC)
- ENST00000546884 660 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ERBB3 - Select products 50% OFF >
- * ERBB3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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OriGene CRISPR knockouts for ERBB3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ERBB3
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERBB3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ERBB3
- Browse OriGene Inhibitory RNA Products For ERBB3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERBB3
Clone Products
- Applied Biological Materials (abm): Clones for ERBB3 - Select products 50% OFF >
- * ERBB3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
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- MG211935
- MG227559
- MR211935
- MR211935L3
- MR211935L4
- MR227559
- MR227559L3
- MR227559L4
- RC209954
- RC209954L1
- RC209954L2
- RC209954L3
- RC209954L4
- RC224398
- RC224398L1
- RC224398L2
- RC224398L3
- RC224398L4
- RC600006
- RC600007
- RG209954
- RG224398
- RR210665
- MR211935L3V
- MR211935L4V
- MR227559L3V
- MR227559L4V
- RC209954L1V
- RC209954L2V
- RC209954L3V
- RC209954L4V
- RC224398L1V
- RC224398L2V
- RC224398L3V
- RC224398L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ERBB3
- Addgene plasmids for ERBB3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ERBB3
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||
| SP12: |
Relevant External Links for ERBB3 Gene
- GeneLoc Exon Structure for
- ERBB3
Expression for ERBB3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Endocardial Cushion Cells Atrioventricular Endocardial Cushion
- Semilunar Valve Cells Semilunar Valves
- Atrioventricular Valve Cells Atrioventricular Valves
- Cushion Mesenchymal Cells Endocardium
- Endocardial Cells Endocardium
-
Peripheral Nervous System (Nervous System)
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Schwann Precursor Cells Peripheral Nerve Domain
- Myelinating Schwann Cells Peripheral Nerve Domain
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Ureteric Bud
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Neocortical Radial Glia Cells Cortical Sub Ventricular Zone
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Myelinating Schwann Cells Peripheral Nerve Domain
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Neural Tube (Nervous System)
- Neocortical Radial Glia Cells Cortical Sub Ventricular Zone
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Testis (26.0), Lung (22.4), Saliva (8.7), and Pancreas (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ERBB3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ERBB3
SOURCE GeneReport for Unigene cluster for ERBB3 Gene:
Hs.118681mRNA Expression by UniProt/SwissProt for ERBB3 Gene:
P21860-ERBB3_HUMAN
Tissue specificity:
Epithelial tissues and brain.
Evidence on tissue expression from TISSUES for ERBB3 Gene
- Nervous system(5)
- Intestine(4.9)
- Skin(4.8)
- Liver(4.6)
- Kidney(3.1)
- Lung(3.1)
- Stomach(3.1)
- Pancreas(2.8)
- Lymph node(2.8)
- Heart(2.6)
- Muscle(2.6)
- Blood(2.6)
- Gall bladder(2.3)
- Bone marrow(2.3)
- Thyroid gland(2.3)
- Adrenal gland(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ERBB3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- chin
- cranial nerve
- eye
- face
- head
- jaw
- mandible
- maxilla
- mouth
- skull
Thorax:
- lung
Abdomen:
- kidney
Pelvis:
- placenta
- ureter
- uterus
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood vessel
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for ERBB3
-
OriGene qPCR primer pairs and template standards for ERBB3
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for ERBB3 Gene
Orthologs for ERBB3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ERBB3 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Dog (Canis familiaris) |
Mammalia | ERBB3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ERBB3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Erbb3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ERBB3 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Erbb3 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ERBB3 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | ERBB3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | erbb3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | erbb3a 31 |
|
OneToMany | |
| erbb3b 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Egfr 32 |
|
|
|
| Worm (Caenorhabditis elegans) |
Secernentea | let-23 32 |
|
|
- Species where no ortholog for ERBB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ERBB3 Gene
- ENSEMBL:
- Gene Tree for ERBB3 (if available)
- TreeFam:
- Gene Tree for ERBB3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ERBB3: view image