Aliases for ERBB3 Gene
Aliases for ERBB3 Gene
- Erb-B2 Receptor Tyrosine Kinase 3 2 3 5
- V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3 2 3
- Tyrosine Kinase-Type Cell Surface Receptor HER3 3 4
- Human Epidermal Growth Factor Receptor 3 2 3
- Proto-Oncogene-Like Protein C-ErbB-3 3 4
- EC 2.7.10.1 4 56
- HER3 3 4
- Lethal Congenital Contracture Syndrome 2 2
- Receptor Tyrosine-Protein Kinase ErbB-3 3
- P180-ErbB3 3
External Ids for ERBB3 Gene
- HGNC: 3431
- Entrez Gene: 2065
- Ensembl: ENSG00000065361
- OMIM: 190151
- UniProtKB: P21860
Previous HGNC Symbols for ERBB3 Gene
- LCCS2
Previous GeneCards Identifiers for ERBB3 Gene
- GC12M056386
- GC12M056841
- GC12P056190
- GC12P054760
- GC12P056473
- GC12P053512
Summaries for ERBB3 Gene
-
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ERBB3 Gene
ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Retroperitoneal Leiomyosarcoma. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is ERBB4.
UniProtKB/Swiss-Prot for ERBB3 Gene
-
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
-
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.
Additional gene information for ERBB3 Gene
- Monarch Initiative
- Search for ERBB3 at DataMed
- Search for ERBB3 at HumanCyc
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERBB3 Gene
Genomics for ERBB3 Gene
GeneHancer (GH) Regulatory Elements for ERBB3 Gene
Promoters and enhancers for ERBB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ERBB3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ERBB3 gene promoter:
Regulatory Element Products
Genomic Locations for ERBB3 Gene
Genomic Locations for ERBB3 Gene
- chr12:56,079,857-56,103,507
- (GRCh38/hg38)
- Size:
- 23,651 bases
- Orientation:
- Plus strand
- chr12:56,473,641-56,497,291
- (GRCh37/hg19)
Genomic View for ERBB3 Gene
Genes around ERBB3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by Ensembl
- 12q13.2 by Entrez Gene
- 12q13.2 by HGNC
ERBB3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ERBB3 Gene
Proteins for ERBB3 Gene
-
Protein details for ERBB3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21860-ERBB3_HUMAN
- Recommended name:
- Receptor tyrosine-protein kinase erbB-3
- Protein Accession:
- P21860
- A8K6L6
- B4DIK7
- B4DV32
- E9PDT8
- Q9BUD7
Protein attributes for ERBB3 Gene
- Size:
- 1342 amino acids
- Molecular mass:
- 148098 Da
- Quaternary structure:
-
- Monomer and homodimer. Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 (PubMed:15358134). Interacts with GRB7 (PubMed:9516479). Interacts with MUC1 (PubMed:12939402). Interacts with MYOC (By similarity). Interacts with isoform 2 of PA2G4 (PubMed:11325528, PubMed:16832058). Found in a ternary complex with NRG1 and ITGAV:ITGB3 or ITGA6:ITGB4 (PubMed:20682778).
Three dimensional structures from OCA and Proteopedia for ERBB3 Gene
Protein Expression for ERBB3 Gene
Selected DME Specific Peptides for ERBB3 Gene
- P21860:
-
- CPHNFVVD
- QTVDSSNID
- MVKCWMID
- SLQLVTQ
- SDVWSYGVT
- DTDCFAC
- CFSCHPEC
- CEVVMGNLEI
- FNDSGACVPRCP
- AARNVLL
- VCDPLCS
- SLKEISAG
- MARDPPRYLVI
- YGVTVWE
- REVTGYVLVA
- KETELRK
- PLVYNKLTFQLEPNPH
- YTHQSDVWS
- AFDNPDYW
- TCNGSGS
- LNIQSWPP
- ECAGGCSGP
Post-translational modifications for ERBB3 Gene
- Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
- Glycosylation at posLast=126126, Asn250, Asn353, Asn408, Asn414, posLast=437437, posLast=469469, Asn522, Asn566, and posLast=616616
Other Protein References for ERBB3 Gene
Antibody Products
- R&D Systems Antibodies for ERBB3 (ErbB3/Her3)
- Cell Signaling Technology (CST) Antibodies for ERBB3 (HER3)
-
Custom Antibody ServicesOriGene Antibodies for ERBB3
- AM00054BT-N
- AM00054PU-N
- AM00055PU-N
- AM06263SU-N
- AM06264SU-N
- AM06356SU-N
- AM20448SU-N
- AM31752PU-N
- AM31753PU-N
- AM31754PU-N
- AP01222PU-N
- AP08032PU-N
- AP08032PU-S
- AP08087PU-N
- AP08087PU-S
- AP08497PU-N
- AP09510PU-N
- AP09510PU-S
- AP14328PU-N
- AP15472PU-N
- AP15472PU-S
- AP20237PU-N
- DM1221
- SM1444P
- TA303054
- TA303500
- TA313843
- TA319323
- TA323486
- TA323487
- TA323488
- TA332752
- TA353168
- TA353739
- TA353740
- TA590106
- TA803687
- CF803687
- TA803694
- CF803694
- TA803702
- CF803702
- TA803738
- CF803738
- TA803819
- CF803819
- TA803828
- CF803828
- TA806202
- CF806202
- TA809228
- CF809228
- TA809282
- CF809282
- Novus Biologicals Antibodies for ERBB3
-
Abcam antibodies for ERBB3
-
Cloud-Clone Corp. Antibodies for ERBB3
- Invitrogen Antibodies for ERBB3
- antibodies-online: Search results for 546 available ERBB3 Antibodies ranked by validation data
- Compare Top ERBB3 Antibodies
-
Recommended
- 300 WB Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 43 FACS Antibodies (anti-human)
- 25 IHC (p) Antibodies (anti-human)
- 17 IP Antibodies (anti-human)
- 11 IF Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 7 Neut Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 100 WB Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 4 FACS Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 115 WB Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 4 FACS Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 CC Antibody (anti-mouse)
- GeneTex ERBB3 antibody for ERBB3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ERBB3
- Sino Biological Antibodies for ERBB3
Protein Products
- R&D Systems Proteins and Enzymes for ERBB3 (ErbB3/Her3)
- Search Origene for MassSpec and Protein Over-expression Lysates for ERBB3
- Origene Custom Protein Services for ERBB3
- Sino Biological Recombinant Proteins for ERBB3
- Sino Biological Cell Lysates for ERBB3
- ProSpec Recombinant Proteins for ERBB3
-
Cloud-Clone Corp. Proteins for ERBB3
- Search GeneTex for Proteins for ERBB3
-
Abcam proteins for ERBB3
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for ERBB3 (ErbB3/Her3)
- Novus Biologicals ELISA Kits for ERBB3
- Cell Signaling Technology (CST) Sandwich ELISA Kits for ERBB3 (HER3)
-
Cloud-Clone Corp. Assay Kits for ERBB3
- Sino Biological Assays for ERBB3
Domains & Families for ERBB3 Gene
Gene Families for ERBB3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ERBB3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ERBB3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (B3KWG5_HUMAN)
- cDNA FLJ59207, highly similar to Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (B4DGQ7_HUMAN)
- Tyrosine kinase-type cell surface receptor HER3 (ERBB3_HUMAN)
- ErbB-3 R1 (O75810_HUMAN)
- ErbB-3 R2 (O75811_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P21860UniProtKB/Swiss-Prot:
ERBB3_HUMAN :- The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
- Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
- Domain:
-
- The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Function for ERBB3 Gene
Molecular function for ERBB3 Gene
- GENATLAS Biochemistry:
- avian erythroblastic leukemia,viral (v-erb-b) oncogene homolog 3,heregulin beta 1 receptor,signal transducer receptor,heterodimerizing with the ligand less recetpor ERBB2
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot Function:
- Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Enzyme Numbers (IUBMB) for ERBB3 Gene
Phenotypes From GWAS Catalog for ERBB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA,TAS | -- |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA | -- |
| GO:0004888 | transmembrane signaling receptor activity | ISS | 7514177 |
Phenotypes for ERBB3 Gene
- MGI mutant phenotypes for ERBB3:
-
inferred from 11 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- GenomeRNAi human phenotypes for ERBB3:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased substrate adherent cell growth
- Decreased shRNA abundance (Z-score < -2)
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Condensed cis-Golgi
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Decreased viability with SS1P at EC30
Animal Models for ERBB3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ERBB3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ERBB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ERBB3 gene
- Search ViGene Biosciences for ERBB3
CRISPR Products
-
OriGene CRISPR knockouts for ERBB3
- genomics-online: gRNA clones - Search results for 131 available ERBB3 gene related products
- Overview of 131 available ERBB3 gene related products
- Applied Biological Materials CRISPR for ERBB3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERBB3
- GenScript: Design CRISPR guide RNA sequences for ERBB3
miRNA for ERBB3 Gene
- miRTarBase miRNAs that target ERBB3
-
- hsa-mir-125b-5p (MIRT002938)
- hsa-mir-205-5p (MIRT003659)
- hsa-mir-125a-5p (MIRT005117)
- hsa-mir-22-3p (MIRT006210)
- hsa-mir-24-3p (MIRT030589)
- hsa-mir-199a-5p (MIRT053607)
- hsa-mir-143-3p (MIRT053647)
- hsa-mir-33a-3p (MIRT065956)
- hsa-mir-592 (MIRT065961)
- hsa-mir-2113 (MIRT065963)
- hsa-mir-4698 (MIRT065968)
- hsa-mir-6507-5p (MIRT065971)
- hsa-mir-597-5p (MIRT537654)
- hsa-mir-8063 (MIRT537655)
- hsa-mir-7109-3p (MIRT537656)
- hsa-mir-548e-5p (MIRT537657)
- hsa-mir-4446-5p (MIRT615956)
- hsa-mir-3679-3p (MIRT615957)
- hsa-mir-6826-3p (MIRT615958)
- hsa-mir-4732-5p (MIRT615959)
- hsa-mir-6832-5p (MIRT615960)
- hsa-mir-331-3p (MIRT615961)
- hsa-mir-6810-3p (MIRT615962)
- hsa-mir-6801-3p (MIRT615963)
- hsa-mir-4328 (MIRT630919)
- hsa-mir-301a-5p (MIRT719394)
- hsa-mir-5701 (MIRT719395)
- hsa-mir-323b-3p (MIRT719396)
- hsa-mir-219a-2-3p (MIRT733913)
- hsa-mir-143-5p (MIRT734641)
- hsa-mir-1273f (MIRT783296)
- hsa-mir-1276 (MIRT783358)
- hsa-mir-4311 (MIRT785707)
- hsa-mir-583 (MIRT787937)
- hsa-mir-6751-5p (MIRT788557)
- hsa-mir-6752-5p (MIRT788561)
- hsa-mir-6803-5p (MIRT788821)
- hsa-mir-6835-5p (MIRT789021)
- hsa-mir-6842-5p (MIRT789043)
- hsa-mir-7110-5p (MIRT789412)
miRNA Products
- Search ViGene Biosciences for ERBB3
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for ERBB3
- Browse OriGene Inhibitory RNA Products For ERBB3
- genomics-online: shRNA clones - Search results for 131 available ERBB3 gene related products
- Overview of 131 available ERBB3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ERBB3 gene
Clone Products
- Sino Biological Human cDNA Clone for ERBB3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ERBB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ERBB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ERBB3
- Applied Biological Materials Clones for ERBB3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ERBB3 (ErbB3/Her3)
Cell Line Products
-
Horizon Cell Lines for ERBB3
-
ViGene Biosciences adenoviral particle packaged cDNA for ERBB3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ERBB3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ERBB3 gene
No data available for Transcription Factor Targets and HOMER Transcription for ERBB3 Gene
Localization for ERBB3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ERBB3 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 3 |
| nucleus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| endosome | 1 |
- Plasma membrane (3)
- Actin filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 11389077 |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | 17701904 |
| GO:0005887 | integral component of plasma membrane | TAS | 2687875 |
Pathways & Interactions for ERBB3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | GPCR Pathway |
.73
.62
|
.55
|
| 3 | PI3K/AKT activation |
.89
|
|
| 4 | Signaling by ERBB2 | ||
| 5 | ERK Signaling |
.61
.58
|
.49
|
Pathways by source for ERBB3 Gene
1 Cell Signaling Technology pathway for ERBB3 Gene
7 BioSystems pathways for ERBB3 Gene
69 Reactome pathways for ERBB3 Gene
1 PharmGKB pathway for ERBB3 Gene
5 KEGG pathways for ERBB3 Gene
3 GeneGo (Thomson Reuters) pathways for ERBB3 Gene
3 R&D Systems pathways for ERBB3 Gene
4 Tocris pathways for ERBB3 Gene
Interacting Proteins for ERBB3 Gene
Selected Interacting proteins:
ENSP00000267101
P21860-ERBB3_HUMAN
for ERBB3 Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for ERBB3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0003197 | endocardial cushion development | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007162 | negative regulation of cell adhesion | IDA | 7556068 |
| GO:0007165 | signal transduction | IDA | 10572067 |
Drugs & Compounds for ERBB3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Gefitinib | Approved, Investigational | Pharma | Biomarker, inhibitor | EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors | 374 | |
| Poziotinib | Investigational | Pharma | inhibitor | irreversible pan-HER inhibitor | 0 | |
| ATP | Investigational | Nutra | Agonist | 0 | ||
| Momelotinib | Investigational | Pharma | Inhibitor | Epidermal growth factor receptor (EGFR) inhibitors | 0 | |
| Sapitinib | Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| AG 490 |
|
133550-30-8 |
|
|
||
| CP 724714 |
|
383432-38-0 |
|
|
(4) Tocris Compounds for ERBB3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AG 490 | EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor | 133550-30-8 |
| CGP 52411 | EGFR inhibitor. Also inhibits Abeta42 fibril formation | 145915-58-8 |
| CP 724714 | Potent and selective ErbB2 inhibitor | 383432-38-0 |
| Genistein | EGFR kinase inhibitor. Also estrogen and PPARgamma ligand | 446-72-0 |
(3) ApexBio Compounds for ERBB3 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD8931 (Sapitinib) | ErbB inhibitor | 848942-61-0 |
| Poziotinib | irreversible pan-HER inhibitor | 1092364-38-9 |
| Varlitinib (ARRY334543) | ErbB inhibitor | 845272-21-1 |
Transcripts for ERBB3 Gene
mRNA/cDNA for ERBB3 Gene
- (2) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (234) Selected AceView cDNA sequences:
- (21) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ERBB3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ERBB3
- genomics-online: gRNA clones - Search results for 131 available ERBB3 gene related products
- Overview of 131 available ERBB3 gene related products
- Applied Biological Materials CRISPR for ERBB3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ERBB3
- GenScript: Design CRISPR guide RNA sequences for ERBB3
miRNA Products
- Search ViGene Biosciences for ERBB3
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for ERBB3
- Browse OriGene Inhibitory RNA Products For ERBB3
- genomics-online: shRNA clones - Search results for 131 available ERBB3 gene related products
- Overview of 131 available ERBB3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ERBB3 gene
Clone Products
- Sino Biological Human cDNA Clone for ERBB3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ERBB3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ERBB3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ERBB3
- Applied Biological Materials Clones for ERBB3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ERBB3 (ErbB3/Her3)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||
| SP12: |
Expression for ERBB3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Endocardial Cushion Cells Atrioventricular Endocardial Cushion
- Semilunar Valve Cells Semilunar Valves
- Atrioventricular Valve Cells Atrioventricular Valves
- Cushion Mesenchymal Cells Endocardium
- Endocardial Cells Endocardium
-
Peripheral Nervous System (Nervous System)
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
- Schwann Precursor Cells Peripheral Nerve Domain
- Myelinating Schwann Cells Peripheral Nerve Domain
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Ureteric Bud
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Neocortical Radial Glia Cells Cortical Sub Ventricular Zone
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
- Myelinating Schwann Cells Peripheral Nerve Domain
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Neural Tube (Nervous System)
- Neocortical Radial Glia Cells Cortical Sub Ventricular Zone
- Intestine (Gastrointestinal Tract)
-
Colon (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Testis (26.0), Lung (22.4), Saliva (8.7), and Pancreas (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ERBB3 Gene
NURSA nuclear receptor signaling pathways regulating expression of ERBB3 Gene:
ERBB3SOURCE GeneReport for Unigene cluster for ERBB3 Gene:
Hs.118681mRNA Expression by UniProt/SwissProt for ERBB3 Gene:
P21860-ERBB3_HUMAN
Tissue specificity:
Epithelial tissues and brain.
Evidence on tissue expression from TISSUES for ERBB3 Gene
- Nervous system(4.9)
- Intestine(4.8)
- Skin(4.6)
- Liver(4.5)
- Lung(2.9)
- Stomach(2.4)
- Kidney(2.3)
- Pancreas(2.2)
- Lymph node(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ERBB3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- chin
- cranial nerve
- eye
- face
- head
- jaw
- mandible
- maxilla
- mouth
- skull
Thorax:
- lung
Abdomen:
- kidney
Pelvis:
- placenta
- ureter
- uterus
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood vessel
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs and template standards for ERBB3
-
OriGene qPCR primer pairs for ERBB3
- genomics-online: primer clones - Search results for 131 available ERBB3 gene related products
- Overview of 131 available ERBB3 gene related products
No data available for mRNA differential expression in normal tissues for ERBB3 Gene
Orthologs for ERBB3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ERBB3 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | ERBB3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ERBB3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Erbb3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ERBB3 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Erbb3 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | ERBB3 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ERBB3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | erbb3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | erbb3a 34 |
|
OneToMany | |
| erbb3b 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Egfr 35 |
|
|
|
| worm (Caenorhabditis elegans) |
Secernentea | let-23 35 |
|
|
- Species where no ortholog for ERBB3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ERBB3 Gene
(16) SIMAP similar genes for ERBB3 Gene using alignment to 9 proteins:
Variants for ERBB3 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519803 | likely-pathogenic, Colonic Neoplasms, Neoplasm of stomach | 56,088,138(+) | G/A | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1057519817 | likely-pathogenic, Neoplasm | 56,088,073(+) | C/A/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1057519891 | likely-pathogenic, Uterine Carcinosarcoma, Malignant neoplasm of body of uterus, Adenocarcinoma of stomach, Transitional cell carcinoma of the bladder, Neoplasm of the breast | 56,088,557(+) | G/A/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1057519892 | likely-pathogenic, Transitional cell carcinoma of the bladder, Adenocarcinoma of stomach, Neoplasm of the breast, Uterine Carcinosarcoma, Malignant neoplasm of body of uterus | 56,088,558(+) | A/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1057519893 | likely-pathogenic, Adenocarcinoma of stomach, Uterine Carcinosarcoma, Uterine cervical neoplasms, Neoplasm of the breast, Colorectal Neoplasms, Malignant neoplasm of body of uterus, Transitional cell carcinoma of the bladder, Carcinoma of gallbladder | 56,085,070(+) | G/A/T | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv832427 | CNV | loss | 17160897 |
| nsv1122738 | CNV | deletion | 24896259 |
| nsv1120091 | OTHER | inversion | 24896259 |
| nsv1051961 | CNV | gain | 25217958 |
| esv275479 | CNV | gain+loss | 21479260 |
| esv1499550 | CNV | insertion | 17803354 |
Residual Variation Intolerance Score:
13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.28;
70.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ERBB3 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERBB3 Gene
Disorders for ERBB3 Gene
(23) MalaCards diseases for ERBB3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lethal congenital contracture syndrome 2 |
|
|
| retroperitoneal leiomyosarcoma |
|
|
| ovary transitional cell carcinoma |
|
|
| childhood medulloblastoma |
|
|
| gestational trophoblastic tumor |
|
Search ERBB3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ERBB3_HUMAN- Lethal congenital contracture syndrome 2 (LCCS2) [MIM:607598]: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology. {ECO:0000269 PubMed:17701904}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ERBB3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ERBB3 Gene
Publications for ERBB3 Gene
- No association between the ERBB3 gene and schizophrenia in a Japanese population. (PMID: 17275115) Watanabe Y … Someya T (Neuroscience research 2007) 3 22 44 58
- c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase. (PMID: 7685162) Katoh M … Terada M (Biochemical and biophysical research communications 1993) 3 4 22 58
- A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 44 58
- Spatial structure and dimer--monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles. (PMID: 21575594) Mineev KS … Arseniev AS (Biochimica et biophysica acta 2011) 3 4 58
- Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 44 58
Products for ERBB3 Gene
- R&D Systems Antibodies for ERBB3 (ErbB3/Her3)
- R&D Systems Proteins and Enzymes for ERBB3 (ErbB3/Her3)
- R&D Systems ELISAs, Luminex Assays,