Aliases for ERBB2 Gene
- Erb-B2 Receptor Tyrosine Kinase 2 2 3 5
- HER2 2 3 4
- NEU 2 3 4
- V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 2 3
- Tyrosine Kinase-Type Cell Surface Receptor HER2 3 4
- Neuro/Glioblastoma Derived Oncogene Homolog 2 3
- Human Epidermal Growth Factor Receptor 2 2 3
- Receptor Tyrosine-Protein Kinase ErbB-2 3 4
- Metastatic Lymph Node Gene 19 Protein 3 4
- Proto-Oncogene C-ErbB-2 3 4
- Proto-Oncogene Neu 3 4
- EC 220.127.116.11 4 51
- MLN 19 3 4
- CD340 2 3
- HER-2 2 3
- NGL 3 4
- V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog) 2
- V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog 3
- V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncoprotein 2 3
- Neuroblastoma/Glioblastoma Derived Oncogene Homolog 3
- C-Erb B2/Neu Protein 3
- CD340 Antigen 4
- HER-2/Neu 3
- Herstatin 3
- P185erbB2 4
- EC 2.7.10 51
- ERBB2 5
- MLN19 4
- TKR1 3
External Ids for ERBB2 Gene
Previous HGNC Symbols for ERBB2 Gene
Previous GeneCards Identifiers for ERBB2 Gene
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
ERBB2, commonly referred to as HER2, is amplified and/or overexpressed in 20-30% of invasive breast carcinomas. HER2-positive breast cancer is treated in a separate manner from other subtypes of breast cancer and commonly presents as more aggressive disease. Metastatic HER2-positive breast cancer is now commonly treated with HER2-targeted therapy. Apart from being amplified/overexpressed, ERBB2 activating mutations have been shown to have clinical importance in HER2-negative breast cancer. These mutations have shown sensitivity to the tyrosine kinase inhibitor neratinib, and highlight the importance of clinical sequencing efforts in treating breast cancer.
GeneCards Summary for ERBB2 Gene
ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with ERBB2 include Glioma Susceptibility 1 and Gastric Cancer. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and RET signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is EGFR.
UniProtKB/Swiss-Prot Summary for ERBB2 Gene
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase of the ErbB family. Four members of the ErbB family have been identified; EGFR (ErbB1, HER1), ErbB2 (HER2), ErbB3 (HER3) and ErbB4 (HER4). EGFR signaling drives many cellular responses.