Aliases for ERAS Gene
External Ids for ERAS Gene
Previous HGNC Symbols for ERAS Gene
Previous GeneCards Identifiers for ERAS Gene
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
GeneCards Summary for ERAS Gene
ERAS (ES Cell Expressed Ras) is a Protein Coding gene. Diseases associated with ERAS include Orbital Tenonitis and Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia. Among its related pathways are PI3K / Akt Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is KRAS.
UniProtKB/Swiss-Prot for ERAS Gene
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).