Aliases for ERAP2 Gene
External Ids for ERAP2 Gene
Previous GeneCards Identifiers for ERAP2 Gene
This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]
GeneCards Summary for ERAP2 Gene
ERAP2 (Endoplasmic Reticulum Aminopeptidase 2) is a Protein Coding gene. Diseases associated with ERAP2 include Spondylitis and Birdshot Chorioretinopathy. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and aminopeptidase activity. An important paralog of this gene is ERAP1.
UniProtKB/Swiss-Prot Summary for ERAP2 Gene
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.