ERAP1 Gene (Protein Coding)

Endoplasmic Reticulum Aminopeptidase 1

GC05M096760
GIFtS:
44
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different i... See more...

Aliases for ERAP1 Gene

Aliases for ERAP1 Gene

  • Endoplasmic Reticulum Aminopeptidase 1 2 3 4 5
  • Puromycin-Insensitive Leucyl-Specific Aminopeptidase 2 3 4
  • Adipocyte-Derived Leucine Aminopeptidase 2 3 4
  • PILS-AP 2 3 4
  • ARTS-1 2 3 4
  • A-LAP 2 3 4
  • Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator 3 4
  • Aminopeptidase Regulator Of TNFR1 Shedding 2 3
  • Aminopeptidase PILS 3 4
  • KIAA0525 2 4
  • APPILS 3 4
  • ERAAP1 2 3
  • ARTS1 3 4
  • Endoplasmic Reticulum Aminopeptidase Associated With Antigen Processing 3
  • CTD-2260A17.2 3
  • EC 3.4.11.3 50
  • EC 3.4.11.- 4
  • EC 3.4.11 50
  • PILSAP 3
  • ERAAP 3
  • ERAP1 5
  • ALAP 3

External Ids for ERAP1 Gene

Previous GeneCards Identifiers for ERAP1 Gene

  • GC05M096124
  • GC05M091286

Summaries for ERAP1 Gene

Entrez Gene Summary for ERAP1 Gene

  • The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for ERAP1 Gene

ERAP1 (Endoplasmic Reticulum Aminopeptidase 1) is a Protein Coding gene. Diseases associated with ERAP1 include Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads and Behcet Syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is ERAP2.

UniProtKB/Swiss-Prot Summary for ERAP1 Gene

  • Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.

Gene Wiki entry for ERAP1 Gene

Additional gene information for ERAP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ERAP1 Gene

Genomics for ERAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ERAP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ERAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ERAP1

Top Transcription factor binding sites by QIAGEN in the ERAP1 gene promoter:
  • E47
  • HNF-1
  • HNF-1A
  • HOXA5
  • Nkx2-5
  • POU2F1c
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Zic3

Genomic Locations for ERAP1 Gene

Latest Assembly
chr5:96,760,273-96,935,983
(GRCh38/hg38)
Size:
175,711 bases
Orientation:
Minus strand

Previous Assembly
chr5:96,096,517-96,149,848
(GRCh37/hg19 by Entrez Gene)
Size:
53,332 bases
Orientation:
Minus strand

chr5:96,096,521-96,143,803
(GRCh37/hg19 by Ensembl)
Size:
47,283 bases
Orientation:
Minus strand

Genomic View for ERAP1 Gene

Genes around ERAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ERAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ERAP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ERAP1 Gene

Proteins for ERAP1 Gene

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  • Protein details for ERAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ08-ERAP1_HUMAN
    Recommended name:
    Endoplasmic reticulum aminopeptidase 1
    Protein Accession:
    Q9NZ08
    Secondary Accessions:
    • O60278
    • Q6UWY6
    • Q8NEL4
    • Q8TAD0
    • Q9UHF8
    • Q9UKY2

    Protein attributes for ERAP1 Gene

    Size:
    941 amino acids
    Molecular mass:
    107235 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer. May also exist as a heterodimer; with ERAP2. Interacts with RBMX.
    SequenceCaution:
    • Sequence=BAA25451.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ERAP1 Gene

    Alternative splice isoforms for ERAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ERAP1 Gene

Protein Expression for ERAP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ERAP1 Gene

Q9NZ08:
  • WWNDLWLNE
  • GAMENWG
  • FSIKIRRE
  • STYLVAF
  • GYYIVHY
  • WFGNLVT
  • HELAHQWFG
  • TWTLQKG
  • WLNEGFA

Post-translational modifications for ERAP1 Gene

  • N-glycosylated.
  • Glycosylation at Asn70, Asn154, Asn414, Asn760, and Asn901
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ERAP1_HUMAN (1203)

Other Protein References for ERAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Assay products for research

  • Boster Bio ELISA Kits for ERAP1

Domains & Families for ERAP1 Gene

Gene Families for ERAP1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ERAP1 Gene

InterPro:
Blocks:
  • Membrane alanyl dipeptidase (M1) family signature

Suggested Antigen Peptide Sequences for ERAP1 Gene

GenScript: Design optimal peptide antigens:
  • Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator (ERAP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NZ08

UniProtKB/Swiss-Prot:

ERAP1_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with ERAP1: view

Function for ERAP1 Gene

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  6. Cell Lines for research

Molecular function for ERAP1 Gene

UniProtKB/Swiss-Prot Function:
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
UniProtKB/Swiss-Prot Induction:
By IFNG/IFN-gamma.

Enzyme Numbers (IUBMB) for ERAP1 Gene

Phenotypes From GWAS Catalog for ERAP1 Gene

Gene Ontology (GO) - Molecular Function for ERAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA,IDA 10220586
GO:0005138 interleukin-6 receptor binding IPI 12748171
GO:0005151 interleukin-1, type II receptor binding TAS 15691326
GO:0005515 protein binding IPI 18445477
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with ERAP1: view
genes like me logo Genes that share phenotypes with ERAP1: view

Human Phenotype Ontology for ERAP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ERAP1 Gene

MGI Knock Outs for ERAP1:

Animal Models for research

  • Taconic Biosciences Mouse Models for ERAP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERAP1

Clone products for research

  • Addgene plasmids for ERAP1

No data available for Transcription Factor Targets and HOMER Transcription for ERAP1 Gene

Localization for ERAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERAP1 Gene

Endoplasmic reticulum membrane. Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ERAP1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
cytosol 5
plasma membrane 4
nucleus 3
endosome 2
lysosome 2
cytoskeleton 1
mitochondrion 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ERAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 11056387
GO:0005615 extracellular space HDA 16502470
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum NAS 12748171
GO:0005788 endoplasmic reticulum lumen TAS 15691326
genes like me logo Genes that share ontologies with ERAP1: view

Pathways & Interactions for ERAP1 Gene

genes like me logo Genes that share pathways with ERAP1: view

Pathways by source for ERAP1 Gene

1 GeneGo (Thomson Reuters) pathway for ERAP1 Gene
  • Apoptosis and survival TNFR1 signaling pathway

Gene Ontology (GO) - Biological Process for ERAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 15691326
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0006508 proteolysis IEA,IBA 21873635
genes like me logo Genes that share ontologies with ERAP1: view

No data available for SIGNOR curated interactions for ERAP1 Gene

Drugs & Compounds for ERAP1 Gene

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(3) Drugs for ERAP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bradykinin Investigational Pharma Endogenous agonist at bradykinin receptors (B2 > B1) 66

(2) Additional Compounds for ERAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ERAP1: view

Transcripts for ERAP1 Gene

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mRNA/cDNA for ERAP1 Gene

4 REFSEQ mRNAs :
45 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ERAP1

Clone products for research

  • Addgene plasmids for ERAP1

Alternative Splicing Database (ASD) splice patterns (SP) for ERAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^
SP1: - -
SP2:
SP3:
SP4: - - - - - - - -
SP5:
SP6: - - - -
SP7: - -
SP8: -
SP9:

ExUns: 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ERAP1 Gene

GeneLoc Exon Structure for
ERAP1

Expression for ERAP1 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ERAP1 Gene

mRNA expression in normal human tissues for ERAP1 Gene
mRNA expression by GTEx for ERAP1 GenemRNA expression by BioGPS for ERAP1 Gene

Protein differential expression in normal tissues from HIPED for ERAP1 Gene

This gene is overexpressed in Tlymphocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ERAP1 Gene



Protein tissue co-expression partners for ERAP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ERAP1

SOURCE GeneReport for Unigene cluster for ERAP1 Gene:

Hs.666524

mRNA Expression by UniProt/SwissProt for ERAP1 Gene:

Q9NZ08-ERAP1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ERAP1 Gene

  • Nervous system(4.7)
  • Blood(4.6)
  • Liver(4.4)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Intestine(2.5)
  • Skin(2.5)
  • Eye(2.3)
  • Stomach(2.2)
  • Heart(2.1)
  • Lung(2)
  • Bone marrow(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with ERAP1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ERAP1 Gene

Orthologs for ERAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ERAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ERAP1 29 30
  • 99.61 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ERAP1 29 30
  • 86.96 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ERAP1 29 30
  • 86.44 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Erap1 29 16 30
  • 86.3 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Erap1 29
  • 85.79 (n)
Oppossum
(Monodelphis domestica)
 Mammalia ERAP1 30
  • 76 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 75 (a)
 OneToMany
-- 30
  • 70 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves ERAP1 29 30
  • 70.82 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ERAP1 30
  • 66 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia erap1 29
  • 67.64 (n)
Zebrafish
(Danio rerio)
 Actinopterygii zgc:56194 29
  • 65.44 (n)
ERAP1 (2 of 2) 30
  • 60 (a)
 OneToMany
ERAP1 (1 of 2) 30
  • 57 (a)
 OneToMany
-- 29
Fruit Fly
(Drosophila melanogaster)
 Insecta CG4467 30
  • 21 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea F49B2.6 30
  • 24 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 35 (a)
 OneToMany
Species where no ortholog for ERAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ERAP1 Gene

ENSEMBL:
Gene Tree for ERAP1 (if available)
TreeFam:
Gene Tree for ERAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ERAP1: view image
Alliance of Genome Resources:
Additional Orthologs for ERAP1

Paralogs for ERAP1 Gene

Paralogs for ERAP1 Gene

(8) SIMAP similar genes for ERAP1 Gene using alignment to 3 proteins:

  • ERAP1_HUMAN
  • D6RAL9_HUMAN
  • H0Y9X5_HUMAN
genes like me logo Genes that share paralogs with ERAP1: view

Variants for ERAP1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ERAP1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
1032571 Pathogenic: Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads 96,765,261(-) C/CT
NM_001750.7(CAST):c.1974dup (p.Asp659Ter) 		NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs113716524 Benign: not provided 96,765,218(-) C/T
NM_001750.7(CAST):c.1933-3C>T 		INTRON
rs114703312 Benign: not provided 96,785,968(-) A/C
NM_001040458.3(ERAP1):c.1763T>G (p.Val588Gly) 		MISSENSE
rs1188343598 Likely Benign: not provided 96,785,975(-) G/C
NM_001040458.3(ERAP1):c.1760-4C>G 		INTRON
rs1394921907 Likely Benign: not provided 96,785,901(-) C/A
NM_001040458.3(ERAP1):c.1830G>T (p.Val610=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ERAP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ERAP1 Gene

Variant ID Type Subtype PubMed ID
esv3605865 CNV loss 21293372
nsv1021263 CNV loss 25217958
nsv1028741 CNV gain 25217958
nsv436983 CNV loss 16327808
nsv476820 CNV novel sequence insertion 20440878
nsv516293 CNV gain+loss 19592680
nsv598962 CNV gain 21841781
nsv598963 CNV gain 21841781
nsv830411 CNV loss 17160897

Variation tolerance for ERAP1 Gene

Residual Variation Intolerance Score: 71.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.01; 98.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ERAP1 Gene

Human Gene Mutation Database (HGMD)
ERAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ERAP1
Leiden Open Variation Database (LOVD)
ERAP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERAP1 Gene

Disorders for ERAP1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for ERAP1 Gene - From: CVR, ORP, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ERAP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ERAP1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ERAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ERAP1 Gene

Publications for ERAP1 Gene

  1. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. (PMID: 16286653) Chang SC … Goldberg AL (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 22
  2. Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase/oxytocinase. (PMID: 10220586) Hattori A … Tsujimoto M (Journal of biochemistry 1999) 2 3 4 22
  3. Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis. (PMID: 20032103) Pazár B … Poór G (The Journal of rheumatology 2010) 3 22 40
  4. Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis. (PMID: 19433412) Tsui FW … Inman RD (Annals of the rheumatic diseases 2010) 3 22 40
  5. Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis. (PMID: 19404951) Maksymowych WP … Rahman P (Arthritis and rheumatism 2009) 3 22 40

ExternalLinks

View latest publications for ERAP1 gene in Mastermind

Products for ERAP1 Gene

  • Addgene plasmids for ERAP1

Sources for ERAP1 Gene