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This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]
EPX (Eosinophil Peroxidase) is a Protein Coding gene. Diseases associated with EPX include Eosinophil Peroxidase Deficiency and Proctitis. Among its related pathways are Innate Immune System and Allograft rejection. Gene Ontology (GO) annotations related to this gene include heme binding and peroxidase activity. An important paralog of this gene is MPO.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004601 | peroxidase activity | TAS,IBA | 21873635 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0020037 | heme binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | -- |
GO:0034774 | secretory granule lumen | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | Allograft rejection |
.44
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002215 | defense response to nematode | IEA | -- |
GO:0006952 | defense response | IEA | -- |
GO:0006979 | response to oxidative stress | IEA | -- |
GO:0032693 | negative regulation of interleukin-10 production | IEA | -- |
GO:0032714 | negative regulation of interleukin-5 production | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Melatonin | Approved, Vet_approved | Nutra | Antagonist, Agonist, Full agonist, Target, inhibitor | Melatonin receptors MT inhibitor, Endogenous hormone; agonist at MT1 and MT2 | 398 | |
Formaldehyde | Approved, Vet_approved | Pharma | 142 | |||
Hydrogen peroxide | Approved, Vet_approved | Pharma | 115 | |||
Iron | Approved, Experimental | Pharma | 1560 | |||
Water | Approved | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2-Phenylacetamide |
|
103-81-1 |
|
|||
methanol |
|
67-56-1 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EPX 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EPX 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Epx 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Epx 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | EPX 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | EPX 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
African clawed frog (Xenopus laevis) |
Amphibia | PMR-1 30 |
|
||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.12335 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mpx 30 |
|
||
CU184832.2 31 |
|
ManyToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10211 32 |
|
|
|
CG6879 32 |
|
|
|||
CG5873 32 |
|
|
|||
CG6969 32 |
|
|
|||
pxt 32 |
|
|
|||
CG8913 32 |
|
|
|||
Pxt 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | F32A5.2a 32 |
|
|
|
F32A5.2b 32 |
|
|
|||
ZK430.8 32 |
|
|
|||
C46A5.4 32 |
|
|
|||
F09F3.5 32 |
|
|
|||
R08F11.7 32 |
|
|
|||
K10B4.1 31 32 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714738 | Benign: not provided | 58,197,052(+) | C/T | SYNONYMOUS_VARIANT | |
715463 | Likely Benign: not provided | 58,197,059(+) | T/C | MISSENSE_VARIANT | |
718158 | Benign: not provided | 58,203,244(+) | G/A | SYNONYMOUS_VARIANT | |
720759 | Benign: not provided | 58,193,064(+) | G/A | MISSENSE_VARIANT | |
727637 | Likely Benign: not provided | 58,193,136(+) | A/G | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
eosinophil peroxidase deficiency |
|
|
proctitis |
|
|
allergic rhinitis |
|
|
hypereosinophilic syndrome |
|
|
rhinitis |
|