EPS15 Gene (Protein Coding)

Epidermal Growth Factor Receptor Pathway Substrate 15

GC01M051354
GIFtS:
46
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009] See more...

Aliases for EPS15 Gene

Aliases for EPS15 Gene

  • Epidermal Growth Factor Receptor Pathway Substrate 15 2 3 5
  • Epidermal Growth Factor Receptor Substrate 15 3 4
  • Protein AF-1p 3 4
  • AF-1P 2 3
  • MLLT5 2 3
  • AF1P 3 4
  • ALL1 Fused Gene From Chromosome 1 3
  • Protein Eps15 4
  • EPS15 5

External Ids for EPS15 Gene

Previous GeneCards Identifiers for EPS15 Gene

  • GC01M051447
  • GC01M050709
  • GC01M051179
  • GC01M051190
  • GC01M051532
  • GC01M051819
  • GC01M049937

Summaries for EPS15 Gene

Entrez Gene Summary for EPS15 Gene

  • This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

GeneCards Summary for EPS15 Gene

EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15) is a Protein Coding gene. Diseases associated with EPS15 include Vaccinia and Cataract 8, Multiple Types. Among its related pathways are Endocytic Trafficking of EGFR and Development HGF signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and SH3 domain binding. An important paralog of this gene is EPS15L1.

UniProtKB/Swiss-Prot Summary for EPS15 Gene

  • Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.

Gene Wiki entry for EPS15 Gene

Additional gene information for EPS15 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EPS15 Gene

Genomics for EPS15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for EPS15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EPS15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EPS15

Top Transcription factor binding sites by QIAGEN in the EPS15 gene promoter:
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1

Genomic Locations for EPS15 Gene

Latest Assembly
chr1:51,354,263-51,519,275
(GRCh38/hg38)
Size:
165,013 bases
Orientation:
Minus strand

Previous Assembly
chr1:51,819,935-51,984,938
(GRCh37/hg19 by Entrez Gene)
Size:
165,004 bases
Orientation:
Minus strand

chr1:51,819,935-51,985,000
(GRCh37/hg19 by Ensembl)
Size:
165,066 bases
Orientation:
Minus strand

Genomic View for EPS15 Gene

Genes around EPS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPS15 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for EPS15 Gene

Proteins for EPS15 Gene

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  • Protein details for EPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42566-EPS15_HUMAN
    Recommended name:
    Epidermal growth factor receptor substrate 15
    Protein Accession:
    P42566
    Secondary Accessions:
    • B2R8J7
    • D3DPJ2
    • Q5SRH4

    Protein attributes for EPS15 Gene

    Size:
    896 amino acids
    Molecular mass:
    98656 Da
    Quaternary structure:
    • Interacts with SGIP1 (PubMed:26822536). Interacts with HGS; the interaction bridges the interaction of STAM or STAM2 with EPS15. Isoform 2 interacts with HGS and AP2A2. Part of a complex at least composed of EPS15, HGS, and either STAM or STAM2. Binds AP2A2. Interacts with AP2B1; clathrin competes with EPS15. Binds STON2 and EPN1. Interacts (via its SH3-binding sites) with CRK. Interacts with SH3BP4/TTP. Interacts with ERBB2. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. Interacts (via UIM repeats) with CORO7 (when ubiquitinated at 'Lys-472'). Interacts (via UIM domains) with UBQLN1 (via ubiquitin-like domain) and can interact with both the ubiquitinated and the non-ubiquitinated forms of UBQLN1. Interacts with UBQLN2 (By similarity) (PubMed:10757979, PubMed:11062555, PubMed:12551915, PubMed:16159959, PubMed:16314522, PubMed:16325581, PubMed:16903783, PubMed:18199683, PubMed:18200045, PubMed:18362181, PubMed:20448150, PubMed:21762413, PubMed:22484487, PubMed:22648170, PubMed:24768539, PubMed:8662907, PubMed:9721102, PubMed:9723620).
    • (Microbial infection) Interacts with vaccinia virus protein A36.

    Three dimensional structures from OCA and Proteopedia for EPS15 Gene

    Alternative splice isoforms for EPS15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPS15 Gene

Protein Expression for EPS15 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for EPS15 Gene

  • Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.
  • Ubiquitinated.
  • Ubiquitination at Lys413, Lys495, Lys638, Lys754, Lys788, Lys793, Lys801, Lys818, Lys860, and Lys890
  • Modification sites at PhosphoSitePlus

Other Protein References for EPS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EPS15 Gene

Domains & Families for EPS15 Gene

Gene Families for EPS15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for EPS15 Gene

InterPro:
Blocks:
  • Ubiquitin interacting motif
  • EPS15 homology (EH)

Suggested Antigen Peptide Sequences for EPS15 Gene

GenScript: Design optimal peptide antigens:
  • Protein AF-1p (EPS15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42566

UniProtKB/Swiss-Prot:

EPS15_HUMAN :
  • The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
Domain:
  • The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
  • The UIM (ubiquitin-interacting motif) repeats specifically bind 'Lys-33'-linked ubiquitin.
genes like me logo Genes that share domains with EPS15: view

Function for EPS15 Gene

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  6. Cell Lines for research

Molecular function for EPS15 Gene

UniProtKB/Swiss-Prot Function:
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
GENATLAS Biochemistry:
EGFR pathway substrate,mouse eps15 homolog,likely involved in cell growth regulation

Phenotypes From GWAS Catalog for EPS15 Gene

Gene Ontology (GO) - Molecular Function for EPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10064583
GO:0017124 SH3 domain binding IEA --
GO:0031593 polyubiquitin modification-dependent protein binding IDA 24768539
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with EPS15: view
genes like me logo Genes that share phenotypes with EPS15: view

Animal Models for EPS15 Gene

MGI Knock Outs for EPS15:
  • Eps15 Eps15<tm1Noff>
  • Eps15 Eps15<tm1a(KOMP)Wtsi>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPS15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPS15 Gene

Localization for EPS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPS15 Gene

Cytoplasm. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. {ECO:0000269 PubMed:16159959}.
[Isoform 2]: Early endosome membrane. Peripheral membrane protein. Cytoplasmic side. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPS15 gene
Compartment Confidence
plasma membrane 5
cytosol 5
endosome 4
nucleus 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol IEA,TAS --
GO:0005886 plasma membrane IDA 15465819
genes like me logo Genes that share ontologies with EPS15: view

Pathways & Interactions for EPS15 Gene

genes like me logo Genes that share pathways with EPS15: view

Pathways by source for EPS15 Gene

1 KEGG pathway for EPS15 Gene
2 GeneGo (Thomson Reuters) pathways for EPS15 Gene
  • Transport Clathrin-coated vesicle cycle
  • wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
1 Qiagen pathway for EPS15 Gene
  • Endocytic Trafficking of EGFR
1 Cell Signaling Technology pathway for EPS15 Gene

SIGNOR curated interactions for EPS15 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IEA --
GO:0006895 Golgi to endosome transport IMP 24768539
GO:0006897 endocytosis IBA 21873635
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with EPS15: view

Drugs & Compounds for EPS15 Gene

Products:

  1. Drug products for research

(2) Drugs for EPS15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for EPS15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EPS15: view

Transcripts for EPS15 Gene

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mRNA/cDNA for EPS15 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPS15

Alternative Splicing Database (ASD) splice patterns (SP) for EPS15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - -
SP5:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for EPS15 Gene

GeneLoc Exon Structure for
EPS15

Expression for EPS15 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPS15 Gene

mRNA expression in normal human tissues for EPS15 Gene
mRNA expression by GTEx for EPS15 GenemRNA expression by BioGPS for EPS15 Gene

Protein differential expression in normal tissues from HIPED for EPS15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EPS15 Gene



Protein tissue co-expression partners for EPS15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EPS15

SOURCE GeneReport for Unigene cluster for EPS15 Gene:

Hs.83722

mRNA Expression by UniProt/SwissProt for EPS15 Gene:

P42566-EPS15_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for EPS15 Gene

  • Blood(4.5)
  • Liver(4.5)
  • Nervous system(4.5)
  • Kidney(2.8)
  • Muscle(2.6)
  • Heart(2.6)
  • Intestine(2.6)
  • Adrenal gland(2.5)
  • Skin(2.5)
  • Spleen(2.5)
  • Lymph node(2.5)
  • Lung(2.4)
  • Pancreas(2.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with EPS15: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPS15 Gene

Orthologs for EPS15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EPS15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia EPS15 30
  • 100 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia EPS15 29 30
  • 93.12 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia EPS15 30
  • 92 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Eps15 29 16 30
  • 89.45 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Eps15 29
  • 88.85 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia EPS15 30
  • 69 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia EPS15 30
  • 59 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves EPS15 29 30
  • 77.64 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia EPS15 30
  • 72 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia eps15 29
  • 65.79 (n)
Zebrafish
(Danio rerio)
 Actinopterygii eps15 29 30
  • 60.63 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Eps-15 30
  • 23 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea ehs-1 30
  • 27 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes EDE1 30 32
  • 14 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 38 (a)
 OneToMany
Species where no ortholog for EPS15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EPS15 Gene

ENSEMBL:
Gene Tree for EPS15 (if available)
TreeFam:
Gene Tree for EPS15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EPS15: view image
Alliance of Genome Resources:
Additional Orthologs for EPS15

Paralogs for EPS15 Gene

Paralogs for EPS15 Gene

(2) SIMAP similar genes for EPS15 Gene using alignment to 4 proteins:

  • EPS15_HUMAN
  • B1AUU8_HUMAN
  • H7BYP0_HUMAN
  • S4R3U1_HUMAN
genes like me logo Genes that share paralogs with EPS15: view

Variants for EPS15 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EPS15 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17567 -- p.Ile822Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EPS15 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EPS15 Gene

Variant ID Type Subtype PubMed ID
esv25434 CNV loss 19812545
esv2659806 CNV deletion 23128226
esv3307818 CNV mobile element insertion 20981092
esv3308869 CNV mobile element insertion 20981092
esv3363534 CNV insertion 20981092
esv3367601 CNV duplication 20981092
esv3422673 CNV insertion 20981092
esv3577854 CNV loss 25503493
esv3577855 CNV loss 25503493
esv3586035 CNV loss 21293372
esv3586036 CNV loss 21293372
nsv1077820 CNV deletion 25765185
nsv478230 CNV novel sequence insertion 20440878

Variation tolerance for EPS15 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.45; 88.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EPS15 Gene

Human Gene Mutation Database (HGMD)
EPS15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPS15
Leiden Open Variation Database (LOVD)
EPS15

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPS15 Gene

Disorders for EPS15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for EPS15 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search EPS15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EPS15_HUMAN
  • Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Additional Disease Information for EPS15

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with EPS15: view

No data available for Genatlas for EPS15 Gene

Publications for EPS15 Gene

  1. The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. (PMID: 8183552) Wong WT … Di Fiore PP (Oncogene 1994) 2 3 4 22
  2. An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor. (PMID: 18362181) Roxrud I … Stenmark H (The Journal of cell biology 2008) 3 4 22
  3. STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. (PMID: 12551915) Bache KG … Stenmark H (The Journal of biological chemistry 2003) 3 4 22
  4. Molecular mechanism of NPF recognition by EH domains. (PMID: 11062555) de Beer T … Overduin M (Nature structural biology 2000) 3 4 22
  5. Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites. (PMID: 10757979) Enmon JL … Overduin M (Biochemistry 2000) 3 4 22

ExternalLinks

View latest publications for EPS15 gene in Mastermind

Products for EPS15 Gene

  • Addgene plasmids for EPS15

Sources for EPS15 Gene