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EPN3 (Epsin 3) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (WikiPathways) and Endocytic Trafficking of EGFR. Gene Ontology (GO) annotations related to this gene include lipid binding and EH domain binding. An important paralog of this gene is EPN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 20709745 |
GO:0005543 | phospholipid binding | IBA | 21873635 |
GO:0008289 | lipid binding | IEA | -- |
GO:0030276 | clathrin binding | IBA | 21873635 |
GO:1990175 | EH domain binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 11359770 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005768 | endosome | IBA | 21873635 |
GO:0005886 | plasma membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
|
Sertoli-Sertoli Cell Junction Dynamics
.38
|
2 | Endocytosis | ||
3 | Notch Signaling Pathway (WikiPathways) | ||
4 | Endocytic Trafficking of EGFR |
Endocytic Trafficking of EGFR
.41
|
|
5 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006897 | endocytosis | IBA | 21873635 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP12: | - |
ExUns: | 13 |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: | |
SP6: | |
SP7: | |
SP8: | |
SP9: | |
SP10: | |
SP11: | |
SP12: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EPN3 30 |
|
||
Dog (Canis familiaris) |
Mammalia | EPN3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Epn3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Epn3 30 |
|
||
Cow (Bos Taurus) |
Mammalia | EPN3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | EPN3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | EPN3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | EPN3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EPN3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | epn3 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC571453 30 |
|
||
EPN3 (1 of 2) 31 |
|
OneToMany | |||
EPN3 (2 of 2) 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | lqf 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | epn-1 31 |
|
OneToMany | |
T04C10.2a 32 |
|
|
|||
T04C10.2b 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ENT3 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv424e201 | CNV | deletion | 23290073 |
esv2716034 | CNV | deletion | 23290073 |
esv2716036 | CNV | deletion | 23290073 |
nsv833477 | CNV | loss | 17160897 |
No disorders were found for EPN3 Gene.