Aliases for EPN1 Gene
Aliases for EPN1 Gene
External Ids for EPN1 Gene
- HGNC: 21604
- Entrez Gene: 29924
- Ensembl: ENSG00000063245
- OMIM: 607262
- UniProtKB: Q9Y6I3
Previous GeneCards Identifiers for EPN1 Gene
- GC19P057065
- GC19P056640
- GC19P060862
- GC19P060878
- GC19P056186
- GC19P052497
Summaries for EPN1 Gene
-
This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
GeneCards Summary for EPN1 Gene
EPN1 (Epsin 1) is a Protein Coding gene. Diseases associated with EPN1 include Erythrocytosis, Familial, 1. Among its related pathways are EGF/EGFR Signaling Pathway and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). Gene Ontology (GO) annotations related to this gene include transcription factor binding and phospholipid binding. An important paralog of this gene is EPN2.
UniProtKB/Swiss-Prot for EPN1 Gene
-
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPN1 Gene
Genomics for EPN1 Gene
GeneHancer (GH) Regulatory Elements for EPN1 Gene
Promoters and enhancers for EPN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around EPN1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EPN1 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- c-Ets-1
- NF-kappaB1
- c-Myc
Regulatory Element Products
Genomic Locations for EPN1 Gene
Genomic Locations for EPN1 Gene
- chr19:55,675,195-55,709,858
- (GRCh38/hg38)
- Size:
- 34,664 bases
- Orientation:
- Plus strand
- chr19:56,186,561-56,221,224
- (GRCh37/hg19)
- Size:
- 34,664 bases
- Orientation:
- Plus strand
Genomic View for EPN1 Gene
Genes around EPN1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.42 by Entrez Gene
- 19q13.42 by HGNC
- 19q13.42 by Ensembl
EPN1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPN1 Gene
Proteins for EPN1 Gene
-
Protein details for EPN1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6I3-EPN1_HUMAN
- Recommended name:
- Epsin-1
- Protein Accession:
- Q9Y6I3
- Q86ST3
- Q9HA18
Protein attributes for EPN1 Gene
- Size:
- 576 amino acids
- Molecular mass:
- 60293 Da
- Quaternary structure:
-
- Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1 (By similarity). Binds ubiquitinated proteins (By similarity). Binds REPS2, EPS15, AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. Interacts with UBQLN2.
Protein Expression for EPN1 Gene
Post-translational modifications for EPN1 Gene
- Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation.
- Ubiquitinated.
- Ubiquitination at isoforms=2, 3239, Lys228, isoforms=2, 3218, Lys208, Lys197, and isoforms=2, 3122
- Modification sites at PhosphoSitePlus
Other Protein References for EPN1 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EPN1
- Novus Biologicals Antibodies for EPN1
-
Abcam antibodies for EPN1
- Invitrogen Antibodies for EPN1 (AFLGC-EPN1)
- GeneTex EPN1 Antibody for EPN1
-
Boster Bio Antibodies for EPN1
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPN1
Protein Products
-
OriGene Purified Proteins for EPN1
- Search Origene for MassSpec and Protein Over-expression Lysates for EPN1
- Origene Custom Protein Services for EPN1
- Search GeneTex for Proteins for EPN1
-
Abcam proteins for EPN1
Assay Products
- antibodies-online: Search results for available EPN1 related products ranked by validation data
No data available for DME Specific Peptides for EPN1 Gene
Domains & Families for EPN1 Gene
Gene Families for EPN1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EPN1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EPN1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6I3UniProtKB/Swiss-Prot:
EPN1_HUMAN :- The NPF repeat domain is involved in EPS15 binding.
- Belongs to the epsin family.
- Domain:
-
- The NPF repeat domain is involved in EPS15 binding.
- The DPW repeat domain is involved in AP2A2 and clathrin binding.
- The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction with the AP-2 complex subunit AP2B1.
- Family:
-
- Belongs to the epsin family.
Function for EPN1 Gene
Molecular function for EPN1 Gene
- UniProtKB/Swiss-Prot Function:
- Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9422736 |
| GO:0008289 | lipid binding | IEA | -- |
Phenotypes for EPN1 Gene
- MGI mutant phenotypes for EPN1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for EPN1:
Animal Models for EPN1 Gene
- MGI Knock Outs for EPN1:
-
- Epn1 Epn1<tm1Ocr>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPN1
-
CRISPR Products
-
OriGene CRISPR knockouts for EPN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPN1
- genomics-online: gRNA clones - Search results for available EPN1 gene related products
- Applied Biological Materials CRISPR for EPN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPN1
- GenScript: Design CRISPR guide RNA sequences for EPN1
miRNA for EPN1 Gene
- miRTarBase miRNAs that target EPN1
-
- hsa-mir-744-5p (MIRT037415)
- hsa-mir-423-5p (MIRT038071)
- hsa-mir-3153 (MIRT082754)
- hsa-mir-6733-5p (MIRT082764)
- hsa-mir-6739-5p (MIRT082766)
- hsa-mir-6819-5p (MIRT484325)
- hsa-mir-6812-5p (MIRT484327)
- hsa-mir-6737-5p (MIRT484328)
- hsa-mir-6742-5p (MIRT484329)
- hsa-mir-92a-2-5p (MIRT484330)
- hsa-mir-6766-5p (MIRT484331)
- hsa-mir-6756-5p (MIRT484332)
- hsa-mir-6747-5p (MIRT484333)
- hsa-mir-608 (MIRT484334)
- hsa-mir-4651 (MIRT484335)
- hsa-mir-4664-5p (MIRT484336)
- hsa-mir-342-5p (MIRT484337)
- hsa-mir-6799-5p (MIRT484338)
- hsa-mir-6825-5p (MIRT484339)
- hsa-mir-4668-5p (MIRT484340)
- hsa-mir-6851-5p (MIRT484341)
- hsa-mir-3689d (MIRT484342)
- hsa-mir-6077 (MIRT484343)
- hsa-mir-6134 (MIRT484344)
- hsa-mir-6845-3p (MIRT484345)
- hsa-mir-6889-5p (MIRT484346)
- hsa-mir-6784-5p (MIRT484347)
- hsa-mir-6777-5p (MIRT484348)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPN1
- Browse OriGene Inhibitory RNA Products For EPN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPN1
- genomics-online: shRNA clones - Search results for available EPN1 gene related products
Clone Products
-
OriGene ORF clones in human for EPN1
- RC207099
- RC207099L1
- RC207099L2
- RC207099L3
- RC207099L4
- RC225973
- RC225973L1
- RC225973L2
- RC225973L3
- RC225973L4
- RC226076
- RC226076L1
- RC226076L2
- RC226076L3
- RC226076L4
- RG207099
- RG225973
- RG226076
- RC207099L1V
- RC207099L2V
- RC207099L3V
- RC207099L4V
- RC225973L1V
- RC225973L2V
- RC225973L3V
- RC225973L4V
- RC226076L1V
- RC226076L2V
- RC226076L3V
- RC226076L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EPN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPN1
- genomics-online: cdna clones - Search results for available EPN1 gene related products
- orf clones - Search results for available EPN1 gene related products
- Applied Biological Materials Clones for EPN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for EPN1
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPN1 Gene
Localization for EPN1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPN1 Gene
- Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Membrane, clathrin-coated pit. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| nucleus | 4 |
| extracellular | 1 |
| lysosome | 1 |
| endosome | 1 |
- Cytosol (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005905 | clathrin-coated pit | IEA | -- |
Pathways & Interactions for EPN1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sertoli-Sertoli Cell Junction Dynamics | ||
| 2 | Clathrin-mediated endocytosis | ||
| 3 | Vesicle-mediated transport | ||
| 4 | wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) | ||
| 5 | Endocytosis | ||
Pathways by source for EPN1 Gene
2 BioSystems pathways for EPN1 Gene
7 Reactome pathways for EPN1 Gene
1 KEGG pathway for EPN1 Gene
2 GeneGo (Thomson Reuters) pathways for EPN1 Gene
2 R&D Systems pathways for EPN1 Gene
4 Qiagen pathways for EPN1 Gene
Interacting Proteins for EPN1 Gene
Selected Interacting proteins:
Q9Y6I3-EPN1_HUMAN
ENSP00000406209
for EPN1 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for EPN1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006897 | endocytosis | IEA,TAS | -- |
| GO:0007219 | Notch signaling pathway | IEA | -- |
| GO:0007565 | female pregnancy | IEA | -- |
| GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | TAS | -- |
Transcripts for EPN1 Gene
mRNA/cDNA for EPN1 Gene
- (12) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000270460 16219 bps (uc002qlw.4)
- ENST00000085079 2355 bps (uc002qlv.4)
- ENST00000411543 2621 bps (uc002qlx.4)
- ENST00000591743 593 bps (uc061dcr.1)
- ENST00000586194 583 bps (uc061dct.1)
Unigene Clusters for EPN1 Gene
- Epsin 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for EPN1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPN1
- genomics-online: gRNA clones - Search results for available EPN1 gene related products
- Applied Biological Materials CRISPR for EPN1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPN1
- GenScript: Design CRISPR guide RNA sequences for EPN1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPN1
- Browse OriGene Inhibitory RNA Products For EPN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPN1
- genomics-online: shRNA clones - Search results for available EPN1 gene related products
Clone Products
-
OriGene ORF clones in human for EPN1
- RC207099
- RC207099L1
- RC207099L2
- RC207099L3
- RC207099L4
- RC225973
- RC225973L1
- RC225973L2
- RC225973L3
- RC225973L4
- RC226076
- RC226076L1
- RC226076L2
- RC226076L3
- RC226076L4
- RG207099
- RG225973
- RG226076
- RC207099L1V
- RC207099L2V
- RC207099L3V
- RC207099L4V
- RC225973L1V
- RC225973L2V
- RC225973L3V
- RC225973L4V
- RC226076L1V
- RC226076L2V
- RC226076L3V
- RC226076L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EPN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPN1
- genomics-online: cdna clones - Search results for available EPN1 gene related products
- orf clones - Search results for available EPN1 gene related products
- Applied Biological Materials Clones for EPN1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for EPN1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Brain (14.9), Frontal cortex (9.9), and Bone marrow stromal cell (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EPN1 Gene
NURSA nuclear receptor signaling pathways regulating expression of EPN1 Gene:
EPN1SOURCE GeneReport for Unigene cluster for EPN1 Gene:
Hs.279953Evidence on tissue expression from TISSUES for EPN1 Gene
- Nervous system(4.5)
- Liver(4.4)
- Blood(4.1)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for EPN1
-
OriGene qPCR primer pairs and template standards for EPN1
- genomics-online: primer clones - Search results for available EPN1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPN1 Gene
Orthologs for EPN1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EPN1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EPN1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EPN1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Epn1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Epn1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EPN1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | EPN1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | epn2 33 |
|
||
| Str.711 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398106 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | epn1 34 |
|
OneToOne | |
| wufd51f09 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007396 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | lqf 34 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | epn-1 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ENT3 34 |
|
OneToMany | |
| ENT1 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for EPN1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for EPN1 Gene
- ENSEMBL:
- Gene Tree for EPN1 (if available)
- TreeFam:
- Gene Tree for EPN1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EPN1: view image
Paralogs for EPN1 Gene
Variants for EPN1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000316040 | -- | 55,681,827(+) | A/G | intron_variant | |
| rs1000386636 | -- | 55,674,841(+) | G/A | upstream_transcript_variant | |
| rs1000605800 | -- | 55,691,032(+) | G/C | intron_variant | |
| rs1000618920 | -- | 55,691,195(+) | A/G | intron_variant | |
| rs1000729814 | -- | 55,673,982(+) | G/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
16.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.79;
47.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EPN1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- EPN1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPN1 Gene
Disorders for EPN1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| erythrocytosis, familial, 1 |
|
|
Search EPN1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EPN1
No data available for UniProtKB/Swiss-Prot and Genatlas for EPN1 Gene
Publications for EPN1 Gene
- Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin. (PMID: 12836669) Koshiba S … Yokoyama S (Journal of structural and functional genomics 2002) 3 4 22 58
- Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis. (PMID: 10557078) Morinaka K … Kikuchi A (Oncogene 1999) 2 3 4 58
- Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits. (PMID: 19054389) Kazazic M … Madshus IH (Traffic (Copenhagen, Denmark) 2009) 3 22 58
- Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability. (PMID: 19478092) Murakami T … Antonetti DA (The Journal of biological chemistry 2009) 3 22 58
- The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis. (PMID: 18199683) N'Diaye EN … Brown EJ (Molecular biology of the cell 2008) 3 4 58
Products for EPN1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EPN1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EPN1
- Search Origene for MassSpec and Protein Over-expression Lysates for EPN1
- Origene Custom Protein Services for EPN1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPN1
- Browse OriGene Inhibitory RNA Products For EPN1
- OriGene qPCR primer pairs for EPN1
- OriGene qPCR primer pairs and template standards for EPN1
- OriGene CRISPR knockouts for EPN1
- OriGene ORF clones in human for EPN1
- RC207099
- RC207099L1
- RC207099L2
- RC207099L3
- RC207099L4
- RC225973
- RC225973L1
- RC225973L2
- RC225973L3
- RC225973L4
- RC226076
- RC226076L1
- RC226076L2
- RC226076L3
- RC226076L4
- RG207099
- RG225973
- RG226076
- RC207099L1V
- RC207099L2V
- RC207099L3V
- RC207099L4V
- RC225973L1V
- RC225973L2V
- RC225973L3V
- RC225973L4V
- RC226076L1V
- RC226076L2V
- RC226076L3V
- RC226076L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EPN1
- GenScript: Next-day shipping of latest version cDNA ORF clones for EPN1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EPN1
- GenScript Custom Assay Services for EPN1
- GenScript Custom overexpressing Cell Line Services for EPN1
- GenScript: Design CRISPR guide RNA sequences for EPN1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EPN1
- Sino Biological Human cDNA Clone for EPN1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for EPN1
- Novus Biologicals proteins and lysates for EPN1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for EPN1
- Abcam proteins for EPN1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for EPN1 (AFLGC-EPN1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPN1
- antibodies-online: Search results for 61 available EPN1 Antibodies ranked by validation data
- Compare Top EPN1 Antibodies
- antibodies-online: Search results for available EPN1 related products ranked by validation data
- antibodies-online: Search results for 8 available EPN1 Proteins ranked by validation data
- Compare Top EPN1 Proteins
- GeneTex EPN1 Antibody for EPN1
- Search GeneTex for Proteins for EPN1
- Santa Cruz Biotechnology (SCBT) Antibodies for EPN1
- Search Santa Cruz Biotechnology (SCBT) for EPN1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPN1
- Horizon Cell Lines for EPN1
- genomics-online: cdna clones - Search results for available EPN1 gene related products
- orf clones - Search results for available EPN1 gene related products
- genomics-online: gRNA clones - Search results for available EPN1 gene related products
- genomics-online: primer clones - Search results for available EPN1 gene related products
- genomics-online: shRNA clones - Search results for available EPN1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPN1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPN1
- GeneCopoeia miRNA 3'UTR Target clone products for EPN1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPN1
- Boster Bio Antibodies for EPN1
- Browse Boster Bio ELISA Kits
Sources for EPN1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt