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This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
EPN1 (Epsin 1) is a Protein Coding gene. Diseases associated with EPN1 include Metagonimiasis and Erythrocytosis, Familial, 1. Among its related pathways are RET signaling and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include transcription factor binding and phospholipid binding. An important paralog of this gene is EPN2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 18199683 |
GO:0005543 | phospholipid binding | IBA | 21873635 |
GO:0008289 | lipid binding | IEA | -- |
GO:0030276 | clathrin binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005768 | endosome | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Sertoli-Sertoli Cell Junction Dynamics |
Germ Cell-Sertoli Cell Junction Dynamics
.38
|
Sertoli-Sertoli Cell Junction Dynamics
.38
|
2 | Clathrin-mediated endocytosis | ||
3 | Vesicle-mediated transport | ||
4 | Delta508-CFTR traffic / ER-to-Golgi in CF |
Transport Clathrin-coated vesicle cycle
.32
|
wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
.31
|
5 | Endocytosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001701 | in utero embryonic development | IEA | -- |
GO:0006897 | endocytosis | TAS,IBA | 21873635 |
GO:0007219 | Notch signaling pathway | IEA | -- |
GO:0007565 | female pregnancy | IEA | -- |
GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | TAS | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | EPN1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | EPN1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | EPN1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Epn1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Epn1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | EPN1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | EPN1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | epn2 30 |
|
||
Str.711 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398106 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | epn1 31 |
|
OneToOne | |
wufd51f09 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007396 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | lqf 30 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | epn-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ENT3 31 |
|
OneToMany | |
ENT1 33 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
metagonimiasis |
|
|
erythrocytosis, familial, 1 |
|
|