Aliases for EPHX4 Gene

Aliases for EPHX4 Gene

  • Epoxide Hydrolase 4 2 3 4 5
  • EPHXRP 2 3 4
  • EH4 2 3 4
  • Abhydrolase Domain-Containing Protein 7 3 4
  • Epoxide Hydrolase-Related Protein 3 4
  • Abhydrolase Domain Containing 7 2 3
  • ABHD7 3 4
  • EC 3.3.-.- 4
  • FLJ90341 2
  • EPHX4 5

External Ids for EPHX4 Gene

Previous HGNC Symbols for EPHX4 Gene

  • ABHD7

Previous GeneCards Identifiers for EPHX4 Gene

  • GC01P092268
  • GC01P092495
  • GC01P090615

Summaries for EPHX4 Gene

GeneCards Summary for EPHX4 Gene

EPHX4 (Epoxide Hydrolase 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is EPHX3.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EPHX4 Gene

Genomics for EPHX4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EPHX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J092029 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 263.8 +0.4 408 2.4 ZNF600 ZNF580 ZNF223 ZNF10 ZIC2 ZBTB10 ZNF639 ZNF341 KLF9 ZNF610 EPHX4 lnc-SETSIP-2 DIPK1A SNORA66 SETSIP
GH01J092031 Enhancer 0.4 FANTOM5 256.3 +2.0 1951 0.2 ZNF341 ZNF189 EPHX4 HSALNG0005184 lnc-SETSIP-2 BTBD8 SETSIP
GH01J091798 Enhancer 0.6 Ensembl dbSUPER 9.9 -230.9 -230885 2.2 RBM22 RAD21 CTCF ZNF157 EPHX4 EVI5 piR-43325-005 RF00004-004 lnc-SETSIP-3 TGFBR3 CDC7
GH01J092117 Enhancer 0.5 Ensembl 11.2 +87.6 87616 0.8 MAFF ZNF316 MAFK MAFG ZBTB40 ZBTB17 EMSY GAPDHP46 piR-42694-011 EPHX4 BRDT BTBD8 C1orf146
GH01J092123 Enhancer 0.3 Ensembl 11.2 +93.9 93866 0.5 PRDM4 PRKAR1AP1 lnc-EPHX4-2 EPHX4 BRDT DIPK1A piR-42694-011 BTBD8 C1orf146
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EPHX4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EPHX4

Top Transcription factor binding sites by QIAGEN in the EPHX4 gene promoter:
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-3
  • HNF-3beta
  • Max1

Genomic Locations for EPHX4 Gene

Latest Assembly
33,554 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
33,554 bases
Plus strand

(GRCh37/hg19 by Ensembl)
33,555 bases
Plus strand

Genomic View for EPHX4 Gene

Genes around EPHX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHX4 Gene

Proteins for EPHX4 Gene

  • Protein details for EPHX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epoxide hydrolase 4
    Protein Accession:
    Secondary Accessions:
    • Q8NCC6

    Protein attributes for EPHX4 Gene

    362 amino acids
    Molecular mass:
    42324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EPHX4 Gene

Post-translational modifications for EPHX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EPHX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for EPHX4
  • Boster Bio Antibodies for EPHX4

No data available for DME Specific Peptides for EPHX4 Gene

Domains & Families for EPHX4 Gene

Gene Families for EPHX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for EPHX4 Gene

  • Alpha/beta hydrolase fold
  • Alpha/beta hydrolase fold signature
  • Epoxide hydrolase signature
  • Prolyl aminopeptidase (S33) family signature

Suggested Antigen Peptide Sequences for EPHX4 Gene

GenScript: Design optimal peptide antigens:
  • Epoxide hydrolase-related protein (EPHX4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
genes like me logo Genes that share domains with EPHX4: view

Function for EPHX4 Gene

Enzyme Numbers (IUBMB) for EPHX4 Gene

Phenotypes From GWAS Catalog for EPHX4 Gene

Gene Ontology (GO) - Molecular Function for EPHX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 32296183
GO:0016787 hydrolase activity IBA 21873635
genes like me logo Genes that share ontologies with EPHX4: view
genes like me logo Genes that share phenotypes with EPHX4: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHX4

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EPHX4 Gene

Localization for EPHX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHX4 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPHX4 gene
Compartment Confidence
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EPHX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EPHX4: view

Pathways & Interactions for EPHX4 Gene

PathCards logo

SuperPathways for EPHX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for EPHX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for EPHX4 Gene

Drugs & Compounds for EPHX4 Gene

No Compound Related Data Available

Transcripts for EPHX4 Gene

mRNA/cDNA for EPHX4 Gene

3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHX4

Alternative Splicing Database (ASD) splice patterns (SP) for EPHX4 Gene

No ASD Table

Relevant External Links for EPHX4 Gene

GeneLoc Exon Structure for

Expression for EPHX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPHX4 Gene

mRNA differential expression in normal tissues according to GTEx for EPHX4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.0), Brain - Cortex (x7.2), Brain - Putamen (basal ganglia) (x6.1), Brain - Nucleus accumbens (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Caudate (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for EPHX4 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EPHX4 Gene

Protein tissue co-expression partners for EPHX4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EPHX4

SOURCE GeneReport for Unigene cluster for EPHX4 Gene:


Evidence on tissue expression from TISSUES for EPHX4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with EPHX4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHX4 Gene

Orthologs for EPHX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EPHX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EPHX4 29 30
  • 99.72 (n)
(Canis familiaris)
Mammalia EPHX4 29 30
  • 94.76 (n)
(Bos Taurus)
Mammalia EPHX4 29
  • 93.37 (n)
ABHD7 30
  • 93 (a)
(Mus musculus)
Mammalia Ephx4 29 16 30
  • 87.12 (n)
(Ornithorhynchus anatinus)
Mammalia EPHX4 30
  • 87 (a)
(Rattus norvegicus)
Mammalia Ephx4 29
  • 85.41 (n)
(Monodelphis domestica)
Mammalia EPHX4 30
  • 85 (a)
(Gallus gallus)
Aves EPHX4 29 30
  • 80.3 (n)
(Anolis carolinensis)
Reptilia EPHX4 30
  • 82 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ephx4 29
  • 74.34 (n)
(Danio rerio)
Actinopterygii ephx4 29 30
  • 67.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011972 29
  • 47.01 (n)
(Caenorhabditis elegans)
Secernentea ceeh-1 29 30
  • 52.46 (n)
ceeh-2 30
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 32
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 31 (a)
Species where no ortholog for EPHX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EPHX4 Gene

Gene Tree for EPHX4 (if available)
Gene Tree for EPHX4 (if available)
Evolutionary constrained regions (ECRs) for EPHX4: view image
Alliance of Genome Resources:
Additional Orthologs for EPHX4

Paralogs for EPHX4 Gene

(2) SIMAP similar genes for EPHX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EPHX4: view

Variants for EPHX4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EPHX4 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17854127 -- p.Tyr321Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EPHX4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EPHX4 Gene

Variant ID Type Subtype PubMed ID
dgv365n54 CNV gain 21841781
esv2714684 CNV deletion 23290073
esv2750842 CNV gain 17911159
nsv1002730 CNV gain 25217958
nsv1006318 CNV gain 25217958
nsv1009079 CNV gain 25217958
nsv1855 CNV insertion 18451855
nsv462517 CNV gain 19166990
nsv524845 CNV gain 19592680
nsv546821 CNV gain 21841781
nsv830581 CNV loss 17160897

Variation tolerance for EPHX4 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EPHX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHX4 Gene

Disorders for EPHX4 Gene

Additional Disease Information for EPHX4

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for EPHX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHX4 Gene

Publications for EPHX4 Gene

  1. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. (PMID: 22798687) Decker M … Arand M (Journal of lipid research 2012) 2 3
  2. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms. (PMID: 20723587) Bagryantseva Y … Sram RJ (Toxicology letters 2010) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for EPHX4 Gene

  • Boster Bio Antibodies for EPHX4
  • Boster Bio ELISA Kits for EPHX4

Sources for EPHX4 Gene