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Aliases for EPHX4 Gene

Aliases for EPHX4 Gene

  • Epoxide Hydrolase 4 2 3 5
  • Abhydrolase Domain-Containing Protein 7 3 4
  • Epoxide Hydrolase-Related Protein 3 4
  • Abhydrolase Domain Containing 7 2 3
  • EPHXRP 3 4
  • ABHD7 3 4
  • EH4 3 4
  • EC 3.3.-.- 4

External Ids for EPHX4 Gene

Previous HGNC Symbols for EPHX4 Gene

  • ABHD7

Previous GeneCards Identifiers for EPHX4 Gene

  • GC01P092268
  • GC01P092495
  • GC01P090615

Summaries for EPHX4 Gene

GeneCards Summary for EPHX4 Gene

EPHX4 (Epoxide Hydrolase 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is EPHX3.

Additional gene information for EPHX4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHX4 Gene

Genomics for EPHX4 Gene

GeneHancer (GH) Regulatory Elements for EPHX4 Gene

Promoters and enhancers for EPHX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I092029 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 563.9 +0.6 617 2 HDGF ARNT GLI4 ZNF2 GLIS2 ZNF213 KLF13 ZNF518A ZNF610 GLIS1 EPHX4 FAM69A SNORA66 GC01P092039
GH01I092031 Enhancer 0.4 FANTOM5 556.4 +2.0 1960 0.2 ZNF189 ZNF341 EPHX4 BTBD8 GC01P092039
GH01I091798 Enhancer 0.5 Ensembl dbSUPER 9.9 -231.5 -231475 0.6 ZNF157 EPHX4 EVI5 GC01M091783 GC01M091786 TGFBR3
GH01I092016 Enhancer 0.6 ENCODE 0.4 -13.1 -13140 0.9 HDAC1 SOX6 TEAD4 TAL1 CBFA2T3 TCF12 NCOR1 HDAC2 CBFA2T2 KDM1A EPHX4 GC01P091968
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around EPHX4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EPHX4 gene promoter:

Genomic Locations for EPHX4 Gene

Genomic Locations for EPHX4 Gene
33,561 bases
Plus strand

Genomic View for EPHX4 Gene

Genes around EPHX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHX4 Gene

Proteins for EPHX4 Gene

  • Protein details for EPHX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epoxide hydrolase 4
    Protein Accession:
    Secondary Accessions:
    • Q8NCC6

    Protein attributes for EPHX4 Gene

    362 amino acids
    Molecular mass:
    42324 Da
    Quaternary structure:
    No Data Available

neXtProt entry for EPHX4 Gene

Post-translational modifications for EPHX4 Gene

No Post-translational modifications

Other Protein References for EPHX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EPHX4 Gene

Domains & Families for EPHX4 Gene

Gene Families for EPHX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for EPHX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
  • Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
genes like me logo Genes that share domains with EPHX4: view

Function for EPHX4 Gene

Enzyme Numbers (IUBMB) for EPHX4 Gene

Gene Ontology (GO) - Molecular Function for EPHX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with EPHX4: view
genes like me logo Genes that share phenotypes with EPHX4: view

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EPHX4 Gene

Localization for EPHX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHX4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPHX4 gene
Compartment Confidence
mitochondrion 3
cytosol 2
golgi apparatus 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EPHX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EPHX4: view

Pathways & Interactions for EPHX4 Gene

SuperPathways for EPHX4 Gene

No Data Available

Interacting Proteins for EPHX4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359410 Q8IUS5-EPHX4_HUMAN for EPHX4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for EPHX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for EPHX4 Gene

Drugs & Compounds for EPHX4 Gene

No Compound Related Data Available

Transcripts for EPHX4 Gene

mRNA/cDNA for EPHX4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHX4 Gene

Epoxide hydrolase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHX4 Gene

No ASD Table

Relevant External Links for EPHX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPHX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EPHX4 Gene

mRNA differential expression in normal tissues according to GTEx for EPHX4 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.0), Brain - Cortex (x7.2), Brain - Putamen (basal ganglia) (x6.1), Brain - Nucleus accumbens (basal ganglia) (x5.9), Brain - Anterior cingulate cortex (BA24) (x5.7), and Brain - Caudate (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for EPHX4 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EPHX4 Gene

Protein tissue co-expression partners for EPHX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EPHX4 Gene:


SOURCE GeneReport for Unigene cluster for EPHX4 Gene:


Evidence on tissue expression from TISSUES for EPHX4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with EPHX4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHX4 Gene

Orthologs for EPHX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EPHX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EPHX4 33 34
  • 99.72 (n)
(Canis familiaris)
Mammalia EPHX4 33 34
  • 94.76 (n)
(Bos Taurus)
Mammalia EPHX4 33
  • 93.37 (n)
ABHD7 34
  • 93 (a)
(Mus musculus)
Mammalia Ephx4 33 16 34
  • 87.12 (n)
(Ornithorhynchus anatinus)
Mammalia EPHX4 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Ephx4 33
  • 85.41 (n)
(Monodelphis domestica)
Mammalia EPHX4 34
  • 85 (a)
(Gallus gallus)
Aves EPHX4 33 34
  • 80.3 (n)
(Anolis carolinensis)
Reptilia EPHX4 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ephx4 33
  • 74.34 (n)
(Danio rerio)
Actinopterygii ephx4 33 34
  • 67.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011972 33
  • 47.01 (n)
(Caenorhabditis elegans)
Secernentea ceeh-1 33 34
  • 52.46 (n)
ceeh-2 34
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for EPHX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPHX4 Gene

Gene Tree for EPHX4 (if available)
Gene Tree for EPHX4 (if available)

Paralogs for EPHX4 Gene

Paralogs for EPHX4 Gene

(2) SIMAP similar genes for EPHX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EPHX4: view

Variants for EPHX4 Gene

Sequence variations from dbSNP and Humsavar for EPHX4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000105920 -- 92,053,365(+) A/G intron_variant
rs1000287522 -- 92,028,788(+) G/A upstream_transcript_variant
rs1000368206 -- 92,055,891(+) G/A intron_variant
rs1000457239 -- 92,034,749(+) C/G intron_variant
rs1000568671 -- 92,041,519(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EPHX4 Gene

Variant ID Type Subtype PubMed ID
nsv524845 CNV gain 19592680
nsv546821 CNV gain 21841781
nsv830581 CNV loss 17160897
nsv462517 CNV gain 19166990
nsv1855 CNV insertion 18451855
nsv1009079 CNV gain 25217958
nsv1006318 CNV gain 25217958
nsv1002730 CNV gain 25217958
esv2750842 CNV gain 17911159
esv2714684 CNV deletion 23290073
dgv365n54 CNV gain 21841781

Variation tolerance for EPHX4 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EPHX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHX4 Gene

Disorders for EPHX4 Gene

Additional Disease Information for EPHX4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for EPHX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHX4 Gene

Publications for EPHX4 Gene

  1. Oxidative damage to biological macromolecules in Prague bus drivers and garagemen: impact of air pollution and genetic polymorphisms. (PMID: 20723587) Bagryantseva Y … Sram RJ (Toxicology letters 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for EPHX4 Gene

Sources for EPHX4 Gene

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