Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The ... See more...

Aliases for EPHB3 Gene

Aliases for EPHB3 Gene

  • EPH Receptor B3 2 3 5
  • HEK2 3 4 4
  • Tyrosine-Protein Kinase TYRO6 3 4
  • EPH-Like Tyrosine Kinase 2 3 4
  • Ephrin Type-B Receptor 3 3 4
  • Embryonic Kinase 2 3 4
  • EC 2.7.10.1 4 50
  • TYRO6 3 4
  • ETK2 3 4
  • EK2 3 4
  • Human Embryo Kinase 2 3
  • EPH-Like Kinase 2 4
  • EC 2.7.10 50
  • EphB3 2
  • EPHB3 5
  • Tyro6 2
  • Hek2 2

External Ids for EPHB3 Gene

Previous HGNC Symbols for EPHB3 Gene

  • ETK2

Previous GeneCards Identifiers for EPHB3 Gene

  • GC03P180979
  • GC03U900008
  • GC03P185682
  • GC03P185600
  • GC03P185762
  • GC03P184279
  • GC03P181691

Summaries for EPHB3 Gene

Entrez Gene Summary for EPHB3 Gene

  • Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]

GeneCards Summary for EPHB3 Gene

EPHB3 (EPH Receptor B3) is a Protein Coding gene. Diseases associated with EPHB3 include Craniofrontonasal Syndrome and Subdural Empyema. Among its related pathways are Nanog in Mammalian ESC Pluripotency and EphB-EphrinB Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHB2.

UniProtKB/Swiss-Prot Summary for EPHB3 Gene

  • Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.

Tocris Summary for EPHB3 Gene

  • Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

Gene Wiki entry for EPHB3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EPHB3 Gene

Genomics for EPHB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EPHB3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EPHB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EPHB3

Top Transcription factor binding sites by QIAGEN in the EPHB3 gene promoter:
  • AML1a
  • AP-1
  • c-Myc
  • Evi-1
  • FOXO4
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • Sox9

Genomic Locations for EPHB3 Gene

Latest Assembly
chr3:184,561,785-184,582,408
(GRCh38/hg38)
Size:
20,624 bases
Orientation:
Plus strand

Previous Assembly
chr3:184,279,573-184,300,196
(GRCh37/hg19 by Entrez Gene)
Size:
20,624 bases
Orientation:
Plus strand

chr3:184,279,572-184,300,197
(GRCh37/hg19 by Ensembl)
Size:
20,626 bases
Orientation:
Plus strand

Genomic View for EPHB3 Gene

Genes around EPHB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHB3 Gene

Proteins for EPHB3 Gene

  • Protein details for EPHB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54753-EPHB3_HUMAN
    Recommended name:
    Ephrin type-B receptor 3
    Protein Accession:
    P54753
    Secondary Accessions:
    • Q7Z740

    Protein attributes for EPHB3 Gene

    Size:
    998 amino acids
    Molecular mass:
    110330 Da
    Quaternary structure:
    • Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).

    Three dimensional structures from OCA and Proteopedia for EPHB3 Gene

neXtProt entry for EPHB3 Gene

Selected DME Specific Peptides for EPHB3 Gene

P54753:
  • MNYVHRDLAARN
  • LYNVICKKC
  • QLVGMLRG
  • RDLAARN
  • GAGEFGEV
  • RWTAPEAI
  • TGAEPTSLVIAPGTC
  • WSYGIVMWEVMS
  • CKETFNL
  • RKFTSASD
  • TTNQAAPS
  • EDLLRIG
  • YIDPFTYEDPNEAV
  • SDVWSYGI
  • EVSVPLKLYCNGDG
  • YVHRDLAARNILVN
  • SDPTYTS
  • TYQVCNV
  • CSRCDDNV
  • GERPYWD
  • VRSFGPL
  • YRLPPPMDCP
  • PRQLGLT
  • LEGVVTKS
  • RNAASLKV
  • NLVCKVSDFGLSR
  • MSNQDVI
  • WEVMSYGERPY
  • QDMRLQM
  • QNNWLRT
  • GWEEVSGYDE
  • CNGDGEW
  • EYTEKLQQY
  • REFAKEID
  • GMLRGIAAGM
  • GFYLAFQD
  • NIIRLEGV
  • DGQFTVIQL
  • ISNVNETS
  • EASIMGQF
  • QLMLDCW
  • LLDRTVPDYTTF
  • LAGHQKKIL
  • VQVRARTVAGYG
  • SYGERPYW
  • IMGQFDHPNII
  • GYTERQR
  • ELKFTVRDCNS

Post-translational modifications for EPHB3 Gene

  • Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-614 is required for interaction with SH2 domain-containing proteins.
  • Glycosylation at Asn351 and Asn445
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • EPHB3_HUMAN (1213)

Other Protein References for EPHB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for EPHB3 Gene

Gene Families for EPHB3 Gene

Protein Domains for EPHB3 Gene

InterPro:
Blocks:
  • Tyrosine protein kinase, active site
  • Sterile alpha motif SAM
  • Fibronectin type III repeat signature
  • Ephrin receptor, ligand binding
  • Receptor tyrosine kinase, class V

Suggested Antigen Peptide Sequences for EPHB3 Gene

GenScript: Design optimal peptide antigens:
  • EPH receptor B3, isoform CRA_a (D3DNT9_HUMAN)
  • Tyrosine-protein kinase TYRO6 (EPHB3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54753

UniProtKB/Swiss-Prot:

EPHB3_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHB3: view

Function for EPHB3 Gene

Molecular function for EPHB3 Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
GENATLAS Biochemistry:
EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involved in short-range contact-mediated exonal guidance,human embryonic kinase 2,expressed in various tissues

Enzyme Numbers (IUBMB) for EPHB3 Gene

Phenotypes From GWAS Catalog for EPHB3 Gene

Gene Ontology (GO) - Molecular Function for EPHB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005003 ephrin receptor activity IDA 8397371
genes like me logo Genes that share ontologies with EPHB3: view
genes like me logo Genes that share phenotypes with EPHB3: view

Animal Models for EPHB3 Gene

MGI Knock Outs for EPHB3:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHB3 Gene

Localization for EPHB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHB3 Gene

Cell membrane. Single-pass type I membrane protein. Cell projection, dendrite.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPHB3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 4
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for EPHB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA,IDA 8397371
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EPHB3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EPHB3 Gene

Pathways & Interactions for EPHB3 Gene

PathCards logo

SuperPathways for EPHB3 Gene

SuperPathway Contained pathways
1 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
2 EPH-Ephrin signaling
.35
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
5 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
genes like me logo Genes that share pathways with EPHB3: view

Pathways by source for EPHB3 Gene

1 KEGG pathway for EPHB3 Gene
2 GeneGo (Thomson Reuters) pathways for EPHB3 Gene
  • Cell adhesion Ephrins signaling
  • Cytoskeleton remodeling Reverse signaling by ephrin B
31 Qiagen pathways for EPHB3 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR

SIGNOR curated interactions for EPHB3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for EPHB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0001655 urogenital system development IEA,ISS --
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0007275 multicellular organism development IBA 21873635
genes like me logo Genes that share ontologies with EPHB3: view

Drugs & Compounds for EPHB3 Gene

(2) Drugs for EPHB3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra 0

(1) Additional Compounds for EPHB3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with EPHB3: view

Transcripts for EPHB3 Gene

mRNA/cDNA for EPHB3 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB3

Alternative Splicing Database (ASD) splice patterns (SP) for EPHB3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for EPHB3 Gene

GeneLoc Exon Structure for
EPHB3

Expression for EPHB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPHB3 Gene

mRNA differential expression in normal tissues according to GTEx for EPHB3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.0), Skin - Not Sun Exposed (Suprapubic) (x5.9), and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for EPHB3 Gene

This gene is overexpressed in Fetal Brain (22.4) and Salivary gland (16.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EPHB3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EPHB3

SOURCE GeneReport for Unigene cluster for EPHB3 Gene:

Hs.2913

mRNA Expression by UniProt/SwissProt for EPHB3 Gene:

P54753-EPHB3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for EPHB3 Gene

  • Intestine(2.7)
  • Skin(2.6)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with EPHB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHB3 Gene

Orthologs for EPHB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHB3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EPHB3 29 30
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EPHB3 29 30
  • 92.78 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EPHB3 29 30
  • 92.51 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ephb3 29 16 30
  • 89.03 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EPHB3 30
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ephb3 29
  • 88.95 (n)
Chicken
(Gallus gallus)
Aves EPHB3 29 30
  • 80.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EPHB3 30
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100489199 29
  • 70.38 (n)
Str.3998 29
African clawed frog
(Xenopus laevis)
Amphibia LOC397834 29
Zebrafish
(Danio rerio)
Actinopterygii EPHB3 (2 of 2) 30
  • 82 (a)
OneToMany
LOC555957 29
  • 74.77 (n)
ephb3a 30
  • 73 (a)
OneToMany
ek3 29
Fruit Fly
(Drosophila melanogaster)
Insecta hop 31
  • 38 (a)
Eph 30 31
  • 37 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 44 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
CSA.7809 30
  • 42 (a)
ManyToMany
CSA.1664 30
  • 40 (a)
ManyToMany
Species where no ortholog for EPHB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for EPHB3 Gene

ENSEMBL:
Gene Tree for EPHB3 (if available)
TreeFam:
Gene Tree for EPHB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EPHB3: view image
Alliance of Genome Resources:
Additional Orthologs for EPHB3

Paralogs for EPHB3 Gene

genes like me logo Genes that share paralogs with EPHB3: view

Variants for EPHB3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EPHB3 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs34076689 Benign: not provided 184,577,143(+) G/A
NM_004443.4(EPHB3):c.1314G>A (p.Pro438=)
SYNONYMOUS
rs371378866 A lung neuroendocrine carcinoma sample p.Arg724Trp
rs56102565 Likely Benign: not provided 184,577,669(+) C/T
NM_004443.4(EPHB3):c.1491C>T (p.Ile497=)
SYNONYMOUS
rs61483346 Benign: not provided 184,578,010(+) C/T
NM_004443.4(EPHB3):c.1748+4C>T
INTRON
rs61730730 Benign: not provided 184,579,829(+) T/C
NM_004443.4(EPHB3):c.2067T>C (p.Phe689=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EPHB3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EPHB3 Gene

Variant ID Type Subtype PubMed ID
esv3598946 CNV gain 21293372
nsv461034 CNV loss 19166990
nsv508972 CNV insertion 20534489
nsv592671 CNV loss 21841781
nsv829814 CNV loss 17160897

Variation tolerance for EPHB3 Gene

Residual Variation Intolerance Score: 1.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EPHB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPHB3
Leiden Open Variation Database (LOVD)
EPHB3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHB3 Gene

Disorders for EPHB3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for EPHB3 Gene - From: COP

Disorder Aliases PubMed IDs
craniofrontonasal syndrome
  • cfns
subdural empyema
  • subdural abscess
patella, chondromalacia of
  • chondromalacia patellae
transient global amnesia
  • amnesia, transient global
- elite association - COSMIC cancer census association via MalaCards
Search EPHB3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EPHB3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with EPHB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPHB3 Gene

Publications for EPHB3 Gene

  1. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. (PMID: 15536074) Miao H … Wang B (The Journal of biological chemistry 2005) 3 4 22
  2. PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. (PMID: 8397371) Böhme B … Rübsamen-Waigmann H (Oncogene 1993) 2 3 4
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 40
  4. Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells. (PMID: 19483190) Chiu ST … Hsieh FJ (Carcinogenesis 2009) 3 22
  5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 40

Products for EPHB3 Gene

  • Addgene plasmids for EPHB3

Sources for EPHB3 Gene