Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiatio... See more...
Aliases for EPHB2 Gene
Aliases for EPHB2 Gene
- EPH Receptor B2 2 3 5
- Developmentally-Regulated Eph-Related Tyrosine Kinase 3 4
- Tyrosine-Protein Kinase Receptor EPH-3 3 4
- Renal Carcinoma Antigen NY-REN-47 3 4
- Tyrosine-Protein Kinase TYRO5 3 4
- Ephrin Type-B Receptor 2 3 4
- EPH-Like Kinase 5 3 4
- EC 2.7.10.1 4 50
- EPHT3 3 4
- Tyro5 2 3
- Hek5 2 3
- HEK5 4 4
- DRT 3 4
- EK5 3 4
External Ids for EPHB2 Gene
- HGNC: 3393
- NCBI Entrez Gene: 2048
- Ensembl: ENSG00000133216
- OMIM®: 600997
- UniProtKB/Swiss-Prot: P29323
Previous HGNC Symbols for EPHB2 Gene
- DRT
- ERK
- EPHT3
Previous GeneCards Identifiers for EPHB2 Gene
- GC01P022677
- GC01P022143
- GC01P022506
- GC01P022782
- GC01P022910
- GC01P023037
- GC01P021351
Summaries for EPHB2 Gene
-
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
GeneCards Summary for EPHB2 Gene
EPHB2 (EPH Receptor B2) is a Protein Coding gene. Diseases associated with EPHB2 include Bleeding Disorder, Platelet-Type, 22 and Prostate Cancer/Brain Cancer Susceptibility. Among its related pathways are Nanog in Mammalian ESC Pluripotency and EphB-EphrinB Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHB1.
UniProtKB/Swiss-Prot Summary for EPHB2 Gene
-
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874).
-
Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.
Additional gene information for EPHB2 Gene
No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EPHB2 Gene
Genomics for EPHB2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for EPHB2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J022710 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 250.7 | +0.7 | 691 | 3.3 | BCLAF1 ZNF600 JUND POLR2A ZIC2 ZBTB10 NONO BCL11A CEBPB KLF9 | EPHB2 ENSG00000225952 TCEA3 KDM1A MIR4684 LACTBL1 | |
| GH01J022709 | Enhancer | 0.4 | CraniofacialAtlas | 250.7 | -1.2 | -1162 | 0.2 | CTCF RAD21 ZFP36 | EPHB2 piR-61101-006 C1QB | |
| GH01J022708 | Enhancer | 0.3 | FANTOM5 | 250.7 | -1.8 | -1804 | 0.2 | ZNF664 | EPHB2 piR-61101-006 C1QB | |
| GH01J022805 | Enhancer | 1.1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 26 | +96.1 | 96131 | 5.8 | RXRA RAD21 PRDM10 MAFK ZNF398 ZMYM3 KLF1 ATM ZNF366 POLR2A | EPHB2 ENSG00000225952 ZBTB40 lnc-C1QB-2 LACTBL1 | |
| GH01J022814 | Enhancer | 1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 25.6 | +104.7 | 104713 | 2.2 | ZNF341 PTBP1 ZNF189 RFX1 ZNF768 ZMYM3 KDM1A BCOR MNT | EPHB2 ENSG00000225952 lnc-C1QB-2 LACTBL1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around EPHB2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EPHB2
- Top Transcription factor binding sites by QIAGEN in the EPHB2 gene promoter:
-
- ATF-2
- CREB
- deltaCREB
- STAT3
Genomic Locations for EPHB2 Gene
Latest Assembly
- chr1:22,710,770-22,921,500
- (GRCh38/hg38)
- Size:
- 210,731 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:23,037,331-23,247,993
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 210,663 bases
- Orientation:
- Plus strand
Genomic View for EPHB2 Gene
Genes around EPHB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.12 by HGNC
- 1p36.12 by Entrez Gene
- 1p36.12 by Ensembl
EPHB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPHB2 Gene
Proteins for EPHB2 Gene
-
Protein details for EPHB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29323-EPHB2_HUMAN
- Recommended name:
- Ephrin type-B receptor 2
- Protein Accession:
- P29323
- O43477
- Q5T0U6
- Q5T0U7
- Q5T0U8
Protein attributes for EPHB2 Gene
- Size:
- 1055 amino acids
- Molecular mass:
- 117493 Da
- Quaternary structure:
-
- Heterotetramer upon binding of the ligand (By similarity). The heterotetramer is composed of an ephrin dimer and a receptor dimer (PubMed:17897949). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome (By similarity). Interacts with AQP1; involved in endolymph production in the inner ear (By similarity). Interacts with SPSB1 and SPSB4 (PubMed:28931592). The phosphorylated form interacts with RASA1 (via SH2 domain 1) (By similarity). Interacts with EFNA5 (By similarity). Interacts with SH2D3C (By similarity).
Three dimensional structures from OCA and Proteopedia for EPHB2 Gene
Protein Expression for EPHB2 Gene
Selected DME Specific Peptides for EPHB2 Gene
- P29323:
-
- MNYVHRDLAARN
- QLVGMLRG
- RDLAARN
- GAGEFGEV
- RWTAPEAI
- WSYGIVMWEVMS
- CKETFNL
- RKFTSASD
- RRGFERADSEYTDKLQHYTSGH
- PPSGWEE
- TTNQAAPS
- GYTEKQRRDFL
- FQETLSGAESTSLVA
- YIDPFTYEDPNEAV
- SDVWSYGI
- DTIAADE
- YVHRDLAARNILVN
- SDPTYTS
- TYQVCNV
- GERPYWD
- YRLPPPMDCP
- PRQLGLT
- LEGVVTKS
- NLVCKVSDFGLSR
- WEVMSYGERPY
- PVMIITE
- LDSFLRQ
- LDKMIRNP
- QNNWLRT
- QPDQPNGVILDY
- GWEEVSGYDE
- CNGDGEW
- REFAKEID
- TEFMENG
- GMLRGIAAGM
- GFYLAFQD
- DGQFTVIQL
- EASIMGQF
- IRNPNSLK
- QLMLDCW
- TATAELGW
- LMLDCWQK
- LAGHQKKIL
- SYGERPYW
- QVRARTVAGYGRYS
- LKLPGKR
- AEEVDVPIK
- YSGKMYFQT
Post-translational modifications for EPHB2 Gene
- Autophosphorylated; ligand binding stimulates autophosphorylation on tyrosine residues.
- Polyubiquitinated; ligand binding stimulates ubiquitination.
- Ligand binding induces cleavage by matrix metalloproteinases (MMPs) such as MMP7/MMP9, producing an EphB2/N-terminal fragment (NTF) and a C-terminal long fragment (EphB2-LF). EphB2-LF is further cleaved by MMPs, producing EphB2/CTF1 which is further cleaved by the PS1/gamma-secretase producing EphB2/CTF2.
-
Glycosylation at Asn265, Asn336, Asn428, and Asn482
- NX_P29323 (NX_P29323-1)
- Modification sites at PhosphoSitePlus
Other Protein References for EPHB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences EPHB2 / EPH Receptor B2 Monoclonal Antibody and EPHB2 / EPH Receptor B2 Antibody
- G Biosciences Immunotag™ EPHB2 Antibody
- NSJ Bioreagents EPHB2 Antibody (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for EPHB2
- Novus Biologicals Antibodies for EPHB2
-
Abcam antibodies for EPHB2
- Invitrogen Antibodies for EPHB2 (AFLGC-EPHB2)
- antibodies-online: Show 53 available EPH Receptor B2 Antibodies ranked by validation data
- Compare Top EPH Receptor B2 Antibodies
-
Recommended
- 133 WB Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 10 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 26 WB Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPHB2
- Sino Biological Antibodies for EPHB2
Protein products for research
- G Biosciences Human EphB2/Ephrin type-B receptor 2, Lyophilized
-
OriGene Purified Proteins for EPHB2
- Search Origene for MassSpec and Protein Over-expression Lysates for EPHB2
- Origene Custom Protein Services for EPHB2
- Novus Biologicals proteins for EPHB2
- Sino Biological Recombinant Proteins for EPHB2
- Sino Biological Cell Lysates for EPHB2
- ProSpec Recombinant Proteins for EPHB2
-
ProSci Proteins for EPHB2
-
Abcam proteins for EPHB2
Assay products for research
- RayBiotech Human Phosphotyrosine EphB2 ELISA and Custom Human EphB2 ELISA
-
Boster Bio ELISA Kits for EPHB2
Domains & Families for EPHB2 Gene
Gene Families for EPHB2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for EPHB2 Gene
- InterPro:
-
- Ig-like_fold
- Galactose-bd-like_sf
- Kinase-like_dom_sf
- Prot_kinase_dom
- Protein_kinase_ATP_BS
- Ser-Thr/Tyr_kinase_cat_dom
- Tyr_kinase_AS
- FN3_dom
- FN3_sf
- Tyr_kinase_cat_dom
- Growth_fac_rcpt_cys_sf
- SAM
- SAM/pointed_sf
- Tyr-kin_ephrin_A/B_rcpt-like
- Eph_TM
- Ephrin_rcpt_lig-bd_dom
- Tyr_kinase_ephrin_rcpt
- Tyr_kinase_rcpt_V_CS
- EphB2_rcpt_lig-bd
- Blocks:
-
- Tyrosine protein kinase, active site
- Sterile alpha motif SAM
- Fibronectin type III repeat signature
- Ephrin receptor, ligand binding
- Receptor tyrosine kinase, class V
Suggested Antigen Peptide Sequences for EPHB2 Gene
- GenScript: Design optimal peptide antigens:
-
- Ephrin type-B receptor 2 variant (E2I6F7_HUMAN)
- Tyrosine-protein kinase receptor EPH-3 (EPHB2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P29323UniProtKB/Swiss-Prot:
EPHB2_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Function for EPHB2 Gene
Molecular function for EPHB2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
- GENATLAS Biochemistry:
- EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,developmentally regulated,expressed in brain,and other tissues,likely involved in neurogenesis and oncogenesis (neuroblastoma,SCLC),phosphorylating and interacting with RRAS to control integrin activity
Enzyme Numbers (IUBMB) for EPHB2 Gene
Phenotypes From GWAS Catalog for EPHB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0001540 | amyloid-beta binding | TAS | 26871627 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA,ISS | -- |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA,IBA | 21873635 |
Phenotypes for EPHB2 Gene
- MGI mutant phenotypes for EPHB2:
-
inferred from 8 alleles
- nervous system phenotype
- growth/size/body region phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for EPHB2:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- no effect
- Decreased viability
- Increased S DNA content
- Decreased vaccinia virus (VACV) infection
- Decreased substrate adherent cell growth
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased Nanog expression
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased cell number in G2M, increased nuclei size in G2M
- Decreased cell migration
- Increased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, decreased FA abundance
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for EPHB2 - Starting at $85 >
- * EPHB2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for EPHB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPHB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHB2
miRNA for EPHB2 Gene
- miRTarBase miRNAs that target EPHB2
-
- mmu-miR-26a-5p (MIRT011099)
- hsa-miR-92a-3p (MIRT049727)
- hsa-miR-128-3p (MIRT438670)
- hsa-miR-185-5p (MIRT438732)
- hsa-miR-218-5p (MIRT440719)
- hsa-miR-6780a-5p (MIRT477292)
- hsa-miR-6779-5p (MIRT477293)
- hsa-miR-3689c (MIRT477294)
- hsa-miR-3689b-3p (MIRT477295)
- hsa-miR-3689a-3p (MIRT477296)
- hsa-miR-30b-3p (MIRT477297)
- hsa-miR-1273h-5p (MIRT477298)
- hsa-miR-7150 (MIRT477299)
- hsa-miR-1233-5p (MIRT477300)
- hsa-miR-6778-5p (MIRT477301)
- hsa-miR-6799-5p (MIRT477302)
- hsa-miR-6883-5p (MIRT477303)
- hsa-miR-6785-5p (MIRT477304)
- hsa-miR-4728-5p (MIRT477305)
- hsa-miR-149-3p (MIRT477306)
- hsa-miR-4736 (MIRT477307)
- hsa-miR-7106-5p (MIRT477308)
- hsa-miR-6797-5p (MIRT477309)
- hsa-miR-1249-5p (MIRT477310)
- hsa-miR-765 (MIRT477311)
- hsa-miR-6077 (MIRT477312)
- hsa-miR-3665 (MIRT477313)
- hsa-miR-9500 (MIRT477314)
- hsa-miR-4779 (MIRT477315)
- mmu-miR-3065-5p (MIRT583748)
- mmu-miR-1192 (MIRT587311)
- mmu-miR-495-3p (MIRT587312)
- mmu-miR-185-5p (MIRT604055)
- mmu-miR-882 (MIRT604056)
- mmu-miR-3473a (MIRT604057)
- hsa-miR-4713-5p (MIRT658573)
- hsa-miR-2116-3p (MIRT658574)
- hsa-miR-6814-5p (MIRT658575)
- hsa-miR-532-3p (MIRT658576)
- hsa-miR-150-5p (MIRT658577)
- hsa-miR-129-1-3p (MIRT658578)
- hsa-miR-129-2-3p (MIRT658579)
- mmu-miR-204-5p (MIRT735385)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPHB2
- Browse OriGene Inhibitory RNA Products For EPHB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB2
Clone products for research
- Applied Biological Materials (abm): Clones for EPHB2 - Starting at $45 >
- * EPHB2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG225676
- MR225676
- MR225676L3
- MR225676L4
- MR231460
- RC223219
- RC223219L1
- RC223219L2
- RC223219L3
- RC223219L4
- RC223882
- RC223882L3
- RC223882L4
- RC600049
- RG223219
- RG223882
- RR203198
- RR203198L3
- RR203198L4
- MR225676L3V
- MR225676L4V
- RC223219L1V
- RC223219L2V
- RC223219L3V
- RC223219L4V
- RC223882L3V
- RC223882L4V
- RR203198L3V
- RR203198L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EPHB2
- Addgene plasmids for EPHB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPHB2
Cell Lines for research
-
Horizon Cell Lines for EPHB2
No data available for Transcription Factor Targets and HOMER Transcription for EPHB2 Gene
Localization for EPHB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPHB2 Gene
- Cell membrane. Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 4 |
| cytosol | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| peroxisome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA,ISS | -- |
Pathways & Interactions for EPHB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 2 | EPH-Ephrin signaling |
Cell adhesion Ephrins signaling
.35
|
.01
|
| 3 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
| 5 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
|
Pathways by source for EPHB2 Gene
2 Sino Biological pathways for EPHB2 Gene
7 BioSystems pathways for EPHB2 Gene
7 Reactome pathways for EPHB2 Gene
1 KEGG pathway for EPHB2 Gene
2 GeneGo (Thomson Reuters) pathways for EPHB2 Gene
- Cell adhesion Ephrins signaling
- Cytoskeleton remodeling Reverse signaling by ephrin B
31 Qiagen pathways for EPHB2 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
3 Cell Signaling Technology pathways for EPHB2 Gene
Interacting Proteins for EPHB2 Gene
Selected Interacting proteins:
P29323-EPHB2_HUMAN
ENSP00000363763
for EPHB2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for EPHB2
SIGNOR curated interactions for EPHB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001525 | angiogenesis | ISS | -- |
| GO:0001655 | urogenital system development | ISS | -- |
| GO:0001933 | negative regulation of protein phosphorylation | ISS | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
Drugs & Compounds for EPHB2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
58-64-0 |
|
Drug products for research
- G Biosciences Human EphB2/Ephrin type-B receptor 2, Lyophilized
Transcripts for EPHB2 Gene
mRNA/cDNA for EPHB2 Gene
- 4 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374627 4014 nts (view in UCSC)
- ENST00000374630 11035 nts (view in UCSC)
- ENST00000374632 3677 nts (view in UCSC)
- ENST00000400191 10816 nts (view in UCSC)
- ENST00000465676 1006 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for EPHB2 - Starting at $85 >
- * EPHB2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for EPHB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPHB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHB2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPHB2
- Browse OriGene Inhibitory RNA Products For EPHB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB2
Clone products for research
- Applied Biological Materials (abm): Clones for EPHB2 - Starting at $45 >
- * EPHB2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG225676
- MR225676
- MR225676L3
- MR225676L4
- MR231460
- RC223219
- RC223219L1
- RC223219L2
- RC223219L3
- RC223219L4
- RC223882
- RC223882L3
- RC223882L4
- RC600049
- RG223219
- RG223882
- RR203198
- RR203198L3
- RR203198L4
- MR225676L3V
- MR225676L4V
- RC223219L1V
- RC223219L2V
- RC223219L3V
- RC223219L4V
- RC223882L3V
- RC223882L4V
- RR203198L3V
- RR203198L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EPHB2
- Addgene plasmids for EPHB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPHB2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for EPHB2 Gene
- GeneLoc Exon Structure for
- EPHB2
Expression for EPHB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Arterial Endothelial Cells Paired Dorsal Aorta
-
Endothelium (Cardiovascular System)
- Arterial Endothelial Cells Paired Dorsal Aorta
- Eye (Sensory Organs)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for EPHB2 Gene
This gene is overexpressed in Colon - Transverse (x6.7).
This gene is overexpressed in Fetal Brain (37.6) and Ovary (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EPHB2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EPHB2
SOURCE GeneReport for Unigene cluster for EPHB2 Gene:
Hs.523329mRNA Expression by UniProt/SwissProt for EPHB2 Gene:
P29323-EPHB2_HUMAN
Tissue specificity:
Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
Evidence on tissue expression from TISSUES for EPHB2 Gene
- Nervous system(4.7)
- Intestine(3.3)
- Skin(2.3)
- Eye(2.2)
- Blood(2.2)
- Heart(2.2)
- Lymph node(2.2)
- Kidney(2.1)
- Spleen(2.1)
- Lung(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHB2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- reproductive
Regions:
Head and neck:
- brain
- cerebellum
- head
Pelvis:
- prostate
General:
- spinal cord
Primer products for research
-
OriGene qPCR primer pairs for EPHB2
Gene Expression Assays for research
Orthologs for EPHB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | EPHB2 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | EPHB2 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | EPHB2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | EPHB2 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ephb2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ephb2 29 16 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | EPHB2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.506 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ephb2b 30 |
|
OneToMany | |
| ephb2a 30 |
|
OneToMany | |||
| ephb2 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Eph 30 31 |
|
OneToMany | |
| hop 31 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| CSA.7809 30 |
|
ManyToMany | |||
| CSA.1664 30 |
|
ManyToMany |
- Species where no ortholog for EPHB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for EPHB2 Gene
- ENSEMBL:
- Gene Tree for EPHB2 (if available)
- TreeFam:
- Gene Tree for EPHB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EPHB2: view image
- Alliance of Genome Resources:
- Additional Orthologs for EPHB2
Paralogs for EPHB2 Gene
Paralogs for EPHB2 Gene
- EPHB1 5
- EPHB3 5
- EPHA5 5
- EPHA7 5
- EPHA4 5
- EPHB4 5
- EPHA3 5
- EPHA6 5
- EPHA8 5
- EPHA2 5
- EPHA10 5
- EPHA1 5
- AXL 5
- MERTK 5
- TYRO3 5
- FLT1 5
- ROR2 5
- KDR 5
- FLT4 5
- DDR1 5
- EGFR 5
- ROS1 5
- ROR1 5
- ERBB4 5
- DDR2 5
- PDGFRA 5
- KIT 5
- ERBB2 5
- ERBB3 5
- RET 5
- INSR 5
- ALK 5
- MST1R 5
- FGFR2 5
- MET 5
- PDGFRB 5
- IGF1R 5
- FLT3 5
- TEK 5
- FGFR3 5
- NTRK2 5
- FGFR1 5
- TIE1 5
- CSF1R 5
- NTRK3 5
- FGFR4 5
- NTRK1 5
- INSRR 5
- MUSK 5
- ENSG00000282278 5
- LMTK2 5
- EPHB6 5
- LTK 5
- RYK 5
(32) SIMAP similar genes for EPHB2 Gene using alignment to 4 proteins:
- EPHB2_HUMAN
- B1AKC9_HUMAN
- E2I6F7_HUMAN
- Q6NVW1_HUMAN
Variants for EPHB2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EPHB2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 783133 | Benign: not provided | 22,893,000(+) |
T/. NM_004442.7(EPHB2):c.1545C>T (p.Gly515=) |
SYNONYMOUS_VARIANT,NO_SEQUENCE_ALTERATION | |
| rs1020423787 | Not Provided: not provided | 22,784,860(+) |
C/T NM_004442.7(EPHB2):c.595C>T (p.Arg199Cys) |
MISSENSE | |
| rs121912582 | Pathogenic: Prostate cancer/brain cancer susceptibility | 22,907,980(+) |
C/T NM_004442.7(EPHB2):c.2167C>T (p.Gln723Ter) |
NONSENSE | |
| rs1256565919 | Likely Benign: not provided | 22,863,134(+) |
T/C NM_004442.7(EPHB2):c.909T>C (p.Cys303=) |
SYNONYMOUS | |
| rs1329983524 | Likely Benign: not provided | 22,906,948(+) |
C/T NM_004442.7(EPHB2):c.2130C>T (p.Ser710=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1389294 | CNV | deletion | 17803354 |
| esv2538911 | CNV | insertion | 19546169 |
| esv34161 | CNV | loss | 18971310 |
| esv3577785 | CNV | loss | 25503493 |
| nsv1012432 | CNV | loss | 25217958 |
| nsv1075734 | CNV | deletion | 25765185 |
| nsv1116592 | CNV | tandem duplication | 24896259 |
| nsv1118106 | CNV | deletion | 24896259 |
| nsv469829 | CNV | loss | 16826518 |
| nsv476503 | CNV | novel sequence insertion | 20440878 |
| nsv481144 | CNV | novel sequence insertion | 20440878 |
| nsv509036 | CNV | insertion | 20534489 |
| nsv512725 | CNV | insertion | 21212237 |
| nsv528926 | CNV | loss | 19592680 |
| nsv6409 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
2.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.95;
49.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EPHB2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHB2 Gene
Disorders for EPHB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bleeding disorder, platelet-type, 22 |
|
|
| prostate cancer/brain cancer susceptibility |
|
|
| prostate cancer |
|
|
| brain cancer |
|
|
| transitional cell carcinoma |
|
|
Search EPHB2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EPHB2_HUMAN- Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:15300251, ECO:0000269 PubMed:16155194}. Note=The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
- Bleeding disorder, platelet-type 22 (BDPLT22) [MIM:618462]: An autosomal recessive disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after minor injuries, and menorrhagia. {ECO:0000269 PubMed:30213874}. Note=The disease may be caused by variants affecting the gene represented in this entry.
Additional Disease Information for EPHB2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for EPHB2 Gene
Publications for EPHB2 Gene
- A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. (PMID: 16155194) Kittles RA … Carpten JD (Journal of medical genetics 2006) 3 4 22 40 72
- eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. (PMID: 1648701) Chan J … Watt VM (Oncogene 1991) 2 3 4 22
- A mutation of the human EPHB2 gene leads to a major platelet functional defect. (PMID: 30213874) Berrou E … Bryckaert M (Blood 2018) 3 4 72
- Germline EPHB2 receptor variants in familial colorectal cancer. (PMID: 18682749) Zogopoulos G … Gallinger S (PloS one 2008) 3 40 72
- EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis. (PMID: 16740153) Kokko A … Aaltonen LA (BMC cancer 2006) 3 22 40
ExternalLinks
Products for EPHB2 Gene
- View all 17 R&D Systems EPHB2 (EphB2) Products
- View all R&D Systems EPHB2 (EphB2) Proteins and Enzymes
- View all 14 R&D Systems EPHB2 (EphB2) Primary Antibodies
- View all R&D Systems EPHB2 (EphB2) Proteome Profiler Antibody Arrays
- View all R&D Systems EPHB2 (EphB2) cDNA Clones
- Learn more about R&D Systems custom EPHB2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for EPHB2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EPHB2
- Search Origene for MassSpec and Protein Over-expression Lysates for EPHB2
- Origene Custom Protein Services for EPHB2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPHB2
- Browse OriGene Inhibitory RNA Products For EPHB2
- OriGene qPCR primer pairs for EPHB2
- OriGene CRISPR knockouts for EPHB2
- MG225676
- MR225676
- MR225676L3
- MR225676L4
- MR231460
- RC223219
- RC223219L1
- RC223219L2
- RC223219L3
- RC223219L4
- RC223882
- RC223882L3
- RC223882L4
- RC600049
- RG223219
- RG223882
- RR203198
- RR203198L3
- RR203198L4
- MR225676L3V
- MR225676L4V
- RC223219L1V
- RC223219L2V
- RC223219L3V
- RC223219L4V
- RC223882L3V
- RC223882L4V
- RR203198L3V
- RR203198L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EPHB2
- Sino Biological Human cDNA Clone for EPHB2
- Sino Biological Recombinant Proteins for EPHB2
- Sino Biological Cell Lysates for EPHB2
- Sino Biological Antibodies for EPHB2
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for EPHB2
- Novus Biologicals proteins for EPHB2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for EPHB2
- Abcam proteins for EPHB2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for EPHB2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for EPHB2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for EPHB2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for EPHB2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for EPHB2
- Addgene plasmids for EPHB2
- antibodies-online: Show 53 available EPH Receptor B2 Antibodies ranked by validation data
- Compare Top EPH Receptor B2 Antibodies
- Recommended
- 133 WB Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 10 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 26 WB Antibodies (anti-mouse)
- 12 FACS Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 9 available EPH Receptor B2 Elisa Kits ranked by validation data
- Compare Top EPH Receptor B2 Elisa Kits
- Quality Products:
- antibodies-online: Show 21 available EPH Receptor B2 Proteins ranked by validation data
- Compare Top EPH Receptor B2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for EPHB2
- Search Santa Cruz Biotechnology (SCBT) for EPHB2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPHB2
- Custom Antibody ServicesProSci Antibodies for EPHB2
- ProSci Proteins for EPHB2
- Horizon Cell Lines for EPHB2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPHB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPHB2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for EPHB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB2
Sources for EPHB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources