Aliases for EPHB2 Gene
Aliases for EPHB2 Gene
- EPH Receptor B2 2 3 5
- Developmentally-Regulated Eph-Related Tyrosine Kinase 3 4
- Tyrosine-Protein Kinase Receptor EPH-3 3 4
- Renal Carcinoma Antigen NY-REN-47 3 4
- Tyrosine-Protein Kinase TYRO5 3 4
- EPH-Like Kinase 5 3 4
- EPHT3 3 4
- HEK5 4 4
- DRT 3 4
- ERK 3 4
- EK5 3 4
- Protein-Tyrosine Kinase HEK5 3
- Elk-Related Tyrosine Kinase 3
External Ids for EPHB2 Gene
- HGNC: 3393
- Entrez Gene: 2048
- Ensembl: ENSG00000133216
- OMIM: 600997
- UniProtKB: P29323
Previous HGNC Symbols for EPHB2 Gene
- DRT
- ERK
- EPHT3
Previous GeneCards Identifiers for EPHB2 Gene
- GC01P022677
- GC01P022143
- GC01P022506
- GC01P022782
- GC01P022910
- GC01P023037
- GC01P021351
Summaries for EPHB2 Gene
-
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
GeneCards Summary for EPHB2 Gene
EPHB2 (EPH Receptor B2) is a Protein Coding gene. Diseases associated with EPHB2 include Prostate Cancer/Brain Cancer Susceptibility and Prostate Cancer. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHB1.
UniProtKB/Swiss-Prot for EPHB2 Gene
-
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.
-
Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.
Additional gene information for EPHB2 Gene
- Monarch Initiative
- Search for EPHB2 at DataMed
- Search for EPHB2 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHB2 Gene
Genomics for EPHB2 Gene
GeneHancer (GH) Regulatory Elements for EPHB2 Gene
Promoters and enhancers for EPHB2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J022712 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +0.2 | 212 | 1.6 | MXI1 ARNT ZIC2 ZNF335 FOXM1 ZNF121 ZFHX2 GLIS2 POLR2A ZBTB48 | EPHB2 TCEA3 MIR4684 | |
| GH01J022711 | Enhancer | 1 | ENCODE dbSUPER | 650.7 | +1.8 | 1771 | 1.2 | ATF1 RB1 STAT5A BATF IRF4 GLIS2 ATF7 FOS ETV6 BCLAF1 | EPHB2 ENSG00000225952 KDM1A MIR4684 | |
| GH01J022710 | Enhancer | 0.8 | ENCODE dbSUPER | 650.7 | -0.7 | -687 | 0.2 | ZNF740 ZNF121 ZNF335 GLIS2 ZFHX2 ZBTB48 PATZ1 KLF9 PRDM10 EGR2 | EPHB2 GC01P022705 | |
| GH01J022708 | Enhancer | 0.7 | FANTOM5 Ensembl | 650.7 | -1.5 | -1495 | 0.8 | ZNF664 CTCF ZFP36 | EPHB2 GC01P022705 | |
| GH01J022824 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 22.6 | +118.2 | 118164 | 8.4 | NFXL1 RAD21 BRCA1 YY1 ZSCAN5C RCOR1 FOS EGR2 SMARCA5 SMARCC1 | EPHB2 KDM1A LINC01355 ELOA ENSG00000225952 GC01M022785 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around EPHB2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the EPHB2 gene promoter:
-
- STAT3
- CREB
- deltaCREB
- ATF-2
Regulatory Element Products
Genomic Locations for EPHB2 Gene
Genomic Locations for EPHB2 Gene
- chr1:22,710,770-22,921,500
- (GRCh38/hg38)
- Size:
- 210,731 bases
- Orientation:
- Plus strand
- chr1:23,037,331-23,241,823
- (GRCh37/hg19)
- Size:
- 204,493 bases
- Orientation:
- Plus strand
Genomic View for EPHB2 Gene
Genes around EPHB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.12 by Entrez Gene
- 1p36.12 by HGNC
- 1p36.12 by Ensembl
EPHB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EPHB2 Gene
Proteins for EPHB2 Gene
-
Protein details for EPHB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29323-EPHB2_HUMAN
- Recommended name:
- Ephrin type-B receptor 2
- Protein Accession:
- P29323
- O43477
- Q5T0U6
- Q5T0U7
- Q5T0U8
Protein attributes for EPHB2 Gene
- Size:
- 1055 amino acids
- Molecular mass:
- 117493 Da
- Quaternary structure:
-
- Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome. Interacts with AQP1; involved in endolymph production in the inner ear.
Three dimensional structures from OCA and Proteopedia for EPHB2 Gene
Protein Expression for EPHB2 Gene
Post-translational modifications for EPHB2 Gene
Other Protein References for EPHB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for EPHB2 (EphB2)
-
Custom Antibody ServicesOriGene Antibodies for EPHB2
- Novus Biologicals Antibodies for EPHB2
-
Abcam antibodies for EPHB2
- Invitrogen Antibodies for EPHB2 (AFLGC-EPHB2)
- antibodies-online: Search results for 172 available EPH Receptor B2 Antibodies ranked by validation data
- Compare Top EPH Receptor B2 Antibodies
-
Recommended
- 119 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 26 WB Antibodies (anti-mouse)
- 20 FACS Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 3 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- GeneTex Ephb2 Antibody for EPHB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for EPHB2
- Sino Biological Antibodies for EPHB2
Protein Products
- R&D Systems Proteins and Enzymes for EPHB2 (EphB2)
-
OriGene Purified Proteins for EPHB2
- Search Origene for MassSpec and Protein Over-expression Lysates for EPHB2
- Origene Custom Protein Services for EPHB2
- Sino Biological Recombinant Proteins for EPHB2
- Sino Biological Cell Lysates for EPHB2
- ProSpec Recombinant Proteins for EPHB2
- Search GeneTex for Proteins for EPHB2
-
ProSci Proteins for EPHB2
-
Abcam proteins for EPHB2
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for EPHB2 (EphB2)
No data available for DME Specific Peptides for EPHB2 Gene
Domains & Families for EPHB2 Gene
Gene Families for EPHB2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for EPHB2 Gene
- InterPro:
-
- Ig-like_fold
- Kinase-like_dom_sf
- Prot_kinase_dom
- Tyr_kinase_AS
- Ser-Thr/Tyr_kinase_cat_dom
- Protein_kinase_ATP_BS
- FN3_dom
- FN3_sf
- Tyr_kinase_cat_dom
- Growth_fac_rcpt_cys_sf
- Galactose-bd-like_sf
- SAM/pointed_sf
- SAM
- Tyr_kinase_ephrin_rcpt
- Tyr_kinase_rcpt_V_CS
- Ephrin_rcpt_lig-bd_dom
- Tyr-kin_ephrin_A/B_rcpt-like
- Eph_TM
- EphB2_rcpt_lig-bd
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EPHB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P29323UniProtKB/Swiss-Prot:
EPHB2_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Function for EPHB2 Gene
Molecular function for EPHB2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- GENATLAS Biochemistry:
- EPH-related tyrosine kinase receptor,binding ephrins B,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,developmentally regulated,expressed in brain,and other tissues,likely involved in neurogenesis and oncogenesis (neuroblastoma,SCLC),phosphorylating and interacting with RRAS to control integrin activity
Enzyme Numbers (IUBMB) for EPHB2 Gene
Phenotypes From GWAS Catalog for EPHB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001540 | amyloid-beta binding | ISS | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004709 | MAP kinase kinase kinase activity | IBA | -- |
| GO:0004713 | protein tyrosine kinase activity | ISS,IEA | -- |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA,IBA | -- |
Phenotypes for EPHB2 Gene
- MGI mutant phenotypes for EPHB2:
-
inferred from 7 alleles
- vision/eye phenotype
- digestive/alimentary phenotype
- nervous system phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- reproductive system phenotype
- hearing/vestibular/ear phenotype
- renal/urinary system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for EPHB2:
-
- Decreased substrate adherent cell growth
- Increased G1 DNA content
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased Nanog expression
- Decreased cell migration
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased cell number in S
- shRNA abundance <= 50%
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPHB2
-
CRISPR Products
-
OriGene CRISPR knockouts for EPHB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPHB2
- Applied Biological Materials CRISPR for EPHB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHB2
- GenScript: Design CRISPR guide RNA sequences for EPHB2
miRNA for EPHB2 Gene
- miRTarBase miRNAs that target EPHB2
-
- hsa-mir-92a-3p (MIRT049727)
- hsa-mir-128-3p (MIRT438670)
- hsa-mir-185-5p (MIRT438732)
- hsa-mir-218-5p (MIRT440719)
- hsa-mir-6780a-5p (MIRT477292)
- hsa-mir-6779-5p (MIRT477293)
- hsa-mir-3689c (MIRT477294)
- hsa-mir-3689b-3p (MIRT477295)
- hsa-mir-3689a-3p (MIRT477296)
- hsa-mir-30b-3p (MIRT477297)
- hsa-mir-1273h-5p (MIRT477298)
- hsa-mir-7150 (MIRT477299)
- hsa-mir-1233-5p (MIRT477300)
- hsa-mir-6778-5p (MIRT477301)
- hsa-mir-6799-5p (MIRT477302)
- hsa-mir-6883-5p (MIRT477303)
- hsa-mir-6785-5p (MIRT477304)
- hsa-mir-4728-5p (MIRT477305)
- hsa-mir-149-3p (MIRT477306)
- hsa-mir-4736 (MIRT477307)
- hsa-mir-7106-5p (MIRT477308)
- hsa-mir-6797-5p (MIRT477309)
- hsa-mir-1249-5p (MIRT477310)
- hsa-mir-765 (MIRT477311)
- hsa-mir-6077 (MIRT477312)
- hsa-mir-3665 (MIRT477313)
- hsa-mir-9500 (MIRT477314)
- hsa-mir-4779 (MIRT477315)
- hsa-mir-4713-5p (MIRT658573)
- hsa-mir-2116-3p (MIRT658574)
- hsa-mir-6814-5p (MIRT658575)
- hsa-mir-532-3p (MIRT658576)
- hsa-mir-150-5p (MIRT658577)
- hsa-mir-129-1-3p (MIRT658578)
- hsa-mir-129-2-3p (MIRT658579)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPHB2
- Browse OriGene Inhibitory RNA Products For EPHB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB2
Clone Products
- Sino Biological Human cDNA Clone for EPHB2
- Addgene plasmids for EPHB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPHB2
- genomics-online: cdna clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- orf clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- Applied Biological Materials Clones for EPHB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for EPHB2 (EphB2)
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPHB2 Gene
Localization for EPHB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EPHB2 Gene
- Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Plasma membrane (3)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS,IDA | -- |
Pathways & Interactions for EPHB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
.73
.62
|
.55
|
| 2 | EPH-Ephrin signaling |
.01
|
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 5 | MAPK-Erk Pathway |
.38
|
|
Pathways by source for EPHB2 Gene
3 Sino Biological pathways for EPHB2 Gene
7 BioSystems pathways for EPHB2 Gene
7 Reactome pathways for EPHB2 Gene
1 KEGG pathway for EPHB2 Gene
2 GeneGo (Thomson Reuters) pathways for EPHB2 Gene
31 Qiagen pathways for EPHB2 Gene
3 Cell Signaling Technology pathways for EPHB2 Gene
Interacting Proteins for EPHB2 Gene
Selected Interacting proteins:
P29323-EPHB2_HUMAN
ENSP00000363763
for EPHB2 Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for EPHB2
SIGNOR curated interactions for EPHB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001525 | angiogenesis | ISS | -- |
| GO:0001655 | urogenital system development | ISS | -- |
| GO:0001933 | negative regulation of protein phosphorylation | ISS | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
Drugs & Compounds for EPHB2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| fostamatinib | Approved, Investigational | Pharma | Target, inhibitor | Kinase Inhibitors | 0 | |
| Phosphoaminophosphonic Acid-Adenylate Ester | Experimental | Pharma | Target | 0 | ||
| ATP | Investigational | Nutra | Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for EPHB2 Gene
mRNA/cDNA for EPHB2 Gene
- (7) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (135) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000374630 3152 bps (uc001bgf.4)
- ENST00000400191 10816 bps (uc009vqj.2)
- ENST00000374632 3677 bps (uc001bge.4)
- ENST00000374627 4014 bps (uc057dee.1)
- ENST00000465676 1006 bps (uc057def.1)
CRISPR Products
-
OriGene CRISPR knockouts for EPHB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPHB2
- Applied Biological Materials CRISPR for EPHB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EPHB2
- GenScript: Design CRISPR guide RNA sequences for EPHB2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EPHB2
- Browse OriGene Inhibitory RNA Products For EPHB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB2
Clone Products
- Sino Biological Human cDNA Clone for EPHB2
- Addgene plasmids for EPHB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPHB2
- genomics-online: cdna clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- orf clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- Applied Biological Materials Clones for EPHB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for EPHB2 (EphB2)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP5: |
Expression for EPHB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Arterial Endothelial Cells Paired Dorsal Aorta
-
Endothelium (Cardiovascular System)
- Arterial Endothelial Cells Paired Dorsal Aorta
- Eye (Sensory Organs)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for EPHB2 Gene
This gene is overexpressed in Colon - Transverse (x6.7).
This gene is overexpressed in Fetal Brain (37.6) and Ovary (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EPHB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of EPHB2 Gene:
EPHB2SOURCE GeneReport for Unigene cluster for EPHB2 Gene:
Hs.523329mRNA Expression by UniProt/SwissProt for EPHB2 Gene:
P29323-EPHB2_HUMAN
Tissue specificity:
Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain.
Evidence on tissue expression from TISSUES for EPHB2 Gene
- Nervous system(4.6)
- Intestine(3.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHB2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- reproductive
Regions:
Head and neck:
- brain
- cerebellum
- head
Pelvis:
- prostate
General:
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for EPHB2
Gene Expression Assay Products
Orthologs for EPHB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EPHB2 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | EPHB2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | EPHB2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EPHB2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ephb2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ephb2 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | EPHB2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.506 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ephb2b 34 |
|
OneToMany | |
| ephb2a 34 |
|
OneToMany | |||
| ephb2 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Eph 34 35 |
|
OneToMany | |
| hop 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| CSA.7809 34 |
|
ManyToMany | |||
| CSA.1664 34 |
|
ManyToMany |
- Species where no ortholog for EPHB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for EPHB2 Gene
- ENSEMBL:
- Gene Tree for EPHB2 (if available)
- TreeFam:
- Gene Tree for EPHB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for EPHB2: view image
Paralogs for EPHB2 Gene
Paralogs for EPHB2 Gene
(32) SIMAP similar genes for EPHB2 Gene using alignment to 4 proteins:
- EPHB2_HUMAN
- B1AKC9_HUMAN
- E2I6F7_HUMAN
- Q6NVW1_HUMAN
Variants for EPHB2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121912582 | pathogenic, Prostate cancer/brain cancer susceptibility | 22,907,980(+) | C/T | coding_sequence_variant, stop_gained | |
| rs138551214 | likely-pathogenic, Colorectal Neoplasms | 22,909,025(+) | G/A | coding_sequence_variant, missense_variant | |
| rs142173175 | Prostate cancer (PC) [MIM:176807] | 22,906,770(+) | T/C | coding_sequence_variant, missense_variant | |
| rs150803261 | likely-benign, Peters anomaly | 22,785,052(+) | G/A | coding_sequence_variant, missense_variant | |
| rs201754821 | Prostate cancer (PC) [MIM:176807] | 22,784,861(+) | G/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1389294 | CNV | deletion | 17803354 |
| esv2538911 | CNV | insertion | 19546169 |
| esv34161 | CNV | loss | 18971310 |
| esv3577785 | CNV | loss | 25503493 |
| nsv1012432 | CNV | loss | 25217958 |
| nsv1075734 | CNV | deletion | 25765185 |
| nsv1116592 | CNV | tandem duplication | 24896259 |
| nsv1118106 | CNV | deletion | 24896259 |
| nsv469829 | CNV | loss | 16826518 |
| nsv476503 | CNV | novel sequence insertion | 20440878 |
| nsv481144 | CNV | novel sequence insertion | 20440878 |
| nsv509036 | CNV | insertion | 20534489 |
| nsv512725 | CNV | insertion | 21212237 |
| nsv528926 | CNV | loss | 19592680 |
| nsv6409 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
2.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.95;
49.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EPHB2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHB2 Gene
Disorders for EPHB2 Gene
(8) MalaCards diseases for EPHB2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer/brain cancer susceptibility |
|
|
| prostate cancer |
|
|
| sclerosing liposarcoma |
|
|
| brain cancer |
|
|
| doxorubicin induced cardiomyopathy |
|
|
Search EPHB2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EPHB2_HUMAN- Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:15300251, ECO:0000269 PubMed:16155194}. Note=The gene represented in this entry may be involved in disease pathogenesis. EPHB2 mutations have been found in a prostate cancer cell line derived from a brain metastasis.
Additional Disease Information for EPHB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for EPHB2 Gene
Publications for EPHB2 Gene
- A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. (PMID: 16155194) Kittles RA … Carpten JD (Journal of medical genetics 2006) 3 4 22 44 58
- eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. (PMID: 1648701) Chan J … Watt VM (Oncogene 1991) 2 3 4 22 58
- EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis. (PMID: 16740153) Kokko A … Aaltonen LA (BMC cancer 2006) 3 22 44 58
- Oligomeric structure of the human EphB2 receptor SAM domain. (PMID: 9933164) Thanos CD … Bowie JU (Science (New York, N.Y.) 1999) 3 4 22 58
- A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals. (PMID: 9696046) Tang XX … Ikegaki N (Oncogene 1998) 3 4 22 58
Products for EPHB2 Gene
- R&D Systems Antibodies for EPHB2 (EphB2)
- R&D Systems Proteins and Enzymes for EPHB2 (EphB2)
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for EPHB2 (EphB2)
- R&D Systems cDNA Clones for EPHB2 (EphB2)
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- Custom Antibody ServicesOriGene Antibodies for EPHB2
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Browse OriGene Inhibitory RNA Products For EPHB2
- OriGene qPCR primer pairs for EPHB2
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- GenScript: Next-day shipping of latest version cDNA ORF clones for EPHB2 in any vector
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- GenScript: Design CRISPR guide RNA sequences for EPHB2
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- Sino Biological Human cDNA Clone for EPHB2
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for EPHB2
- Novus Biologicals lysates and proteins for EPHB2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam proteins for EPHB2
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- ProSpec Recombinant Proteins for EPHB2
- Invitrogen Antibodies for EPHB2 (AFLGC-EPHB2)
- Cyagen custom Knockout/knockin (KOKI) mouse models for EPHB2
- Addgene plasmids for EPHB2
- antibodies-online: Search results for 172 available EPH Receptor B2 Antibodies ranked by validation data
- Compare Top EPH Receptor B2 Antibodies
- Recommended
- 119 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 26 WB Antibodies (anti-mouse)
- 20 FACS Antibodies (anti-mouse)
- 6 IHC (p) Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 3 WB Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for 8 available EPH Receptor B2 Elisa Kits ranked by validation data
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- Recommended
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- GeneTex Ephb2 Antibody for EPHB2
- Search GeneTex for Proteins for EPHB2
- Santa Cruz Biotechnology (SCBT) Antibodies for EPHB2
- Search Santa Cruz Biotechnology (SCBT) for EPHB2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EPHB2
- Search for EPHB2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for EPHB2
- Horizon Cell Lines for EPHB2
- genomics-online: cdna clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- orf clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- genomics-online: gRNA clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- genomics-online: primer clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- genomics-online: shRNA clones - Search results for 116 available EPH Receptor B2 gene related products
- Overview of 116 available EPH Receptor B2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for EPHB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for EPHB2
- GeneCopoeia miRNA 3'UTR Target clone products for EPHB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EPHB2
Sources for EPHB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt