Aliases for EPHA6 Gene
External Ids for EPHA6 Gene
Previous GeneCards Identifiers for EPHA6 Gene
GeneCards Summary for EPHA6 Gene
EPHA6 (EPH Receptor A6) is a Protein Coding gene. Diseases associated with EPHA6 include Cefuroxime Allergy and Oculoauricular Syndrome. Among its related pathways are G-protein signaling_RhoA regulation pathway and MAPK-Erk Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA3.
UniProtKB/Swiss-Prot Summary for EPHA6 Gene
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.