This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ep... See more...

Aliases for EPHA2 Gene

Aliases for EPHA2 Gene

  • EPH Receptor A2 2 3 5
  • Tyrosine-Protein Kinase Receptor ECK 3 4
  • Ephrin Type-A Receptor 2 3 4
  • EC 2.7.10.1 4 54
  • ECK 3 4
  • Epithelial Cell Receptor Protein Tyrosine Kinase 3
  • Soluble EPHA2 Variant 1 3
  • Epithelial Cell Kinase 4
  • EC 2.7.10 54
  • CTRCT6 3
  • ARCC2 3
  • CTPP1 3
  • EphA2 2
  • CTPA 3

External Ids for EPHA2 Gene

Previous HGNC Symbols for EPHA2 Gene

  • ECK

Previous GeneCards Identifiers for EPHA2 Gene

  • GC01M015783
  • GC01M015564
  • GC01M015679
  • GC01M015831
  • GC01M016196
  • GC01M016323
  • GC01M016450
  • GC01M014968

Summaries for EPHA2 Gene

Entrez Gene Summary for EPHA2 Gene

  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]

GeneCards Summary for EPHA2 Gene

EPHA2 (EPH Receptor A2) is a Protein Coding gene. Diseases associated with EPHA2 include Cataract 6, Multiple Types and Early-Onset Posterior Subcapsular Cataract. Among its related pathways are MAPK-Erk Pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA5.

UniProtKB/Swiss-Prot Summary for EPHA2 Gene

  • Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
  • (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

Tocris Summary for EPHA2 Gene

  • Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

Gene Wiki entry for EPHA2 Gene

Additional gene information for EPHA2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EPHA2 Gene

Genomics for EPHA2 Gene

GeneHancer (GH) Regulatory Elements for EPHA2 Gene

Promoters and enhancers for EPHA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EPHA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EPHA2 gene promoter:
  • CREB
  • CUTL1
  • deltaCREB
  • E47
  • Elk-1
  • Ik-2
  • MAZR
  • RelA
  • STAT5A

Genomic Locations for EPHA2 Gene

Genomic Locations for EPHA2 Gene
chr1:16,124,337-16,156,087
(GRCh38/hg38)
Size:
31,751 bases
Orientation:
Minus strand
chr1:16,450,832-16,482,582
(GRCh37/hg19)
Size:
31,751 bases
Orientation:
Minus strand

Genomic View for EPHA2 Gene

Genes around EPHA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA2 Gene

Proteins for EPHA2 Gene

  • Protein details for EPHA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29317-EPHA2_HUMAN
    Recommended name:
    Ephrin type-A receptor 2
    Protein Accession:
    P29317
    Secondary Accessions:
    • B5A968
    • Q8N3Z2

    Protein attributes for EPHA2 Gene

    Size:
    976 amino acids
    Molecular mass:
    108266 Da
    Quaternary structure:
    • Homodimer. Interacts with SLA. Interacts (phosphorylated form) with VAV2, VAV3 and PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3); critical for the EFNA1-induced activation of RAC1 which stimulates cell migration (By similarity). Interacts with INPPL1; regulates activated EPHA2 endocytosis and degradation. Interacts (inactivated form) with PTK2/FAK1 and interacts (EFNA1 ligand-activated form) with PTPN11; regulates integrin-mediated adhesion. Interacts with ARHGEF16, DOCK4 and ELMO2; mediates ligand-independent activation of RAC1 which stimulates cell migration. Interacts with CLDN4; phosphorylates CLDN4 and may regulate tight junctions. Interacts with ACP1. Interacts (via SAM domain) with ANKS1A (via SAM domain). Interacts with CEMIP. Interacts with NCK1; may regulate EPHA2 activity in cell migration and adhesion.
    • (Microbial infection) Interacts with human herpes virus 8/HHV-8 glycoprotein L/gL and glycoprotein H/gH heterodimer; this interaction triggers EPHA2 phosphorylation and endocytosis, allowing virus entry.
    • (Microbial infection) Interacts with Epstein-Barr virus/HHV-4 glycoprotein L/gL and glycoprotein H/gH heterodimer; this interaction facilitates virus internalization and fusion.

    Three dimensional structures from OCA and Proteopedia for EPHA2 Gene

    Alternative splice isoforms for EPHA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EPHA2 Gene

Selected DME Specific Peptides for EPHA2 Gene

P29317:
  • MNYVHRDLAARN
  • QLVGMLRG
  • RDLAARN
  • GAGEFGEV
  • RWTAPEAI
  • RKFTSASD
  • CKETFNL
  • SVRVYYKKCP
  • YVHRDLAARNILVN
  • CTRPPSAP
  • NWLRTNW
  • NLVCKVSDFGLSR
  • LPGHQKRI
  • GMLRGIAAGM
  • NIIRLEGV
  • GFYLAFQD
  • VAIKTLKAGY
  • TYEDPNQAV
  • DPHTYEDP
  • ELKFTVRDCNS

Post-translational modifications for EPHA2 Gene

  • Autophosphorylates. Phosphorylated on tyrosine upon binding and activation by EFNA1. Phosphorylated residues Tyr-588 and Tyr-594 are required for binding VAV2 and VAV3 while phosphorylated residues Tyr-735 and Tyr-930 are required for binding PI3-kinase p85 subunit (PIK3R1, PIK3R2 or PIK3R3). These phosphorylated residues are critical for recruitment of VAV2 and VAV3 and PI3-kinase p85 subunit which transduce downstream signaling to activate RAC1 GTPase and cell migration. Dephosphorylation of Tyr-930 by PTPRF prevents the interaction of EPHA2 with NCK1. Phosphorylated at Ser-897 by PKB; serum-induced phosphorylation which targets EPHA2 to the cell leading edge and stimulates cell migration. Phosphorylation by PKB is inhibited by EFNA1-activated EPHA2 which regulates PKB activity via a reciprocal regulatory loop. Phosphorylated at Ser-897 in response to TNF by RPS6KA1 and RPS6KA3; RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Phosphorylated at Ser-897 by PKA; blocks cell retraction induced by EPHA2 kinase activity (PubMed:27385333). Dephosphorylated by ACP1.
  • Ubiquitinated by CHIP/STUB1. Ubiquitination is regulated by the HSP90 chaperone and regulates the receptor stability and activity through proteasomal degradation. ANKS1A prevents ubiquitination and degradation (By similarity).
  • Glycosylation at Asn407 and Asn435
  • Ubiquitination at Lys578
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • EPHA2_HUMAN (777)

Other Protein References for EPHA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for EPHA2 Gene

Gene Families for EPHA2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for EPHA2 Gene

GenScript: Design optimal peptide antigens:
  • Soluble EPHA2 variant 1 (B5A968_HUMAN)
  • Tyrosine-protein kinase receptor ECK (EPHA2_HUMAN)
  • Protein tyrosine kinase (Q8IZL0_HUMAN)
  • EPHA2 protein (Q96HF4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P29317

UniProtKB/Swiss-Prot:

EPHA2_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA2: view

Function for EPHA2 Gene

Molecular function for EPHA2 Gene

UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU10028, ECO:0000269 PubMed:2174105};.
UniProtKB/Swiss-Prot Induction:
Up-regulated by UV irradiation via a TP53-independent, MAPK-dependent mechanism.
GENATLAS Biochemistry:
EPH related tyrosine kinase receptor,binding ephrins A,expressed in projecting neurons and their target fields,involved in short-range contact-mediated axonal guidance,highly expressed in metastatic melanoma cells

Enzyme Numbers (IUBMB) for EPHA2 Gene

Phenotypes From GWAS Catalog for EPHA2 Gene

Gene Ontology (GO) - Molecular Function for EPHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA,IDA 10655584
GO:0005003 ephrin receptor activity IEA --
genes like me logo Genes that share ontologies with EPHA2: view
genes like me logo Genes that share phenotypes with EPHA2: view

Human Phenotype Ontology for EPHA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EPHA2 Gene

MGI Knock Outs for EPHA2:

Animal Model Products

CRISPR Products

miRNA for EPHA2 Gene

miRTarBase miRNAs that target EPHA2

Clone Products

  • Addgene plasmids for EPHA2

No data available for Transcription Factor Targets and HOMER Transcription for EPHA2 Gene

Localization for EPHA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA2 Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311). Relocates from the plasma membrane to the cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797). {ECO:0000269 PubMed:18794797, ECO:0000269 PubMed:19573808, ECO:0000269 PubMed:20861311, ECO:0000269 PubMed:26158630}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPHA2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
  • Golgi apparatus (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EPHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA,IBA 10655584
GO:0005925 focal adhesion IDA,IEA 10655584
GO:0009986 cell surface IDA 25063885
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EPHA2: view

Pathways & Interactions for EPHA2 Gene

PathCards logo

SuperPathways for EPHA2 Gene

SuperPathway Contained pathways
1 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
4 EPHA forward signaling
.30
5 MAPK-Erk Pathway
genes like me logo Genes that share pathways with EPHA2: view

Pathways by source for EPHA2 Gene

32 Qiagen pathways for EPHA2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
2 Cell Signaling Technology pathways for EPHA2 Gene

SIGNOR curated interactions for EPHA2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for EPHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001525 angiogenesis IEA --
GO:0001568 blood vessel development IEA --
GO:0001570 vasculogenesis IEA --
GO:0001649 osteoblast differentiation ISS --
genes like me logo Genes that share ontologies with EPHA2: view

Drugs & Compounds for EPHA2 Gene

(8) Drugs for EPHA2 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Target, antagonist, Inhibition, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 312
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(5) Additional Compounds for EPHA2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with EPHA2: view

Transcripts for EPHA2 Gene

mRNA/cDNA for EPHA2 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for EPHA2

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for EPHA2 Gene

GeneLoc Exon Structure for
EPHA2
ECgene alternative splicing isoforms for
EPHA2

Expression for EPHA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EPHA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EPHA2 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.7).

Protein differential expression in normal tissues from HIPED for EPHA2 Gene

This gene is overexpressed in Amniocyte (33.1) and Adrenal (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EPHA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of EPHA2 Gene:

EPHA2

SOURCE GeneReport for Unigene cluster for EPHA2 Gene:

Hs.171596

mRNA Expression by UniProt/SwissProt for EPHA2 Gene:

P29317-EPHA2_HUMAN
Tissue specificity: Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.

Evidence on tissue expression from TISSUES for EPHA2 Gene

  • Pancreas(4.6)
  • Liver(4.4)
  • Lung(2.8)
  • Blood(2.4)
  • Heart(2.4)
  • Intestine(2.4)
  • Lymph node(2.2)
  • Nervous system(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHA2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with EPHA2: view

No data available for Protein tissue co-expression partners for EPHA2 Gene

Orthologs for EPHA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for EPHA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPHA2 33 32
  • 97.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EPHA2 33 32
  • 90.5 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EPHA2 33 32
  • 90.02 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Epha2 17 33 32
  • 86.63 (n)
rat
(Rattus norvegicus)
Mammalia Epha2 32
  • 86.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia EPHA2 33
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EPHA2 33
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPHA2 33 32
  • 75.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPHA2 33
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epha2 32
  • 73.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia epha2-A 32
zebrafish
(Danio rerio)
Actinopterygii EPHA2 (2 of 2) 33
  • 59 (a)
OneToMany
epha2a 33
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12568 32
fruit fly
(Drosophila melanogaster)
Insecta hop 34
  • 41 (a)
Eph 33 34
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-24 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 39 (a)
ManyToMany
-- 33
  • 38 (a)
ManyToMany
CSA.7809 33
  • 37 (a)
ManyToMany
CSA.1664 33
  • 37 (a)
ManyToMany
Species where no ortholog for EPHA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EPHA2 Gene

ENSEMBL:
Gene Tree for EPHA2 (if available)
TreeFam:
Gene Tree for EPHA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EPHA2: view image

Paralogs for EPHA2 Gene

Paralogs for EPHA2 Gene