Aliases for EPHA10 Gene
External Ids for EPHA10 Gene
Previous GeneCards Identifiers for EPHA10 Gene
Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
GeneCards Summary for EPHA10 Gene
EPHA10 (EPH Receptor A10) is a Protein Coding gene. Diseases associated with EPHA10 include Craniofrontonasal Syndrome and Persistent Hyperplastic Primary Vitreous. Among its related pathways are EPHA forward signaling and Developmental Biology. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA7.
UniProtKB/Swiss-Prot Summary for EPHA10 Gene
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.