Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EPHA10 Gene

Aliases for EPHA10 Gene

  • EPH Receptor A10 2 3 5
  • Ephrin Type-A Receptor 10 3
  • EphA10s Protein 3
  • EC 4

External Ids for EPHA10 Gene

Previous GeneCards Identifiers for EPHA10 Gene

  • GC01M037895
  • GC01M037952
  • GC01M038181
  • GC01M036298

Summaries for EPHA10 Gene

Entrez Gene Summary for EPHA10 Gene

  • Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]

GeneCards Summary for EPHA10 Gene

EPHA10 (EPH Receptor A10) is a Protein Coding gene. Among its related pathways are Developmental Biology and EPHA forward signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is EPHA2.

UniProtKB/Swiss-Prot for EPHA10 Gene

  • Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.

Tocris Summary for EPHA10 Gene

  • Eph receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB. Originally identified as mediators of axon guidance, Eph receptors are implicated in many processes, particularly cancer development and progression.

Additional gene information for EPHA10 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EPHA10 Gene

Genomics for EPHA10 Gene

GeneHancer (GH) Regulatory Elements for EPHA10 Gene

Promoters and enhancers for EPHA10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J037752 Promoter 1.3 EPDnew Ensembl 650.4 +12.3 12251 0.2 MXI1 MAZ POLR2A SUZ12 IKZF1 ZFX EPHA10 C1orf122 YRDC ENSG00000233728 ENSG00000200421
GH01J037765 Promoter 0.8 EPDnew 650.7 +0.0 12 0.1 SP1 MXI1 POLR2A SP2 EPHA10 ENSG00000200421
GH01J037688 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37.9 +74.0 74030 4.9 CLOCK ZFP64 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D C1orf109 CDCA8 SF3A3 EPHA10 GNL2 FTH1P1 RSPO1 YRDC DNALI1 GC01P037645
GH01J037682 Enhancer 0.6 ENCODE 36.4 +82.5 82477 0.8 CTCF ZNF654 LEF1 TRIM22 SIN3A REST RAD21 XRCC5 SKIL ATF3 EPHA10 GNL2 ENSG00000233728 C1orf109 GC01P037645
GH01J037810 Enhancer 1 Ensembl ENCODE 10.5 -45.9 -45949 0.6 HDGF RB1 ARID4B RAD21 ZNF335 ZNF614 ZNF143 CREM SMARCA5 PHF21A GC01M037825 GC01M037828 PIR56555 PIR40914 PIR49672 PIR60496 INPP5B MTF1 ENSG00000230955 EPHA10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EPHA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the EPHA10 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • HFH-1
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • p53

Genomic Locations for EPHA10 Gene

Genomic Locations for EPHA10 Gene
51,273 bases
Minus strand
51,273 bases
Minus strand

Genomic View for EPHA10 Gene

Genes around EPHA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPHA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPHA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPHA10 Gene

Proteins for EPHA10 Gene

  • Protein details for EPHA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ephrin type-A receptor 10
    Protein Accession:
    Secondary Accessions:
    • A4FU89
    • J3KPB5
    • Q6NW42

    Protein attributes for EPHA10 Gene

    1008 amino acids
    Molecular mass:
    109716 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI12934.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EPHA10 Gene


neXtProt entry for EPHA10 Gene

Post-translational modifications for EPHA10 Gene

  • Glycosylation at Asn486 and isoforms=3311
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EPHA10 Gene

Domains & Families for EPHA10 Gene

Gene Families for EPHA10 Gene

Suggested Antigen Peptide Sequences for EPHA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
genes like me logo Genes that share domains with EPHA10: view

Function for EPHA10 Gene

Molecular function for EPHA10 Gene

UniProtKB/Swiss-Prot Function:
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme Numbers (IUBMB) for EPHA10 Gene

Phenotypes From GWAS Catalog for EPHA10 Gene

Gene Ontology (GO) - Molecular Function for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004709 MAP kinase kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity IEA,IBA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA,IEA --
GO:0004888 transmembrane signaling receptor activity IBA --
genes like me logo Genes that share ontologies with EPHA10: view
genes like me logo Genes that share phenotypes with EPHA10: view

Animal Models for EPHA10 Gene

MGI Knock Outs for EPHA10:
  • Epha10 Epha10<tm1.1(KOMP)Vlcg>

Animal Model Products

  • Taconic Biosciences Mouse Models for EPHA10

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for EPHA10 Gene

Localization for EPHA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPHA10 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPHA10 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
cytosol 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with EPHA10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for EPHA10 Gene

Pathways & Interactions for EPHA10 Gene

genes like me logo Genes that share pathways with EPHA10: view

Gene Ontology (GO) - Biological Process for EPHA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007275 multicellular organism development IBA --
GO:0008150 biological_process ND --
GO:0009968 negative regulation of signal transduction IBA --
genes like me logo Genes that share ontologies with EPHA10: view

No data available for SIGNOR curated interactions for EPHA10 Gene

Drugs & Compounds for EPHA10 Gene

(1) Drugs for EPHA10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for EPHA10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with EPHA10: view

Transcripts for EPHA10 Gene

mRNA/cDNA for EPHA10 Gene

(5) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for EPHA10 Gene

EPH receptor A10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPHA10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - -
SP2: - -

Relevant External Links for EPHA10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EPHA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EPHA10 Gene

mRNA differential expression in normal tissues according to GTEx for EPHA10 Gene

This gene is overexpressed in Colon - Transverse (x9.7) and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for EPHA10 Gene

This gene is overexpressed in Spleen (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EPHA10 Gene

Protein tissue co-expression partners for EPHA10 Gene

NURSA nuclear receptor signaling pathways regulating expression of EPHA10 Gene:


SOURCE GeneReport for Unigene cluster for EPHA10 Gene:


mRNA Expression by UniProt/SwissProt for EPHA10 Gene:

Tissue specificity: Mainly expressed in testis.

Evidence on tissue expression from TISSUES for EPHA10 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with EPHA10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPHA10 Gene

Orthologs for EPHA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPHA10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EPHA10 34 33
  • 91.07 (n)
(Mus musculus)
Mammalia Epha10 16 33
  • 87.85 (n)
(Rattus norvegicus)
Mammalia Epha10 33
  • 84.81 (n)
(Gallus gallus)
Aves EPHA10 34 33
  • 68.84 (n)
(Danio rerio)
Actinopterygii epha4b 34
  • 45 (a)
Species where no ortholog for EPHA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EPHA10 Gene

Gene Tree for EPHA10 (if available)
Gene Tree for EPHA10 (if available)
Evolutionary constrained regions (ECRs) for EPHA10: view image

Paralogs for EPHA10 Gene

Paralogs for EPHA10 Gene

genes like me logo Genes that share paralogs with EPHA10: view

Variants for EPHA10 Gene

Sequence variations from dbSNP and Humsavar for EPHA10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs771803475 A gastric adenocarcinoma sample 37,761,806(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
VAR_042163 A breast infiltrating ductal carcinoma sample p.His775Arg
rs1000001272 -- 37,752,210(-) G/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000010124 -- 37,763,347(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000047687 -- 37,739,328(-) C/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for EPHA10 Gene

Variant ID Type Subtype PubMed ID
esv1005346 CNV deletion 20482838
esv2276987 CNV deletion 18987734
esv2660836 CNV deletion 23128226
esv2671162 CNV deletion 23128226
esv2747230 CNV deletion 23290073
esv2747241 CNV deletion 23290073
esv2747253 CNV deletion 23290073
esv2747264 CNV deletion 23290073
esv3560926 CNV deletion 23714750
esv3585759 CNV loss 21293372
nsv1078328 CNV deletion 25765185
nsv1122330 CNV deletion 24896259
nsv1122331 CNV deletion 24896259
nsv1136076 CNV deletion 24896259
nsv519553 CNV loss 19592680
nsv525226 CNV loss 19592680
nsv956619 CNV deletion 24416366

Variation tolerance for EPHA10 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.93; 95.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EPHA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EPHA10 Gene

Disorders for EPHA10 Gene

Additional Disease Information for EPHA10

No disorders were found for EPHA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EPHA10 Gene

Publications for EPHA10 Gene

  1. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. (PMID: 15777695) Aasheim HC … Finne EF (Biochimica et biophysica acta 2005) 3 4 22 58
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 44 58
  3. Expression profile of Eph receptors and ephrin ligands in healthy human B lymphocytes and chronic lymphocytic leukemia B-cells. (PMID: 18819711) Alonso-C LM … Zapata AG (Leukemia research 2009) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for EPHA10 Gene

Sources for EPHA10 Gene

Loading form....