The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reporte... See more...

Aliases for EPGN Gene

Aliases for EPGN Gene

  • Epithelial Mitogen 2 3 4 5
  • Epigen 3 4
  • EPG 3 4
  • Epithelial Mitogen Homolog (Mouse) 2
  • Epithelial Mitogen Homolog 3
  • ALGV3072 3
  • PRO9904 3

External Ids for EPGN Gene

Previous GeneCards Identifiers for EPGN Gene

  • GC04P075540
  • GC04P075394
  • GC04P075174
  • GC04P070985

Summaries for EPGN Gene

Entrez Gene Summary for EPGN Gene

  • The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for EPGN Gene

EPGN (Epithelial Mitogen) is a Protein Coding gene. Diseases associated with EPGN include Trichostrongylosis and Trichostrongyloidiasis. Gene Ontology (GO) annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is EREG.

UniProtKB/Swiss-Prot Summary for EPGN Gene

  • Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

Additional gene information for EPGN Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EPGN Gene

Genomics for EPGN Gene

GeneHancer (GH) Regulatory Elements for EPGN Gene

Promoters and enhancers for EPGN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J074307 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 500.7 +0.5 516 2.4 POLR2A EP300 FOS CEBPB GTF2F1 GATA3 STAT3 JUND NFYB RFX5 EPGN lnc-EPGN-1 LOC105377276 lnc-CXCL2-1
GH04J074363 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.1 +58.4 58353 5.8 EP300 TCF12 ZBTB5 POLR2A ZNF263 ZBTB26 CTBP1 EZH2 KDM5B KDM1A EREG PARM1-AS1 EPGN AREG piR-33422-319
GH04J074617 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +317.6 317631 16.6 EP300 CTCF TCF12 POLR2G JUND FOS REST RFX1 RUNX1 RAD21 EPGN EREG AREG piR-46381-057 piR-48369-134
GH04J074228 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -77.5 -77455 4.4 CTCF TCF12 REST MYC RAD21 EP300 TRIM22 SMC3 GABPA CEBPG CXCL8 EREG CXCL2 CXCL3 EPGN MTHFD2L ENSG00000269559
GH04J074205 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11 -101.3 -101257 3.8 ZBTB40 TEAD4 TAF9B HDAC3 NCOR1 TRIM25 TCF12 NFIC ZNF384 TRIM24 EREG CXCL8 CXCL2 CXCL3 EPGN MTHFD2L ENSG00000269559
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EPGN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EPGN

Top Transcription factor binding sites by QIAGEN in the EPGN gene promoter:
  • aMEF-2
  • Cart-1
  • Chx10
  • GATA-1
  • GATA-2
  • GATA-3
  • LCR-F1
  • MEF-2A
  • POU2F1
  • POU2F1a

Genomic Locations for EPGN Gene

Genomic Locations for EPGN Gene
chr4:74,308,270-74,317,298
(GRCh38/hg38)
Size:
9,029 bases
Orientation:
Plus strand
chr4:75,174,190-75,181,024
(GRCh37/hg19)
Size:
6,835 bases
Orientation:
Plus strand

Genomic View for EPGN Gene

Genes around EPGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EPGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EPGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EPGN Gene

Proteins for EPGN Gene

  • Protein details for EPGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW88-EPGN_HUMAN
    Recommended name:
    Epigen
    Protein Accession:
    Q6UW88
    Secondary Accessions:
    • A1BMM3
    • A1BMM4
    • A1BMM5
    • A1BMM6
    • A1BMM7
    • A1BMM8
    • A8K090

    Protein attributes for EPGN Gene

    Size:
    154 amino acids
    Molecular mass:
    17091 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for EPGN Gene

    Alternative splice isoforms for EPGN Gene

neXtProt entry for EPGN Gene

Post-translational modifications for EPGN Gene

  • Glycosylation at Asn37 and Asn41
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EPGN Gene

Domains & Families for EPGN Gene

Gene Families for EPGN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for EPGN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EPGN Gene

GenScript: Design optimal peptide antigens:
  • Epithelial mitogen (EPGN_HUMAN)
genes like me logo Genes that share domains with EPGN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EPGN Gene

Function for EPGN Gene

Molecular function for EPGN Gene

UniProtKB/Swiss-Prot Function:
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

Phenotypes From GWAS Catalog for EPGN Gene

Gene Ontology (GO) - Molecular Function for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IDA 15611079
GO:0008083 growth factor activity IDA 15611079
genes like me logo Genes that share ontologies with EPGN: view
genes like me logo Genes that share phenotypes with EPGN: view

Animal Models for EPGN Gene

MGI Knock Outs for EPGN:
  • Epgn Epgn<tm1b(KOMP)Wtsi>
  • Epgn Epgn<tm1.1Msdr>

Animal Model Products

  • Taconic Biosciences Mouse Models for EPGN

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EPGN Gene

Localization for EPGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for EPGN Gene

[Isoform 1]: Membrane; Single-pass type I membrane protein.
[Isoform 2]: Membrane; Single-pass type I membrane protein.
[Isoform 3]: Secreted.
[Isoform 4]: Secreted.
[Isoform 5]: Secreted.
[Isoform 6]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EPGN gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytosol 3
mitochondrion 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005887 integral component of plasma membrane IDA 15611079
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with EPGN: view

Pathways & Interactions for EPGN Gene

PathCards logo

SuperPathways for EPGN Gene

No Data Available

Interacting Proteins for EPGN Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000411898 Q6UW88-EPGN_HUMAN for EPGN Gene via STRING IID

;

SIGNOR curated interactions for EPGN Gene

Activates:

Gene Ontology (GO) - Biological Process for EPGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity ISS --
GO:0001525 angiogenesis IDA 15611079
GO:0007165 signal transduction TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with EPGN: view

No data available for Pathways by source for EPGN Gene

Drugs & Compounds for EPGN Gene

No Compound Related Data Available

Transcripts for EPGN Gene

mRNA/cDNA for EPGN Gene

6 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EPGN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: -
SP3: - -

Relevant External Links for EPGN Gene

GeneLoc Exon Structure for
EPGN

Expression for EPGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EPGN Gene

mRNA differential expression in normal tissues according to GTEx for EPGN Gene

This gene is overexpressed in Esophagus - Mucosa (x27.7), Vagina (x5.5), and Minor Salivary Gland (x5.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EPGN

SOURCE GeneReport for Unigene cluster for EPGN Gene:

Hs.401237

Evidence on tissue expression from TISSUES for EPGN Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with EPGN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EPGN Gene

Orthologs for EPGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for EPGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EPGN 31 30
  • 99.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia EPGN 31 30
  • 90.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia EPGN 31 30
  • 89.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Epgn 17 31 30
  • 81.63 (n)
rat
(Rattus norvegicus)
Mammalia Epgn 30
  • 78.15 (n)
oppossum
(Monodelphis domestica)
Mammalia EPGN 31
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EPGN 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves EPGN 31 30
  • 66.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EPGN 31
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia epgn 30
  • 56.57 (n)
Species where no ortholog for EPGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for EPGN Gene

ENSEMBL:
Gene Tree for EPGN (if available)
TreeFam:
Gene Tree for EPGN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EPGN: view image

Paralogs for EPGN Gene

Paralogs for EPGN Gene

(3) SIMAP similar genes for EPGN Gene using alignment to 3 proteins:

  • EPGN_HUMAN
  • A0PK19_HUMAN
  • H3BM13_HUMAN
genes like me logo Genes that share paralogs with EPGN: view

Variants for EPGN Gene

Additional dbSNP identifiers (rs#s) for EPGN Gene

Structural Variations from Database of Genomic Variants (DGV) for EPGN Gene

Variant ID Type Subtype PubMed ID
nsv1009099 CNV gain 25217958
nsv525980 CNV gain 19592680

Variation tolerance for EPGN Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EPGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EPGN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EPGN Gene

Disorders for EPGN Gene

MalaCards: The human disease database

(29) MalaCards diseases for EPGN Gene - From: DISEASES

Disorder Aliases PubMed IDs
trichostrongylosis
  • infection by trichostrongylus
trichostrongyloidiasis
dicrocoeliasis
  • disease due to dicrocoeliidae
capillariasis
  • capillaria infection
ancylostomiasis
  • ancylostoma duodenale infection
- elite association - COSMIC cancer census association via MalaCards
Search EPGN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EPGN

genes like me logo Genes that share disorders with EPGN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EPGN Gene

Publications for EPGN Gene

  1. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. (PMID: 16469638) Amsellem-Ouazana D … Lidereau R (The Journal of urology 2006) 3 23 54
  2. Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. (PMID: 15611079) Kochupurakkal BS … Yarden Y (The Journal of biological chemistry 2005) 3 4 54
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 54
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  5. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. (PMID: 28988771) Freed DM … Lemmon MA (Cell 2017) 3 54

Products for EPGN Gene

  • Signalway ELISA kits for EPGN
  • Signalway Proteins for EPGN

Sources for EPGN Gene