Aliases for EPGN Gene
External Ids for EPGN Gene
Previous GeneCards Identifiers for EPGN Gene
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for EPGN Gene
EPGN (Epithelial Mitogen) is a Protein Coding gene. Diseases associated with EPGN include Trichostrongylosis and Trichostrongyloidiasis. Gene Ontology (GO) annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is EREG.
UniProtKB/Swiss-Prot Summary for EPGN Gene
Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.