Aliases for EPC1 Gene
External Ids for EPC1 Gene
Previous GeneCards Identifiers for EPC1 Gene
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
GeneCards Summary for EPC1 Gene
EPC1 (Enhancer Of Polycomb Homolog 1) is a Protein Coding gene. Diseases associated with EPC1 include Adult T-Cell Leukemia. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity. An important paralog of this gene is EPC2.
UniProtKB/Swiss-Prot Summary for EPC1 Gene
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.