Aliases for EP400 Gene
External Ids for EP400 Gene
Previous HGNC Symbols for EP400 Gene
Previous GeneCards Identifiers for EP400 Gene
GeneCards Summary for EP400 Gene
EP400 (E1A Binding Protein P400) is a Protein Coding gene. Diseases associated with EP400 include Ossifying Fibromyxoid Tumor and Epilepsy, Familial Temporal Lobe, 1. Among its related pathways are Chromatin organization and DNA Damage/Telomere Stress Induced Senescence. Gene Ontology (GO) annotations related to this gene include chromatin binding and helicase activity. An important paralog of this gene is SRCAP.
UniProtKB/Swiss-Prot Summary for EP400 Gene
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.