Aliases for EP400 Gene

Aliases for EP400 Gene

  • E1A Binding Protein P400 2 3 5
  • CAGH32 2 3 4
  • Trinucleotide Repeat-Containing Gene 12 Protein 3 4
  • Trinucleotide Repeat Containing 12 2 3
  • P400 KDa SWI2/SNF2-Related Protein 3 4
  • E1A-Binding Protein P400 3 4
  • CAG Repeat Protein 32 3 4
  • Domino Homolog 3 4
  • HDomino(P400) 2 3
  • KIAA1498 2 4
  • KIAA1818 2 4
  • HDomino 3 4
  • TNRC12 3 4
  • P400 2 3
  • P400 SWI2/SNF2-Related Protein 3
  • DKFZP434I225 2
  • EC 3.6.4.- 4
  • EC 3.6.1 50
  • EP400 5

External Ids for EP400 Gene

Previous HGNC Symbols for EP400 Gene

  • TNRC12

Previous GeneCards Identifiers for EP400 Gene

  • GC12U990164
  • GC12P132315
  • GC12P130928
  • GC12P131111
  • GC12P131000
  • GC12P132434
  • GC12P129320

Summaries for EP400 Gene

GeneCards Summary for EP400 Gene

EP400 (E1A Binding Protein P400) is a Protein Coding gene. Diseases associated with EP400 include Ossifying Fibromyxoid Tumor and Epilepsy, Familial Temporal Lobe, 1. Among its related pathways are Chromatin organization and DNA Damage/Telomere Stress Induced Senescence. Gene Ontology (GO) annotations related to this gene include chromatin binding and helicase activity. An important paralog of this gene is SRCAP.

UniProtKB/Swiss-Prot Summary for EP400 Gene

  • Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.

Gene Wiki entry for EP400 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EP400 Gene

Genomics for EP400 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EP400 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J131948 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 269.7 +0.2 232 3.7 BCLAF1 ZNF207 NCOR1 ZNF600 MYC ZNF580 POLR2A BRCA1 ZIC2 NONO EP400 NOC4L DDX51 SFSWAP ANKLE2 GOLGA3 EP400P1 PUS1 RF00017-1226
GH12J132597 Promoter 1.1 CraniofacialAtlas 173.2 +647.7 647673 0.4 ZNF580 ZSCAN16 ZBTB10 ZNF639 ZEB1 KLF7 MCM7 ZNF148 HES1 ZNF610 ENSG00000277186 lnc-FBRSL1-5 ZNF140 EP400 ZNF84 ZNF268 ZNF26 ZNF891 GOLGA3 ZNF605
GH12J132598 Enhancer 1 ENCODE 173.2 +648.0 647988 0.2 ZNF580 ZSCAN16 ZBTB10 ZNF639 ZEB1 KLF7 MCM7 ZNF148 HES1 KLF9 ENSG00000277186 lnc-FBRSL1-5 ZNF140 EP400 ZNF84 ZNF268 ZNF891 ZNF26 GOLGA3 ZNF605
GH12J132827 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 70.8 +878.6 878649 2.8 BCLAF1 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 SIX5 JUND ZNF580 GOLGA3 HSALNG0095343 ANKLE2 ZNF140 EP400 ZNF26 NOC4L CHFR ZNF891 POLE
GH12J132064 Promoter 0.5 EPDnew 250.1 +114.9 114927 0.1 EBF1 CTCF EP400 SNORA49 5MWI_A-040 ENSG00000257000 DDX51
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EP400 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EP400

Top Transcription factor binding sites by QIAGEN in the EP400 gene promoter:
  • c-Ets-1
  • CUTL1
  • E47
  • HNF-4alpha1
  • HNF-4alpha2
  • HTF
  • Pax-3
  • STAT5A
  • Tal-1beta
  • XBP-1

Genomic Locations for EP400 Gene

Latest Assembly
chr12:131,949,942-132,080,460
(GRCh38/hg38)
Size:
130,519 bases
Orientation:
Plus strand

Previous Assembly
chr12:132,434,487-132,565,005
(GRCh37/hg19 by Entrez Gene)
Size:
130,519 bases
Orientation:
Plus strand

chr12:132,434,508-132,565,005
(GRCh37/hg19 by Ensembl)
Size:
130,498 bases
Orientation:
Plus strand

Genomic View for EP400 Gene

Genes around EP400 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EP400 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EP400 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EP400 Gene

Proteins for EP400 Gene

  • Protein details for EP400 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L91-EP400_HUMAN
    Recommended name:
    E1A-binding protein p400
    Protein Accession:
    Q96L91
    Secondary Accessions:
    • O15411
    • Q6P2F5
    • Q8N8Q7
    • Q8NE05
    • Q96JK7
    • Q9P230

    Protein attributes for EP400 Gene

    Size:
    3159 amino acids
    Molecular mass:
    343489 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. The NuA4 complex interacts with MYC and the adenovirus E1A protein. EP400 interacts with TRRAP, RUVBL1 and RUVBL2. Component of a SWR1-like complex. Interacts with ZNF42. Interacts with PHF5A. Interacts with human cytomegalovirus UL27. Interacts with human adenovirus 5 E1A protein; this interaction stabilizes MYC (PubMed:18413597).
    SequenceCaution:
    • Sequence=AAB91441.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH37208.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH64554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA96022.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for EP400 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EP400 Gene

Selected DME Specific Peptides for EP400 Gene

Q96L91:
  • NGILADE
  • GLGKTVQ

Post-translational modifications for EP400 Gene

  • Ubiquitination at Lys1096, Lys1291, Lys1634, and Lys2202
  • Modification sites at PhosphoSitePlus

Other Protein References for EP400 Gene

Domains & Families for EP400 Gene

Gene Families for EP400 Gene

Protein Domains for EP400 Gene

InterPro:
Blocks:
  • ATP-dependent helicase, DEAH-box
  • SNF2 related domain
  • HSA

Suggested Antigen Peptide Sequences for EP400 Gene

GenScript: Design optimal peptide antigens:
  • p400 kDa SWI2/SNF2-related protein (EP400_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96L91

UniProtKB/Swiss-Prot:

EP400_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
Family:
  • Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
genes like me logo Genes that share domains with EP400: view

Function for EP400 Gene

Molecular function for EP400 Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.

Enzyme Numbers (IUBMB) for EP400 Gene

Phenotypes From GWAS Catalog for EP400 Gene

Gene Ontology (GO) - Molecular Function for EP400 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16601686
genes like me logo Genes that share ontologies with EP400: view
genes like me logo Genes that share phenotypes with EP400: view

Animal Models for EP400 Gene

MGI Knock Outs for EP400:
  • Ep400 Ep400<tm1Fuku>
  • Ep400 Ep400<tm1b(EUCOMM)Hmgu>
  • Ep400 Ep400<tm3.1Fuku>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EP400

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for EP400 Gene

Localization for EP400 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EP400 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EP400 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EP400 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IEA,ISS --
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with EP400: view

Pathways & Interactions for EP400 Gene

genes like me logo Genes that share pathways with EP400: view

Gene Ontology (GO) - Biological Process for EP400 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0043967 histone H4 acetylation IDA 14966270
GO:0043968 histone H2A acetylation IDA 14966270
genes like me logo Genes that share ontologies with EP400: view

No data available for SIGNOR curated interactions for EP400 Gene

Drugs & Compounds for EP400 Gene

No Compound Related Data Available

Transcripts for EP400 Gene

mRNA/cDNA for EP400 Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EP400

Alternative Splicing Database (ASD) splice patterns (SP) for EP400 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41a · 41b ·
SP1: -
SP2:
SP3: - -
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 41c ^ 42 ^ 43a · 43b ^ 44a · 44b · 44c ^ 45a · 45b · 45c
SP1:
SP2:
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for EP400 Gene

GeneLoc Exon Structure for
EP400

Expression for EP400 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EP400 Gene

Protein differential expression in normal tissues from HIPED for EP400 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1), CD8 Tcells (10.2), Lymph node (9.3), Blymphocyte (9.2), and Placenta (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for EP400 Gene



Protein tissue co-expression partners for EP400 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EP400

SOURCE GeneReport for Unigene cluster for EP400 Gene:

Hs.723478

mRNA Expression by UniProt/SwissProt for EP400 Gene:

Q96L91-EP400_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for EP400 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Intestine(2.5)
  • Kidney(2.3)
  • Skin(2.3)
  • Blood(2.1)
  • Heart(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with EP400: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for EP400 Gene

Orthologs for EP400 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EP400 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EP400 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia EP400 29 30
  • 82.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ep400 29
  • 82.52 (n)
Mouse
(Mus musculus)
Mammalia Ep400 29 16 30
  • 82.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EP400 29 30
  • 80.9 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 79 (a)
OneToMany
-- 30
  • 70 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia EP400 30
  • 37 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100857793 29
  • 69.88 (n)
EP400 30
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EP400 30
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ep400 29
  • 63.95 (n)
Str.11174 29
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-227i14.2 29
  • 60.71 (n)
EP400 30
  • 53 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta dom 30
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea ssl-1 30
  • 21 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWR1 30
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 32 (a)
OneToMany
Species where no ortholog for EP400 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EP400 Gene

ENSEMBL:
Gene Tree for EP400 (if available)
TreeFam:
Gene Tree for EP400 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EP400: view image
Alliance of Genome Resources:
Additional Orthologs for EP400

Paralogs for EP400 Gene

(1) SIMAP similar genes for EP400 Gene using alignment to 2 proteins:

  • EP400_HUMAN
  • A7E2D7_HUMAN
genes like me logo Genes that share paralogs with EP400: view

Variants for EP400 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EP400 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
996262 Uncertain Significance: not specified 131,986,574(+) A/G
NM_015409.5(EP400):c.1990A>G (p.Thr664Ala)
MISSENSE
rs1002404890 Likely Benign: not provided 132,062,557(+) G/A
NM_015409.5(EP400):c.8190G>A (p.Gln2730=)
SYNONYMOUS
rs10902490 Likely Benign: not provided 132,062,548(+) A/G
NM_015409.5(EP400):c.8181A>G (p.Gln2727=)
SYNONYMOUS
rs112368551 Benign: not provided 131,979,801(+) G/A
NM_015409.5(EP400):c.1435+8G>A
INTRON
rs113601340 Benign: not provided 132,006,215(+) C/T
NM_015409.5(EP400):c.3039C>T (p.Ile1013=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for EP400 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for EP400 Gene

Variant ID Type Subtype PubMed ID
esv1602214 CNV insertion 17803354
esv2512701 CNV insertion 19546169
esv2746909 CNV deletion 23290073
esv2746910 CNV deletion 23290073
esv2751042 CNV gain 17911159
esv3631282 CNV gain 21293372
esv3631283 CNV gain 21293372
esv3631284 CNV gain 21293372
esv7722 CNV gain 19470904
nsv1041402 CNV gain 25217958
nsv1143717 CNV deletion 24896259
nsv428285 CNV gain 18775914
nsv476750 CNV novel sequence insertion 20440878
nsv560928 CNV gain 21841781
nsv560930 CNV loss 21841781

Variation tolerance for EP400 Gene

Residual Variation Intolerance Score: 1.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.55; 95.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EP400 Gene

Human Gene Mutation Database (HGMD)
EP400
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EP400
Leiden Open Variation Database (LOVD)
EP400

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EP400 Gene

Disorders for EP400 Gene

MalaCards: The human disease database

(2) MalaCards diseases for EP400 Gene - From: COP

Disorder Aliases PubMed IDs
ossifying fibromyxoid tumor
  • ossifying fibromyxoid tumour
epilepsy, familial temporal lobe, 1
  • etl1
- elite association - COSMIC cancer census association via MalaCards
Search EP400 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for EP400

genes like me logo Genes that share disorders with EP400: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EP400 Gene

Publications for EP400 Gene

  1. The p400 complex is an essential E1A transformation target. (PMID: 11509179) Fuchs M … Livingston DM (Cell 2001) 2 3 4 22
  2. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis RL … Ross CA (Human genetics 1997) 2 3 4
  3. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A … Hamiche A (Nature 2014) 3 4
  4. Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest. (PMID: 21320693) Reitsma JM … Terhune SS (Cell host & microbe 2011) 3 4
  5. The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways. (PMID: 19169279) Mattera L … Trouche D (Oncogene 2009) 3 22

Products for EP400 Gene

Sources for EP400 Gene