This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in... See more...

Aliases for EOMES Gene

Aliases for EOMES Gene

  • Eomesodermin 2 3 5
  • TBR2 2 3 4
  • T-Box Brain Protein 2 3 4
  • Eomesodermin Homolog 3 4
  • Eomesodermin (Xenopus Laevis) Homolog 2
  • T-Box Brain2 2
  • T-Brain-2 4
  • EOMES 5
  • TBR-2 4

External Ids for EOMES Gene

Previous GeneCards Identifiers for EOMES Gene

  • GC03M027209
  • GC03M027607
  • GC03M027732
  • GC03M027757
  • GC03M027700

Summaries for EOMES Gene

Entrez Gene Summary for EOMES Gene

  • This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for EOMES Gene

EOMES (Eomesodermin) is a Protein Coding gene. Diseases associated with EOMES include Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome and Bilateral Polymicrogyria. Among its related pathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Downstream signaling in naive CD8+ T cells. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is TBR1.

UniProtKB/Swiss-Prot Summary for EOMES Gene

  • Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

Gene Wiki entry for EOMES Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for EOMES Gene

Genomics for EOMES Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for EOMES Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J027712 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 607 +4.7 4659 11.9 HNRNPL GATAD2A CTCF ZBTB33 TEAD4 PRDM10 BACH1 ZHX2 LARP7 ZNF143 LINC02084 EOMES SLC4A7
GH03J027756 Enhancer 0.8 Ensembl ENCODE 11.7 -34.8 -34825 2.9 CEBPB JUN PKNOX1 JUND EP300 FOSL2 PRDM1 RAD21 RFX5 DPF2 EOMES RF00017-3947 CMC1
GH03J028008 Enhancer 0.7 FANTOM5 7.7 -285.6 -285649 0.4 BACH1 IKZF2 DPF2 RELB GATAD2B ELF1 NBN IKZF1 NR2F1 CHD1 EOMES CMC1 piR-53351-003 piR-58537-023 LINC01967
GH03J028081 Enhancer 1 FANTOM5 Ensembl ENCODE 4.1 -359.3 -359286 2.8 POLR2A TCF12 PKNOX1 RELB GATAD2B ARNT IKZF1 NR2C1 NR2F1 BATF EOMES CMC1 piR-49322-451 lnc-AZI2-4
GH03J028134 Enhancer 0.5 FANTOM5 6.1 -411.9 -411876 0.2 ARNT NFIC NFIB TBX21 ATF7 LCORL RAD51 RF00017-3948 lnc-AZI2-4 EOMES CMC1 LOC105377008
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around EOMES on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for EOMES

Top Transcription factor binding sites by QIAGEN in the EOMES gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • p53
  • Pax-4a
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for EOMES Gene

Genomic Locations for EOMES Gene
chr3:27,715,949-27,722,715
(GRCh38/hg38)
Size:
6,767 bases
Orientation:
Minus strand
chr3:27,757,440-27,764,206
(GRCh37/hg19)
Size:
6,767 bases
Orientation:
Minus strand

Genomic View for EOMES Gene

Genes around EOMES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EOMES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EOMES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EOMES Gene

Proteins for EOMES Gene

  • Protein details for EOMES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95936-EOMES_HUMAN
    Recommended name:
    Eomesodermin homolog
    Protein Accession:
    O95936
    Secondary Accessions:
    • B7Z4I2
    • B7ZA51
    • G3XAI5
    • Q8TAZ2
    • Q9UPM7

    Protein attributes for EOMES Gene

    Size:
    686 amino acids
    Molecular mass:
    72732 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 2]: Dubious isoform produced through aberrant splice sites.

    Alternative splice isoforms for EOMES Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EOMES Gene

Post-translational modifications for EOMES Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EOMES Gene

No data available for DME Specific Peptides for EOMES Gene

Domains & Families for EOMES Gene

Gene Families for EOMES Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for EOMES Gene

InterPro:
Blocks:
  • Transcription factor, T-box
ProtoNet:

Suggested Antigen Peptide Sequences for EOMES Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79065, highly similar to Eomesodermin homolog (B7ZA51_HUMAN)
  • T-box brain protein 2 (EOMES_HUMAN)
genes like me logo Genes that share domains with EOMES: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for EOMES Gene

Function for EOMES Gene

Molecular function for EOMES Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.
UniProtKB/Swiss-Prot Induction:
Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4.
GENATLAS Biochemistry:
eomesodermin,expressed in forebrain and T lymphocyte (T,brachyury,TBR1 subfamily),involved in developmental regulation

Phenotypes From GWAS Catalog for EOMES Gene

Gene Ontology (GO) - Molecular Function for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001102 RNA polymerase II activating transcription factor binding IBA,ISS --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding ISS --
genes like me logo Genes that share ontologies with EOMES: view
genes like me logo Genes that share phenotypes with EOMES: view

Human Phenotype Ontology for EOMES Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for EOMES Gene

MGI Knock Outs for EOMES:

Animal Model Products

CRISPR Products

Targeted motifs for EOMES Gene
HOMER Transcription Factor Regulatory Elements motif EOMES
  • Consensus sequence: ATTAACACCT Submotif: canonical Cell Type: H9 GEO ID: GSE26097

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EOMES

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for EOMES Gene

Localization for EOMES Gene

Subcellular locations from UniProtKB/Swiss-Prot for EOMES Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EOMES gene
Compartment Confidence
nucleus 4
extracellular 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IBA 21873635
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with EOMES: view

Pathways & Interactions for EOMES Gene

genes like me logo Genes that share pathways with EOMES: view

Pathways by source for EOMES Gene

SIGNOR curated interactions for EOMES Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for EOMES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001706 endoderm formation ISS --
GO:0001707 mesoderm formation ISS --
GO:0001708 cell fate specification IBA 21873635
GO:0001714 endodermal cell fate specification IBA 21873635
genes like me logo Genes that share ontologies with EOMES: view

Drugs & Compounds for EOMES Gene

No Compound Related Data Available

Transcripts for EOMES Gene

mRNA/cDNA for EOMES Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for EOMES

Alternative Splicing Database (ASD) splice patterns (SP) for EOMES Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: -

Relevant External Links for EOMES Gene

GeneLoc Exon Structure for
EOMES

Expression for EOMES Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for EOMES Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for EOMES Gene

This gene is overexpressed in Whole Blood (x12.8), Brain - Cerebellar Hemisphere (x11.7), Brain - Cerebellum (x11.4), and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for EOMES Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for EOMES Gene



Protein tissue co-expression partners for EOMES Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for EOMES

SOURCE GeneReport for Unigene cluster for EOMES Gene:

Hs.591663

mRNA Expression by UniProt/SwissProt for EOMES Gene:

O95936-EOMES_HUMAN
Tissue specificity: Expressed in CD8+ T-cells.

Evidence on tissue expression from TISSUES for EOMES Gene

  • Nervous system(4.7)
  • Spleen(3.2)
  • Blood(3.1)
  • Lymph node(3)
  • Bone marrow(2.7)
  • Heart(2.7)
  • Kidney(2.6)
  • Skin(2.6)
  • Liver(2.5)
  • Muscle(2.5)
  • Intestine(2.3)
  • Lung(2.3)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with EOMES: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for EOMES Gene

Orthologs for EOMES Gene

This gene was present in the common ancestor of animals.

Orthologs for EOMES Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia EOMES 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia EOMES 30 31
  • 93.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia EOMES 30 31
  • 91.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eomes 30
  • 88.37 (n)
Mouse
(Mus musculus)
Mammalia Eomes 30 17 31
  • 86.99 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia EOMES 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia EOMES 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves EOMES 30 31
  • 77.26 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia EOMES 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eomes 30
  • 70.42 (n)
Str.14985 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398065 30
Zebrafish
(Danio rerio)
Actinopterygii eomesa 30 31
  • 64.37 (n)
OneToMany
eomesb 31
  • 58 (a)
OneToMany
eomes 30
Worm
(Caenorhabditis elegans)
Secernentea tbx-9 31 32
  • 30 (a)
ManyToMany
tbx-8 31 32
  • 27 (a)
ManyToMany
tbx-37 31
  • 26 (a)
ManyToMany
tbx-43 31
  • 24 (a)
ManyToMany
tbx-38 31
  • 24 (a)
ManyToMany
tbx-11 31
  • 23 (a)
ManyToMany
tbx-34 31
  • 20 (a)
ManyToMany
tbx-35 31
  • 20 (a)
ManyToMany
tbx-42 31
  • 17 (a)
ManyToMany
tbx-30 31
  • 17 (a)
ManyToMany
tbx-40 31
  • 16 (a)
ManyToMany
tbx-39 31
  • 15 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7001 31
  • 16 (a)
OneToMany
Species where no ortholog for EOMES was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for EOMES Gene

ENSEMBL:
Gene Tree for EOMES (if available)
TreeFam:
Gene Tree for EOMES (if available)
Aminode:
Evolutionary constrained regions (ECRs) for EOMES: view image

Paralogs for EOMES Gene

(6) SIMAP similar genes for EOMES Gene using alignment to 3 proteins:

  • EOMES_HUMAN
  • B7ZA51_HUMAN
  • G3XAI5_HUMAN
genes like me logo Genes that share paralogs with EOMES: view

Variants for EOMES Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for EOMES Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
718935 Likely Benign: not provided 27,722,024(-) T/G MISSENSE_VARIANT,INTRON_VARIANT
727252 Likely Benign: not provided 27,721,956(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
771348 Benign: not provided 27,721,936(-) G/GCGC INFRAME_INSERTION,INTRON_VARIANT
771851 Likely Benign: not provided 27,718,876(-) G/A SYNONYMOUS_VARIANT
791474 Likely Benign: not provided 27,722,279(-) G/C MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for EOMES Gene

Structural Variations from Database of Genomic Variants (DGV) for EOMES Gene

Variant ID Type Subtype PubMed ID
esv3575558 CNV gain 25503493

Variation tolerance for EOMES Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for EOMES Gene

Human Gene Mutation Database (HGMD)
EOMES
SNPedia medical, phenotypic, and genealogical associations of SNPs for
EOMES

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EOMES Gene

Disorders for EOMES Gene

MalaCards: The human disease database

(10) MalaCards diseases for EOMES Gene - From: Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search EOMES in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

EOMES_HUMAN
  • Note=A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.

Additional Disease Information for EOMES

genes like me logo Genes that share disorders with EOMES: view

No data available for Genatlas for EOMES Gene

Publications for EOMES Gene

  1. Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19. (PMID: 9888994) Yi CH … Brook JD (Genomics 1999) 2 3 4 23
  2. The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. (PMID: 17566017) Atreya I … Neurath MF (Gut 2007) 3 4 23
  3. Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis. (PMID: 17353897) Baala L … Lyonnet S (Nature genetics 2007) 3 4 23
  4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 41
  5. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos NA … de Bakker PI (Annals of neurology 2011) 3 41

Products for EOMES Gene

  • Signalway ELISA kits for EOMES

Sources for EOMES Gene