Aliases for ENY2 Gene

Aliases for ENY2 Gene

  • ENY2 Transcription And Export Complex 2 Subunit 2 3 5
  • Enhancer Of Yellow 2 Transcription Factor Homolog 3 4
  • Transcription And MRNA Export Factor ENY2 3 4
  • Sus1 2 3
  • DC6 2 3
  • ENY2, Transcription And Export Complex 2 Subunit 2
  • Enhancer Of Yellow 2 Homolog (Drosophila) 2
  • Enhancer Of Yellow 2 Homolog 3
  • FLJ20480 2
  • E(Y)2 3
  • ENY2 5

External Ids for ENY2 Gene

Previous GeneCards Identifiers for ENY2 Gene

  • GC08P110416
  • GC08P110417
  • GC08P110346
  • GC08P105668

Summaries for ENY2 Gene

GeneCards Summary for ENY2 Gene

ENY2 (ENY2 Transcription And Export Complex 2 Subunit) is a Protein Coding gene. Diseases associated with ENY2 include Arthrogryposis, Distal, Type 6 and Arthrogryposis, Distal, Type 7. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot Summary for ENY2 Gene

  • Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).

Additional gene information for ENY2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENY2 Gene

Genomics for ENY2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENY2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENY2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENY2

Top Transcription factor binding sites by QIAGEN in the ENY2 gene promoter:
  • AML1a
  • HNF-1
  • HNF-1A
  • HOXA9
  • HOXA9B
  • ISGF-3
  • Meis-1
  • Meis-1b
  • Nkx6-1
  • Sp1

Genomic Locations for ENY2 Gene

Genomic Locations for ENY2 Gene
chr8:109,334,324-109,345,954
(GRCh38/hg38)
Size:
11,631 bases
Orientation:
Plus strand
chr8:110,346,552-110,358,189
(GRCh37/hg19)
Size:
11,638 bases
Orientation:
Plus strand

Genomic View for ENY2 Gene

Genes around ENY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENY2 Gene

Proteins for ENY2 Gene

  • Protein details for ENY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA8-ENY2_HUMAN
    Recommended name:
    Transcription and mRNA export factor ENY2
    Protein Accession:
    Q9NPA8
    Secondary Accessions:
    • B2RE52
    • G3V117

    Protein attributes for ENY2 Gene

    Size:
    101 amino acids
    Molecular mass:
    11529 Da
    Quaternary structure:
    • Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, the isoform GANP of the MCM3AP gene, PCID2, SEM1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (PubMed:23591820, PubMed:22307388). Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H/SPT3, TAF10, TRRAP and USP22 (PubMed:18206972, PubMed:21746879, PubMed:23591820, PubMed:27601583). Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module) (PubMed:18206972, PubMed:21746879, PubMed:27601583). Interacts with RNA polymerase II subunit POLR2A (PubMed:22307388). Interacts with ATXN7L3B (PubMed:27601583).

    Three dimensional structures from OCA and Proteopedia for ENY2 Gene

    Alternative splice isoforms for ENY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENY2 Gene

Post-translational modifications for ENY2 Gene

  • Ubiquitination at Lys19 and Lys74
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ENY2 Gene

Domains & Families for ENY2 Gene

Gene Families for ENY2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for ENY2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENY2 Gene

GenScript: Design optimal peptide antigens:
  • Enhancer of yellow 2 transcription factor homolog (ENY2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPA8

UniProtKB/Swiss-Prot:

ENY2_HUMAN :
  • Belongs to the ENY2 family.
Family:
  • Belongs to the ENY2 family.
genes like me logo Genes that share domains with ENY2: view

Function for ENY2 Gene

Molecular function for ENY2 Gene

UniProtKB/Swiss-Prot Function:
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).

Phenotypes From GWAS Catalog for ENY2 Gene

Gene Ontology (GO) - Molecular Function for ENY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0003713 transcription coactivator activity IEA,IDA 18206972
GO:0005515 protein binding IPI 23591820
GO:0030374 nuclear receptor transcription coactivator activity IEA,IDA 18206972
genes like me logo Genes that share ontologies with ENY2: view
genes like me logo Genes that share phenotypes with ENY2: view

Animal Model Products

CRISPR Products

miRNA for ENY2 Gene

miRTarBase miRNAs that target ENY2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENY2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENY2 Gene

Localization for ENY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENY2 Gene

Nucleus, nucleoplasm. Note=Localization at the nuclear pore complex requires NUP153 and TPR. {ECO:0000269 PubMed:23591820}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENY2 gene
Compartment Confidence
nucleus 5
mitochondrion 4
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ENY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IEA,IDA 18206972
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm IEA,IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with ENY2: view

Pathways & Interactions for ENY2 Gene

PathCards logo

SuperPathways for ENY2 Gene

genes like me logo Genes that share pathways with ENY2: view

Pathways by source for ENY2 Gene

Gene Ontology (GO) - Biological Process for ENY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0006368 transcription elongation from RNA polymerase II promoter IEA --
GO:0006406 mRNA export from nucleus IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with ENY2: view

No data available for SIGNOR curated interactions for ENY2 Gene

Drugs & Compounds for ENY2 Gene

No Compound Related Data Available

Transcripts for ENY2 Gene

mRNA/cDNA for ENY2 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENY2

Alternative Splicing Database (ASD) splice patterns (SP) for ENY2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: - - - -
SP13: -
SP14: -

Relevant External Links for ENY2 Gene

GeneLoc Exon Structure for
ENY2

Expression for ENY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ENY2 Gene

This gene is overexpressed in Tlymphocyte (9.4), Peripheral blood mononuclear cells (6.9), Ovary (6.8), and Bone (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENY2 Gene



Protein tissue co-expression partners for ENY2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENY2

SOURCE GeneReport for Unigene cluster for ENY2 Gene:

Hs.492555

Evidence on tissue expression from TISSUES for ENY2 Gene

  • Nervous system(4.8)
  • Spleen(4.5)
  • Blood(4.5)
  • Lymph node(4.5)
  • Liver(2.9)
  • Lung(2.6)
  • Skin(2.6)
  • Kidney(2.5)
  • Intestine(2.4)
  • Muscle(2.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ENY2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENY2 Gene

Orthologs for ENY2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENY2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ENY2 30 31
  • 99.67 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ENY2 30 31
  • 99.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ENY2 30 31
  • 99.01 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Eny2 30 17 31
  • 98.02 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Eny2 30
  • 98.02 (n)
Oppossum
(Monodelphis domestica)
Mammalia ENY2 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ENY2 31
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ENY2 30 31
  • 88.54 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 98 (a)
OneToMany
-- 31
  • 94 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia eny2 30
  • 78.12 (n)
Str.821 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8036 30
Zebrafish
(Danio rerio)
Actinopterygii eny2 30 31
  • 74.74 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta e(y)2 31
  • 41 (a)
OneToMany
e(y)2b 31
  • 33 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SUS1 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G27100 30
  • 59.85 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0920200 30
  • 56.38 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.4647 30
Species where no ortholog for ENY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ENY2 Gene

ENSEMBL:
Gene Tree for ENY2 (if available)
TreeFam:
Gene Tree for ENY2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ENY2: view image

Paralogs for ENY2 Gene

Pseudogenes.org Pseudogenes for ENY2 Gene

genes like me logo Genes that share paralogs with ENY2: view

No data available for Paralogs for ENY2 Gene

Variants for ENY2 Gene

Additional dbSNP identifiers (rs#s) for ENY2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ENY2 Gene

Variant ID Type Subtype PubMed ID
esv3309347 CNV mobile element insertion 20981092
esv3340473 CNV insertion 20981092

Variation tolerance for ENY2 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENY2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENY2 Gene

Disorders for ENY2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ENY2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ENY2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ENY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENY2 Gene

Publications for ENY2 Gene

  1. The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates. (PMID: 11438676) Georgieva S … Soldatov A (Molecular and cellular biology 2001) 2 3 4
  2. Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. (PMID: 27601583) Li W … Dent SYR (Molecular and cellular biology 2016) 3 4
  3. The human TREX-2 complex is stably associated with the nuclear pore basket. (PMID: 23591820) Umlauf D … Tora L (Journal of cell science 2013) 3 4
  4. The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements. (PMID: 21746879) Lang G … Tora L (Molecular and cellular biology 2011) 3 4
  5. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PMID: 18206972) Zhao Y … Devys D (Molecular cell 2008) 3 4

Products for ENY2 Gene

Sources for ENY2 Gene