Aliases for ENY2 Gene
External Ids for ENY2 Gene
Previous GeneCards Identifiers for ENY2 Gene
GeneCards Summary for ENY2 Gene
ENY2 (ENY2 Transcription And Export Complex 2 Subunit) is a Protein Coding gene. Diseases associated with ENY2 include Arthrogryposis, Distal, Type 6 and Arthrogryposis, Distal, Type 7. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot Summary for ENY2 Gene
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation (PubMed:18206972, PubMed:21746879). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (PubMed:23591820).