The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009] See more...

Aliases for ENTPD5 Gene

Aliases for ENTPD5 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 5 (Inactive) 2 3 5
  • Ectonucleoside Triphosphate Diphosphohydrolase 5 2 3 4
  • Guanosine-Diphosphatase ENTPD5 3 4
  • Uridine-Diphosphatase ENTPD5 3 4
  • Nucleoside Diphosphatase 3 4
  • CD39 Antigen-Like 4 3 4
  • Proto-Oncogene CPH 2 3
  • GDPase ENTPD5 3 4
  • UDPase ENTPD5 3 4
  • EC 3.6.1.6 4 50
  • NTPDase-5 2 3
  • ER-UDPase 3 4
  • NTPDase 5 3 4
  • CD39L4 3 4
  • PCPH 3 4
  • Pcph Proto-Oncogene Protein 3
  • CD39-Like 4 3
  • EC 3.6.1.42 4
  • EC 3.6.1 50
  • ENTPD5 5

External Ids for ENTPD5 Gene

Previous HGNC Symbols for ENTPD5 Gene

  • CD39L4
  • PCPH

Previous GeneCards Identifiers for ENTPD5 Gene

  • GC14M071938
  • GC14M068228
  • GC14M072414
  • GC14M072423
  • GC14M073502
  • GC14M074433
  • GC14M054600
  • GC14M074424

Summaries for ENTPD5 Gene

Entrez Gene Summary for ENTPD5 Gene

  • The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

GeneCards Summary for ENTPD5 Gene

ENTPD5 (Ectonucleoside Triphosphate Diphosphohydrolase 5 (Inactive)) is a Protein Coding gene. Diseases associated with ENTPD5 include Coenzyme Q10 Deficiency, Primary, 6 and Scrapie. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and guanosine-diphosphatase activity. An important paralog of this gene is ENTPD6.

UniProtKB/Swiss-Prot Summary for ENTPD5 Gene

  • Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.

Gene Wiki entry for ENTPD5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENTPD5 Gene

Genomics for ENTPD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENTPD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENTPD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENTPD5

Top Transcription factor binding sites by QIAGEN in the ENTPD5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Hlf
  • POU3F2
  • RFX1

Genomic Locations for ENTPD5 Gene

Latest Assembly
chr14:73,955,329-74,019,399
(GRCh38/hg38)
Size:
64,071 bases
Orientation:
Minus strand

Previous Assembly
chr14:74,422,032-74,485,991
(GRCh37/hg19 by Entrez Gene)
Size:
63,960 bases
Orientation:
Minus strand

chr14:74,424,713-74,486,102
(GRCh37/hg19 by Ensembl)
Size:
61,390 bases
Orientation:
Minus strand

Genomic View for ENTPD5 Gene

Genes around ENTPD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD5 Gene

Proteins for ENTPD5 Gene

  • Protein details for ENTPD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75356-ENTP5_HUMAN
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 5
    Protein Accession:
    O75356
    Secondary Accessions:
    • A1L4C5
    • Q96RX0

    Protein attributes for ENTPD5 Gene

    Size:
    428 amino acids
    Molecular mass:
    47517 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Exists both as a monomer and a disulfide-linked homodimer, the dimers are enzymatically inactive.
    Miscellaneous:
    • May mediate some of the cancer-related phenotypes associated with AKT1 activation: its up-regulation by AKT1 leads to the elevation of aerobic glycolysis seen in tumor cells, a phenomenon known as the Warburg effect.

neXtProt entry for ENTPD5 Gene

Selected DME Specific Peptides for ENTPD5 Gene

O75356:
  • FYAFSYYYD
  • DLGGASTQ
  • GGASTQITF

Post-translational modifications for ENTPD5 Gene

  • N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity.
  • Glycosylation at Asn232 and Asn368
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ENTP5_HUMAN (1194)

Domains & Families for ENTPD5 Gene

Gene Families for ENTPD5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ENTPD5 Gene

InterPro:

Suggested Antigen Peptide Sequences for ENTPD5 Gene

GenScript: Design optimal peptide antigens:
  • Uridine-diphosphatase ENTPD5 (ENTP5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75356

UniProtKB/Swiss-Prot:

ENTP5_HUMAN :
  • Belongs to the GDA1/CD39 NTPase family.
Family:
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD5: view

Function for ENTPD5 Gene

Molecular function for ENTPD5 Gene

UniProtKB/Swiss-Prot Function:
Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=GDP + H2O = GMP + H(+) + phosphate; Xref=Rhea:RHEA:22156, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58115, ChEBI:CHEBI:58189; EC=3.6.1.42;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate; Xref=Rhea:RHEA:36799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:58043; EC=3.6.1.6;.
UniProtKB/Swiss-Prot Induction:
Up-regulated in cell lines and primary tumor samples with active AKT1.

Enzyme Numbers (IUBMB) for ENTPD5 Gene

Phenotypes From GWAS Catalog for ENTPD5 Gene

Gene Ontology (GO) - Molecular Function for ENTPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004382 guanosine-diphosphatase activity IBA,ISS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ENTPD5: view
genes like me logo Genes that share phenotypes with ENTPD5: view

Animal Models for ENTPD5 Gene

MGI Knock Outs for ENTPD5:

miRNA for ENTPD5 Gene

miRTarBase miRNAs that target ENTPD5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENTPD5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENTPD5 Gene

Localization for ENTPD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD5 Gene

Endoplasmic reticulum. Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENTPD5 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
nucleus 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ENTPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum ISS --
GO:0016020 membrane IBA 21873635
genes like me logo Genes that share ontologies with ENTPD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENTPD5 Gene

Pathways & Interactions for ENTPD5 Gene

genes like me logo Genes that share pathways with ENTPD5: view

Pathways by source for ENTPD5 Gene

UniProtKB/Swiss-Prot O75356-ENTP5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ENTPD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation ISS --
GO:0009134 nucleoside diphosphate catabolic process IBA 21873635
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling ISS --
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
genes like me logo Genes that share ontologies with ENTPD5: view

No data available for SIGNOR curated interactions for ENTPD5 Gene

Drugs & Compounds for ENTPD5 Gene

(12) Drugs for ENTPD5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Thiamine Approved, Investigational, Vet_approved Nutra Enzyme, substrate 180,180
Water Approved Pharma 0
CDP Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0

(4) Additional Compounds for ENTPD5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
491-97-4
IDP
  • 5'-IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
  • Inosine 5'-pyrophosphate
86-04-4
genes like me logo Genes that share compounds with ENTPD5: view

Transcripts for ENTPD5 Gene

mRNA/cDNA for ENTPD5 Gene

14 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENTPD5

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - - - -
SP2: -
SP3: - - - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for ENTPD5 Gene

GeneLoc Exon Structure for
ENTPD5

Expression for ENTPD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ENTPD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENTPD5 Gene

This gene is overexpressed in Liver (x6.3) and Colon - Transverse (x4.8).

Protein differential expression in normal tissues from HIPED for ENTPD5 Gene

This gene is overexpressed in Stomach (22.5), Liver (15.7), and Breast (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENTPD5 Gene



Protein tissue co-expression partners for ENTPD5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENTPD5

SOURCE GeneReport for Unigene cluster for ENTPD5 Gene:

Hs.720540

mRNA Expression by UniProt/SwissProt for ENTPD5 Gene:

O75356-ENTP5_HUMAN
Tissue specificity: Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.

Evidence on tissue expression from TISSUES for ENTPD5 Gene

  • Liver(4.6)
  • Nervous system(4.4)
  • Bone marrow(4.1)
  • Kidney(2.6)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with ENTPD5: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ENTPD5 Gene

Orthologs for ENTPD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ENTPD5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ENTPD5 29 30
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ENTPD5 29 30
  • 93.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ENTPD5 29 30
  • 91.12 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Entpd5 29 16 30
  • 87.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Entpd5 29
  • 87.09 (n)
Oppossum
(Monodelphis domestica)
Mammalia ENTPD5 30
  • 69 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 49 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ENTPD5 29 30
  • 73.91 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ENTPD5 30
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia entpd5 29
  • 59.64 (n)
Zebrafish
(Danio rerio)
Actinopterygii entpd5b 29 30
  • 61.26 (n)
OneToMany
entpd5a 30
  • 52 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta NTPase 29 30 31
  • 49.63 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009265 29
  • 48.95 (n)
Worm
(Caenorhabditis elegans)
Secernentea uda-1 29 30
  • 46.76 (n)
OneToMany
K08H10.4 31
  • 35 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GDA1 29 30
  • 47.45 (n)
OneToMany
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16863g 29
  • 46.55 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons APY2 29
  • 45.02 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0682800 29
  • 47.81 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gda1 29
  • 47.53 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU03713 29
  • 45.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 34 (a)
OneToMany
Species where no ortholog for ENTPD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ENTPD5 Gene

ENSEMBL:
Gene Tree for ENTPD5 (if available)
TreeFam:
Gene Tree for ENTPD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ENTPD5: view image
Alliance of Genome Resources:
Additional Orthologs for ENTPD5

Paralogs for ENTPD5 Gene

Paralogs for ENTPD5 Gene

(1) SIMAP similar genes for ENTPD5 Gene using alignment to 5 proteins:

  • ENTP5_HUMAN
  • G3V3Y0_HUMAN
  • G3V450_HUMAN
  • G3V4I0_HUMAN
  • H0YJH1_HUMAN

Pseudogenes.org Pseudogenes for ENTPD5 Gene

genes like me logo Genes that share paralogs with ENTPD5: view

Variants for ENTPD5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENTPD5 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
1039323 Uncertain Significance: not provided 73,961,290(-) A/G
NM_182476.3(COQ6):c.1009A>G (p.Arg337Gly)
MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON
992501 Pathogenic: Coenzyme Q10 deficiency, primary, 6 73,959,044(-) A/C
NM_182476.3(COQ6):c.686A>C (p.Gln229Pro)
MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON
rs1057519349 Pathogenic: Coenzyme Q10 deficiency, primary, 6 73,958,229(-) G/A
NM_182476.3(COQ6):c.564G>A (p.Trp188Ter)
NONSENSE,THREE_PRIME_UTR
rs1057519350 Pathogenic: Coenzyme Q10 deficiency, primary, 6 73,959,204(-) G/A
NM_182476.3(COQ6):c.763G>A (p.Gly255Arg)
MISSENSE_VARIANT,THREE_PRIME_UTR
rs1057519351 Pathogenic: Coenzyme Q10 deficiency, primary, 6 73,961,867(-) G/A
NM_182476.3(COQ6):c.1341G>A (p.Trp447Ter)
NONSENSE,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ENTPD5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ENTPD5 Gene

Variant ID Type Subtype PubMed ID
dgv1936n100 CNV gain 25217958
dgv1937n100 CNV gain 25217958
dgv1938n100 CNV gain 25217958
esv1198173 CNV deletion 17803354
esv2671078 CNV deletion 23128226
esv3634926 CNV loss 21293372
esv3634927 CNV loss 21293372
esv3634929 CNV loss 21293372
nsv1046028 CNV loss 25217958
nsv1051583 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv1113662 CNV deletion 24896259
nsv1352 CNV deletion 18451855
nsv456339 CNV loss 19166990
nsv524396 CNV gain 19592680
nsv565181 CNV loss 21841781
nsv976354 CNV duplication 23825009

Variation tolerance for ENTPD5 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENTPD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ENTPD5
Leiden Open Variation Database (LOVD)
ENTPD5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD5 Gene

Disorders for ENTPD5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ENTPD5 Gene - From: CVR, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ENTPD5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ENTPD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENTPD5 Gene

Publications for ENTPD5 Gene

  1. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase. (PMID: 15698960) Murphy-Piedmonte DM … Kirley TL (Biochimica et biophysica acta 2005) 3 4 22
  2. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. (PMID: 10400613) Mulero JJ … Ford JE (The Journal of biological chemistry 1999) 3 4 22
  3. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PMID: 9676430) Chadwick BP … Frischauf AM (Genomics 1998) 2 3 4
  4. The ENTPD5/mt-PCPH oncoprotein is a catalytically inactive member of the ectonucleoside triphosphate diphosphohydrolase family. (PMID: 23921441) MacCarthy CM … Notario V (International journal of oncology 2013) 2 3
  5. The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. (PMID: 21074248) Fang M … Wang X (Cell 2010) 3 4

Products for ENTPD5 Gene

Sources for ENTPD5 Gene