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Aliases for ENTPD4 Gene

Aliases for ENTPD4 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 4 2 3 3 5
  • Lysosomal Apyrase-Like Protein Of 70 KDa 3 4
  • Lysosomal Apyrase-Like 1 2 3
  • Uridine-Diphosphatase 3 4
  • LYSAL1 3 4
  • LALP70 3 4
  • UDPase 3 4
  • Guanosine-Diphosphatase Like Protein 3
  • Golgi Luminal UDPase 3
  • EC 4
  • NTPDase-4 3
  • NTPDase 4 4
  • KIAA0392 4
  • LAP70 3

External Ids for ENTPD4 Gene

Previous HGNC Symbols for ENTPD4 Gene

  • LYSAL1

Previous GeneCards Identifiers for ENTPD4 Gene

  • GC00U990801
  • GC08M021834
  • GC08M023243

Summaries for ENTPD4 Gene

Entrez Gene Summary for ENTPD4 Gene

  • This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]

GeneCards Summary for ENTPD4 Gene

ENTPD4 (Ectonucleoside Triphosphate Diphosphohydrolase 4) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and uridine-diphosphatase activity. An important paralog of this gene is ENTPD7.

UniProtKB/Swiss-Prot for ENTPD4 Gene

  • Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.

Additional gene information for ENTPD4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD4 Gene

Genomics for ENTPD4 Gene

GeneHancer (GH) Regulatory Elements for ENTPD4 Gene

Promoters and enhancers for ENTPD4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J023454 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.1 +1.2 1248 4 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 ENTPD4 GC08M023453 CCAR2 ENSG00000253200 C8orf58 ENSG00000251034 ENSG00000253390 SLC25A37 LOXL2 GC08P023434
GH08J023159 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.4 +295.3 295342 5.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TNFRSF10D ENSG00000253200 ENTPD4 C8orf58 POLR3D CCAR2 BIN3 CHMP7 LOC389641 TNFRSF10A
GH08J022692 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.3 +763.1 763148 3.6 HDGF ARID4B SIN3A YBX1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 E2F8 EGR3 LOC105379321 LOC105379322 ENSG00000253200 FAM160B2 ENSG00000245025 BMP1 C8orf58 LOXL2 CCAR2
GH08J022603 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.3 +852.7 852723 3.6 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC CCAR2 GC08P022605 PIR54985 PIR42411 PIR62346 C8orf58 ENSG00000253200 FAM160B2 ENTPD4 BIN3
GH08J023538 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 28.4 -83.2 -83188 5.5 SIN3A FEZF1 RAD21 RARA YY1 ZNF766 SCRT2 ZNF143 SMARCC2 RCOR1 ENTPD4 ENSG00000253200 C8orf58 BIN3 ENSG00000245025 CHMP7 ENSG00000253390 SLC25A37 STC1 TNFRSF10B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENTPD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENTPD4 gene promoter:
  • E4BP4
  • deltaCREB
  • CREB
  • CP2
  • SRY

Genomic Locations for ENTPD4 Gene

Genomic Locations for ENTPD4 Gene
71,949 bases
Minus strand
71,949 bases
Minus strand

Genomic View for ENTPD4 Gene

Genes around ENTPD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD4 Gene

Proteins for ENTPD4 Gene

  • Protein details for ENTPD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 4
    Protein Accession:
    Secondary Accessions:
    • D3DSS3
    • O15092

    Protein attributes for ENTPD4 Gene

    616 amino acids
    Molecular mass:
    70255 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD4 Gene


neXtProt entry for ENTPD4 Gene

Post-translational modifications for ENTPD4 Gene

  • Glycosylation at isoforms=2407 and isoforms=2404
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD4 Gene

No data available for DME Specific Peptides for ENTPD4 Gene

Domains & Families for ENTPD4 Gene

Gene Families for ENTPD4 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ENTPD4 Gene

Suggested Antigen Peptide Sequences for ENTPD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD4: view

Function for ENTPD4 Gene

Molecular function for ENTPD4 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.
UniProtKB/Swiss-Prot CatalyticActivity:
A nucleoside diphosphate + H(2)O = a nucleoside phosphate + phosphate.

Enzyme Numbers (IUBMB) for ENTPD4 Gene

Phenotypes From GWAS Catalog for ENTPD4 Gene

Gene Ontology (GO) - Molecular Function for ENTPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0017110 nucleoside-diphosphatase activity EXP 9556635
GO:0017111 nucleoside-triphosphatase activity EXP 9556635
GO:0045134 uridine-diphosphatase activity IDA,IEA 9556635
genes like me logo Genes that share ontologies with ENTPD4: view
genes like me logo Genes that share phenotypes with ENTPD4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ENTPD4

miRNA for ENTPD4 Gene

miRTarBase miRNAs that target ENTPD4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ENTPD4 Gene

Localization for ENTPD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD4 Gene

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Note=Localizes in the Golgi and autophagic vacuoles/lysosomes.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENTPD4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ENTPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0000421 autophagosome membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENTPD4: view

Pathways & Interactions for ENTPD4 Gene

genes like me logo Genes that share pathways with ENTPD4: view

Pathways by source for ENTPD4 Gene

Gene Ontology (GO) - Biological Process for ENTPD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006256 UDP catabolic process IDA 9556635
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
genes like me logo Genes that share ontologies with ENTPD4: view

No data available for SIGNOR curated interactions for ENTPD4 Gene

Drugs & Compounds for ENTPD4 Gene

(12) Drugs for ENTPD4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0
CDP Experimental Pharma 0

(4) Additional Compounds for ENTPD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
  • 5'-IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
  • Inosine 5'-pyrophosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with ENTPD4: view

Transcripts for ENTPD4 Gene

mRNA/cDNA for ENTPD4 Gene

Unigene Clusters for ENTPD4 Gene

Ectonucleoside triphosphate diphosphohydrolase 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: -
SP4: -
SP5: -
SP7: -

ExUns: 17 ^ 18
SP1: -

Relevant External Links for ENTPD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENTPD4 Gene

Protein differential expression in normal tissues from HIPED for ENTPD4 Gene

This gene is overexpressed in Cervix (61.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENTPD4 Gene

Protein tissue co-expression partners for ENTPD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ENTPD4 Gene:


SOURCE GeneReport for Unigene cluster for ENTPD4 Gene:


mRNA Expression by UniProt/SwissProt for ENTPD4 Gene:

Tissue specificity: Ubiquitous. Highest expression in testis and lowest in bladder.

Evidence on tissue expression from TISSUES for ENTPD4 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ENTPD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENTPD4 Gene

Orthologs for ENTPD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENTPD4 34 33
  • 99.57 (n)
(Bos Taurus)
Mammalia ENTPD4 34
  • 94 (a)
(Canis familiaris)
Mammalia ENTPD4 34 33
  • 90.53 (n)
(Monodelphis domestica)
Mammalia ENTPD4 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ENTPD4 34
  • 89 (a)
(Mus musculus)
Mammalia Entpd4 34 33
  • 86.13 (n)
Entpd4b 16
(Rattus norvegicus)
Mammalia Entpd4 33
  • 85.28 (n)
(Gallus gallus)
Aves ENTPD4 34 33
  • 78.35 (n)
(Anolis carolinensis)
Reptilia ENTPD4 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd4 33
  • 70.92 (n)
Str.13999 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33899 33
(Danio rerio)
Actinopterygii entpd4 34 33
  • 68.53 (n)
wufd44h12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7450 33
(Caenorhabditis elegans)
Secernentea ntp-1 34
  • 33 (a)
mig-23 34
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR006W 33
  • 45.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 34
  • 25 (a)
Species where no ortholog for ENTPD4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD4 Gene

Gene Tree for ENTPD4 (if available)
Gene Tree for ENTPD4 (if available)
Evolutionary constrained regions (ECRs) for ENTPD4: view image

Paralogs for ENTPD4 Gene

Paralogs for ENTPD4 Gene

(1) SIMAP similar genes for ENTPD4 Gene using alignment to 5 proteins:

  • Q8NE73_HUMAN
genes like me logo Genes that share paralogs with ENTPD4: view

Variants for ENTPD4 Gene

Sequence variations from dbSNP and Humsavar for ENTPD4 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000114003 -- 23,457,462(-) C/G intron_variant
rs1000184773 -- 23,455,961(-) C/G intron_variant
rs1000206855 -- 23,438,048(-) C/T intron_variant
rs1000214253 -- 23,443,209(-) T/C intron_variant
rs1000235128 -- 23,457,612(-) G/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD4 Gene

Variant ID Type Subtype PubMed ID
dgv7139n100 CNV loss 25217958
dgv7140n100 CNV gain 25217958
nsv1017570 CNV gain 25217958
nsv1026345 CNV gain 25217958
nsv1119172 CNV deletion 24896259
nsv470206 CNV gain 18288195
nsv508499 CNV deletion 20534489
nsv610779 CNV gain 21841781
nsv831268 CNV gain 17160897

Variation tolerance for ENTPD4 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENTPD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD4 Gene

Disorders for ENTPD4 Gene

Additional Disease Information for ENTPD4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ENTPD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD4 Gene

Publications for ENTPD4 Gene

  1. A human intracellular apyrase-like protein, LALP70, localizes to lysosomal/autophagic vacuoles. (PMID: 10393803) Biederbick A … Elsässer HP (Journal of cell science 1999) 2 3 4 22 58
  2. Golgi localization and functional expression of human uridine diphosphatase. (PMID: 9556635) Wang TF … Guidotti G (The Journal of biological chemistry 1998) 3 4 22 58
  3. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  4. An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia. (PMID: 20537721) Saito A … Akiyama K (Psychiatry research 2011) 3 44 58
  5. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58

Products for ENTPD4 Gene

Sources for ENTPD4 Gene

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