Aliases for ENTPD4 Gene
External Ids for ENTPD4 Gene
Previous HGNC Symbols for ENTPD4 Gene
Previous GeneCards Identifiers for ENTPD4 Gene
This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]
GeneCards Summary for ENTPD4 Gene
ENTPD4 (Ectonucleoside Triphosphate Diphosphohydrolase 4) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Purine metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and uridine-diphosphatase activity. An important paralog of this gene is ENTPD7.
UniProtKB/Swiss-Prot for ENTPD4 Gene
Hydrolyzes preferentially nucleoside 5-diphosphates, nucleoside 5-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP.