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Aliases for ENTPD3 Gene

Aliases for ENTPD3 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 3 2 3 3 5
  • Ecto-ATP Diphosphohydrolase 3 3 4
  • CD39 Antigen-Like 3 3 4
  • Ecto-ATPDase 3 3 4
  • Ecto-Apyrase 3 3 4
  • Ecto-ATPase 3 3 4
  • NTPDase 3 3 4
  • CD39L3 3 4
  • HB6 3 4
  • EC 4
  • NTPDase-3 3

External Ids for ENTPD3 Gene

Previous HGNC Symbols for ENTPD3 Gene

  • CD39L3

Previous GeneCards Identifiers for ENTPD3 Gene

  • GC03P039737
  • GC03P039656
  • GC03P040241
  • GC03P040389

Summaries for ENTPD3 Gene

Entrez Gene Summary for ENTPD3 Gene

  • This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]

GeneCards Summary for ENTPD3 Gene

ENTPD3 (Ectonucleoside Triphosphate Diphosphohydrolase 3) is a Protein Coding gene. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD2.

UniProtKB/Swiss-Prot for ENTPD3 Gene

  • Has a threefold preference for the hydrolysis of ATP over ADP.

Tocris Summary for ENTPD3 Gene

  • Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are constitutively expressed ectoenzymes that hydrolyze extracellular nucleotides. There are four known major families of ectonucleotidases.

Gene Wiki entry for ENTPD3 Gene

Additional gene information for ENTPD3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD3 Gene

Genomics for ENTPD3 Gene

GeneHancer (GH) Regulatory Elements for ENTPD3 Gene

Promoters and enhancers for ENTPD3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J040387 Promoter 1.4 EPDnew Ensembl 650.7 +0.0 45 0.4 L3MBTL2 ZNF740 SUZ12 NRF1 ZEB2 ZNF148 SP1 CCNT2 CTBP1 POLR2A ENTPD3 ENTPD3-AS1 GC03P040390
GH03J040388 Enhancer 0.4 ENCODE 650.7 +1.3 1329 0.2 NFIC ZSCAN4 ENTPD3 GC03P040390 ENTPD3-AS1
GH03J040456 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.5 +70.6 70645 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 RPL14 ENTPD3-AS1 ZNF619 CTNNB1 ENTPD3 PIR56082
GH03J040382 Enhancer 0.7 ENCODE 0.7 -4.3 -4271 0.2 HDAC1 MEIS2 ATF1 PKNOX1 NFATC3 TEAD4 TAL1 JUN FOSL1 TCF12 GC03M040381 ENTPD3 ENTPD3-AS1
GH03J040417 Enhancer 0.8 ENCODE 0.3 +30.9 30903 0.8 HDAC1 PKNOX1 CLOCK ATF1 NFXL1 CHAMP1 TCF12 ZNF766 GATA2 RCOR1 ENTPD3-AS1 RPL14 GC03P040390 ENTPD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENTPD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENTPD3 gene promoter:
  • AML1a
  • POU2F1a
  • POU2F1
  • Pax-6
  • FOXD1
  • Pax-2
  • Pax-2a
  • Pax-2b
  • p300

Genomic Locations for ENTPD3 Gene

Genomic Locations for ENTPD3 Gene
41,471 bases
Plus strand
41,464 bases
Plus strand

Genomic View for ENTPD3 Gene

Genes around ENTPD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD3 Gene

Proteins for ENTPD3 Gene

  • Protein details for ENTPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 3
    Protein Accession:
    Secondary Accessions:
    • B2R8D0
    • G5E9N0
    • O60495
    • Q8N6K2

    Protein attributes for ENTPD3 Gene

    529 amino acids
    Molecular mass:
    59105 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD3 Gene


neXtProt entry for ENTPD3 Gene

Post-translational modifications for ENTPD3 Gene

  • Glycosylation at isoforms=454, isoforms=2402, isoforms=2392, isoforms=2381, isoforms=2238, isoforms=2149, and Asn81
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD3 Gene

No data available for DME Specific Peptides for ENTPD3 Gene

Domains & Families for ENTPD3 Gene

Gene Families for ENTPD3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for ENTPD3 Gene

Suggested Antigen Peptide Sequences for ENTPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD3: view

Function for ENTPD3 Gene

Molecular function for ENTPD3 Gene

UniProtKB/Swiss-Prot Function:
Has a threefold preference for the hydrolysis of ATP over ADP.
UniProtKB/Swiss-Prot CatalyticActivity:
A nucleoside 5-triphosphate + 2 H(2)O = a nucleoside 5-phosphate + 2 phosphate.

Enzyme Numbers (IUBMB) for ENTPD3 Gene

Phenotypes From GWAS Catalog for ENTPD3 Gene

Gene Ontology (GO) - Molecular Function for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0017110 nucleoside-diphosphatase activity TAS --
GO:0017111 nucleoside-triphosphatase activity TAS --
genes like me logo Genes that share ontologies with ENTPD3: view
genes like me logo Genes that share phenotypes with ENTPD3: view

Animal Models for ENTPD3 Gene

MGI Knock Outs for ENTPD3:

Animal Model Products

CRISPR Products

miRNA for ENTPD3 Gene

miRTarBase miRNAs that target ENTPD3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENTPD3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ENTPD3 Gene

Localization for ENTPD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENTPD3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ENTPD3: view

Pathways & Interactions for ENTPD3 Gene

genes like me logo Genes that share pathways with ENTPD3: view

Pathways by source for ENTPD3 Gene

1 GeneGo (Thomson Reuters) pathway for ENTPD3 Gene

Gene Ontology (GO) - Biological Process for ENTPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009134 nucleoside diphosphate catabolic process IEA --
GO:0009143 nucleoside triphosphate catabolic process IEA --
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
genes like me logo Genes that share ontologies with ENTPD3: view

No data available for SIGNOR curated interactions for ENTPD3 Gene

Drugs & Compounds for ENTPD3 Gene

(21) Drugs for ENTPD3 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0

(7) Additional Compounds for ENTPD3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
  • 5'-IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
  • Inosine 5'-pyrophosphate
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • Inosine 5'-triphosphate
  • Inosine tripolyphosphate
  • O(5')-(Tetrahydroxytriphosphoryl)inosine
  • 2'-Inosine-5'-triphosphoric acid
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid

(4) Tocris Compounds for ENTPD3 Gene

Compound Action Cas Number
ARL 67156 trisodium salt NTPDase inhibitor 1021868-83-6
POM 1 Inhibitor of E-NTPDases 12141-67-2
PSB 06126 NTPDase 3 inhibitor 1052089-16-3
PSB 069 Non-selective NTPDase inhibitor 78510-31-3
genes like me logo Genes that share compounds with ENTPD3: view

Transcripts for ENTPD3 Gene

mRNA/cDNA for ENTPD3 Gene

Unigene Clusters for ENTPD3 Gene

Ectonucleoside triphosphate diphosphohydrolase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENTPD3

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -

Relevant External Links for ENTPD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENTPD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENTPD3 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x7.2) and Brain - Caudate (basal ganglia) (x5.3).

Protein differential expression in normal tissues from HIPED for ENTPD3 Gene

This gene is overexpressed in Milk (45.8) and Amniocyte (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ENTPD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ENTPD3 Gene:


SOURCE GeneReport for Unigene cluster for ENTPD3 Gene:


mRNA Expression by UniProt/SwissProt for ENTPD3 Gene:

Tissue specificity: Expressed in adult brain, pancreas, spleen and prostate. Moderate or low expression is seen in most tissues. Not expressed in liver and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ENTPD3 Gene

  • Nervous system(4.5)
  • Skin(4)
genes like me logo Genes that share expression patterns with ENTPD3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENTPD3 Gene

Orthologs for ENTPD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENTPD3 34 33
  • 99.62 (n)
(Canis familiaris)
Mammalia ENTPD3 34 33
  • 86.7 (n)
(Bos Taurus)
Mammalia ENTPD3 34 33
  • 86.09 (n)
(Mus musculus)
Mammalia Entpd3 16 34 33
  • 83.3 (n)
(Rattus norvegicus)
Mammalia Entpd3 33
  • 82.86 (n)
(Ornithorhynchus anatinus)
Mammalia ENTPD3 34
  • 73 (a)
(Monodelphis domestica)
Mammalia ENTPD3 34
  • 71 (a)
(Gallus gallus)
Aves ENTPD3 34 33
  • 68.01 (n)
(Anolis carolinensis)
Reptilia ENTPD3 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd3 33
  • 64.35 (n)
(Danio rerio)
Actinopterygii entpd3 34 33
  • 57.61 (n)
(Caenorhabditis elegans)
Secernentea ntp-1 34
  • 22 (a)
mig-23 34
  • 19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 34
  • 17 (a)
Species where no ortholog for ENTPD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD3 Gene

Gene Tree for ENTPD3 (if available)
Gene Tree for ENTPD3 (if available)
Evolutionary constrained regions (ECRs) for ENTPD3: view image

Paralogs for ENTPD3 Gene

Paralogs for ENTPD3 Gene

(12) SIMAP similar genes for ENTPD3 Gene using alignment to 3 proteins:

  • C9J0J3_HUMAN
  • G5E9N0_HUMAN
genes like me logo Genes that share paralogs with ENTPD3: view

Variants for ENTPD3 Gene

Sequence variations from dbSNP and Humsavar for ENTPD3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs193921050 uncertain-significance, Malignant tumor of prostate 40,416,054(+) T/A coding_sequence_variant, missense_variant
rs1000012181 -- 40,427,114(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000019235 -- 40,407,201(+) G/A intron_variant
rs1000035189 -- 40,423,739(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000075095 -- 40,393,239(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD3 Gene

Variant ID Type Subtype PubMed ID
esv2671271 CNV deletion 23128226
esv2763760 CNV loss 21179565
esv3595947 CNV loss 21293372
esv3595948 CNV loss 21293372
esv3595949 CNV loss 21293372
esv3595950 CNV loss 21293372
esv3893685 CNV loss 25118596
nsv520025 CNV loss 19592680
nsv590110 CNV loss 21841781
nsv818137 CNV loss 17921354

Variation tolerance for ENTPD3 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENTPD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD3 Gene

Disorders for ENTPD3 Gene

Additional Disease Information for ENTPD3

No disorders were found for ENTPD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENTPD3 Gene

Publications for ENTPD3 Gene

  1. Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling. (PMID: 15966724) Ivanenkov VV … Kirley TL (Biochemistry 2005) 3 4 22 58
  2. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. (PMID: 9676430) Chadwick BP … Frischauf AM (Genomics 1998) 2 3 4 58
  3. Cystic fibrosis remodels the regulation of purinergic signaling by NTPDase1 (CD39) and NTPDase3. (PMID: 20190036) Fausther M … Picher M (American journal of physiology. Lung cellular and molecular physiology 2010) 3 22 58
  4. Conserved polar residues stabilize transmembrane domains and promote oligomerization in human nucleoside triphosphate diphosphohydrolase 3. (PMID: 19743837) Gaddie KJ … Kirley TL (Biochemistry 2009) 3 22 58
  5. Site-directed mutagenesis of human nucleoside triphosphate diphosphohydrolase 3: the importance of residues in the apyrase conserved regions. (PMID: 11300774) Yang F … Kirley TL (Biochemistry 2001) 3 4 58

Products for ENTPD3 Gene

Sources for ENTPD3 Gene

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