Aliases for ENTPD2 Gene
External Ids for ENTPD2 Gene
Previous HGNC Symbols for ENTPD2 Gene
Previous GeneCards Identifiers for ENTPD2 Gene
The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
GeneCards Summary for ENTPD2 Gene
ENTPD2 (Ectonucleoside Triphosphate Diphosphohydrolase 2) is a Protein Coding gene. Diseases associated with ENTPD2 include Cholera and Granulomatous Amebic Encephalitis. Among its related pathways are ATP/ITP metabolism and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD8.
UniProtKB/Swiss-Prot Summary for ENTPD2 Gene
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.
Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are constitutively expressed ectoenzymes that hydrolyze extracellular nucleotides. There are four known major families of ectonucleotidases.