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Aliases for ENTPD2 Gene

Aliases for ENTPD2 Gene

  • Ectonucleoside Triphosphate Diphosphohydrolase 2 2 3 3 5
  • Ecto-ATP Diphosphohydrolase 2 3 4
  • CD39 Antigen-Like 1 3 4
  • Ecto-ATPDase 2 3 4
  • Ecto-ATPase 2 3 4
  • NTPDase 2 3 4
  • CD39L1 3 4
  • CD39-Like-1 2
  • Ecto-ATPase 2
  • EC 3.6.1.- 4
  • NTPDase-2 3

External Ids for ENTPD2 Gene

Previous HGNC Symbols for ENTPD2 Gene

  • CD39L1

Previous GeneCards Identifiers for ENTPD2 Gene

  • GC09M131164
  • GC09M131632
  • GC09M133383
  • GC09M135299
  • GC09M135300
  • GC09M137218
  • GC09M139062
  • GC09M139942
  • GC09M109402

Summaries for ENTPD2 Gene

Entrez Gene Summary for ENTPD2 Gene

  • The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for ENTPD2 Gene

ENTPD2 (Ectonucleoside Triphosphate Diphosphohydrolase 2) is a Protein Coding gene. Diseases associated with ENTPD2 include Dentin Sensitivity. Among its related pathways are Pyrimidine metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and nucleoside-diphosphatase activity. An important paralog of this gene is ENTPD8.

UniProtKB/Swiss-Prot for ENTPD2 Gene

  • In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

Tocris Summary for ENTPD2 Gene

  • Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are constitutively expressed ectoenzymes that hydrolyze extracellular nucleotides. There are four known major families of ectonucleotidases.

Gene Wiki entry for ENTPD2 Gene

Additional gene information for ENTPD2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENTPD2 Gene

Genomics for ENTPD2 Gene

GeneHancer (GH) Regulatory Elements for ENTPD2 Gene

Promoters and enhancers for ENTPD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137051 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 -0.1 -136 4.6 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS NFKBIZ SP3 ENTPD2 LOC105376327 MAN1B1 UAP1L1 DPP7 GRIN1 CCDC183 RABL6 NPDC1 ENSG00000229257
GH09J136895 Enhancer 0.4 dbSUPER 11.8 +157.3 157346 2 GLIS2 GLIS1 MNT FUT7 ABCA2 NPDC1 ENTPD2 TMEM141 PAXX PHPT1 MIR4479 TRAF2 PIR43412
GH09J136894 Enhancer 0.3 dbSUPER 11.8 +159.2 159169 1.4 SREBF2 FUT7 ABCA2 NPDC1 ENTPD2 PAXX MIR4479 TRAF2 PIR43412
GH09J137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.3 -184.2 -184237 9.9 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TUBB4B EHMT1 ENTR1 ANAPC2 NDOR1 DPH7 INPP5E LOC100418938 MAN1B1 SNHG7
GH09J137518 Enhancer 0.8 FANTOM5 1.5 -464.7 -464683 0.4 HDAC1 ZBTB2 GATAD2B YBX1 BCL11B FOSL1 MEF2D ARHGAP35 HDAC2 ZNF366 EXD3 GRIN1 PNPLA7 CACNA1B ABCA2 RNF208 ENTPD2 PIR51097 PIR44519
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENTPD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ENTPD2 gene promoter:
  • NRSF form 1
  • NRSF form 2
  • AhR
  • GATA-3
  • HSF2
  • RFX1
  • SEF-1 (1)
  • Pax-5
  • Tal-1beta

Genomic Locations for ENTPD2 Gene

Genomic Locations for ENTPD2 Gene
5,972 bases
Minus strand
5,956 bases
Minus strand

Genomic View for ENTPD2 Gene

Genes around ENTPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENTPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENTPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ENTPD2 Gene

Proteins for ENTPD2 Gene

  • Protein details for ENTPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ectonucleoside triphosphate diphosphohydrolase 2
    Protein Accession:
    Secondary Accessions:
    • O15464
    • Q5SPY6
    • Q5SPY7

    Protein attributes for ENTPD2 Gene

    495 amino acids
    Molecular mass:
    53665 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ENTPD2 Gene


neXtProt entry for ENTPD2 Gene

Post-translational modifications for ENTPD2 Gene

  • Glycosylation at Asn443, Asn378, Asn294, Asn129, and isoforms=2, 364
  • Modification sites at PhosphoSitePlus

Other Protein References for ENTPD2 Gene

No data available for DME Specific Peptides for ENTPD2 Gene

Domains & Families for ENTPD2 Gene

Gene Families for ENTPD2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ENTPD2 Gene

Suggested Antigen Peptide Sequences for ENTPD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GDA1/CD39 NTPase family.
  • Belongs to the GDA1/CD39 NTPase family.
genes like me logo Genes that share domains with ENTPD2: view

Function for ENTPD2 Gene

Molecular function for ENTPD2 Gene

UniProtKB/Swiss-Prot Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

Enzyme Numbers (IUBMB) for ENTPD2 Gene

Gene Ontology (GO) - Molecular Function for ENTPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0017110 nucleoside-diphosphatase activity IEA --
GO:0017111 nucleoside-triphosphatase activity EXP 10510450
genes like me logo Genes that share ontologies with ENTPD2: view
genes like me logo Genes that share phenotypes with ENTPD2: view

Animal Models for ENTPD2 Gene

MGI Knock Outs for ENTPD2:

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ENTPD2 Gene

Localization for ENTPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENTPD2 Gene

Isoform Long: Cell membrane; Multi-pass membrane protein.
Isoform Short: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Isoform gamma: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENTPD2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ENTPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005605 basal lamina IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ENTPD2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENTPD2 Gene

Pathways & Interactions for ENTPD2 Gene

genes like me logo Genes that share pathways with ENTPD2: view

Pathways by source for ENTPD2 Gene

1 GeneGo (Thomson Reuters) pathway for ENTPD2 Gene

Gene Ontology (GO) - Biological Process for ENTPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0009181 purine ribonucleoside diphosphate catabolic process IEA --
GO:0030168 platelet activation IEA --
GO:0034656 nucleobase-containing small molecule catabolic process TAS --
genes like me logo Genes that share ontologies with ENTPD2: view

No data available for SIGNOR curated interactions for ENTPD2 Gene

Drugs & Compounds for ENTPD2 Gene

(12) Drugs for ENTPD2 Gene - From: HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Magnesium Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0

(6) Additional Compounds for ENTPD2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid

(4) Tocris Compounds for ENTPD2 Gene

Compound Action Cas Number
ARL 67156 trisodium salt NTPDase inhibitor 1021868-83-6
POM 1 Inhibitor of E-NTPDases 12141-67-2
PSB 06126 NTPDase 3 inhibitor 1052089-16-3
PSB 069 Non-selective NTPDase inhibitor 78510-31-3
genes like me logo Genes that share compounds with ENTPD2: view

Transcripts for ENTPD2 Gene

mRNA/cDNA for ENTPD2 Gene

Unigene Clusters for ENTPD2 Gene

Ectonucleoside triphosphate diphosphohydrolase 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENTPD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - -
SP2: -

Relevant External Links for ENTPD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ENTPD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ENTPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ENTPD2 Gene

This gene is overexpressed in Nerve - Tibial (x5.3).

Protein differential expression in normal tissues from HIPED for ENTPD2 Gene

This gene is overexpressed in Spinal cord (50.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ENTPD2 Gene

Protein tissue co-expression partners for ENTPD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ENTPD2 Gene:


SOURCE GeneReport for Unigene cluster for ENTPD2 Gene:


mRNA Expression by UniProt/SwissProt for ENTPD2 Gene:

Tissue specificity: Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ENTPD2 Gene

  • Nervous system(4.5)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with ENTPD2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ENTPD2 Gene

Orthologs for ENTPD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENTPD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ENTPD2 34 33
  • 98.65 (n)
(Bos Taurus)
Mammalia ENTPD2 34 33
  • 85.25 (n)
(Canis familiaris)
Mammalia ENTPD2 34 33
  • 83.97 (n)
(Mus musculus)
Mammalia Entpd2 16 34 33
  • 83.1 (n)
(Rattus norvegicus)
Mammalia Entpd2 33
  • 82.42 (n)
(Monodelphis domestica)
Mammalia ENTPD2 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia ENTPD2 34
  • 55 (a)
(Gallus gallus)
Aves ENTPD2 34 33
  • 65.15 (n)
(Anolis carolinensis)
Reptilia ENTPD2 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia entpd2 33
  • 64.16 (n)
Str.5534 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1360 33
(Danio rerio)
Actinopterygii entpd2a.1 34 33
  • 57.65 (n)
entpd2a.2 34
  • 50 (a)
entpd2b 34
  • 45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.992 33
(Caenorhabditis elegans)
Secernentea ntp-1 34
  • 21 (a)
mig-23 34
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YND1 34
  • 17 (a)
Species where no ortholog for ENTPD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ENTPD2 Gene

Gene Tree for ENTPD2 (if available)
Gene Tree for ENTPD2 (if available)
Evolutionary constrained regions (ECRs) for ENTPD2: view image

Paralogs for ENTPD2 Gene

Paralogs for ENTPD2 Gene

(3) SIMAP similar genes for ENTPD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ENTPD2: view

Variants for ENTPD2 Gene

Sequence variations from dbSNP and Humsavar for ENTPD2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000232900 -- 137,051,965(-) C/T intron_variant
rs1000289239 -- 137,055,110(-) C/T upstream_transcript_variant
rs1000550387 -- 137,055,396(-) G/A upstream_transcript_variant
rs1000661676 -- 137,051,519(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs1000829072 -- 137,055,061(-) T/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ENTPD2 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2520970 CNV insertion 19546169
esv2761561 CNV gain 21179565
nsv1143386 CNV deletion 24896259
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616004 CNV loss 21841781
nsv616005 CNV loss 21841781
nsv831761 CNV loss 17160897
nsv951206 CNV deletion 24416366

Variation tolerance for ENTPD2 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ENTPD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ENTPD2 Gene

Disorders for ENTPD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ENTPD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ENTPD2

genes like me logo Genes that share disorders with ENTPD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ENTPD2 Gene

Publications for ENTPD2 Gene

  1. Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. (PMID: 9271669) Chadwick BP … Frischauf AM (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 2 3 4 22 58
  2. Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme. (PMID: 12888562) Mateo J … Boyer JL (The Journal of biological chemistry 2003) 3 4 22 58
  3. Functional expression of a cDNA encoding a human ecto-ATPase. (PMID: 10510450) Mateo J … Boyer JL (British journal of pharmacology 1999) 3 4 22 58
  4. Inhibition of human NTPDase 2 by modification of an intramembrane cysteine by p-chloromercuriphenylsulfonate and oxidative cross-linking of the transmembrane domains. (PMID: 18656957) Chiang WC … Knowles AF (Biochemistry 2008) 3 22 58
  5. Mutagenesis of lysine 62, asparagine 64, and conserved region 1 reduces the activity of human ecto-ATPase (NTPDase 2). (PMID: 17489562) Javed R … Knowles AF (Biochemistry 2007) 3 22 58

Products for ENTPD2 Gene

Sources for ENTPD2 Gene

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