Aliases for ENSG00000288380 Gene

Aliases for ENSG00000288380 Gene

  • Cysteine Rich PAK1 Inhibitor 5
  • Cysteine-Rich PAK1 Inhibitor 4
  • CRIPAK 5
  • CRIPak 4

External Ids for ENSG00000288380 Gene

Summaries for ENSG00000288380 Gene

GeneCards Summary for ENSG00000288380 Gene

ENSG00000288380 is a Protein Coding gene. Diseases associated with ENSG00000288380 include Hypophosphatasia, Infantile and Laryngeal Benign Neoplasm.

UniProtKB/Swiss-Prot Summary for ENSG00000288380 Gene

  • Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.

Additional gene information for ENSG00000288380 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENSG00000288380 Gene

Genomics for ENSG00000288380 Gene

GeneHancer (GH) Regulatory Elements for ENSG00000288380 Gene

Promoters and enhancers for ENSG00000288380 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENSG00000288380 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ENSG00000288380

Genomic Locations for ENSG00000288380 Gene

Genomic Locations for ENSG00000288380 Gene
chr4:1,391,552-1,395,992
(GRCh38/hg38)
Size:
4,441 bases
Orientation:
Plus strand
chr4:1,385,340-1,389,782
(GRCh37/hg19)
Size:
4,443 bases
Orientation:
Plus strand

Genomic View for ENSG00000288380 Gene

Genes around ENSG00000288380 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000288380 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000288380 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000288380 Gene

Proteins for ENSG00000288380 Gene

  • Protein details for ENSG00000288380 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1N5-CRPAK_HUMAN
    Recommended name:
    Cysteine-rich PAK1 inhibitor
    Protein Accession:
    Q8N1N5
    Secondary Accessions:
    • Q8NB03

    Protein attributes for ENSG00000288380 Gene

    Size:
    446 amino acids
    Molecular mass:
    48076 Da
    Quaternary structure:
    • Interacts with PAK1.

neXtProt entry for ENSG00000288380 Gene

Post-translational modifications for ENSG00000288380 Gene

No Post-translational modifications

Other Protein References for ENSG00000288380 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000288380 Gene

Domains & Families for ENSG00000288380 Gene

Protein Domains for ENSG00000288380 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ENSG00000288380 Gene

GenScript: Design optimal peptide antigens:
  • Cysteine-rich PAK1 inhibitor (CRPAK_HUMAN)
genes like me logo Genes that share domains with ENSG00000288380: view

No data available for Gene Families , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ENSG00000288380 Gene

Function for ENSG00000288380 Gene

Molecular function for ENSG00000288380 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estrogen.

Phenotypes From GWAS Catalog for ENSG00000288380 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENSG00000288380

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000288380 Gene

Localization for ENSG00000288380 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENSG00000288380 Gene

Cytoplasm. Membrane. Nucleus. Note=Translocated to the nuclear compartment upon hormonal treatment by estrogen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ENSG00000288380 gene
Compartment Confidence
plasma membrane 4
nucleus 4
endoplasmic reticulum 4
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ENSG00000288380 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ENSG00000288380: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000288380 Gene

Pathways & Interactions for ENSG00000288380 Gene

PathCards logo

SuperPathways for ENSG00000288380 Gene

No Data Available

Interacting Proteins for ENSG00000288380 Gene

;

SIGNOR curated interactions for ENSG00000288380 Gene

Activates:

Gene Ontology (GO) - Biological Process for ENSG00000288380 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA --
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA --
GO:0043627 response to estrogen IDA --
GO:0051493 regulation of cytoskeleton organization IDA --
genes like me logo Genes that share ontologies with ENSG00000288380: view

No data available for Pathways by source for ENSG00000288380 Gene

Drugs & Compounds for ENSG00000288380 Gene

(1) Drugs for ENSG00000288380 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IPA-3 Pharma Non-ATP competitive Pak1 inhibitor 0

(1) ApexBio Compounds for ENSG00000288380 Gene

Compound Action Cas Number
IPA-3 Non-ATP competitive Pak1 inhibitor 42521-82-4
genes like me logo Genes that share compounds with ENSG00000288380: view

Drug Products

Transcripts for ENSG00000288380 Gene

mRNA/cDNA for ENSG00000288380 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ENSG00000288380

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000288380 Gene

No ASD Table

Relevant External Links for ENSG00000288380 Gene

GeneLoc Exon Structure for
ENSG00000288380

Expression for ENSG00000288380 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ENSG00000288380

mRNA Expression by UniProt/SwissProt for ENSG00000288380 Gene:

Q8N1N5-CRPAK_HUMAN
Tissue specificity: Widely expressed with a highest expression observed in trachea, prostate and adrenal glands. Expressed in many cancer cell lines including breast cancer cells.

Evidence on tissue expression from TISSUES for ENSG00000288380 Gene

  • Lung(4.1)
  • Nervous system(2.2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000288380 Gene

Orthologs for ENSG00000288380 Gene

Evolution for ENSG00000288380 Gene

ENSEMBL:
Gene Tree for ENSG00000288380 (if available)
TreeFam:
Gene Tree for ENSG00000288380 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ENSG00000288380: view image

No data available for Orthologs for ENSG00000288380 Gene

Paralogs for ENSG00000288380 Gene

No data available for Paralogs for ENSG00000288380 Gene

Variants for ENSG00000288380 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ENSG00000288380 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs9328733 -. - p.His95Prop.His95Arg
rs13097 - p.Cys89Tyr
rs141796647 - p.Val120Met

Structural Variations from Database of Genomic Variants (DGV) for ENSG00000288380 Gene

Variant ID Type Subtype PubMed ID
esv1697030 CNV deletion 17803354
esv21856 CNV gain+loss 19812545
esv2726793 CNV deletion 23290073
nsv1073287 CNV deletion 25765185
nsv4197 CNV insertion 18451855
nsv593278 CNV loss 21841781
nsv593302 CNV loss 21841781
nsv822425 CNV loss 20364138

Variation tolerance for ENSG00000288380 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.50; 97.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Additional dbSNP identifiers (rs#s) and Additional Variant Information for ENSG00000288380 Gene

Disorders for ENSG00000288380 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ENSG00000288380 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypophosphatasia, infantile
  • hops
laryngeal benign neoplasm
  • laryngeal tumor
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ENSG00000288380: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000288380 Gene

Publications for ENSG00000288380 Gene

  1. CRIPak, a novel endogenous Pak1 inhibitor. (PMID: 16278681) Talukder AH … Kumar R (Oncogene 2006) 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54

Products for ENSG00000288380 Gene

Sources for ENSG00000288380 Gene