Aliases for ENSG00000285188 Gene

Aliases for ENSG00000285188 Gene

  • CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4C 4 5
  • EC 3.1.4.17 51
  • EC 3.1.4.53 4
  • AC008397.2 5
  • EC 3.1.4 51
  • DPDE1 4
  • PDE21 4

External Ids for ENSG00000285188 Gene

Summaries for ENSG00000285188 Gene

GeneCards Summary for ENSG00000285188 Gene

ENSG00000285188 is a Protein Coding gene. An important paralog of this gene is PDE4C.

UniProtKB/Swiss-Prot Summary for ENSG00000285188 Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Additional gene information for ENSG00000285188 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENSG00000285188 Gene

Genomics for ENSG00000285188 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENSG00000285188 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J018253 Promoter/Enhancer 1.2 FANTOM5 Ensembl ENCODE 600.7 +1.0 954 2.6 CTCF KDM1A TCF12 CTBP1 YY1 ZNF189 POLR2A SPI1 ZMYM3 ATF4 ENSG00000285188 LOC729966 PDE4C B3GNT3
GH19J018223 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 +30.5 30518 3 SP1 CREB1 PRDM10 ZNF629 LEF1 IKZF1 KDM1A ZNF692 JUND LARP7 PDE4C RF00017-2896 IQCN MPV17L2 LSM4 PLVAP RAB3A ENSG00000285188
GH19J018202 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 +49.6 49565 6.5 SP1 CREB1 CTCF PRDM10 ZNF629 TFE3 IKZF1 KDM1A BACH1 FOS ENSG00000268650 LOC102725254 RAB3A lnc-PDE4C-1 piR-34822-156 ENSG00000268030 IQCN UPF1 PDE4C ENSG00000268938
GH19J018251 Enhancer 0.9 Ensembl ENCODE 0.7 +3.4 3435 0.6 CTCF KDM1A JUND ZNF143 PATZ1 REST RAD21 TRIM22 SCRT2 ZNF792 PDE4C IQCN ENSG00000285188 LOC729966
GH19J018231 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 0.4 +22.7 22717 1.8 GATAD2A CTCF ZBTB33 REST TFE3 IKZF1 NFKBIZ ZNF692 ZNF7 MTA2 PDE4C IQCN JUND RF00017-2896 ENSG00000285188 RAB3A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENSG00000285188 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ENSG00000285188 Gene

Genomic Locations for ENSG00000285188 Gene
chr19:18,207,961-18,255,419
(GRCh38/hg38)
Size:
47,459 bases
Orientation:
Minus strand

Genomic View for ENSG00000285188 Gene

Genes around ENSG00000285188 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000285188 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000285188 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000285188 Gene

Proteins for ENSG00000285188 Gene

  • Protein details for ENSG00000285188 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08493-PDE4C_HUMAN
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C
    Protein Accession:
    Q08493
    Secondary Accessions:
    • B3KTC4
    • Q9UN44
    • Q9UN45
    • Q9UN46
    • Q9UPJ6

    Protein attributes for ENSG00000285188 Gene

    Size:
    712 amino acids
    Molecular mass:
    79902 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

    Three dimensional structures from OCA and Proteopedia for ENSG00000285188 Gene

    Alternative splice isoforms for ENSG00000285188 Gene

neXtProt entry for ENSG00000285188 Gene

Selected DME Specific Peptides for ENSG00000285188 Gene

Q08493:
  • SVLENHH
  • VLATDMS
  • IVTPFAQVLASLR
  • HLWRQPR
  • AVFTDLEILAA
  • LDTLEDNR
  • QERDLLKTF
  • PIRIQQR
  • EMASNKFKR
  • LNRELTHLSE
  • LLADLKTMVE
  • FELTLEE
  • CDIFQNL
  • VHCADLSNP
  • SVLENHHLAVGFKLLQ
  • NREWYQS
  • IDMVLAT
  • TPALEAVFTDLE
  • QSTHVLL
  • RRESFLYR
  • EKSQVGFIDYI
  • QLETLQTR
  • HDVDHPG
  • HNSLHAADV
  • TDMSKHM
  • ETWADLV
  • RQWTDRI
  • GVLLLDNY

Post-translational modifications for ENSG00000285188 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ENSG00000285188 Gene

ENSEMBL proteins:

Domains & Families for ENSG00000285188 Gene

Gene Families for ENSG00000285188 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted intracellular proteins

Protein Domains for ENSG00000285188 Gene

Graphical View of Domain Structure for InterPro Entry

Q08493

UniProtKB/Swiss-Prot:

PDE4C_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with ENSG00000285188: view

No data available for Suggested Antigen Peptide Sequences for ENSG00000285188 Gene

Function for ENSG00000285188 Gene

Molecular function for ENSG00000285188 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165, ChEBI:CHEBI:456215; EC=3.1.4.53;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram.

Enzyme Numbers (IUBMB) for ENSG00000285188 Gene

Phenotypes From GWAS Catalog for ENSG00000285188 Gene

Gene Ontology (GO) - Molecular Function for ENSG00000285188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity IEA --
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity TAS --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ENSG00000285188: view

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000285188 Gene

Localization for ENSG00000285188 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENSG00000285188 Gene

Cell projection, cilium.

Gene Ontology (GO) - Cellular Components for ENSG00000285188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA --
GO:0005829 cytosol TAS --
GO:0005929 cilium ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ENSG00000285188: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000285188 Gene

Pathways & Interactions for ENSG00000285188 Gene

PathCards logo

SuperPathways for ENSG00000285188 Gene

No Data Available

UniProtKB/Swiss-Prot Q08493-PDE4C_HUMAN

  • Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Gene Ontology (GO) - Biological Process for ENSG00000285188 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ENSG00000285188: view

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000285188 Gene

Drugs & Compounds for ENSG00000285188 Gene

No Compound Related Data Available

Transcripts for ENSG00000285188 Gene

mRNA/cDNA for ENSG00000285188 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000285188 Gene

No ASD Table

Relevant External Links for ENSG00000285188 Gene

GeneLoc Exon Structure for
ENSG00000285188

Expression for ENSG00000285188 Gene

mRNA Expression by UniProt/SwissProt for ENSG00000285188 Gene:

Q08493-PDE4C_HUMAN
Tissue specificity: Expressed in various tissues but not in cells of the immune system.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000285188 Gene

Orthologs for ENSG00000285188 Gene

Evolution for ENSG00000285188 Gene

ENSEMBL:
Gene Tree for ENSG00000285188 (if available)
TreeFam:
Gene Tree for ENSG00000285188 (if available)

No data available for Orthologs for ENSG00000285188 Gene

Paralogs for ENSG00000285188 Gene

genes like me logo Genes that share paralogs with ENSG00000285188: view

Variants for ENSG00000285188 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000285188 Gene

Disorders for ENSG00000285188 Gene

Additional Disease Information for ENSG00000285188

No disorders were found for ENSG00000285188 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENSG00000285188 Gene

Publications for ENSG00000285188 Gene

  1. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. (PMID: 17727341) Wang H … Ke H (The Biochemical journal 2007) 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4
  4. Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. (PMID: 10574328) Sullivan M … Houslay MD (Cellular signalling 1999) 4
  5. Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C). (PMID: 7843419) Engels P … Lübbert H (FEBS letters 1995) 4

No data available for Mastermind for ENSG00000285188 Gene

Products for ENSG00000285188 Gene

Sources for ENSG00000285188 Gene