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Aliases for ENSG00000285025 Gene

Aliases for ENSG00000285025 Gene

  • MIEF1 Upstream Open Reading Frame Protein 4 5
  • Alternative MIEF1 Protein 4
  • MIEF1 Microprotein 4
  • AL022312.1 5
  • AltMIEF1 4
  • MIEF1-MP 4

External Ids for ENSG00000285025 Gene

Summaries for ENSG00000285025 Gene

GeneCards Summary for ENSG00000285025 Gene

ENSG00000285025 is a Protein Coding gene.

UniProtKB/Swiss-Prot for ENSG00000285025 Gene

  • Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable).

Additional gene information for ENSG00000285025 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ENSG00000285025 Gene

Genomics for ENSG00000285025 Gene

GeneHancer (GH) Regulatory Elements for ENSG00000285025 Gene

Promoters and enhancers for ENSG00000285025 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J039500 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 600.7 -1.8 -1796 3.8 SP1 ZFX ELF3 MNT ZNF148 NKRF POLR2A ZNF687 AHR ZNF24 ENSG00000285025 MIEF1 GC22P039502 GC22P039503 GC22P039505 GC22P039506 GC22P039507 GC22P039509 GC22P039510 LOC105373035
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENSG00000285025 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ENSG00000285025 Gene

Genomic Locations for ENSG00000285025 Gene
chr22:39,504,231-39,504,443
(GRCh38/hg38)
Size:
213 bases
Orientation:
Plus strand

Genomic View for ENSG00000285025 Gene

Genes around ENSG00000285025 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000285025 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000285025 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000285025 Gene

Proteins for ENSG00000285025 Gene

  • Protein details for ENSG00000285025 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    L0R8F8-MIDUO_HUMAN
    Recommended name:
    MIEF1 upstream open reading frame protein
    Protein Accession:
    L0R8F8

    Protein attributes for ENSG00000285025 Gene

    Size:
    70 amino acids
    Molecular mass:
    8445 Da
    Quaternary structure:
    • Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side (PubMed:28892042, PubMed:30215512). Within the complex, MALSU1 mediates interaction with the mitochondrial large ribosomal subunit (PubMed:28892042). Interacts with ribosomal proteins MRPL4 and MRPS27 (PubMed:30215512).

    Three dimensional structures from OCA and Proteopedia for ENSG00000285025 Gene

    Alternative splice isoforms for ENSG00000285025 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ENSG00000285025 Gene

Post-translational modifications for ENSG00000285025 Gene

No Post-translational modifications

Other Protein References for ENSG00000285025 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000285025 Gene

Domains & Families for ENSG00000285025 Gene

Protein Domains for ENSG00000285025 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

L0R8F8

UniProtKB/Swiss-Prot:

MIDUO_HUMAN :
  • Belongs to the complex I LYR family.
Family:
  • Belongs to the complex I LYR family.
genes like me logo Genes that share domains with ENSG00000285025: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ENSG00000285025 Gene

Function for ENSG00000285025 Gene

Molecular function for ENSG00000285025 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable).

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000285025 Gene

Localization for ENSG00000285025 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ENSG00000285025 Gene

Mitochondrion matrix.

Gene Ontology (GO) - Cellular Components for ENSG00000285025 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix IEA --
GO:0005762 mitochondrial large ribosomal subunit IDA --
genes like me logo Genes that share ontologies with ENSG00000285025: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000285025 Gene

Pathways & Interactions for ENSG00000285025 Gene

PathCards logo

SuperPathways for ENSG00000285025 Gene

No Data Available

Interacting Proteins for ENSG00000285025 Gene

Gene Ontology (GO) - Biological Process for ENSG00000285025 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0042254 ribosome biogenesis IEA --
GO:0070131 positive regulation of mitochondrial translation IDA --
genes like me logo Genes that share ontologies with ENSG00000285025: view

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000285025 Gene

Drugs & Compounds for ENSG00000285025 Gene

No Compound Related Data Available

Transcripts for ENSG00000285025 Gene

mRNA/cDNA for ENSG00000285025 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000285025 Gene

No ASD Table

Relevant External Links for ENSG00000285025 Gene

GeneLoc Exon Structure for
ENSG00000285025

Expression for ENSG00000285025 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000285025 Gene

Orthologs for ENSG00000285025 Gene

Evolution for ENSG00000285025 Gene

ENSEMBL:
Gene Tree for ENSG00000285025 (if available)
TreeFam:
Gene Tree for ENSG00000285025 (if available)

No data available for Orthologs for ENSG00000285025 Gene

Paralogs for ENSG00000285025 Gene

No data available for Paralogs for ENSG00000285025 Gene

Variants for ENSG00000285025 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000285025 Gene

Disorders for ENSG00000285025 Gene

No disorders were found for ENSG00000285025 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000285025 Gene

Publications for ENSG00000285025 Gene

  1. MIEF1 Microprotein Regulates Mitochondrial Translation. (PMID: 30215512) Rathore A … Saghatelian A (Biochemistry 2018) 4 58
  2. Structures of the human mitochondrial ribosome in native states of assembly. (PMID: 28892042) Brown A … Ramakrishnan V (Nature structural & molecular biology 2017) 4 58
  3. Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins. (PMID: 29083303) Samandi S … Roucou X (eLife 2017) 4 58
  4. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev DE … Baranov PV (eLife 2015) 4 58
  5. Direct detection of alternative open reading frames translation products in human significantly expands the proteome. (PMID: 23950983) Vanderperre B … Roucou X (PloS one 2013) 4 58

No data available for External Links for ENSG00000285025 Gene

Products for ENSG00000285025 Gene

Sources for ENSG00000285025 Gene

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