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Aliases for ENSG00000277385 Gene

Subcategory (RNA class) for ENSG00000277385 Gene

SRP

Quality Score for this RNA gene is

15

Aliases for ENSG00000277385 Gene

  • RF00017 5

External Ids for ENSG00000277385 Gene

ORGUL Members for ENSG00000277385 Gene

Previous GeneCards Identifiers for ENSG00000277385 Gene

  • GC22M038384
  • GC22M038509
  • GC22M038819
  • GC22M039952
  • GC22M040644
  • GC22M041093
  • GC22M041493
  • GC22M041904

Summaries for ENSG00000277385 Gene

GeneCards Summary for ENSG00000277385 Gene

ENSG00000277385 is an RNA Gene, and is affiliated with the SRP RNA class.

fRNAdb sequence ontologies for ENSG00000277385 Gene

  • Metazoan signal recognition particle RNA: The signal recognition particle (SRP) is a universally conserved ribonucleoprotein. It is involved in the co-translational targeting of proteins to membranes. The eukaryotic SRP consists of a 300-nucleotide 7S RNA and six proteins: SRPs 72, 68, 54, 19, 14, and 9. Archaeal SRP consists of a 7S RNA and homologues of the eukaryotic SRP19 and SRP54 proteins. Eukaryotic and archaeal 7S RNAs have very similar secondary structures, as represented by this family. Eight helical elements fold into the Alu and S domains, separated by a long linker region [1,2]. The Alu domain is thought to mediate the peptide chain elongation retardation function of the SRP [1]. The universally conserved helix which interacts with the SRP54 M domain mediates signal sequence recognition [2,3]. In eukaryotes and archaea, the SRP19-helix 6 complex is thought to be involved in SRP assembly and stabilises helix 8 for SRP54 binding [1]. The Signal Recognition Particle Database (SRPDB) [4] provides compilations of SRP components, with phylogenetic data and structural illustrations. Many sequences below the threshold for this family are clearly closely related, but are most likely to be SRP RNA derived pseudogenes. The human genome in particular is known to contain a large amount of SRP RNA related sequence, including Alu repeats. While the threshold of this family is set high so as to minimise the number of hits to such regions, it is likely that some remain.

View fRNAdb secondary structures for ENSG00000277385

Additional gene information for ENSG00000277385 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for ENSG00000277385 Gene

Genomics for ENSG00000277385 Gene

GeneHancer (GH) Regulatory Elements for ENSG00000277385 Gene

Promoters and enhancers for ENSG00000277385 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J038282 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.7 -2.8 -2820 3.3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF121 ZFP91 FOS MAFF PLA2G6 KCNJ4 KDELR3 PICK1 TMEM184B ANKRD54 ENSG00000277385 CSNK1E
GH22J038308 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 -32.9 -32948 11.9 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CSNK1E DDX17 JOSD1 TMEM184B PICK1 MAFF KCNJ4 KDELR3 SNORD83B PLA2G6
GH22J038294 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 0.4 -19.7 -19653 12.5 HDGF PKNOX1 ARID4B SIN3A IRF4 BRCA1 GLIS2 ZNF143 ATF7 FOS CSNK1E PLA2G6 GGA1 TMEM184B BAIAP2L2 PICK1 SOX10 POLR2F MAFF KCNJ4
GH22J038278 Enhancer 0.9 Ensembl ENCODE 0.7 +2.3 2289 0.4 USF1 FOXA2 NFIB ZSCAN4 ZNF335 NFYB FOS L3MBTL2 NFYA NFYC ENSG00000277385 GC22P038274
GH22J038289 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 0.4 -10.3 -10252 4.7 CTCF HDGF KLF1 ZSCAN4 KLF17 ZIC2 ZFHX2 POLR2A PATZ1 SCRT2 CSNK1E PLA2G6 BAIAP2L2 MAFF KDELR3 KCNJ4 PICK1 GALR3 ENSG00000277385 TPTEP2-CSNK1E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENSG00000277385 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ENSG00000277385 Gene

Genomic Locations for ENSG00000277385 Gene
chr22:38,281,028-38,281,289
(GRCh38/hg38)
Size:
262 bases
Orientation:
Minus strand
chr22:37,758,668-37,758,698
(GRCh37/hg19)
Size:
31 bases
Orientation:
Minus strand

Genomic View for ENSG00000277385 Gene

Genes around ENSG00000277385 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000277385 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000277385 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

ORGUL Member Location for ENSG00000277385 Gene

ORGUL Member Location for ENSG00000277385 gene

No data available for RefSeq DNA sequence for ENSG00000277385 Gene

Proteins for ENSG00000277385 Gene

Post-translational modifications for ENSG00000277385 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ENSG00000277385 Gene

Domains & Families for ENSG00000277385 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ENSG00000277385 Gene

Function for ENSG00000277385 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000277385 Gene

Localization for ENSG00000277385 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ENSG00000277385 Gene

Pathways & Interactions for ENSG00000277385 Gene

SuperPathways for ENSG00000277385 Gene

No Data Available

Interacting Proteins for ENSG00000277385 Gene

Gene Ontology (GO) - Biological Process for ENSG00000277385 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000277385 Gene

Drugs & Compounds for ENSG00000277385 Gene

No Compound Related Data Available

Transcripts for ENSG00000277385 Gene

fRNAdb Secondary structures for ENSG00000277385 Gene

  • RF00017;Metazoa_SRP;AL020993.1/57867-57606

mRNA/cDNA for ENSG00000277385 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000277385 Gene

No ASD Table

Relevant External Links for ENSG00000277385 Gene

GeneLoc Exon Structure for
ENSG00000277385

Expression for ENSG00000277385 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000277385 Gene

Orthologs for ENSG00000277385 Gene

Evolution for ENSG00000277385 Gene

ENSEMBL:
Gene Tree for ENSG00000277385 (if available)
TreeFam:
Gene Tree for ENSG00000277385 (if available)

No data available for Orthologs for ENSG00000277385 Gene

Paralogs for ENSG00000277385 Gene

No data available for Paralogs for ENSG00000277385 Gene

Variants for ENSG00000277385 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000277385 Gene

Disorders for ENSG00000277385 Gene

No disorders were found for ENSG00000277385 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000277385 Gene

Publications for ENSG00000277385 Gene

  1. SRPDB: Signal Recognition Particle Database. (PMID: 12520023) Rosenblad MA … Samuelsson T (Nucleic acids research 2003) 1
  2. Towards the structure of the mammalian signal recognition particle. (PMID: 11839493) Wild K … Cusack S (Current opinion in structural biology 2002) 1
  3. Prediction of signal recognition particle RNA genes. (PMID: 12140321) Regalia M … Samuelsson T (Nucleic acids research 2002) 1
  4. Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. (PMID: 11243816) Batey RT … Doudna JA (Journal of molecular biology 2001) 1
  5. Crystal structure of the ribonucleoprotein core of the signal recognition particle. (PMID: 10678824) Batey RT … Doudna JA (Science (New York, N.Y.) 2000) 1

Products for ENSG00000277385 Gene

Sources for ENSG00000277385 Gene

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