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Aliases for ENSG00000276366 Gene

Subcategory (RNA class) for ENSG00000276366 Gene

snoRNA

Quality Score for this RNA gene is

15

Aliases for ENSG00000276366 Gene

  • RF00012 5

External Ids for ENSG00000276366 Gene

ORGUL Members for ENSG00000276366 Gene

Summaries for ENSG00000276366 Gene

GeneCards Summary for ENSG00000276366 Gene

ENSG00000276366 is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for ENSG00000276366 Gene - the ORGUL cluster for this gene includes several descriptions:

  • U3_snoRNA: U3 snoRNA is a member of the box C/D class of small nucleolar RNAs. The U3 snoRNA secondary structure is characterised by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localization, stability and hypermethylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA.

  • Small nucleolar RNA U3: Small nucleolar RNAs (snoRNAs) are involved in the processing and modification of rRNA in the nucleolus. There are two main classes of snoRNAs: the box C/D class, and the box H/ACA class. U3 snoRNA is a member of the box C/D class. Indeed, the box C/D element is a subset of the six short sequence elements found in all U3 snoRNAs, namely boxes A, A', B, C, C', and D. The U3 snoRNA secondary structure is characterised by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localisation, stability and hyper-methylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA.

View fRNAdb secondary structures for ENSG00000276366

Additional gene information for ENSG00000276366 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for ENSG00000276366 Gene

Genomics for ENSG00000276366 Gene

GeneHancer (GH) Regulatory Elements for ENSG00000276366 Gene

Promoters and enhancers for ENSG00000276366 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240254 Enhancer 1.7 VISTA Ensembl ENCODE dbSUPER 0.3 -31.1 -31065 6.9 MLX ARID4B DMAP1 ZNF48 ETS1 SLC30A9 RXRA SP5 NFYC MXD4 LOC105373968 GPC1 ENSG00000276366
GH02J240368 Enhancer 1.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 0.2 +82.7 82661 7.1 SIN3A RARA EGR1 FOS RXRA USF2 CEBPB REST NR2F2 SP1 GPC1 LOC102723825 ENSG00000276366
GH02J240387 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.2 +98.7 98677 1.8 HDAC1 PKNOX1 TAF9B SIN3A RAD21 ZBTB40 FOS ATF7 NR2F2 SP1 GPC1 LOC102723825 ENSG00000276366
GH02J240319 Enhancer 0.8 Ensembl ENCODE 0.3 +31.1 31109 2.2 ZNF777 BACH1 ZIC2 NR2F2 GLIS2 ZFHX2 EGR1 FOS EGR2 PRR21 ENSG00000276366 LOC102723825
GH02J240293 Enhancer 0.3 ENCODE 0.7 +4.6 4586 1 ZIC2 GPC1 ENSG00000276366 LOC102723825
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ENSG00000276366 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ENSG00000276366 Gene

Genomic Locations for ENSG00000276366 Gene
chr2:240,289,216-240,289,443
(GRCh38/hg38)
Size:
228 bases
Orientation:
Plus strand

Genomic View for ENSG00000276366 Gene

Genes around ENSG00000276366 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000276366 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000276366 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

ORGUL Member Location for ENSG00000276366 Gene

ORGUL Member Location for ENSG00000276366 gene

No data available for RefSeq DNA sequence for ENSG00000276366 Gene

Proteins for ENSG00000276366 Gene

Post-translational modifications for ENSG00000276366 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ENSG00000276366 Gene

Domains & Families for ENSG00000276366 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ENSG00000276366 Gene

Function for ENSG00000276366 Gene

Phenotypes From GWAS Catalog for ENSG00000276366 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000276366 Gene

Localization for ENSG00000276366 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ENSG00000276366 Gene

Pathways & Interactions for ENSG00000276366 Gene

SuperPathways for ENSG00000276366 Gene

No Data Available

Interacting Proteins for ENSG00000276366 Gene

Gene Ontology (GO) - Biological Process for ENSG00000276366 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000276366 Gene

Drugs & Compounds for ENSG00000276366 Gene

No Compound Related Data Available

Transcripts for ENSG00000276366 Gene

fRNAdb Secondary structures for ENSG00000276366 Gene

  • RF00012;U3;DAAB012498018.1/435-208

mRNA/cDNA for ENSG00000276366 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000276366 Gene

No ASD Table

Relevant External Links for ENSG00000276366 Gene

GeneLoc Exon Structure for
ENSG00000276366

Expression for ENSG00000276366 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000276366 Gene

Orthologs for ENSG00000276366 Gene

Evolution for ENSG00000276366 Gene

ENSEMBL:
Gene Tree for ENSG00000276366 (if available)
TreeFam:
Gene Tree for ENSG00000276366 (if available)

No data available for Orthologs for ENSG00000276366 Gene

Paralogs for ENSG00000276366 Gene

No data available for Paralogs for ENSG00000276366 Gene

Variants for ENSG00000276366 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000276366 Gene

Disorders for ENSG00000276366 Gene

No disorders were found for ENSG00000276366 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000276366 Gene

Publications for ENSG00000276366 Gene

  1. Nuclear retention elements of U3 small nucleolar RNA. (PMID: 10567566) Speckmann W … Terns MP (Molecular and cellular biology 1999) 1
  2. The uRNA database. (PMID: 9016512) Zwieb C (Nucleic acids research 1997) 1

Products for ENSG00000276366 Gene

Sources for ENSG00000276366 Gene

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