Aliases for ENSG00000268861 Gene

Aliases for ENSG00000268861 Gene

  • Rho/Rac Guanine Nucleotide Exchange Factor 18 5
  • Rho Guanine Nucleotide Exchange Factor 18 13
  • AC008878.3 5

External Ids for ENSG00000268861 Gene

Previous GeneCards Identifiers for ENSG00000268861 Gene

  • GC19P007446

Summaries for ENSG00000268861 Gene

GeneCards Summary for ENSG00000268861 Gene

ENSG00000268861 is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF18.

Additional gene information for ENSG00000268861 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENSG00000268861 Gene

Genomics for ENSG00000268861 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENSG00000268861 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENSG00000268861 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ENSG00000268861 Gene

Genomic Locations for ENSG00000268861 Gene
chr19:7,382,834-7,470,241
(GRCh38/hg38)
Size:
87,408 bases
Orientation:
Plus strand
chr19:7,445,850-7,535,131
(GRCh37/hg19)
Size:
89,282 bases
Orientation:
Plus strand

Genomic View for ENSG00000268861 Gene

Genes around ENSG00000268861 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000268861 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000268861 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000268861 Gene

Proteins for ENSG00000268861 Gene

  • Protein details for ENSG00000268861 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A590UK10-A0A590UK10_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 18
    Protein Accession:
    A0A590UK10

    Protein attributes for ENSG00000268861 Gene

    Size:
    1089 amino acids
    Molecular mass:
    122104 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ENSG00000268861 Gene

Post-translational modifications for ENSG00000268861 Gene

No Post-translational modifications

Other Protein References for ENSG00000268861 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000268861 Gene

Domains & Families for ENSG00000268861 Gene

Gene Families for ENSG00000268861 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ENSG00000268861 Gene

genes like me logo Genes that share domains with ENSG00000268861: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ENSG00000268861 Gene

Function for ENSG00000268861 Gene

Phenotypes From GWAS Catalog for ENSG00000268861 Gene

Gene Ontology (GO) - Molecular Function for ENSG00000268861 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ENSG00000268861: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000268861 Gene

Localization for ENSG00000268861 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ENSG00000268861 Gene

Pathways & Interactions for ENSG00000268861 Gene

PathCards logo

SuperPathways for ENSG00000268861 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENSG00000268861 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ENSG00000268861: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for ENSG00000268861 Gene

Drugs & Compounds for ENSG00000268861 Gene

No Compound Related Data Available

Transcripts for ENSG00000268861 Gene

mRNA/cDNA for ENSG00000268861 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000268861 Gene

No ASD Table

Relevant External Links for ENSG00000268861 Gene

GeneLoc Exon Structure for
ENSG00000268861

Expression for ENSG00000268861 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000268861 Gene

Orthologs for ENSG00000268861 Gene

This gene was present in the common ancestor of animals.

Orthologs for ENSG00000268861 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 88 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Arhgef18 31
  • 80 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 74 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 70 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 70 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 57 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii arhgef18b 31
  • 47 (a)
ManyToMany
arhgef18a 31
  • 40 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG10188 31
  • 19 (a)
OneToMany
Species where no ortholog for ENSG00000268861 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ENSG00000268861 Gene

ENSEMBL:
Gene Tree for ENSG00000268861 (if available)
TreeFam:
Gene Tree for ENSG00000268861 (if available)

Paralogs for ENSG00000268861 Gene

Paralogs for ENSG00000268861 Gene

genes like me logo Genes that share paralogs with ENSG00000268861: view

Variants for ENSG00000268861 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000268861 Gene

Disorders for ENSG00000268861 Gene

Additional Disease Information for ENSG00000268861

No disorders were found for ENSG00000268861 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENSG00000268861 Gene

Publications for ENSG00000268861 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 13

No data available for Mastermind for ENSG00000268861 Gene

Products for ENSG00000268861 Gene

Sources for ENSG00000268861 Gene