Aliases for ENSG00000268643 Gene

Aliases for ENSG00000268643 Gene

  • Protein Kinase Domain-Containing Protein 13
  • Novel Protein 5
  • AC006486.1 5

External Ids for ENSG00000268643 Gene

Previous GeneCards Identifiers for ENSG00000268643 Gene

  • GC19M042738

Summaries for ENSG00000268643 Gene

GeneCards Summary for ENSG00000268643 Gene

ENSG00000268643 is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is GSK3A.

Additional gene information for ENSG00000268643 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENSG00000268643 Gene

Genomics for ENSG00000268643 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ENSG00000268643 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J042249 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.9 1876 8 SP1 HNRNPL CREB1 ATF7 PRDM10 ZNF629 RFX1 IKZF1 KDM1A ZNF692 ENSG00000268643 ERF lnc-GSK3A-2 ZNF526 HNRNPUL1 ZNF574 CCDC97 CIC POU2F2 MEGF8
GH19J043147 Enhancer 0.7 Ensembl ENCODE 5.4 -893.9 -893883 2.8 PRDM10 ZNF747 ZBTB10 ZNF316 MAFK JUND ZBTB49 REST ZNF280D ZNF280C PSG4 ZNF45 ZNF526 ZNF225 XRCC1 ZNF155 PSG5 ZNF230 CIC ZNF224
GH19J042241 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +10.8 10792 7.5 ZNF221 SP1 HNRNPL CREB1 CTCF TEAD4 PRDM10 ZNF629 REST RFX1 ENSG00000279539 GSK3A lnc-ERF-1 ZNF526 HNRNPUL1 CCDC97 RPS19 ZNF574 CIC GRIK5
GH19J042258 Enhancer 0.7 ENCODE 0.7 -3.6 -3587 1.1 JUND POLR2A EGR1 FOSL1 FOSL2 SAP130 ZNF384 SUPT5H DPF2 ATF3 POU2F2 MEGF8 ENSG00000268643 CIC
GH19J042259 Enhancer 0.6 Ensembl ENCODE 0.7 -4.6 -4569 0.6 PKNOX1 EGR1 FOXA2 TBP DACH1 POU2F2 GRIK5 MEGF8 ENSG00000268643 CIC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ENSG00000268643 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ENSG00000268643 Gene

Genomic Locations for ENSG00000268643 Gene
chr19:42,234,583-42,255,132
(GRCh38/hg38)
Size:
20,550 bases
Orientation:
Minus strand
chr19:42,738,735-42,759,284
(GRCh37/hg19)
Size:
20,550 bases
Orientation:
Minus strand

Genomic View for ENSG00000268643 Gene

Genes around ENSG00000268643 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ENSG00000268643 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ENSG00000268643 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for ENSG00000268643 Gene

Proteins for ENSG00000268643 Gene

  • Protein details for ENSG00000268643 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    M0QYV0-M0QYV0_HUMAN
    Recommended name:
    Protein kinase domain-containing protein
    Protein Accession:
    M0QYV0

    Protein attributes for ENSG00000268643 Gene

    Size:
    167 amino acids
    Molecular mass:
    19274 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ENSG00000268643 Gene

Post-translational modifications for ENSG00000268643 Gene

No Post-translational modifications

Other Protein References for ENSG00000268643 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ENSG00000268643 Gene

Domains & Families for ENSG00000268643 Gene

Gene Families for ENSG00000268643 Gene

Unknown:
  • Belongs to the protein kinase superfamily.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ENSG00000268643 Gene

genes like me logo Genes that share domains with ENSG00000268643: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ENSG00000268643 Gene

Function for ENSG00000268643 Gene

Phenotypes From GWAS Catalog for ENSG00000268643 Gene

Gene Ontology (GO) - Molecular Function for ENSG00000268643 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ENSG00000268643: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000268643 Gene

Localization for ENSG00000268643 Gene

Gene Ontology (GO) - Cellular Components for ENSG00000268643 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IBA --
GO:0030424 axon IBA --
genes like me logo Genes that share ontologies with ENSG00000268643: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ENSG00000268643 Gene

Pathways & Interactions for ENSG00000268643 Gene

PathCards logo

SuperPathways for ENSG00000268643 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ENSG00000268643 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IBA --
GO:0008286 insulin receptor signaling pathway IBA --
GO:0010975 regulation of neuron projection development IBA --
GO:0032007 negative regulation of TOR signaling IBA --
genes like me logo Genes that share ontologies with ENSG00000268643: view

No data available for Pathways by source and SIGNOR curated interactions for ENSG00000268643 Gene

Drugs & Compounds for ENSG00000268643 Gene

No Compound Related Data Available

Transcripts for ENSG00000268643 Gene

mRNA/cDNA for ENSG00000268643 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ENSG00000268643 Gene

No ASD Table

Relevant External Links for ENSG00000268643 Gene

GeneLoc Exon Structure for
ENSG00000268643

Expression for ENSG00000268643 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000268643 Gene

Orthologs for ENSG00000268643 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ENSG00000268643 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GSK3A 31
  • 33 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 32 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Gsk3a 31
  • 32 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia GSK3A 31
  • 32 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii gsk3ab 31
  • 33 (a)
ManyToMany
gsk3aa 31
  • 31 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta gskt 31
  • 20 (a)
ManyToMany
sgg 31
  • 11 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea gsk-3 31
  • 32 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM11 31
  • 22 (a)
ManyToMany
MRK1 31
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToMany
Species where no ortholog for ENSG00000268643 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for ENSG00000268643 Gene

ENSEMBL:
Gene Tree for ENSG00000268643 (if available)
TreeFam:
Gene Tree for ENSG00000268643 (if available)

Paralogs for ENSG00000268643 Gene

Paralogs for ENSG00000268643 Gene

genes like me logo Genes that share paralogs with ENSG00000268643: view

Variants for ENSG00000268643 Gene

Variation tolerance for ENSG00000268643 Gene

Gene Damage Index Score: 5.38; 71.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Additional Variant Information for ENSG00000268643 Gene

Disorders for ENSG00000268643 Gene

Additional Disease Information for ENSG00000268643

No disorders were found for ENSG00000268643 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ENSG00000268643 Gene

Publications for ENSG00000268643 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 13

No data available for Mastermind for ENSG00000268643 Gene

Products for ENSG00000268643 Gene

Sources for ENSG00000268643 Gene