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Aliases for ENSG00000268465 Gene
External Ids for ENSG00000268465 Gene
- Ensembl: ENSG00000268465
- UniProtKB: M0QZ92
Previous GeneCards Identifiers for ENSG00000268465 Gene
- GC19P048969
Summaries for ENSG00000268465 Gene
GeneCards Summary for ENSG00000268465 Gene
ENSG00000268465 is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ARF guanyl-nucleotide exchange factor activity. An important paralog of this gene is CYTH2.
Additional gene information for ENSG00000268465 Gene
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ENSG00000268465 Gene
Genomics for ENSG00000268465 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ENSG00000268465 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J048468 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.7 | +3.7 | 3726 | 3.1 | SP1 CREB1 PRDM10 TFE3 RFX1 ZNF692 POLR2A BACH1 FOS JUND | CYTH2 ENSG00000268530 lnc-LMTK3-5 SNRNP70 BICRA GRWD1 PIH1D1 NOP53-AS1 ALDH16A1 NOP53 | |
| GH19J048462 | Enhancer | 0.7 | ENCODE | 0.7 | -3.3 | -3338 | 0.2 | SIX5 ZNF143 NR2C1 POLR2A EGR1 DEAF1 NR2C2 YY1 HCFC1 IRF2 | SYNGR4 TMEM143 LMTK3 ENSG00000268465 piR-33588 KCNJ14 | |
| GH19J048471 | Enhancer | 0.2 | FANTOM5 | 0.4 | +5.8 | 5826 | 0.1 | ENSG00000268530 CYTH2 ENSG00000268465 lnc-KCNJ14-3 LMTK3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ENSG00000268465 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for ENSG00000268465 Gene
Genomic Locations for ENSG00000268465 Gene
- chr19:48,465,837-48,472,431
- (GRCh38/hg38)
- Size:
- 6,595 bases
- Orientation:
- Plus strand
- chr19:48,969,094-48,975,688
- (GRCh37/hg19)
- Size:
- 6,595 bases
- Orientation:
- Plus strand
Genomic View for ENSG00000268465 Gene
Genes around ENSG00000268465 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by Ensembl
ENSG00000268465 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
No data available for RefSeq DNA sequence for ENSG00000268465 Gene
Proteins for ENSG00000268465 Gene
-
Protein details for ENSG00000268465 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- M0QZ92-M0QZ92_HUMAN
- Recommended name:
- SEC7 domain-containing protein
- Protein Accession:
- M0QZ92
Protein attributes for ENSG00000268465 Gene
- Size:
- 97 amino acids
- Molecular mass:
- 11308 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ENSG00000268465 Gene
No Post-translational modifications
Other Protein References for ENSG00000268465 Gene
- ENSEMBL proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ENSG00000268465
- Origene Custom Protein Services for ENSG00000268465
No data available for DME Specific Peptides for ENSG00000268465 Gene
Domains & Families for ENSG00000268465 Gene
Gene Families for ENSG00000268465 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ENSG00000268465 Gene
- InterPro:
- ProtoNet:
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ENSG00000268465 Gene
Function for ENSG00000268465 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005086 | ARF guanyl-nucleotide exchange factor activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Browse CRISPR knockouts for ENSG00000268465
miRNA Products
Inhibitory RNA Products
Clone Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ENSG00000268465 Gene
Localization for ENSG00000268465 Gene
- Cytosol (1)
- Plasma membrane (1)
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ENSG00000268465 Gene
Pathways & Interactions for ENSG00000268465 Gene
Interacting Proteins for ENSG00000268465 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| ENSG00000272822 | ||
| AKT1 | ||
| ANKHD1 | ||
| ANKHD1-EIF4EBP3 | ||
| ANKRD28 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032012 | regulation of ARF protein signal transduction | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ENSG00000268465 Gene
Transcripts for ENSG00000268465 Gene
mRNA/cDNA for ENSG00000268465 Gene
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000595676 443 nts (view in UCSC)
CRISPR Products
- Browse CRISPR knockouts for ENSG00000268465
miRNA Products
Inhibitory RNA Products
Clone Products
Relevant External Links for ENSG00000268465 Gene
- GeneLoc Exon Structure for
- ENSG00000268465
Expression for ENSG00000268465 Gene
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ENSG00000268465 Gene
Orthologs for ENSG00000268465 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | CYTH2 31 |
|
OneToMany | |
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | CYTH2 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | step 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | grp-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC7 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8851 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for ENSG00000268465 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Paralogs for ENSG00000268465 Gene
Variants for ENSG00000268465 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Additional Variant Information for ENSG00000268465 Gene
Disorders for ENSG00000268465 Gene
No disorders were found for ENSG00000268465 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for ENSG00000268465 Gene
Publications for ENSG00000268465 Gene
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 13
No data available for Mastermind for ENSG00000268465 Gene
Products for ENSG00000268465 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ENSG00000268465
- Origene Custom Protein Services for ENSG00000268465
- Browse OriGene Inhibitory RNA Products For ENSG00000268465
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for ENSG00000268465
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ENSG00000268465
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for ENSG00000268465
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for ENSG00000268465
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ENSG00000268465
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for ENSG00000268465
Sources for ENSG00000268465 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB